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Vishakhapatnam, India

Gandhi Institute of Technology and Management known as GITAM University is an educational institution in India. It was previously known as GITAM College, affiliated to Andhra University. Established in 1980, it was conferred the status of deemed university in 2007. It was the first private engineering institute in Andhra Pradesh to receive university status. GITAM is planning on receiving an ABET International Accreditation. The university has three picturesque campuses – its main campus at Visakhapatnam spreads over 100 acres, and the other two campuses are at Hyderabad and Bangalore. Wikipedia.

Srinivasa Rao R.,Jawaharlal Nehru Technological University Anantapur | Narasimham S.V.L.,University of Hyderabad | Ramalinga Raju M.,Jawaharlal Nehru Technological University Anantapur | Srinivasa Rao A.,Gandhi Institute of Technology and Management
IEEE Transactions on Power Systems | Year: 2011

Electrical distribution network reconfiguration is a complex combinatorial optimization process aimed at finding a radial operating structure that minimizes the system power loss while satisfying operating constraints. In this paper, a harmony search algorithm (HSA) is proposed to solve the network reconfiguration problem to get optimal switching combination in the network which results in minimum loss. The HSA is a recently developed algorithm which is conceptualized using the musical process of searching for a perfect state of harmony. It uses a stochastic random search instead of a gradient search which eliminates the need for derivative information. Simulations are carried out on 33- and 119-bus systems in order to validate the proposed algorithm. The results are compared with other approaches available in the literature. It is observed that the proposed method performed well compared to the other methods in terms of the quality of solution. © 2011 IEEE.

Krishna B.T.,Gandhi Institute of Technology and Management
Signal Processing | Year: 2011

Studies on analysis, design and applications of analog and digital differentiators and integrators of fractional order is the main objective of this paper. Time and frequency domain analysis, different ways of realization of fractance device is presented. Active and passive realization of fractance device of order 12 using continued fraction expansion is carried out. Later, time and frequency domain analysis of fractance based circuits is considered. The variations of rise time, peak time, settling time, time constant, percent overshoot with respect to fractional order α is presented. Digital differentiators and integrators of fractional order can be obtained by using direct and indirect discretization techniques. The s to z transforms used for this purpose are revisited. In this paper by using indirect discretization technique fractional order differentiators and integrators of order 12 and 14 are designed. These digital differentiators and integrators are implemented in real time using TMS320C6713 DSP processor and tested using National instruments education laboratory virtual instrumentation system (NIELVIS). The designed fractional order differentiators have been used for the detection of QRS sequences as well as the occurrence of Sino Atrial Rhythms in an ECG signal and also for the detection of edges in an image. The obtained results are in comparison with the conventional techniques. © 2010 Elsevier B.V. All rights reserved.

Devendra B.N.,Gandhi Institute of Technology and Management
Asian Pacific journal of tropical medicine | Year: 2012

To compare the efficacy for phytochemical, antibacterial and antioxidant activities of petroleum ether, chloroform, ethanol, and aqueous extracts of in vitro propagated plants and field grown plants of Crotalaria sps., for against five human pathogens. The preliminary phytochemistry, antimicrobial and antioxidant activities were evaluated using disc diffusion and DPPH radical scavenging methods. The ethanolic extract of in vitro raised Crotalaria retusa (C. retusa) was effective on tested microorganisms and optimal ZOI values of 38 mm was obtained against Pseudomonas aeruginosa (P. aeruginosa). The optimal concentration (IC50) required for 50% inhibition of the DPPH radical scavenging was 57.6 μ g/mL obtained for ethanolic extract of in vitro propagated C. retusa. The in vitro propagated C. retusa has significant pharmacological activities while the Crotalaria prostrate (C. prostrate) and Crotalaria medicaginea (C. medicaginea) has low pharmacological activites. It was cleared that ethanolic extract of in vitro regenerated plants was most effective. These findings indicate compounds isolated from ethanolic extracts of Crotalaria sps., possesses pharmacological properties and potential to develop natural compounds based pharmaceutical products. The IC(50) values for ethanolic extracts of Crotalaria sps. was evaluated through the Linear regression analysis (R(2) ≤ 1). Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Rajesh V.,Gandhi Institute of Technology and Management
Journal of Engineering Physics and Thermophysics | Year: 2012

An exact solution to the problem of flow due to the impulsive motion of an infinite vertical plate in its own plane in the presence of i) species concentration, ii) Newtonian heating at the plate, and iii) first-order chemical reaction has been derived by the Laplace transform technique. The influence of various parameters entering into the problem on the velocity field and skin friction for both air and water in the cases of both cooling and heating of the plate is discussed. © 2012 Springer Science+Business Media, Inc.

Prakash C.R.,Jawaharlal Nehru Technological University | Raja S.,Gandhi Institute of Technology and Management
Mini-Reviews in Medicinal Chemistry | Year: 2012

Kinases are probably the most important signaling enzymes, which represent about 20% of the druggable genome. Currently, more than 150 kinases are known. So, kinase inhibition therapy has become a very important area of drug research since most of our diseases are related to intra or intercellular signaling by kinases. Indole alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, antitumor. Among this chemical family, indolinone displays very promising antitumor properties by inhibiting various kinase families. These small molecules have a low molecular weight and most of them bind to protein kinases competing with ATP for the ATP-binding site. This review focuses on the indolinone based drugs approved for the treatment of cancer, drugs under clinical trial and then chemical diversity of various synthetic analogues of indolinone and their metabolites as various kinase inhibitors. This review also focused on structural activity relationship (SAR), mechanisms of action and biological targets through which indolinone and its derivatives display their antitumor activity. © 2012 Bentham Science Publishers.

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