Gandhi Institute of Technology and Management
Vishakhapatnam, India

Gandhi Institute of Technology and Management known as GITAM University is an educational institution in India. It was previously known as GITAM College, affiliated to Andhra University. Established in 1980, it was conferred the status of deemed university in 2007. It was the first private engineering institute in Andhra Pradesh to receive university status. GITAM is planning on receiving an ABET International Accreditation. The university has three picturesque campuses – its main campus at Visakhapatnam spreads over 100 acres, and the other two campuses are at Hyderabad and Bangalore. Wikipedia.

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Parhi R.,Gandhi Institute of Technology and Management | Suresh P.,Gandhi Institute of Technology and Management
Current Drug Discovery Technologies | Year: 2012

In the present scenario, most of the developed and new discovered drugs are posing real challenge to the formulation scientists due to their poor aqueous solubility which in turn is responsible for poor bioavailability. One of the approach to overcome above problem is the packaging of the drug in to particulate carrier system. Among various carriers, lipid emerged as very attractive candidate because of its unique property of enhancing the bioavailability of poorly water soluble drugs. Solid lipid, one of the physical forms of lipid, is used to formulate nanoparticles, popularly known as Solid lipid nanoparticles (SLNs), as an alternative carrier system to emulsions, liposomes and polymeric micro- and nano-particles. SLNs combine advantages of the traditional systems but avoid some of their major disadvantages. This paper reviews numerous production techniques for SLNs along with their advantages and disadvantages. Special attention is paid to the characterization of the SLNs by using various analytical tools. It also emphasizes on physical state of lipid (supercooled melts, different lipid modifications). © 2012 Bentham Science Publishers.

Kummitha O.R.,Gandhi Institute of Technology and Management
International Journal of Hydrogen Energy | Year: 2017

In this research paper numerical analysis of scramjet combustor has been carried out with different passive techniques to improve the mixing efficiency of supersonic airstream and hydrogen fuel. The actual mixing rate of air and hydrogen is very less because of the less resident time of supersonic air in the combustion chamber. The mixing of hydrogen fuel with supersonic airstream is greatly affected by the development of shock waves, streamline vortices and shear layer of mixing in the flow filed of the combustor. The experimental DLR scramjet model has been considered as a reference and standard model to compare and validate the numerical results. In this research article three different passive techniques are considered and defined as a uniform zigzag surface, small parabola shape cavities and bumps at lower wall of the combustion chamber. The computational scramjet domains are modeled as modified versions of DLR scramjet by the implementation of passive techniques. Two dimensional numerical analyses are carried out by solving Favre-averaged Navier-Stokes governing equations and SST k-ω turbulence model along with finite rate/eddy dissipation combustion chemistry turbulence model is also considered for accurate analysis of streamline vortices, shear layer development and shock waves. From the numerical results of various passive techniques it is found that the development or creation of gradient fluxes of flow property are increased. By incorporating these types of surfaces at combustor bottom wall it is identified that the growth rate of mixing layer has been increased along the flow field of combustor. Hence the more amount of hydrogen fuel being carried out by streamline vortices and velocity gradients or shock waves and this phenomenon improve the mixing efficiency of scramjet combustor and also it leads to increase in combustion efficiency. From the numerical analysis results and discussion it is to be concluded that highest mixing and combustion efficiency is identified with a uniform zigzag (wavy wall) surface combustor wall design. © 2017 Hydrogen Energy Publications LLC.

Naveen Kumar V.,Gandhi Institute of Technology and Management | Srinivas V.S.S.,Gandhi Institute of Technology and Management
Materials Today: Proceedings | Year: 2016

The present work aims at enhancement of thermal stability of natural rubber. Natural rubber composite was prepared by two step method with boron nitride Nano particles as particulate fillers. Nano fluid was used in preparation of polymer composite. The boron nitride particles were added in various wt% proportions for the preparation of composite. The addition of the filler material into latex rubber matrix was found to be very effective through two step method. Filler particles interaction was observed through peaks in Fourier Transmission and infrared spectroscopy. Thermo gravimetric analysis observations reveal the thermal stability of composite. © 2016 Elsevier Ltd. All rights reserved.

Reddy Kummitha O.,Gandhi Institute of Technology and Management
Materials Today: Proceedings | Year: 2016

In this paper an attempt has been made to analyze the core flow dynamics of solid rocket motor with large eddy simulation viscous model. This present work has been carried out to achieve a comprehensive understanding of dominant issues in the combustion of solid propellant. The numerical analysis of solid rocket motor core flow has been analyzed by using the conservation equations of mass, momentum and energy, turbulence closure is also obtained by using smagorinsky's subgrid scale modeling. All the governing equations and the associated boundary conditions are numerically solved by means of fully coupled implicit scheme capable of treating compressible flows over a wide range of Mach number. The solid rocket motor core flow computational domain and meshing was created by using GAMBIT software, and the numerical analysis of core flow has been performed by using FLUENT 6.3. From this numerical analysis it is to be observed that the large eddy simulation model gives the variation of viscosity along the length of core flow and how it affects the flow parameters. © 2016 Elsevier Ltd. All rights reserved.

Dewanji P.,Gandhi Institute of Technology and Management
International Journal of Mechanical Engineering and Technology | Year: 2016

Gear is the one of the important machine element in the mechanical power transmission system. Spur gear is most basic gear used to transmit power between parallel shafts. Spur gear generally fails by bending failure or contact failure. This paper analyses the bending stresses characteristics of an involute spur gear tooth under static loading conditions. The tooth profile is generated using Catia and the analysis is carried out by Finite element method using ANSYS software. The stresses at the tooth root are evaluated analytically using existing theoretical models. The theoretical and FEM results are compared. The results obtained theoretically are in good agreement with those obtained from software. Also an attempt is made to introduce Stress and displacement characteristics of tooth under dynamic loading conditions. © IAEME Publication.

Dewanji P.,Gandhi Institute of Technology and Management
International Journal of Mechanical Engineering and Technology | Year: 2016

The present paper deals with the Design and analysis of composite leaf spring. The analysis has been conducted by using ANSYS-12 software with the help of static structural tool. A threelayer composite leaf spring with full length leave made of E-Glass/epoxy composite material has been used. The results of Conventional steel leaf spring have been compared with the present results obtained for composite leaf spring. E-glass/epoxy material is better in strength and lighter in weight as compared to the conventional steel leaf spring. Lot of work has been done and is shown in this paper in an interest of justifying the title of the paper. © IAEME Publication.

Rajesh V.,Gandhi Institute of Technology and Management
Journal of Engineering Physics and Thermophysics | Year: 2012

An exact solution to the problem of flow due to the impulsive motion of an infinite vertical plate in its own plane in the presence of i) species concentration, ii) Newtonian heating at the plate, and iii) first-order chemical reaction has been derived by the Laplace transform technique. The influence of various parameters entering into the problem on the velocity field and skin friction for both air and water in the cases of both cooling and heating of the plate is discussed. © 2012 Springer Science+Business Media, Inc.

Krishna B.T.,Gandhi Institute of Technology and Management
Signal Processing | Year: 2011

Studies on analysis, design and applications of analog and digital differentiators and integrators of fractional order is the main objective of this paper. Time and frequency domain analysis, different ways of realization of fractance device is presented. Active and passive realization of fractance device of order 12 using continued fraction expansion is carried out. Later, time and frequency domain analysis of fractance based circuits is considered. The variations of rise time, peak time, settling time, time constant, percent overshoot with respect to fractional order α is presented. Digital differentiators and integrators of fractional order can be obtained by using direct and indirect discretization techniques. The s to z transforms used for this purpose are revisited. In this paper by using indirect discretization technique fractional order differentiators and integrators of order 12 and 14 are designed. These digital differentiators and integrators are implemented in real time using TMS320C6713 DSP processor and tested using National instruments education laboratory virtual instrumentation system (NIELVIS). The designed fractional order differentiators have been used for the detection of QRS sequences as well as the occurrence of Sino Atrial Rhythms in an ECG signal and also for the detection of edges in an image. The obtained results are in comparison with the conventional techniques. © 2010 Elsevier B.V. All rights reserved.

Kandra P.,Gandhi Institute of Technology and Management | Kalangi H.P.J.,Andhra University
Applied Microbiology and Biotechnology | Year: 2015

Recent advances have been made in cancer chemotherapy through the development of conjugates for anticancer drugs. Many drugs have problems of poor stability, water insolubility, low selectivity, high toxicity, and side effects. Most of the chitosan nanoparticles showed to be good drug carriers because of their biocompatibility, biodegradability, and it can be readily modified. The anticancer drug with chitosan nanoparticles displays efficient anticancer effects with a decrease in the adverse effects of the original drug due to the predominant distribution into the tumor site and a gradual release of free drug from the conjugate which enhances drug solubility, stability, and efficiency. In this review, we discuss wider applications of numerous modified chitosan nanoparticles against different tumors and also focusing on the administration of anticancer drugs through various routes. We propose the interaction between nanosized drug carrier and tumor tissue to understand the synergistic interplay. Finally, we elaborate merits of drug delivery system at the tumor site, with emphasizing future challenges in cancer chemotherapy. © 2015, Springer-Verlag Berlin Heidelberg.

Prakash C.R.,Jawaharlal Nehru Technological University | Raja S.,Gandhi Institute of Technology and Management
Mini-Reviews in Medicinal Chemistry | Year: 2012

Kinases are probably the most important signaling enzymes, which represent about 20% of the druggable genome. Currently, more than 150 kinases are known. So, kinase inhibition therapy has become a very important area of drug research since most of our diseases are related to intra or intercellular signaling by kinases. Indole alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, antitumor. Among this chemical family, indolinone displays very promising antitumor properties by inhibiting various kinase families. These small molecules have a low molecular weight and most of them bind to protein kinases competing with ATP for the ATP-binding site. This review focuses on the indolinone based drugs approved for the treatment of cancer, drugs under clinical trial and then chemical diversity of various synthetic analogues of indolinone and their metabolites as various kinase inhibitors. This review also focused on structural activity relationship (SAR), mechanisms of action and biological targets through which indolinone and its derivatives display their antitumor activity. © 2012 Bentham Science Publishers.

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