Gandhi Institute of Technology and Management
Vishakhapatnam, India

Gandhi Institute of Technology and Management known as GITAM University is an educational institution in India. It was previously known as GITAM College, affiliated to Andhra University. Established in 1980, it was conferred the status of deemed university in 2007. It was the first private engineering institute in Andhra Pradesh to receive university status. GITAM is planning on receiving an ABET International Accreditation. The university has three picturesque campuses – its main campus at Visakhapatnam spreads over 100 acres, and the other two campuses are at Hyderabad and Bangalore. Wikipedia.

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Rajesh V.,Gandhi Institute of Technology and Management
Journal of Engineering Physics and Thermophysics | Year: 2012

An exact solution to the problem of flow due to the impulsive motion of an infinite vertical plate in its own plane in the presence of i) species concentration, ii) Newtonian heating at the plate, and iii) first-order chemical reaction has been derived by the Laplace transform technique. The influence of various parameters entering into the problem on the velocity field and skin friction for both air and water in the cases of both cooling and heating of the plate is discussed. © 2012 Springer Science+Business Media, Inc.

Venkateswara Rao B.,Gandhi Institute of Technology and Management | Nagesh Kumar G.V.,Gandhi Institute of Technology and Management
International Journal of Electrical Power and Energy Systems | Year: 2015

Optimal power flow with generation reallocation is a suitable method for better utilization of the existing system. In recent years, Flexible AC Transmission System (FACTS) devices, have led to the development of controllers that provide controllability and flexibility for power transmission. Out of the FACTS devices unified power flow controller (UPFC) is a versatile device, capable of controlling the power system parameters like voltage magnitude, phase angle and line impedance individually or simultaneously. The main aim of this paper is to minimize real power losses in a power system using BAT search algorithm without and with the presence of UPFC. Minimization of real power losses is done by considering the power generated by generator buses, voltage magnitudes at generator buses and reactive power injection from reactive power compensators. The proposed BAT algorithm based Optimal Power Flow (OPF) has been tested on a 5 bus test system and modified IEEE 30 bus system without and with UPFC. The results of the system with and without UPFC are compared in terms of active power losses in the transmission line using BAT algorithm. The obtained results are also compared with Genetic algorithm (GA). © 2014 Elsevier Ltd. All rights reserved.

Devendra B.N.,Gandhi Institute of Technology and Management
Asian Pacific journal of tropical medicine | Year: 2012

To compare the efficacy for phytochemical, antibacterial and antioxidant activities of petroleum ether, chloroform, ethanol, and aqueous extracts of in vitro propagated plants and field grown plants of Crotalaria sps., for against five human pathogens. The preliminary phytochemistry, antimicrobial and antioxidant activities were evaluated using disc diffusion and DPPH radical scavenging methods. The ethanolic extract of in vitro raised Crotalaria retusa (C. retusa) was effective on tested microorganisms and optimal ZOI values of 38 mm was obtained against Pseudomonas aeruginosa (P. aeruginosa). The optimal concentration (IC50) required for 50% inhibition of the DPPH radical scavenging was 57.6 μ g/mL obtained for ethanolic extract of in vitro propagated C. retusa. The in vitro propagated C. retusa has significant pharmacological activities while the Crotalaria prostrate (C. prostrate) and Crotalaria medicaginea (C. medicaginea) has low pharmacological activites. It was cleared that ethanolic extract of in vitro regenerated plants was most effective. These findings indicate compounds isolated from ethanolic extracts of Crotalaria sps., possesses pharmacological properties and potential to develop natural compounds based pharmaceutical products. The IC(50) values for ethanolic extracts of Crotalaria sps. was evaluated through the Linear regression analysis (R(2) ≤ 1). Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Krishna B.T.,Gandhi Institute of Technology and Management
Signal Processing | Year: 2011

Studies on analysis, design and applications of analog and digital differentiators and integrators of fractional order is the main objective of this paper. Time and frequency domain analysis, different ways of realization of fractance device is presented. Active and passive realization of fractance device of order 12 using continued fraction expansion is carried out. Later, time and frequency domain analysis of fractance based circuits is considered. The variations of rise time, peak time, settling time, time constant, percent overshoot with respect to fractional order α is presented. Digital differentiators and integrators of fractional order can be obtained by using direct and indirect discretization techniques. The s to z transforms used for this purpose are revisited. In this paper by using indirect discretization technique fractional order differentiators and integrators of order 12 and 14 are designed. These digital differentiators and integrators are implemented in real time using TMS320C6713 DSP processor and tested using National instruments education laboratory virtual instrumentation system (NIELVIS). The designed fractional order differentiators have been used for the detection of QRS sequences as well as the occurrence of Sino Atrial Rhythms in an ECG signal and also for the detection of edges in an image. The obtained results are in comparison with the conventional techniques. © 2010 Elsevier B.V. All rights reserved.

Kandra P.,Gandhi Institute of Technology and Management | Kalangi H.P.J.,Andhra University
Applied Microbiology and Biotechnology | Year: 2015

Recent advances have been made in cancer chemotherapy through the development of conjugates for anticancer drugs. Many drugs have problems of poor stability, water insolubility, low selectivity, high toxicity, and side effects. Most of the chitosan nanoparticles showed to be good drug carriers because of their biocompatibility, biodegradability, and it can be readily modified. The anticancer drug with chitosan nanoparticles displays efficient anticancer effects with a decrease in the adverse effects of the original drug due to the predominant distribution into the tumor site and a gradual release of free drug from the conjugate which enhances drug solubility, stability, and efficiency. In this review, we discuss wider applications of numerous modified chitosan nanoparticles against different tumors and also focusing on the administration of anticancer drugs through various routes. We propose the interaction between nanosized drug carrier and tumor tissue to understand the synergistic interplay. Finally, we elaborate merits of drug delivery system at the tumor site, with emphasizing future challenges in cancer chemotherapy. © 2015, Springer-Verlag Berlin Heidelberg.

Prakash C.R.,Jawaharlal Nehru Technological University | Raja S.,Gandhi Institute of Technology and Management
Mini-Reviews in Medicinal Chemistry | Year: 2012

Kinases are probably the most important signaling enzymes, which represent about 20% of the druggable genome. Currently, more than 150 kinases are known. So, kinase inhibition therapy has become a very important area of drug research since most of our diseases are related to intra or intercellular signaling by kinases. Indole alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, antitumor. Among this chemical family, indolinone displays very promising antitumor properties by inhibiting various kinase families. These small molecules have a low molecular weight and most of them bind to protein kinases competing with ATP for the ATP-binding site. This review focuses on the indolinone based drugs approved for the treatment of cancer, drugs under clinical trial and then chemical diversity of various synthetic analogues of indolinone and their metabolites as various kinase inhibitors. This review also focused on structural activity relationship (SAR), mechanisms of action and biological targets through which indolinone and its derivatives display their antitumor activity. © 2012 Bentham Science Publishers.

Swapna M.,Gandhi Institute of Technology and Management
Journal of the Brazilian Society of Mechanical Sciences and Engineering | Year: 2010

Wire electrical discharge machining (WEDM) is extensively used inmachining of materials when precision is of major factor. Selection of optimum machining parameter combinations for obtaining higher accuracy is a challenging task in WEDM due to the presence of a large number of process variables and complex stochastic process mechanisms. Inthe present work, WEDM of titanium alloy (Ti6Al4V) is experimentallystudied. The behavior of eight control parameters such as Ignition pulse current (A), Short pulse duration(B), Time between two pulses(C),Servo speed(D), Servo reference voltage(E), Injection pressure(F), Wire speed(G) and Wire tension(H) on surface finish was studied using Taguchi parameter design. A mathematical model is developed by means of linear regression analysis to establish relationship between control parameters and surface finish as process response. An attempt is made to optimize the surface roughness prediction model using Genetic Algorithm (GA). Optimum values of control parameters at level A1, B1,C1, D 3, E1, F3, G2, H3 for the selected range and workpiece material are obtained. copyright © 2010 by ABCM.

Prasad D.S.,Gandhi Institute of Technology and Management | Krishna A.R.,Andhra University
Journal of Materials Science and Technology | Year: 2012

Rice husk ash (RHA) is one of the industrial waste byproduct available abundantly in the world. In the present work, an attempt is made to incorporate the RHA particles in the molten aluminum A356.2 alloy. The RHA particles were added into the matrix melt by creating a vortex with the help of a mechanical stirrer and the melt temperature was maintained between 800 and 850 °C. Dry sliding wear experiments were performed in a pin on disc wear equipment against a chromium steel disc at 30 °C. Scanning electron microscopy is used to study the wear characteristics of the unreinforced Al alloy and the A356.2/RHA composites. From the experiments it is observed that the composites exhibit higher hardness and resistance to wear as compared to unreinforced Al alloy. © 2012 The Chinese Society for Metals.

Krishna B.T.,Gandhi Institute of Technology and Management
Circuits, Systems, and Signal Processing | Year: 2012

This brief presents the use of fractional order logistic equation to generate radar sequences. A generalized expression for logistic equation is presented. Later, the generation of binary phase code sequences using fractional order logistic map is discussed. It has been observed that sequences with good merit factor can be generated by varying fractional order, α. © Springer Science+Business Media, LLC 2011.

Krishna B.T.,Gandhi Institute of Technology and Management
2012 International Conference on Radar, Communication and Computing, ICRCC 2012 | Year: 2012

A Novel first order s to z transform is designed by interpolating Backward and Al-Alaoui Transforms. The proposed transform is used for the design of fractional order differentiators using indirect discretization. The results reveal the efficacy of the proposed transform. © 2012 IEEE.

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