Nottingham, United Kingdom
Nottingham, United Kingdom

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Gamlen M.J.D.,Gamlen Tableting Ltd | Martini L.G.,King's College London | Al Obaidy K.G.,Riyadh College of Dentistry and Pharmacy
Drug Development and Industrial Pharmacy | Year: 2015

The repeated compaction of Avicel PH101, dicalcium phosphate dihydrate (DCP) powder, 50:50 DCP/Avicel PH101 and Starch 1500 was studied using an instrumented laboratory tablet press which measures upper punch force, punch displacement and ejection force and operates using a V-shaped compression profile. The measurement of work compaction was demonstrated, and the test materials were ranked in order of compaction behaviour Avicel PH101>DCP/Avicel PH101>Starch>DCP. The behaviour of the DCP/Avicel PH101 mixture was distinctly non-linear compared with the pure components. Repeated compaction and precompression had no effect on the tensile fracture strength of Avicel PH101 tablets, although small effects on friability and disintegration time were seen. Repeated compaction and precompression reduced the tensile strength and the increased disintegration time of the DCP tablets, but improved the strength and friability of Starch 1500 tablets. Based on the data reported, routine laboratory measurement of tablet work of compaction may have potential as a critical quality attribute of a powder blend for compression. The instrumented press was suitable for student use with minimal supervisor input. © 2015 Informa Healthcare USA, Inc. All rights reserved.


Pitt K.G.,GSK Global Manufacturing and Supply | Webber R.J.,GSK Global Manufacturing and Supply | Hill K.A.,GSK Global Manufacturing and Supply | Dey D.,Gamlen Tableting Ltd | Gamlen M.J.,Gamlen Tableting Ltd
Powder Technology | Year: 2013

Small scale compaction studies which utilise equipment representative of commercial scale tablet presses can be used to develop process understanding of pharmaceutical formulations using minimal quantities of material. In this study the scalability of compressibility (solid fraction vs. compaction pressure), tabletability (tensile strength vs. compaction pressure), compactibility (tensile strength vs. solid fraction) and ejection shear stress was examined over an eight-fold range in tablet size. Tablets of two representative commercially manufactured formulations were compressed and compared using a small scale compaction press and large scale industrial press. Different tablet sizes and shapes were produced from the two types of press. One formulation was manufactured by direction compression and the other by wet granulation. Generally, good agreement was found across the scales for all the measures assessed. In addition, the measurement of ejection shear stress data on the small scale was able to accurately predict tablet failure on commercial rotary presses. © 2013 Elsevier B.V. All rights reserved.


Trademark
Gamlen Tableting Ltd | Date: 2012-09-04

Machines and machine tools, namely, machines for the production of pharmaceuticals in tablet form and machine tools for pharmaceutical tablet pressing. Hand tools and hand operated implements, namely, hand operated pharmaceutical tablet pressing machines, hand operated machines for the compressing of pre-measured pharmaceutically active and inactive ingredients into tablet form, hand operated machines for the production of pharmaceuticals in tablet form. Scientific, weighing, measuring, signalling apparatus and instruments, namely, tablet formulation and compressibility testing apparatus and instruments; calculating machines, data processing equipment and computers; computer hardware; computer firmware for the operation of tablet formulation and compressibility testing apparatus and instruments; computer software for the operation of tablet formulation and compressibility testing apparatus and instruments; downloadable electronic publications in the nature of guides for and scientific papers relating to the operation of tablet formulation and compressibility testing apparatus and instruments; scientific equipment, namely, machines for the compressibility testing and evaluation of pharmaceutical ingredients resulting in the production of pharmaceuticals in tablet form; scientific equipment, namely, machines for the compressing of small volumes of tablets of pre-measured pharmaceutically active and inactive ingredients into tablet form; computerised controls for machines for the production of pharmaceuticals in tablet form. Provision of pharmaceutical tablet pressing services. Scientific and technological services, namely, the design and development of pharmaceutical dosage forms and research and design in the field of tablet formulation relating thereto; industrial analysis and research services in the field of tablet formulation and pharmaceutical dosage forms; design and development of computer hardware and software; installation, maintenance and repair of computer software; design of pharmaceutical tablet pressing machines.


Trademark
Gamlen Tableting Ltd | Date: 2011-06-21

Machines and machine tools, namely, machines for the production of pharmaceuticals in tablet form and machine tools for pharmaceutical tablet pressing. Hand tools and hand operated implements, namely, hand tools for the compressing of pre-measured pharmaceutically active and inactive ingredients into tablet form and hand operated implements for compressing of pre-measured pharmaceutically active and inactive ingredients into tablet form and the production of pharmaceuticals in tablet form. Scientific, weighing, measuring, signaling apparatus and instruments, namely, computerized controls for machines for the production of pharmaceuticals in tablet form; computer hardware; computer firmware and computer software for control of machines for the production of pharmaceuticals in tablet form; furniture adapted for laboratory use; scientific equipment, namely, apparatus for the compressibility testing and evaluation of pharmaceutical ingredients resulting in the production of pharmaceuticals in tablet form; machines for the compressing of small volumes of tablets of pre-measured pharmaceutically active and inactive ingredients into tablet form; machines for the compressing of small volumes of tablets of pharmaceutically active and inactive ingredients into tablet form to assist in pharmaceutical research and development. Provision of pharmaceutical tablet pressing services. Scientific and technological services, namely research and design in the field of pharmaceutical tablet pressing machines; design and development of computer hardware and software relating thereto; industrial analysis and research services in the field of pharmaceutical tablet manufacturing; computer programming; installation, maintenance and repair of computer software; computer consultancy services; design, drawing and commissioned writing for the compilation of web sites; creating, maintaining and hosting the web sites of others.


Trademark
Gamlen Tableting Ltd | Date: 2012-10-08

Machines and machine tools, namely, machines for the production of pharmaceuticals in tablet form and machine tools for pharmaceutical tablet pressing; machines for the compressing of small volumes of tablets of pre-measured pharmaceutically active and inactive ingredients into tablet form; machines for the compressing of small volumes of tablets of pharmaceutically active and inactive ingredients into tablet form to assist in pharmaceutical research and development. Scientific, weighing, measuring, signalling apparatus and instruments, namely, computerized controls for the operation of machines for the production of pharmaceuticals in tablet form; computer hardware; computer firmware and computer software for control of machines for the production of pharmaceuticals in tablet form; furniture adapted for laboratory use; scientific equipment, namely, apparatus for the compressibility testing and evaluation of pharmaceutical ingredients resulting in the production of pharmaceuticals in tablet form.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Innovation Voucher | Award Amount: 5.00K | Year: 2015

Gamlen Tableting Ltd. are developing a new version of their established Gamlen Tableting Press with extended capabilities and provision for a laboratory system with an integrated workflow. The new workflow will generate significantly larger volumes of data and so state of the art analysis and visualisation are required in order to be able to provide insights and innovative recommendations. Innovate UK is assisting with funding to accelerate the development of our products and software by allowing us to use external expertise already familiar with the state of the art tools in use in the pharmaceutical industry.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Development of Prototype | Award Amount: 100.49K | Year: 2014

Gamlen Tabletting (GT) is an SME, established in 2012 to develop an accurate, easy to use, small scale, low cost, instrumented tableting machine for the pharmaceutical industry and academia. The launch product, a 500kg load Gamlen Tablet Press (GTP) has been in the market for a year, and has been independently verified by GSK as manufacturing tablets which accurately replicate the characteristics of those from full-scale production machinery. The 500kg GTP has found use in pre-formulation studies, formulation development, process control, QC testing, teaching and R&D, where it has found widespread acceptance. Feedback from current and potential users indicates the need for higher compaction loads (to enable the compression of a wider range of powders) plus additional instrumentation to better assess powder characteristics. The 500kg GTP already operating at industry-leading tolerances; developing a larger, higher capacity machine while maintaining accuracy poses significant technical challenges to GT in terms of both construction and control. GT proposes a 15 month project to develop and demonstrate a prototype enhanced GTP. Work will focus on: • Machine improvements: to increase the load rating of the machine to more accurately replicate full-scale production processing conditions; • Bolt-on additional functionality: tablet ejection force measurement and tablet labelling modules; • Compression curve analysis: to enable the study material properties during the compression event. This will further extent utility and increase market potential; • Developing standardised powder compressibility tests: this will allow users to easily identify powders that will make high quality tablets. GT will maximise value for money by conducting aspects of the work in-house, while subcontracting tasks that are outside of current capability.


PubMed | Gamlen Tableting Ltd
Type: Journal Article | Journal: Drug development and industrial pharmacy | Year: 2014

The repeated compaction of Avicel PH101, dicalcium phosphate dihydrate (DCP) powder, 50:50 DCP/Avicel PH101 and Starch 1500 was studied using an instrumented laboratory tablet press which measures upper punch force, punch displacement and ejection force and operates using a V-shaped compression profile. The measurement of work compaction was demonstrated, and the test materials were ranked in order of compaction behaviour Avicel PH101>DCP/Avicel PH101>Starch>DCP. The behaviour of the DCP/Avicel PH101 mixture was distinctly non-linear compared with the pure components. Repeated compaction and precompression had no effect on the tensile fracture strength of Avicel PH101 tablets, although small effects on friability and disintegration time were seen. Repeated compaction and precompression reduced the tensile strength and the increased disintegration time of the DCP tablets, but improved the strength and friability of Starch 1500 tablets. Based on the data reported, routine laboratory measurement of tablet work of compaction may have potential as a critical quality attribute of a powder blend for compression. The instrumented press was suitable for student use with minimal supervisor input.

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