PubMed | Aix - Marseille University, Pleural Diseases and Interventional Pulmonology and University Hospitals Galway
Type: | Journal: Case reports in medicine | Year: 2014
Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called dancing eye syndrome, is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We report a 65-year-old patient with opsoclonus-myoclonus syndrome revealing a small-cell lung carcinoma. If serologic antineuronal anti-body screening was negative, autoantibodies against glutamic acid decarboxylase (anti-GAD) were positive. Despite the specific anticancer treatment and high dose corticosteroids, the patient developed a severe and progressive encephalopathy and died 10 days later.