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Peiro-Perez R.,Cancer and Public Health Area | Peiro-Perez R.,CIBER ISCIII | Salas D.,Cancer and Public Health Area | Valles G.,Cancer and Public Health Area | And 17 more authors.
European Journal of Public Health | Year: 2015

Background: The aim is to analyse physical activity (PA), the fulfilment recommendation of at least 150 min of moderate PA, through walking/biking (W&B), sport, both types of PA and the factors associated with inactivity by Spanish women who attended breast cancer screening programmes. Methods: The DDM-Spain is a multicentre cross-sectional study involving 3584 women, aged 45-68, attending screening in seven Spanish cities. Data were collected using a questionnaire, including age, socio-demographic and lifestyle characteristics, family burden and PA. PA was converted into metabolic equivalent of task (METs), categorized as low ≤600 METs min per week (m/w), moderate 600-3000 METs m/w and high ≥3000 METs m/w. A multivariate logistic regression was performed to identify variables associated with inactivity for each type of PA. Results: No women achieved a high level of PA through sport. 79.2% achieved a high or moderate level of PA by W&B. Lack of sport was associated with being overweight (odds ratio OR = 1.31; 95% confidence interval CI: 1.06 to 1.62), body mass index (BMI) ≥30 (OR = 1.85; 95% CI: 1.44 to 2.38), smoking (OR = 1.56; 95% CI: 1.22 to 2.00) and living with a disabled person (OR = 1.64; 95% CI: 1.0 to 2.81), whereas enough sport practice was associated with higher educational or socio-economic level (SEL). Regarding W&B, inactivity was associated with BMI ≥ 30 (OR = 1.91; 95% CI: 1.49 to 2.45) and living with someone >74 (OR = 1.96; 95% CI: 1.48 to 2.58). Inactivity for both types of exercise was associated with a BMI ≥30 (OR = 2.13; 95% CI: 1.63 to 2.8), smoking (OR = 1.41; 95% CI: 1.09 to 1.81) and living with someone >74 (OR = 1.69; 95% CI: 1.24 to 2.28). Conclusions: Family burden and BMI ≥30 are inversely associated with both types of PA. W&B is the most common type of PA regardless of educational and SEL. © 2015 The Author 2015. Published by Oxford University Press on behalf of the European Public Health Association. Source


Fernandez-Navarro P.,Carlos III Institute of Health | Fernandez-Navarro P.,Consortium for Biomedical Research in Epidemiology and Public Health | Pita G.,Human Genotyping Unit CeGen | Santamarina C.,Galicia Breast Cancer Screening Programme | And 14 more authors.
European Journal of Cancer | Year: 2013

Background: Mammographic density (MD) is regarded as an intermediate phenotype in breast cancer development. This association study investigated the influence of 14 breast cancer susceptibility loci identified through previous genome-wide association studies on MD among the participants in the "Determinants of Density in Mammographies in Spain" (DDM-Spain) study. Methods: Our study covered a total of 3348 Caucasian women aged 45-68 years, recruited from seven Spanish breast cancer screening centres having DNA available. Mammographic density was blindly assessed by a single reader using a semiquantitative scale. Ordinal logistic models, adjusted for age, body mass index and menopausal status, were used to estimate the association between each genotype and MD. Results: Evidence of association with MD was found for variant rs3803662 (TOX3) (Odds Ratio (OR) = 1.13, 95% Confidence Interval (CI) = 1.03-1.25), and marginal evidence of association for susceptibility loci rs3817198 (LSP1) (OR = 1.09, 95% CI = 1.00-1.20) and rs2981582 (FGFR2) (OR = 0.92, 95% CI = 0.84-1.01). Two other loci were associated with MD solely among pre-menopausal women, namely, rs4973768 (SLC4A7) (OR = 0.83, 95% CI = 0.70-1.00) and rs4415084 (MEPS30) (OR = 1.22, 95% CI = 1.00-1.49). Conclusions: Our findings lend some support to the hypothesis which links these susceptibility loci to MD. © 2012 Elsevier Ltd. All rights reserved. Source


Isidoro B.,Institute Salud Carlos III | Lope V.,Institute Salud Carlos III | Lope V.,CIBER ISCIII | Lope V.,Cancer Epidemiology Research Group | And 17 more authors.
Menopause | Year: 2016

Objective: The use of some forms of hormone therapy (HT) is associated with an increase in mammographic density-a major risk factor for breast cancer. The role of isoflavones, however, is unclear. Here, we quantify the prevalence of HT and isoflavone use among postmenopausal Spanish women, determine associated risk factors, and explore the relationship between these therapies and mammographic density. Methods: This cross-sectional study included 2,754 postmenopausal women who underwent breast cancer screening in seven geographical areas. Mammographic density was evaluated using Boyd's semiquantitative scale. Multinomial logistic regression models were adjusted to assess risk factors associated with both therapies. Ordinal regression models were fitted to study the association between HT and isoflavone consumption with mammographic density. Results: The prevalence of ever-use of HT was 12%, whereas that of the current use was 2.3%. Isoflavone lifetime prevalence was 3.7%, and current use was 1.7%. The most common HT types were tibolone and estrogens. Surgical menopause, oral contraceptive use, educational level, population density, and years since menopause were positively associated with HT, whereas body mass index and parity were inversely associated. Mammographic density was not associated with current or past HT use. However, women who reported having consumed isoflavones in the past and those who started their use after menopause had a higher mammographic density when compared with never-users (odds ratio 1.98, 95% CI 1.21-3.25, P0.007; and odds ratio 1.60, 95% CI 1.01- 2.53, P0.045 respectively). Conclusions: Our results show a low prevalence of HT and isoflavone use in postmenopausal Spanish women. In this population, HT use was not associated with mammographic density, whereas some categories of isoflavone users had higher density. © 2016 by The North American Menopause Society. Source


Garcia-Arenzana N.,Institute Salud Carlos III | Garcia-Arenzana N.,Preventive Medicine Unit Hospital Infanta Leonor | Navarrete-Munoz E.M.,University Miguel Hernandez | Navarrete-Munoz E.M.,Institute Salud Carlos III | And 15 more authors.
International Journal of Cancer | Year: 2014

High mammographic density (MD) is one of the main risk factors for development of breast cancer. To date, however, relatively few studies have evaluated the association between MD and diet. In this cross-sectional study, we assessed the association between MD (measured using Boyd's semiquantitative scale with five categories: <10%, 10-25%, 25-50%, 50-75% and >75%) and diet (measured using a food frequency questionnaire validated in a Spanish population) among 3,548 peri- and postmenopausal women drawn from seven breast cancer screening programs in Spain. Multivariate ordinal logistic regression models, adjusted for age, body mass index (BMI), energy intake and protein consumption as well as other confounders, showed an association between greater calorie intake and greater MD [odds ratio (OR) = 1.23; 95% confidence interval (CI) = 1.10-1.38, for every increase of 500 cal/day], yet high consumption of olive oil was nevertheless found to reduce the prevalence of high MD (OR = 0.86;95% CI = 0.76-0.96, for every increase of 22 g/day in olive oil consumption); and, while greater intake of whole milk was likewise associated with higher MD (OR = 1.10; 95%CI 1.00-1.20, for every increase of 200 g/day), higher consumption of protein (OR = 0.89; 95% CI 0.80-1.00, for every increase of 30 g/day) and white meat (p for trend 0.041) was found to be inversely associated with MD. Our study, the largest to date to assess the association between diet and MD, suggests that MD is associated with modifiable dietary factors, such as calorie intake and olive oil consumption. These foods could thus modulate the prevalence of high MD, and important risk marker for breast cancer. What's new? Factors that influence mammographic density (MD), which is associated with breast cancer risk, could shed light on various aspects of breast malignancy. In this investigation of 3,548 Spanish women, a validated food frequency questionnaire identified an association between MD and elevated calorie intake. Even though more than 90% of the women consumed raw olive oil on a daily basis, higher olive oil consumption was associated with lower MD. The results support previous studies linking high caloric intake with MD and provide new evidence of an inverse association between MD and olive oil consumption. © 2013 The Authors. Published by Wiley Periodicals, Inc. on behalf of UICC. Source


Fernandez-Navarro P.,Carlos III Institute of Health | Fernandez-Navarro P.,Consortium for Biomedical Research in Epidemiology and Public Health | Gonzalez-Neira A.,Human Genotyping Unit CeGen | Pita G.,Human Genotyping Unit CeGen | And 21 more authors.
International Journal of Cancer | Year: 2015

Mammographic density (MD) is an intermediate phenotype for breast cancer. Previous studies have identified genetic variants associated with MD; however, much of the genetic contribution to MD is unexplained. We conducted a two-stage genome-wide association analysis among the participants in the "Determinants of Density in Mammographies in Spain" study, together with a replication analysis in women from the Australian MD Twins and Sisters Study. Our discovery set covered a total of 3,351 Caucasian women aged 45 to 68 years, recruited from Spanish breast cancer screening centres. MD was blindly assessed by a single reader using Boyd's scale. A two-stage approach was employed, including a feature selection phase exploring 575,374 SNPs in 239 pairs of women with extreme phenotypes and a verification stage for the 183 selected SNPs in the remaining sample (2,873 women). Replication was conducted in 1,786 women aged 40 to 70 years old recruited via the Australian Twin Registry, where MD were measured using Cumulus-3.0, assessing 14 SNPs with a p value <0.10 in stage 2. Finally, two genetic variants in high linkage disequilibrium with our best hit were studied using the whole Spanish sample. Evidence of association with MD was found for variant rs11205277 (OR = 0.74; 95% CI = 0.67-0.81; p = 1.33 × 10-10). In replication analysis, only a marginal association between this SNP and absolute dense area was found. There were also evidence of association between MD and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 (OR = 0.73; 95% CI = 0.66-0.80; p = 2.64 × 10-11) and rs67807996 in gene OTUD7B (OR = 0.72; 95% CI = 0.66-0.80; p = 2.03 × 10-11). Our findings provide additional evidence on common genetic variations that may contribute to MD. © 2014 UICC. Source

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