Galgotias University is a co-educational private university in Greater Noida in the state of Uttar Pradesh, India. Previously known as Galgotias Educational Institutions, it was granted university status in 2011 by the Uttar Pradesh government. Galgotias University was established by the Uttar Pradesh Galgotias University Act No. 14 of 2011 under section 3 of UGC Act 1956. Wikipedia.
Singh B.,Galgotias University |
Garg S.K.,Delhi Technological University |
Sharma S.K.,National Institute of Technology Kurukshetra
International Journal of Advanced Manufacturing Technology | Year: 2011
Value steam mapping (VSM) is a lean manufacturing technique and it has emerged as the preferred way to support and implement the lean approach Grewal (Int J Manuf Technol Manag 15:3-4, 2008); Singh and Sharma (J Measuring Business Excellence 13:58-68, 2009). VSM is different than conventional recording techniques, as it captures the information at individual stations about station cycle time, up time or utilization of resources, set-up time or change over time, work in process inventory, man power requirement and the information flow from raw material to finish goods. It covers both value adding as well as non-value-adding activities. This paper covers the review and classification of literature on VSM, as there is hardly any paper on literature review of VSM, so it will be very beneficiary for both academician and industry people. Applications of VSM are also presented by a case study of a small manufacturing Indian industry and reduction in lead time, processing time, work in process inventory and manpower requirement at individual stations are noticed © 2010 Springer-Verlag London Limited.
Chakraborty C.,Galgotias University |
Agrawal A.,East Tennessee State University
Cell Biochemistry and Biophysics | Year: 2013
Serum C-reactive protein (CRP) is used as a marker of inflammation in several diseases including autoimmune disease and cardiovascular disease. CRP, a member of the pentraxin family, is comprised of five identical subunits. CRP has diverse ligand-binding properties which depend upon different structural states of CRP. However, little is known about the molecular dynamics and interaction properties of CRP. In this study, we used SAPS, SCRATCH protein predictor, PDBsum, ConSurf, ProtScale, Drawhca, ASAView, SCide and SRide server and performed comprehensive analyses of molecular dynamics, protein-protein and residue-residue interactions of CRP. We used 1GNH.pdb file for the crystal structure of human CRP which generated two pentamers (ABCDE and FGHIJ). The number of residues involved in residue-residue interactions between A-B, B-C, C-D, D-E, F-G, G-H, H-I, I-J, A-E and F-J subunits were 12, 11, 10, 11, 12, 11, 10, 11, 10 and 10, respectively. Fifteen antiparallel β sheets were involved in β-sheet topology, and five β hairpins were involved in forming the secondary structure. Analysis of hydrophobic segment distribution revealed deviations in surface hydrophobicity at different cavities present in CRP. Approximately 33 % of all residues were involved in the stabilization centers. We show that the bioinformatics tools can provide a rapid method to predict molecular dynamics and interaction properties of CRP. Our prediction of molecular dynamics and interaction properties of CRP combined with the modeling data based on the known 3D structure of CRP is helpful in designing stable forms of CRP mutants for structure-function studies of CRP and may facilitate in silico drug design for therapeutic targeting of CRP. © 2013 Springer Science+Business Media New York.
Agarwal S.,Galgotias University
Transport in Porous Media | Year: 2014
The present work aims at studying the thermal instability in a rotating porous layer saturated by a nanofluid based on a new boundary condition for the nanoparticle fraction, which is physically more realistic. The model used for nanofluid combines the effect of Brownian motion along with thermophoresis, while for a porous medium Brinkman model has been used. A more realistic set of boundary conditions where the nanoparticle volume fraction adjusts itself including the contributions of the effect of thermophoresis so that the nanoparticle flux is zero at the boundaries has been considered. Using linear stability analysis, the expression for critical Rayleigh number has been obtained in terms of various non-dimensional parameters. The effect of various parameters on the onset of instability has been presented graphically and discussed in detail. © 2014 Springer Science+Business Media Dordrecht.
Chakraborty C.,Galgotias University |
Doss C.G.P.,Vellore Institute of Technology |
Bandyopadhyay S.,Indian Statistical Institute |
Agoramoorthy G.,Tajen University
Wiley Interdisciplinary Reviews: RNA | Year: 2014
The prevalence of type-2 diabetes (T2D) is increasing significantly throughout the globe since the last decade. This heterogeneous and multifactorial disease, also known as insulin resistance, is caused by the disruption of the insulin signaling pathway. In this review, we discuss the existence of various miRNAs involved in regulating the main protein cascades in the insulin signaling pathway that affect insulin resistance. The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed. Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b. We also corroborate from previous evidence how these interactions are related to insulin resistance and T2D. The insights highlighted in this review will provide a better understanding on the impact of miRNA in the insulin signaling pathway and insulin resistance-associated diagnostics and therapeutics for T2D. © 2014 John Wiley & Sons, Ltd.
Awasthi M.K.,Graphic Era University |
Asthana R.,Galgotias University
International Communications in Heat and Mass Transfer | Year: 2013
The capillary instability of the cylindrical interface separating two viscous and incompressible fluids through porous medium is studied using viscous potential flow theory, when there is heat and mass transfer across the interface. The fluids are considered to be viscous and incompressible with different kinematic viscosities. A dispersion relation that accounts for the growth of axisymmetric waves is derived and stability is discussed theoretically as well as numerically. Stability criterion is given in terms of critical value of wave number. Various graphs have been drawn to show the effect of various physical parameters such as heat transfer capillary number, viscosity ratio, permeability and porosity on the stability of the system. It has been observed that porous media and heat transfer both have stabilizing effect while porosity has destabilizing effect on the stability of the system. © 2012 Elsevier Ltd.