Kapic S.,Glaxosmithkline |
Kapic S.,Galagos Research Center Ltd. |
Fajdetic A.,Glaxosmithkline |
Fajdetic A.,Galagos Research Center Ltd. |
And 11 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011
A set of novel macrolones containing the flexible C8 basic linker and quinolone 3-(2′-hydroxyethyl)carboxamido group has been prepared and structurally characterized by NMR and IR spectroscopy, mass spectrometry and molecular modeling. The new compounds were evaluated in vitro against a panel of erythromycin-susceptible and erythromycin-resistant Gram-positive and Gram-negative bacterial strains. Compared to azithromycin, most of the compounds exhibited improved in vitro potency against the key respiratory pathogens. © 2011 Elsevier Ltd. All rights reserved.