Incheon, South Korea
Incheon, South Korea

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Jeon H.J.,Sungkyunkwan University | Lee J.-Y.,Sungkyunkwan University | Lee J.-Y.,Seoul National University | Lee Y.M.,Ajou University | And 8 more authors.
Journal of Nervous and Mental Disease | Year: 2010

This was the first Korean national study to evaluate prevalence and correlates of suicidal behavior, and to compare multiple and single attempts. A total of 6510 adults completed face-to-face interviews (response rate, 81.7%) through randomly chosen one-person-per-households. Lifetime prevalence and correlates were evaluated with the Korean version of Composite International Diagnostic Interview (K-CIDI), and a questionnaire to inquire about suicidal behaviors. The lifetime prevalence of suicidal ideation, plan, and attempt in South Korea was 15.2%, 3.3%, and 3.2% (single 2.1% and multiple 1.1%), respectively. Younger age was associated with attempts and more strongly associated with multiple attempts. Attempts were the most strongly associated with mood disorders, especially bipolar disorder, which was more strongly associated with multiple attempts. In conclusion, suicidal behaviors are highly prevalent in Korea, especially in young adults. Bipolar disorder was the most strongly associated disorder with suicide attempts, more with multiple attempts. Copyright © 2010 by Lippincott Williams & Wilkins.


Kang H.J.,Korea Institute of Radiological and Medical Sciences | Kim W.S.,Sungkyunkwan University | Kim S.J.,Sungkyunkwan University | Lee J.-J.,Chonnam National University | And 13 more authors.
Annals of Hematology | Year: 2012

We conducted a multicenter, phase II trial to investigate the efficacy and safety of rituximab plus CVP (R-CVP) combination therapy for patients with previously untreated stage III or IV marginal zone lymphoma (MZL). The treatment consisted of rituximab 375 mg/m 2, cyclophosphamide 750 mg/m 2 and vincristine 1.4 mg/m 2 (maximum 2.0 mg) being given intravenously on day 1 and oral prednisolone 100 mg on days 1-5. The treatment was repeated every 3 weeks and this was continued for six or eight cycles. Forty-two patients were enrolled from 13 institutes in Korea. Among them, two patients were dropped after the first and second cycles of chemotherapy, respectively, without evaluation. The 40 patients received a total of 287 cycles of R-CVP chemotherapy. The overall response rate was 88% (95% CI, 77-98%) with 24 complete responses (60%). The median duration of response was 28.3 months. After a median follow-up of 38.2 months, the estimated 3-year progression-free survival and overall survival were 59% and 95%, respectively. There were 30/287 cycles (11%) and 5/287 cycles (2%) of grade 3 or 4 neutropenia and febrile neutropenia, respectively. The R-CVP regimen can be an effective and tolerable first-line immunochemotherapy regimen for advanced stage MZL. © Springer-Verlag 2011.


Park B.C.B.,Pennsylvania State University | Im J.S.,Gachon Medical School | Ratcliff K.S.,University of Connecticut
Crisis | Year: 2014

Background: South Korean society faces a serious challenge in the increasing rates of youth suicidal behavior. There is a need both to gain a better understanding of the causes of this behavior and to develop strategies for responding to this critical public health issue. Aims: This article analyzes how psychological, sociopsychological, and subcultural factors influence suicidal proneness among Korean youth as well as makes suggestions for developing social policies that could reduce Korean youth suicidal behaviors. Method: Correlation and multivariate regression analyses on suicide proneness and depression were employed using a sample of 172 South Korean youths (aged 18-24) selected from the 2009 General Social Survey collected through face-to-face interviews. Results: Young people's suicidal proneness is associated with depression, a tolerant attitude toward suicide, strained family relations, living in rural areas, being female, and being closely related to survivors of suicide or potential suicides. Conclusion: The findings from this study reveal the signifi cance of social and cultural factors as influences on recent youth suicidal behavior in Korea. The analysis suggests that the underlying risk factors of suicidal behavior are embedded in the changing social and cultural context of Korean society. Thus, suicide prevention efforts should involve more than merely treating any underlying psychiatric disorders.© 2013 Hogrefe Publishing.


PubMed | Pennsylvania State University, Gachon Medical School and University of Connecticut
Type: Journal Article | Journal: Crisis | Year: 2014

South Korean society faces a serious challenge in the increasing rates of youth suicidal behavior. There is a need both to gain a better understanding of the causes of this behavior and to develop strategies for responding to this critical public health issue.This article analyzes how psychological, sociopsychological, and subcultural factors influence suicidal proneness among Korean youth as well as makes suggestions for developing social policies that could reduce Korean youth suicidal behaviors.Correlation and multivariate regression analyses on suicide proneness and depression were employed using a sample of 172 South Korean youths (aged 18-24) selected from the 2009 General Social Survey collected through face-to-face interviews.Young peoples suicidal proneness is associated with depression, a tolerant attitude toward suicide, strained family relations, living in rural areas, being female, and being closely related to survivors of suicide or potential suicides.The findings from this study reveal the significance of social and cultural factors as influences on recent youth suicidal behavior in Korea. The analysis suggests that the underlying risk factors of suicidal behavior are embedded in the changing social and cultural context of Korean society. Thus, suicide prevention efforts should involve more than merely treating any underlying psychiatric disorders.


Kim S.-J.,Gwangju Veterans Hospital | Kim W.,Kyung Hee University | Woo J.-S.,Kyung Hee University | Ha S.-J.,Kyung Hee University | And 7 more authors.
International Journal of Cardiology | Year: 2012

Background: Several studies have demonstrated that adenosine and nicorandil protect the myocardium against angioplasty-related myocardial injury. We conducted a prospective study to investigate the myocardial protective effects of combination therapy with intracoronary adenosine and nicorandil. Methods: We enrolled 213 consecutive patients with stable or unstable angina who were scheduled for non-urgent PCI for de-novo coronary lesions. Patients were randomized into group I (control saline, n = 55), group II (adenosine 50 μg, n = 54), group III (nicorandil 4 mg, n = 54), or group IV (adenosine-nicorandil combination, n = 50). Serial assessments of CK-MB were used to assess myocardial necrosis before and after PCI. The primary endpoint was the incidence of myocardial necrosis (elevation of CK-MB), and the secondary endpoints were the changes in serum CK-MB and cTnI levels and the incidence of post-procedural myocardial infarction (MI). Results: No significant differences were observed among the four groups with regard to baseline or angiographic characteristics. No major adverse events related to adenosine and nicorandil were observed. There were no significant differences in the incidence of post-procedural myocardial necrosis among the four groups (10.9, 14.8, 14.8, and 14.0%, respectively, p = 0.9). There were no significant differences in the incidence of post-procedural MI among groups (p = 0.6). In multivariate regression analysis, multivessel stenting, median stent length, and the presence of a compromised side branch were independent predictors of myonecrosis. Conclusions: Pretreatment with intracoronary adenosine, nicorandil, or the combination of the two drugs did not reduce the incidences of myocardial necrosis or MI after non-urgent PCI in patients with low-risk angina pectoris. © 2011 Elsevier Ireland Ltd.


Paick J.S.,Seoul National University | Park K.,Seoul National University | Kim S.W.,Seoul National University | Park J.W.,Seoul National University | And 3 more authors.
Actas Urologicas Espanolas | Year: 2012

Objective: We investigated hypoxia inducible factor-1α (HIF-1α), connective tissue growth factor (CTGF) expression and fibrosis in the testis of rats with surgically induced varicocele. Material and methods: A total of 47 adult male Sprague-Dawley rats were arranged in 3 groups, namely group 1 (varicocele operation 4 weeks ago, n = 10; sham operation 4 weeks ago, n = 5), group 2 (8 weeks, n = 11; n = 5), and group 3 (12 weeks, n = 11; n = 5). The rats in every group underwent bilateral orchiectomy 4, 8, and 12 weeks after the operations, respectively. HIF-1α and CTGF expression of both testes in group 3 were studied by real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Fibrotic change was assessed by quantitative image analysis. Results: HIF-1α mRNA expression in testes tissues in varicocele operation and sham controls showed no significant differences in RT-PCR. However, CTGF mRNA expressions in left testes were found to be significantly different between varicocele operation and sham controls. HIF-1α staining was present in both testes of all specimens and CTGF staining was present in 10 left and 8 right testes of 11 specimens. However HIF-1α and CTGF staining were absent in control group. There were significant fibrotic changes of both testes in groups 2 and 3. There were significant differences in fibrotic change along the durations of surgical varicocele. Conclusions: This study reveals that experimental varicocele in the rat is associated with HIF-1α and CTGF expression and it is accompanied by fibrotic change in the testis. © 2011 AEU. Published by Elsevier España, S.L. All rights reserved.


Lee Y.J.,Seoul National University | Kang S.W.,Chungnam National University | Baek H.J.,Gachon Medical School | Choi H.J.,Gachon Medical School | And 5 more authors.
Human Immunology | Year: 2010

Matrix metalloproteinase (MMP)-9 expression is reported to be upregulated in several primary vasculitides. The -1562C>T and -91 [CA]n repeat polymorphisms can affect MMP-9 promoter activity. We investigated the distributions of these functional polymorphisms in 122 patients with Behçet's disease (BD) and in 122 gender- and age-matched healthy controls. Plasma levels of MMP-9 were analyzed. The frequency of "L" alleles with [CA]n <21 was significantly lower in all BD patients (vs controls, odds ratio (OR) = 0.371 [95% confidence interval 0.152-0.905]) and male patients (vs male controls, OR = 0.117 [0.019-0.737]). Furthermore, the frequency of "H/H" homozygote with [CA]n ≤ 21 was significantly higher in BD patients than controls (OR = 2.677 [1.065-6.729]). Moreover, the frequency of CL haplotype with lower promoter activity was significantly lower in BD patients (vs controls, OR = 0.374 [0.149-0.939]) and in BD patients with visceral involvement (OR = 0.202 [0.044-0.916]).Although plasma MMP-9 levels were not different between controls and BD patients, concentrations of this substance were significantly higher in male patients (vs male controls, p = 0.044) or patients with visceral involvements (vs patients without visceral involvement, p = 0.027). These results suggest that MMP-9 is a novel susceptibility gene and its promoter polymorphisms can affect the development of visceral involvement in BD. © 2010 American Society for Histocompatibility and Immunogenetics.


Im J.-S.,Gachon Medical School | Choi S.H.,University of Ulsan | Hong D.,Gachon University | Seo H.J.,Gachon University | And 2 more authors.
Comprehensive Psychiatry | Year: 2011

This study was conducted to examine differences in proximal risk factors and suicide methods by sex and age in the national suicide mortality data in Korea. Data were collected from the National Police Agency and the National Statistical Office of Korea on suicide completers from 2004 to 2006. The 31 711 suicide case records were used to analyze suicide rates, methods, and proximal risk factors by sex and age. Suicide rate increased with age, especially in men. The most common proximal risk factor for suicide was medical illness in both sexes. The most common proximal risk factor for subjects younger than 30 years was found to be a conflict in relationships with family members, partner, or friends. Medical illness was found to increase in prevalence as a risk factor with age. Hanging/Suffocation was the most common suicide method used by both sexes. The use of drug/pesticide poisoning to suicide increased with age. A fall from height or hanging/suffocation was more popular in the younger age groups. Because proximal risk factors and suicide methods varied with sex and age, different suicide prevention measures are required after consideration of both of these parameters. © 2011 Elsevier Inc. All rights reserved.


Hwang Y.J.,Gachon University | Jeung Y.S.,Gachon University | Seo M.H.,Gachon University | Yoon J.Y.,Gachon Medical School | And 4 more authors.
Inhalation Toxicology | Year: 2010

Inhaled particulate matter (PM) might influence many adverse health effects in human body, including increased exacerbations of pulmonary and cardiovascular diseases. In this study, we examined the associations between PM and pulmonary adverse effects. Two types of particles, Asian dust (AD) and titanium dioxide (TiO2), were administered intratracheally to C57BL/6 mice. The mice were exposed to saline and saline suspensions of 20mg/kg of AD, TiO2 particles twice a week for 12 weeks. Following exposure with these particles, the lungs were analyzed histopathologically by hematoxylin and eosin (H&E) and Masson's trichrome (MT) staining. Oxidative injuries were determined by immunohistochemistry (IHC) for 8-oxoguanine in the lungs and Comet assays in peripheral blood mononuclear cells (PBMCs) of C57BL/6 mice. Mice exposed to AD and TiO2 showed significant inflammatory changes and oxidative damages in the lungs as compared with the control group. DNA damage in PBMCs was also increased significantly in AD and TiO2-exposed mice. However, lung fibrosis was minimal and there was no significant difference between PM exposed and control mice. Exposure to AD and TiO2 particlesinduced similar inflammatory damages in the lungs and elicited oxidative DNA damage in the PBMCs. © 2010 Informa Healthcare USA, Inc.


PubMed | Gachon Medical School
Type: Journal Article | Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2016

8237 Background: We conducted this prospective study to assess the changes of quality of life, anxiety and depression in patients receiving palliative chemotherapy for solid cancers.Patients with histologically confirmed metastatic or relapsed cancer, life expectancy of more than 6 months and the ability to fill-up questionnaires by oneself were eligible. The effect of chemotherapy on quality of life and the levels of their anxiety and depression were assessed at baseline and after every 3 cycles of chemotherapy, by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) and Hospital Anxiety and Depression Scale (HADS).Between July 2001 and October 2003, 146 patients were entered onto the protocol. Ninety-eight patients completed the questionnaire and 46 patients withdrew from trial (27 for lost follow-up, 11 for withdrawal of consents, 5 for toxicity, 5 for progression). Their median age was 58 years old (range 28-78) and male to female ratio was 1.6. Chemotherapy was administered as the first, second, and third or more line in 107, 29, and 10 patients respectively (including 52 cases of gastric cancer, 39 of non-small cell lung cancer, 29 of colorectal cancer, 11 of breast cancer, and 15 of others). Compared with baseline, clinically meaningful relief (score decreased more than 10) of symptoms such as pain, dyspnea, and sleep disturbance was observed. There was significant improvement (score increased more than 10) of the functioning scales after the first cycle of chemotherapy, but these effects didnt persist through the whole course of therapy. The incidence of probable anxiety and depression disorder before the chemotherapy were 20% and 29% each. The anxiety scores decreased throughout the whole period of intervention (p<0.01). Pre-treatment anxiety and depression were negatively correlated with baseline QOL scores.The palliative chemotherapy in patients with solid cancer improved the cancer-related symptoms and lessened the anxiety. Also it did not disturb the function and overall quality of life. No significant financial relationships to disclose.

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