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Clermont-Ferrand, France

Guinard-Barbier S.,Groupe Hospitalier Broca Cochin Hotel Dieu | Guinard-Barbier S.,University of Paris Descartes | Grabar S.,University of Paris Descartes | Chenevier-Gobeaux C.,Hospital Cochin | And 14 more authors.
Biomarkers | Year: 2011

Introduction: Mid-regional pro-atrial natriuretic peptide (MRproANP) increases during systemic infections and could possibly correlate with bacteremia. Methods: We determined the characteristics of MRproANP for accuracy to detect positive blood culture. Results: Bacteremia was positive in 58 (15%) of 347 patients. MRproANP levels increased in patients with bacteremia (98.4 pmol/L [interquartile range (IQR) 68.2-153.1] vs. 66.4 pmol/L [IQR 51.0-90.3], p<0.01). Performance of MRproANP to predict bacteremia [AUC=0.69, 95%CI: 0.61-0.77] was equivalent to C-reactive protein (0.66 [95%CI: 0.59-0.74], p=0.53) but less accurate than procalcitonin (0.78 [95%CI: 0.72-0.84], p<0.001). Conclusion: Although MRproANP increased in bacteremic patients with acute pyelonephritis, results of likelihood ratios discarded its use at bedside to predict bacteremia. © 2011 Informa UK, Ltd.


Guinard-Barbier S.,Groupe Hospitalier Broca Cochin Htel Dieu | Guinard-Barbier S.,University of Paris Descartes | Chenevier-Gobeaux C.,Groupe Hospitalier Broca Cochin Htel Dieu | Grabar S.,Groupe Hospitalier Broca Cochin Htel Dieu | And 16 more authors.
Biomarkers | Year: 2011

Background: Mid-regional pro-atrial natriuretic peptide (MR-proANP) increases with severity in community-acquired pneumonia (CAP). We investigated whether changes of MR-proANP correlated to bacteremia. Methods: 392 adult patients with CAP visiting emergency department from a prospective observational multicenter study. Results: MR-proANP levels increased in patients with positive bacteremia (92.8 pmol/L vs. 84.3 pmol/L, p=0.04). Performance of MR-proANP to detect bacteremia (0.60) was equivalent to CRP (0.59) but less accurate than PCT (0.69). Conclusion: MR-ANP poorly predicts bacteremia in CAP patients. © 2011 Informa UK, Ltd.

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