PubMed | Institute of Technology and Science, Institute of Cytology and Preventive Oncology ICMR, Barasat Cancer Hospital and University of Delhi
Type: Journal Article | Journal: Molecular diagnosis & therapy | Year: 2016
To investigate a potential association between single-nucleotide polymorphisms (SNPs) and haplotypes at the TNFA-LTA locus and the development of oral cancer in an Indian population.In this study, 150 oral precancer/cancer samples (50 precancer and 100 cancer), along with an equal number of control samples, were genotyped. Six SNPs at the TNF-LTA locus (i.e., -238G/A, -308G/A, -857C/T, -863C/A, -1031T/C, and +252A/G) were analyzed by use of a polymerase chain reaction-restriction fragment length polymorphism method, the assay was validated by sequencing 10 % of samples.The allelic frequencies of TNFA and LTA SNPs were found to be significantly associated with the risk of oral cancer and precancerous lesions in comparison with controls (P < 0.0003). Further haplotypic analysis showed that two haplotypes (ATCTGG and ACACGG) served as risk haplotypes for oral cancer. These haplotypes were also found to be significantly and positively associated with lifestyle habits (tobacco chewing P=0.04, odds ratio [OR] 3.4) and socioeconomic status (P=0.01, OR3.4). We noticed an increased percentage of risk haplotypes correlating with the aggressiveness of oral cancer. The percentages of risk haplotypes were found to be threefold higher in precancer and fourfold higher in advanced stages of oral cancer in comparison with controls.Five SNPs at the TNF-LTA locus (i.e., -308G>A, -857C>T, -863C>A, -1031T>C, and +252A>G) were found to be associated with the development of oral cancer. Two haplotypes (ATCTGG and ACACGG) emerged as major risk haplotypes for oral carcinoma progression and were also found to be associated with lifestyle factors and clinical aggressiveness. These findings make the TNF-LTA locus a suitable candidate for a future biomarker, which may be used either for early detection or for helping to improve treatment efficacy and effectiveness.
Seth A.,Institute of Technology and Science |
Agarwal H.,Punjabi University |
Singla A.R.,Indian Institute of Foreign Trade
WSEAS Transactions on Computers | Year: 2012
There is a need to understand the existing and future state architecture before you begin selecting platforms and technology, Service Oriented Architecture (SOA) and Cloud, together can provide a complete service based solutions for SMEs. Both SOA and cloud deals with delivering services to business with improved agility, increased speed and reduced cost that can lead to greater innovation and effective returns on investment. In this we proposed an architecture that uses SOA principles to create an overall strategic plan and focus how architectural context support the use of cloud computing.
PubMed | Institute of Technology and science, PDM Dental College and SGT University
Type: | Journal: International journal of biomaterials | Year: 2016
A study was undertaken to evaluate the effect of artificial aging through steam and thermal treatment as influencing the shear bond strength between three different commercially available zirconia core materials, namely, Upcera, Ziecon, and Cercon, layered with VITA VM9 veneering ceramic using Universal Testing Machine. The mode of failure between zirconia and ceramic was further analyzed as adhesive, cohesive, or mixed using stereomicroscope. X-ray diffraction and SEM (scanning electron microscope) analysis were done to estimate the phase transformation (m-phase fraction) and surface grain size of zirconia particles, respectively. The purpose of this study was to simulate the clinical environment by artificial aging through steam and thermal treatment so as the clinical function and nature of the bond between zirconia and veneering material as in a clinical trial of 15 years could be evaluated.
Singh S.,Institute of Technology and Science |
Singh S.Kr.,Indian Institute of Technology Hyderabad
Communications in Computer and Information Science | Year: 2011
Information technology integrations are playing great role in increasing business efficiency. IT based solutions have brought wonders to the enterprises. Organizations are looking for the better technologies for improving their performance at low cost. On the Demand CRM solutions are one of the major tools of increasing business efficiency by providing customer knowledge. This research attempts to study the role of On Demand CRM solutions in creating value for the organizations. The research establishes the importance of on Demand CRM solutions in profitable business implementation with the help of the case of Oracle CRM on Demand solutions. The research focuses at discussing the role of Oracle CRM on Demand solution in improving organizations' performance by analyzing related business and technological issues. © 2011 Springer-Verlag.
Chhabra V.,Institute of Technology and Science |
Rastogi S.,Institute of Technology and Science |
Barua M.,Institute of Technology and Science |
Kumar S.,Institute of Technology and Science
Indian Journal of Dental Research | Year: 2013
Alternaria alternata is one of the rarest fungi associated with paranasal sinusitis. Alternaria species are pigmented (also known as dematiaceous or phaeoid) filamentous fungi, which are well-known soil saprophytes and plant pathogens that infrequently cause infection in humans mainly, cutaneous lesions. We present a case of osteomyelitis of maxilla caused by a rare fungus- A. alternata in a diabetic patient with poor glycemic control who was successfully treated with antifungal and surgical debridement over the period of 6 months.
Baral R.N.,Institute of Technology and Science |
Singhal P.K.,Institute of Technology and Science
Applied Computational Electromagnetics Society Journal | Year: 2010
A design for a microstrip band reject filter is presented in this paper. The proposed filter is compact in structure and provides an accurate band gap. Optimized length is applied to photonic band gap (PBG) structures etched in the ground plane for suppressing periodicity in the frequency response. Detailed analysis of the frequency response of the conventional microstrip filter along with the PBG filter has been carried out in this paper. © 2010 ACES.
Seth A.,Institute of Technology and Science |
Seth K.,Ajay Kumar Garg Engineering College
Proceedings of the 2012 3rd International Conference on Computer and Communication Technology, ICCCT 2012 | Year: 2012
Mining is a process of searching data in huge database to infer useful information and deduces relationships and patterns. Though we can predict certain patterns from our database manually, but as soon as size of data increases (becomes in terabytes) it becomes difficult and tedious to deduce the important information from huge database (or data warehouse). Various data-mining algorithms exist to identify possible patterns in data. 1Rule algorithm is one such algorithm but is capable of classifying rule based on only one attribute. This paper extends 1Rule algorithm by classifying more rules based on multiple attributes, so that more accurate decision or prediction are made thereby improving revenue and reducing costs in a company. 1Rule creates a rule for a data based on one attribute, it chooses the rule that gives the lowest classification error after comparing the error rates from all the attributes. In our work we identified and create more rules based on multiple attributes by considering the lowest error attribute as the new classified attribute. © 2012 IEEE.
Kumar R.,Institute of Technology and Science |
Kumar H.,Institute of Technology and Science
Souvenir of the 2014 IEEE International Advance Computing Conference, IACC 2014 | Year: 2014
Critical role is being played by data related handling in providing efficient working environment for any organization or system. The Tracking related services are being used by various persons and organizations for facilitating day to day working of business. The continuous work and research has done by service providers and researchers for providing exact and efficient information to users of Vehicle Tracking Systems. This is a well known fact that the information can be generated through related and valid data. The need is to handle the received data carefully so that the users could get relevant and exact information. This paper is an attempt for presenting an approach to data handling and tracking of vehicle by using SPSS (A Statistical Tool). The overall scenario starting from data received through GPS device to tracking of the vehicle with position and movement through SPSS is being reflected in this paper. © 2014 IEEE.
Kumar P.,Institute of Technology and Science
Oral health and dental management | Year: 2012
Complete access to the existing pool of biomedical literature and the ability to "hit" upon the exact information of the relevant specialty are becoming essential elements of academic and clinical expertise. With the rapid expansion of the literature database, it is almost impossible to keep up to date with every innovation. Using the Internet, however, most people can freely access this literature at any time, from almost anywhere. This paper highlights the use of the Internet in obtaining valuable biomedical research information, which is mostly available from journals, databases, textbooks and e-journals in the form of web pages, text materials, images, and so on. The authors present an overview of web-based resources for biomedical researchers, providing information about Internet search engines (e.g., Google), web-based bibliographic databases (e.g., PubMed, IndMed) and how to use them, and other online biomedical resources that can assist clinicians in reaching well-informed clinical decisions.
Classification system on the selection of number of implants and superstructure design on the basis available vertical restorative space and interforaminal distance for implant supported mandibular overdenture
PubMed | Institute of Technology and science and SGT University
Type: Journal Article | Journal: Journal of Indian Prosthodontic Society | Year: 2016
The rehabilitation of the edentulous mandible is a challenge due to various limiting factors, of which the available vertical restorative space (AVRS) has been well understood in the literature. However, other anatomic variations such as arch form, arch size, and also the interforaminal distance (IFD) (due to the presence of mandibular nerve) are influential in the selection of size and position of implants, and thereby the prosthetic design.In the present study, 30 edentulous patients from a group of 300 edentulous patients, representing all the three jaw relations (Class I, II, and III) were evaluated for designing a classification that could help in a comprehensive treatment plan for the edentulous mandible. Dental panoramic radiographs of each individual with a trial or final prosthesis were made. The horizontal IFD and AVRS values were calculated.One-way analysis of variance followed by post-hoc test (multiple comparison) and Bonferroni method having P < 0.05 as significant value showed an overall mean of 38.9 mm for horizontal distance and 13.69 mm for the AVRS in 30 edentulous patients.The results showed that in the majority of cases (90%) there is insufficient space to place a bar attachment supported by five implants for mandibular overdentures. This suggests that a universal treatment plan cannot be followed due to varying anatomic factors. Hence, it becomes imperative to have a set of clinical guidelines based on the AVRS and IFD, for the selection of implant number and type of attachment. The article proposes a simple classification system based on the AVRS and IFD for establishing guidelines in the treatment planning of the edentulous mandible, to aid in selection of implant size, number, and position along with the associated prosthetic design.