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Mehdipatnam, India

Babu R.R.,G Pulla Reddy College Pharmacy | Naresh K.,G Pulla Reddy College Pharmacy | Ravi A.,G Pulla Reddy College Pharmacy | Madhava Reddy B.,G Pulla Reddy College Pharmacy | Harinadha Babu V.,G Pulla Reddy College Pharmacy
Medicinal Chemistry Research | Year: 2014

New series of isoniazid incorporated 2-styrylquinazolinone derivatives were synthesized by condensing 2-methyl-4H-3,1-benzoxazin-4-one with isoniazid and subsequent reaction with different aryl/heterocyclic aldehydes. The structures of newly synthesized compounds were confirmed on the basis of physical and spectral data. In anti-tubercular screening, compound 3j was found to be highly active against both H37Rv strain and MDR strain (DKU 156) with MIC values of 0.625 and 0.3125 μg/mL, respectively. © 2014 Springer Science+Business Media New York. Source

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