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Saint-Sauveur-en-Rue, France

Soft tissue pain is a common and debilitating disorder linked to a wide range of unhealthy conditions, mainly involving inflammatory processes. Although frequently prescribed to manage inflammatory conditions and attendant pain, non-steroidal anti-inflammatory drugs (NSAIDs) are nevertheless associated with side and unwanted effects. Accordingly, providing safe and natural alternatives is a current challenge. In this study, an extract of mangosteen rich in α- and γ-mangostins is demonstrated to significantly decrease production of the inflammation marker, tumor necrosis factor-α (TNF-α), in a murine model of inflammation, and to significantly reduce soft tissue pain in volunteers during a clinical investigation. Source


Cases J.,Fytexia SAS | Romain C.,Fytexia SAS | Dallas C.,Fytexia SAS | Gerbi A.,RDVC Produits Sante
International Journal of Food Sciences and Nutrition | Year: 2015

Epidemiological studies suggest that metabolic ageing process of overweight and obese populations is associated with an increased risk of developing non-communicable diseases (NCDs). Inflammation, hyper-glycaemia, dyslipidemia and oxidative stress have been associated with early stages of NCDs development whereas cohort surveys have demonstrated health benefits of dietary polyphenols from various dietary sources to reverse such progress. Obese volunteers were included in a double-blind, randomized, parallel pilot trial where they received daily for a 12-week period 900 mg of a polyphenol-rich treatment extracted from fruit and vegetables frequently consumed within the Mediterranean diet. Anthropometric and blood parameters were assessed before and at the end of the intervention period. After 12 weeks, while the silhouette slimmed down, metabolic parameters were significantly improved and general satisfaction considerably ameliorated. These data suggest that over a 12-week period, the synergistic action of bioactives within the treatment improves metabolic ageing process and quality of life in obese volunteers. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted Source


Cases J.,Fytexia SAS | Romain C.,Fytexia SAS | Dallas C.,Fytexia SAS | Gerbi A.,RDVC Produits Sante | Rouanet J.M.,Montpellier University
International Journal of Food Sciences and Nutrition | Year: 2015

Overweight and obesity are associated to increased risk of developing non-communicable diseases that might dramatically affect life expectancy according World Health Organization. Overweight, obesity, and decline in physical activity are correlated to a significant propensity to lose skeletal muscle mass as a result of prolonged inflammation and oxidative stress whereas cohort surveys and clinical investigations have demonstrated health benefits of Citrus-based polyphenols to reverse such regression. Overweight men were included in a double-blind, randomized, parallel pilot trial where they received daily for a 12-week period 900 mg of a Citrus-based polyphenol extract, Sinetrol® XPur. Body composition, anthropometric, and blood parameters were assessed before and at the end of the intervention period. After 12 weeks, while the silhouette slimmed down, metabolic parameters were significantly improved and skeletal muscle catabolism held back. These data suggest that over a 12-week period, the efficacy of the supplement improve both overweight process and correlated skeletal muscle mass metabolism. © 2015 Informa UK Ltd. Source

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