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Luo Z.-R.,PLA Fuzhou General Hospital | Xie Q.-J.,PLA Fuzhou General Hospital
Chinese Critical Care Medicine | Year: 2012

Objective: To explore the association of osteoprotegerin (OPG) gene polymorphisms 209G/A, 245T/G and 1181G/C in the Han population of Fujian province with acute coronary syndrome (ACS) and its severity. Methods: A prospective study was conducted. Two hundred and fifty-two cases without sibship of Fujian Han people was enrolled from July 2010 to September 2011, in which 68 healthy subjects as controls. One hundred and eighty-four patients with ACS were divided into three groups, 60 had one-vessel, 68 had two-vessel, and 54 had three-vessel lesion, 2 had not been found stegnosis. DNA was extracted from venous blood, different groups of OPG gene polymorphism was identified by Sanger Method. OPG 209G/A, 245T/G and 1181G/C genotype frequencies and allelic frequencies were analyzed between ACS subjects and normal subjects and among the three groups of ACS, and the relationship between gene polymorphisms and ACS severity. Results: No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G between the ACS and control groups. Significant differences were observed in the genotype and allelic frequencies of OPG gene 1181G/C between the ACS and control groups [1181G/C GG: 92(50.0%) vs. 43 (63.2%), CC: 26 (14.1%) vs.0, GC: 66 (35.9%) vs. 25 (36.8%), χ2=11.240, P=0.004; allelic gene G: 250 (67.9%) vs. 111 (81.6%), allelic gene C: 118 (32.1%) vs. 25 (18.4%), χ2=9.148, P=0.002]. No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G and 1181G/C between those groups. Conclusions: There were no significant difference in frequencies OPG genotype and allele in polymorphisms 209G/A, 245T/C between patients with ACS and control group in Han population of Fujian province. There were difference in frequencies OPG genotype and allele in polymorphisms 1181 G/C between patients with ACS and control group, but it was not differently distributed among patients with single-, double-, or triple-vessel lesion. Source

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