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Yang S.-L.,Fuzhou General Hospital of Nanjing Military Command of PLA | Guo J.-Q.,Fuzhou General Hospital of Nanjing Military Command of PLA | Zhang W.,Fuzhou General Hospital of Nanjing Military Command of PLA | Wu X.-Z.,Fuzhou General Hospital of Nanjing Military Command of PLA | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: The organ shortage is the common difficulty faced by the global transplant community. In order to expand the donor sources, to ease the growing tension of the organ shortage and to avoid confusion caused by the absence of brain death legislation and diagnostic criteria, the Ministry of Health and the Red Cross Society of China have jointly promote the cardiac death organ donation. OBJECTIVE: To investigate the feasibility of organ donation from pediatric donors after cardiac death. METHODS: One case of organ donation from a pediatric donor at Fuzhou General Hospital of Nanjing Military Command of PLA was retrospectively analyzed combined with the analysis of the literatures. RESULTS AND CONCLUSION: A 4-year-old boy was independently diagnosed with brain death after cardiopulmonary resuscitation by two groups of specialists at an interval of 24 hours. The criteria included the Diagnostic Criteria for Brain Death (for adults), the Technological Specification for Brain Death (for adults) and atropine test results. The donor parents should be informed and consent with the donor programs and fully expressed the donation willingness, and the program should be approved by the hospital ethics committee. The following steps including donation application, approval, transportation, organ maintaining, mechanical support removal and organ recovery were conducted according to the organ donation guidelines in China after cardiac death. The warm ischemia time was 13 minutes. Two renal grafts were transplanted to two uremic recipients selected by age, weight and human leukocyte antigen matching. The left kidney recipient was a 13-year-old female patient and the right kidney recipient was a 35-year-old female patient. No complications such as delayed graft function, renal graft vascular thrombosis, urinary fistula or ureteral obstruction were observed. The graft length was increased from 7 cm postoperation to 10 cm at 1 year after operation, with negative proteinuria, serum creatinine of 60 μmol/L and estimated glomerular filtration rate was ranged from 70 to 150 mL/min. No long term complications such as serious infections, hypertension, diabetes, hyperlipidemia or liver dysfunction were observed. The recipients have good levels of daily living activities, psychological status and adherence. Organ donation from pediatric donors after cardiac death was one of the alternative solutions to the shortage of organ sources in transitional period. We should explore the standardized operating procedures of pediatric donation after cardiac death based on the top priority principles of patient interests.


Wang Q.-H.,Fuzhou General Hospital of Nanjing Military Command of PLA | Shang L.-L.,Fuzhou General Hospital of Nanjing Military Command of PLA | Chen T.-C.,Fuzhou General Hospital of Nanjing Military Command of PLA | Wang J.,Fuzhou General Hospital of Nanjing Military Command of PLA | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Cylex ImmuKnow is the first and only U S Food and Drug Administration-cleared blood test to measure immune cell function, it can reflect the immune function of the cells directly, which is a valuable tool with good qualities of high sensitivity and specificity. OBJECTIVE: To investigate the correlation between immune cell function and the rejection and infection after renal transplantation through monitoring of immune function intracellular adenosine triphosphatei value. METHODS: We collected 140 renal transplant patients. The immune cell function levels were measured by ImmuKnow™-Cylex®. The patients were divided into three groups according to clinical status of patients, namely, rejection group (n=18), infection group (n=35) and stability group (n=87). In addition, the cellular immune function data in the blood of 61 samples from healthy people were collected as control group. Then the correlation of the immune cell function and infection to rejection after renal transplantation was analyzed. RESULTS AND CONCLUSION: The measurement of intracellular adenosine triphosphatei value showed that about 71.4% (n=25) patients in the infection group distributed in the low immune response zone, and the percentage in the infection group was significantly higher than that in the other three groups (P < 0.05). The intracellular adenosine triphosphatei value in the infection group was significantly lower than that in the other three groups. That indicated that the infection was correlated with low cellular mediated immune function, and the detection of immune cell function played an important role in monitoring the infection after renal transplantation. The immune cell function monitoring with ImmuKnow™-Cylex® assay provides reliable and objective basis for the diagnosis and treatment of infection after renal transplantation, but it has no correlation with the rejection after renal transplantation, and that needs further investigation with a large-sample experiment.


Liu Z.,Fuzhou General Hospital of Nanjing Military Command of PLA | Wei L.,Fuzhou General Hospital of Nanjing Military Command of PLA | Wang H.,Fuzhou General Hospital of Nanjing Military Command of PLA
Scientific Research and Essays | Year: 2011

Three patients with extremely rare aneurysm in the superior clinoid process of internal cardotid artery were treated and the characteristics were reported including tear of aneurysm neck, thinness and tear of parent artery wall, thrombosis, and failure to clip, etc. These situations and findings on imaging were employed to evaluate the features of such aneurysms. The parent artery was irregularly calcified regionally, thickened and deformed, or even the parent artery wall was extremely thin. Such aneurysms occurred in distinct sites with a thin wall at tumor neck and body. Under microscope, the wall of tumor body was thin and carmine. The aneurysms were susceptible to being torn during isolation or clipping of tumor neck which could even cause tear of parent artery and subsequent irreparable bleeding. In 2 patients, the parent artery was stiff due to calcification and its proximal end could not be temporarily blocked. Thrombosis was found in the tumor neck leading to incomplete closure after clipping. Caution should be emphasized, and clipping failure or tear of parent artery may occur during surgery. Preoperative angiography may present obvious features of such aneurysms, and extra-intracranial arterial anastomosis plus isolation is a favorable strategy. ©2011 Academic Journals.

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