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Fuyang, China

Liu Z.,Fuyang Cancer Hospital | Zhao Q.-H.,Shanghai JiaoTong University | Wu X.-Z.,Fuyang Cancer Hospital | Song R.,Fuyang Cancer Hospital | And 2 more authors.
National Medical Journal of China | Year: 2012

Objective: To explore the indications, surgical techniques and prognostic factors of short fusion versus long fusion for elder patients with degenerative lumbar scoliosis. Methods: Thirty-eight patients undergoing different kinds of surgical procedures for lumbar spinal scoliosis between June 2005 and October 2010 were recruited for this retrospective study. The mean patient age at surgery was 64.2 years (range: 61-75). The short fusion group included 13 patients and the long fusion group 25 patients. Results: There were a variety of treatment methods of degenerative scoliosis based on the symptomatology and radiological measurements of scoliosis and stenosis. Thirty-eight patients were followed up for an average of 37 months. The number of fused levels was 2.8 ± 0.7 segments in the short fusion group versus 5.1 ± 1.4 in the long fusion group. The average preoperative Cobb angle was 18.6° (range: 12-27) in the short fusion group versus 33.5° (range: 3-42) in the long fusion group. The correction of Cobb angle averaged 40% in the short fusion group versus 67% in the long fusion group. Clinical symptoms and functional tolerance for daily activities improved postoperatively. Radiographic evaluations showed reduced deformity on the frontal and sagittal planes. There were no infections, pseudoarthrosis, instrument-related failures or reoperations. Conclusions: Long segment fusion is superior to its short segment counterpart in correcting scoliotic curvature and coronal imbalance and improving rotational subluxation of apical vertebra. Careful perioperative preparation is essential in the treatment of elder patients with lumbar spinal scoliosis. Source


Liu Z.,Fuyang Cancer Hospital | Wu X.-Z.,Fuyang Cancer Hospital | Song R.,Fuyang Cancer Hospital | Zong X.-F.,Fuyang Cancer Hospital | And 3 more authors.
National Medical Journal of China | Year: 2013

Objective: To explore the effects of a knockdown of cyclooxygenase 2 upon the growth and migration of SaOS2 cells. Methods: We employed lentivirus mediated-RNA interference technology to knockdown the endogenous expression of gene COX-2 in human osteosarcoma cells (SaOS2) and analyzed their phenotypical changes. The effects of COX-2 silencing on the proliferation, cell cycle and migration of SaOS2 cells were assessed by thiazoyl blue tetrazolium bromide, flow cytometry and migration assays respectively. COX-2, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) mRNA and protein expression were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. Results: A decreased expression of COX-2 in human osteosarcoma cells significantly inhibited the growth and decreased the migration ability of SaOS2 cells. Furthermore, it also reduced VEGF, EGF and bFGF mRNA and protein expression. Conclusion: The COX-2 signaling pathway may provide a novel therapeutic target for the treatment of human osteosarcoma. Copyright © 2013 by the Chinese Medical Association. Source


Shi K.,Fuyang Cancer Hospital | Wang H.,Fuyang Cancer Hospital | Hu S.,Fuyang Cancer Hospital | Wang B.,Fuyang Cancer Hospital | Zhao L.,Fuyang Cancer Hospital
Chinese Journal of Clinical Oncology | Year: 2014

Objective: This study aimed to summarize the diagnosis and treatment of uncommon complications in esophageal and cardiac cancer operations as well as obtain lessons from the failure. Methods: The etiology, clinical diagnosis, treatment, prevention measures, and factors that contribute to the failure of the uncommon complications were analyzed retrospectively. Results: Results showed ten cured cases and eight death cases (except for the reported eight cases). Conclusion: The following conclusions were obtained. 1) The complications described in this paper were rare, but they sometimes occur clinically. If wrong treatment was taken, serious consequences would be expected. 2) Once a jet-like bleeding of aortic esophagus avulsion injury occurs, the surgeon must be calm and take proper treatment to successfully patch up the wounds. 3) The right thoracic approach is a new approach to prevent the injury of azygos vein. 4) Patients with anastomotic stoma fistula easily cause a delay in diagnosis if the leakage was wrapped in the inferior phrenic. 5) Taking preventive measures is the key method for the anastomotic aortoesophageal fistula. 6) Occurrence of pulmonary embolism after operation should be monitored. 7) Thoracic gastric mediastinal hernia would cause serious consequences if treatment was not taken at a proper time. Source

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