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Darwish S.F.,Future University Egypt | El-Bakly W.M.,Ain Shams University | Arafa H.M.,Cairo University | El-Demerdash E.,Ain Shams University
PLoS ONE | Year: 2013

Low dose methotrexate is the cornerstone for the treatment of rheumatoid arthritis. One of its major drawbacks is hepatotoxicity, resulting in poor compliance of therapy. Dissatisfied arthritis patients are likely to seek the option of complementary and alternative medicine such as bee venom. The combination of natural products with modern medicine poses the possibility of potential interaction between the two groups and needs investigation. The present study was aimed to investigate the modulatory effect of bee venom acupuncture on efficacy, toxicity, and pharmacokinetics and tissue disposition of methotrexate. Complete Freund's adjuvant induced arthritic rats were treated for 3 weeks with methotrexate and/or bee venom. Arthritic score, ankle diameter, paw volume and tissue expression of NF-κB and TNF-α were determined to assess anti-arthritic effects, while anti-nociceptive effects were assessed by gait score and thermal hyperalgesia. Methotrexate toxicity was assessed by measuring serum TNF-α, liver enzymes and expression of NF-κB in liver. Combination therapy of bee venom with methotrexate significantly improved arthritic parameters and analgesic effect as compared to methotrexate alone. Bee venom ameliorated serum TNF-α and liver enzymes elevations as well as over expression of NF-κB in liver induced by methotrexate. Histological examination supported the results. And for the first time bee venom acupuncture was approved to increase methotrexate bioavailability with a significant decrease in its elimination. Conclusion: bee venom potentiates the anti-arthritic effects of methotrexate, possibly by increasing its bioavailability. Also, it provides a potent anti-nociceptive effect. Furthermore, bee venom protects against methotrexate induced hepatotoxicity mostly due to its inhibitory effect on TNF-α and NF-κB. © 2013 Darwish et al.


El-Dahshan E.A.-S.,Ain Shams University | El-Dahshan E.A.-S.,Egyptian arning University | Mohsen H.M.,Future University Egypt | Revett K.,University of Westminster | And 2 more authors.
Expert Systems with Applications | Year: 2014

Computer-aided detection/diagnosis (CAD) systems can enhance the diagnostic capabilities of physicians and reduce the time required for accurate diagnosis. The objective of this paper is to review the recent published segmentation and classification techniques and their state-of-the-art for the human brain magnetic resonance images (MRI). The review reveals the CAD systems of human brain MRI images are still an open problem. In the light of this review we proposed a hybrid intelligent machine learning technique for computer-aided detection system for automatic detection of brain tumor through magnetic resonance images. The proposed technique is based on the following computational methods; the feedback pulse-coupled neural network for image segmentation, the discrete wavelet transform for features extraction, the principal component analysis for reducing the dimensionality of the wavelet coefficients, and the feed forward back-propagation neural network to classify inputs into normal or abnormal. The experiments were carried out on 101 images consisting of 14 normal and 87 abnormal (malignant and benign tumors) from a real human brain MRI dataset. The classification accuracy on both training and test images is 99% which was significantly good. Moreover, the proposed technique demonstrates its effectiveness compared with the other machine learning recently published techniques. The results revealed that the proposed hybrid approach is accurate and fast and robust. Finally, possible future directions are suggested. © 2014 Elsevier Ltd. All rights reserved.


Nagy M.M.,Ain Shams University | Tawfik H.E.,Ain Shams University | Hashem A.A.R.,Ain Shams University | Hashem A.A.R.,Future University Egypt | Abu-Seida A.M.,Cairo University
Journal of Endodontics | Year: 2014

Introduction Regenerative endodontics is a promising alternative treatment for immature teeth with necrotic pulps. The present study was performed to assess the regenerative potential of young permanent immature teeth with necrotic pulp after the following treatment protocols: (1) a mineral trioxide aggregate (MTA) apical plug, (2) the regenerative endodontic protocol (blood clot scaffold), and (3) the regenerative endodontic protocol with a blood clot and an injectable scaffold impregnated with basic fibroblast growth factor. Methods Immature necrotic permanent maxillary central incisors (n = 36) of patients 9-13 years old were divided into 3 groups according to the treatment protocol: the MTA group (MTA apical plug), the REG group (regenerative endodontic protocol [blood clot]), and the FGF group (regenerative endodontic protocol [blood clot + injectable scaffold]). Follow-up was done up to 18 months. Standardized radiographs were digitally evaluated for an increase in root length and thickness, a decrease in the apical diameter, and a change in periapical bone density. Results After a follow-up period of 18 months, most of the cases showed radiographic evidence of periapical healing. Groups 2 and 3 showed a progressive increase in root length and width and a decrease in apical diameter. Conclusions The regenerative endodontic procedure allowed the continued development of roots in teeth with necrotic pulps. The use of artificial hydrogel scaffold and basic fibroblast growth factor was not essential for repair. Copyright © 2014 American Association of Endodontists.


Hone K.S.,Brunel University | El Said G.R.,Future University Egypt
Computers and Education | Year: 2016

Massive Open Online Courses (MOOCs) hold the potential to open up educational opportunities to a global audience. However, evidence suggests that only a small proportion of MOOC participants go on to complete their courses and relatively little is understood about the MOOC design and implementation factors that influence retention. This paper reports a survey study of 379 participants enrolled at university in Cairo who were encouraged to take a MOOC of their own choice as part of their development. 122 participants (32.2%) went onto to complete an entire course. There were no significant differences in completion rates by gender, level of study (undergraduate or postgraduate) or MOOC platform. A post-MOOC survey of students' perceptions found that MOOC Course Content was a significant predictor of MOOC retention, with the relationship mediated by the effect of content on the Perceived Effectiveness of the course. Interaction with the instructor of the MOOC was also found to be significant predictor of MOOC retention. Overall these constructs explained 79% of the variance in MOOC retention. © 2016 The Authors. Published by Elsevier Ltd.


El Said G.R.,Future University Egypt
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

The 2011 Egyptian protests began on Tuesday 25 January in Tahrir, one of Cairo's biggest squares. On January 25 and 26, the Egyptian government blocked Twitter in Egypt and later Face book was blocked as well.[1]Most observers of the Egyptian scene at that time, claimed that the responsible governmental authorities did this, in an attempt to stop mobilization for anti-government protests.[2] A report in March 2011[3] highlights a significant increase in the use of the Internet in Egypt in the wake of the January 25 protests. "A large increase in the number of web surfers and users of social networking sites reported to change the pattern of use and the interests of the of the Internet contents". According to the report, the number of Internet users in Egypt prior to January 25 was 21.2 million users, increased by almost 9% after this date to reach 23.1 million in two months. The time Egyptian users spent online was doubled from 900 to 1800 minutes per months after 25 January 2011. Still, Egypt's Internet penetration rate is less than 25%. This paper investigates cultural issues in human computer interaction. The paper explores the specific experiences of young Egyptian Internet users and their interaction through social media during and after the Egyptian protest in 25 January 2011. The paper aims to reveal some the cultural characteristics of this user group in interacting with the Internet. © 2013 Springer-Verlag Berlin Heidelberg.


Taher A.T.,Cairo University | Georgey H.H.,Cairo University | El-Subbagh H.I.,Future University Egypt
European Journal of Medicinal Chemistry | Year: 2012

The synthesis of some new heterodiazole and their annulated imidazo[2,1-b]1,3,4-oxa/thiadiazolone 6a-d, 7a-d; 1,3,4-oxa or thiadiazole[3,2-a]pyrimidine diamine 8a-d and 1,3,4-oxa or thiadiazole-3- piperidino-1-propamide 11a,b derivatives have been described. The obtained compounds were evaluated for their in-vitro antitumor activity. A single dose (10 μM) of the test compounds were used in the full National Cancer Institute (NCI) 60 cell lines panel assay. Compounds 6c and 6d displayed appreciable anticancer activity against leukemia, non-small cell lung, CNS and showed moderate activity against colon, melanoma, and breast cancer cells lines. Compound 6c possessed remarkable broad-spectrum antitumor activity which almost 4 fold more active than the known drug 5-FU with GI 50, TGI, and LC 50 values of 6.0, 17.4, and 55.1 μM, respectively. © 2011 Elsevier Masson SAS. All rights reserved.


Alrawi O.,Future University Egypt
WIT Transactions on Ecology and the Environment | Year: 2014

Sustainable development is not a process to reach an end state but rather an ongoing process. Sustainability is the self-evident term for the dynamic equilibrium between man and nature and for the co-evolution of both within the Gaia mega-system. The complementary system in nature in its profusion of formal language is expressed in infinite multidimensional patterns. Approaches to form generation that operates without employing a priori categories of form have required a new definition of the concept of form. Here the distinction between form and formation becomes significant. If we study architecture as the history of meaningful form, we will discover man, nature and we will know how God gave us the tools for real creativity. Creativity involves the development of original, imaginative ideas, usually for a particular purpose and can be situated in both cognitive and social domains. For the purpose of cultural heritage presence, we shall be dealing with the cybernetics theory, especially the second-order cybernetics that can contribute to symbiotic dialogues between societies, at a side, and art, architecture and urbanism on the other side. In this regard, we shall try to reach an understanding for the sustainable creative process considering changes in human faculties in Islamic cities. This paper tries to discover the ability of historic cities to become a source of inspiration which enables a society to innovate by re-interpreting the past, overcoming the dichotomies resulting from a single-minded pursuit of a narrow vision of progress. It will also try to identify the way in which a creative exploration and a careful evolution of historic cities can give birth to cultural continuity that can re-establish an organic link with the past, for the sake of re-integrating human wholeness and for motivations that goes beyond the rationality of these cities. © 2013 WIT Press.


Abdellatif M.,Future University Egypt
Color Research and Application | Year: 2015

The spectral overlap of color-sampling filters increases errors when using a diagonal matrix transform, for color correction and reduces color distinction. Spectral sharpening is a transformation of colors that was introduced to reduce color-constancy errors when the colors are collected through spectrally overlapping filters. The earlier color-constancy methods improved color precision when the illuminant color is changed, but they overlooked the color distinction. In this article, we introduce a new spectral sharpening technique that has a good compromise of color precision and distinction, based on real physical constraints. The spectral overlap is measured through observing a gray reference chart with a set of real and spectrally disjoint filters selected by the user. The new sharpening method enables to sharpen colors obtained by a sensor without knowing the camera response functions. Experiments with real images showed that the colors sharpened by the new method have good levels of color precision and distinction as well. The color-constancy performance is compared with the data-based sharpening method in terms of both precision and distinction. © 2014 Wiley Periodicals, Inc. Col Res Appl, 40, 564-576, 2015 © 2014 Wiley Periodicals, Inc.


Fahmy O.M.,Future University Egypt
2015 22nd International Conference on Systems, Signals and Image Processing - Proceedings of IWSSIP 2015 | Year: 2015

In multimedia forensics, source-based image classification problem is a well known problem. It addresses the issue of identifying those images that were captured by a specific source camera from a given set of N data images. This is possible as each camera has a unique Photo Response Non-Uniformity (PRNU) that is registered in every image captured by this camera. Classification is made by clustering images having the same PRNU. In this paper, an efficient technique is proposed to group images originated by the same camera. It is based on evaluating the similarity functions between the estimated PRNUs as well as their Hu's moment invariant information. The proposed technique has the ability to group images taken by a specific camera, even if the input images correspond to the same scene that was captured by different cameras. The classification algorithm is performed by means of a hierarchical clustering. Simulation examples are given to verify the superiority of the proposed technique compared to other techniques. © 2015 IEEE.


El Said G.R.,Future University Egypt
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

Various undergraduate and post graduate educational bodies, now a day, employ blended learning systems to complement the face to face communication between educator and learner. While E-learning tools in general have been found to improve access to resources, these tools need to be reliable and usable; the ease of use of E-learning would have a meaningful impact on the learning experience.[1] This paper investigates learners' perception of quality and willingness to use of E-learning environments. It also explores the attitude of users from two different cultural groups towards a number of E-learning sites. The paper aims to reveal some of the perception of quality for these groups of users in interacting with learning virtual communities. In September/ October 2013, series of card sorting sessions were conducted with number of learners enrolled in a joint venture European-Arab Master Program. In the individual sessions, each participant was asked to look at card of selected E-Learning sites, and to choose a single criterion by which the E-learning main pages could be differentiated from one another. Cards were then sorted based on different categories under each criterion. Participants repeated sorting the cards according to criteria and categories they generated. A second round of sorting sessions were conducted by the same participants, where they sorted the same cards according to the Willingness to Use criterion, and provided a reason for the sorting decisions made. The analysis of the card sorting sessions reveals some interesting findings concerning interface elements which seem to be salient for users in E-learning environment, such as: Interface Comprehensibility and Obviousness, Content Usefulness, and Site Affiliation and Reputation. Some differences in quality perception were also found between the two cultural groups. This paper makes a contribution to universal access in HCI by describing the quality perception, preferences, and general attitude for different group of users in the context of E-learning environment. © 2014 Springer International Publishing.

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