Fuqing Municipal Hospital
Fuqing Municipal Hospital
Wang S.,Lanzhou University |
Liu M.-J.,Lanzhou University |
Yang Q.-S.,Peoples Hospital of Gansu Province |
Du B.,Xian Ninth Hospital |
And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2016
BACKGROUND: There are many ways for surgical treatment of distal radius fractures. Both volar locking plates and Kirschner wires are common methods. Doctors have considerable flexibility in the choice of the ways of fixation, but both at home and abroad there is no comparison between the effects of the two operations for treating distal radius fractures. OBJECTIVE: To systematically review the differences in effectiveness and safety of volar locking plates versus Kirschner wires for distal radial fracture. METHODS: Databases such as CBM, CNKI, VIP, PubMed and Cochrane Library were electronically searched. Chinese Journal of Orthopaedics, Chinese Journal of Orthopaedic Trauma, Chinese Journal of Trauma and Journal of Practical Orthopaedics were searched by hand. In strict accordance with inclusion and exclusion criteria, articles were screened. Methodological quality of included studies was evaluated according to Cochrane Handbook. Data were extracted, and then analyzed with RevMan 5.2 software. RESULTS AND CONCLUSION: Nine randomized controlled trials were included. Meta-analysis results demonstrated that upper limb function scores were better in the volar locking plate group than in the Kirschner wire group [MD= -4.55(-7.89, -1.21), P=0.008] at 3 months of follow-up and [MD= -3.13(-6.08, -0.18), P=0.004] at 12 months. The incidence of infection was lower in the volar locking plate group than in the Kirschner wire group [OR= 0.42(0.23, 0.79), P=0.007]. No significant difference in incidence of complex regional pain syndrome [OR=0.28(0.05, 1.38), P=0.12], incidence of carpal tunnel syndrome [OR=0.75(0.20, 2.76), P=0.66] and tendon injury [OR= 1.66(0.51, 5.41), P=0.64] was detected between the volar locking plate group and Kirschner wire group. These results indicated that compared with the Kirschner wire, volar locking plate fixation for the repair of distal radial fracture is safe and effective. In the permission of economic circumstances, it is suggested that elder osteoporosis patients with distal radial fracture should receive plate fixation. © 2016, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.
Ni G.-X.,Southern Medical University |
Shu B.,Third Military Medical University |
Huang G.,Fuqing Municipal Hospital |
Lu W.W.,University of Hong Kong |
Pan H.-B.,University of Hong Kong
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2012
In this study, the effects of a series of strontium (Sr)-substituted HA ceramics (0, 1, 5, and 10 mol % Sr substitution) were tested on their physical and biological properties. The crystal structure, composition, and solubility were investigated by TEM, XRD, and solid titration solubility isotherms, respectively. In addition, rat MSCs were cultured with culture media containing ions released from the strontium-substituted HA ceramics as they dissolved. MTT test, alkaline phosphatase activity, and osteoblast transcription factor gene (cbfa1) expression were conducted at different time points. Our results suggested that HA with Sr substitution may change its physical properties, especially its solubility, and consequently enhance undifferentiated MSCs into osteoblast lineage. The results from this and the previous study suggested that 5-10 mol % Sr substitution into HA may be a suitable choice for its use in bone regenerative field. © 2011 Wiley Periodicals, Inc.
Yao Z.-P.,Fujian Medical University |
Huang G.-T.,Fuqing Municipal Hospital |
Liu W.-G.,Fujian Medical University |
Lu W.W.,University of Hong Kong
Journal of Materials Science: Materials in Medicine | Year: 2011
The purpose of this study was to test the effects of a series of strontium-substituted HA (Sr-HA) ceramics (0, 1, 5, and 10 mol% Sr substitution) on osteoblasts, thereby demonstrating whether strontium incorporation with HA would favor osteoblast metabolism. Rat primary osteoblasts were cultured with culture media containing ions released from the Sr-HA ceramics as they dissolved. MTT test, alkaline phosphatase activity, osteoblast transcription factor gene (cbfa1) expression and Alizarin Red staining were conducted at different time-points. There is no significant difference in cell proliferation between groups. However, compared with HA group, Sr-HA groups presented significant enhancement with regard to ALP activity, cbfa1 mRNA expression, and mineralization nodules. Among Sr-HA groups, 5 and 10% groups showed much better performances in ALP activity, cbfa1 mRNA expression, and mineralization nodules than 1% group, however, no significant difference was found between 5 and 10% groups. This study has demonstrated that Sr incorporation in HA ceramic enhanced osteoblastic cell differentiation and mineralization. However, further detailed studies are needed to understand the mechanistic effects of this Sr incorporation on osteoblastic cells and the optimal percentage of calcium should be substituted with strontium in HA. © Springer Science+Business Media, LLC 2011.
Xue F.,Fuqing Municipal Hospital |
Ye Y.-S.,Fuqing Municipal Hospital
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: Percutaneous vertebroplasty with bone cement injection for osteoporotic vertebral compression fractures can quickly relieve pain and increase vertebral strength, but vertebral re-fractures often occur because of osteoporosis. OBJECTIVE: To investigate the therapeutic effect of percutaneous vertebroplasty with bone cement injection combined with zoledronic acid in the treatment of osteoporotic vertebral compression fractures. METHODS: Six patients with osteoporotic vertebral compression fractures were enrolled, including two males and four females, aged 60-86 years. These patients with T12-L4 vertebral fractures underwent percutaneous vertebroplasty with polymethyl methacrylate acrylate bone cement treatment. At 4 weeks after bone cement injection, all patients were administrated with intravenous injection of zoledronic acid (100 mL: 5 mg) as anti-osteoporosis treatment, 30 drops per minute, once a year, for consecutive 2 years. The 2-year periodic imaging was performed to observe the clinical efficacy on vertebral compression fractures, bone density and adjacent vertebral fractures. RESULTS AND CONCLUSION: At 48 hours after bone cement injection, pain symptoms were relieved in the six cases. At the end of 2-year follow-up, fractures healed in all the six cases without delayed union or nonunion, and there was no bone cement leakage, nerve root compression, dural involvement, needle opening or wound infection and pulmonary embolism; the bone density was significantly higher than that before treatment (P < 0.05), and no adjacent vertebral fractures occurred. These findings indicate that the percutaneous vertebroplasty with bone cement injection combined with zoledronic acid can significantly relieve pain, improve vertebral stability and bone density, and reduce the incidence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.