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Nawange S.R.,Fungal Disease Diagnostic and Research Center | Nawange S.R.,Rani Durgavati University | Singh S.M.,Fungal Disease Diagnostic and Research Center | Naidu J.,Biotechnology Research Laboratory | And 4 more authors.
Asian Journal of Microbiology, Biotechnology and Environmental Sciences

Geographical distribution of serotypes of Cryptococcus neoformans and Cryptococcus gattii has been useful in understanding the global epidemiology of Cryptococcosis. In this study done between 1998-2004, 14 strains of C. neoformans and C. gattii from clinical cases and 53 from environment were isolated from the Jabalpur city of Central India. Of the total 53 environmental strains, 51 (96.2%) were Cryptococcus neoformans and 02 (3.7%) Cryptococcus gattii. Among 51 C. neoformans isolates 45 (84.9%) were serotype A; and both serotype D and AD were 03 (5.66%).The two C. gattii strains isolated were serotype B. Human urine soaked soil is reported as a new site for the isolation of C. gattii serotype B. In India C. neoformans serotype AD has been, for the first time, isolated from the environment in our study. Out of 14 clinical cases investigated, 09 (64.3%) yielded C. neoformans serotype A and 02 (14.3%) C. neoformans serotype D followed by 03 (21.4%) C. gattii serotype B. In Central India C. neoformans (serotype D) has been, for the first time, reported both from the environment as well as from clinical cases. Our results suggest that the distribution of different serotypes of C. neoformans (A,D and AD) and C. gattii (B) in the environment and among patients here may vary from other climatically different regions of India. © Global Science Publications. Source

Nawange S.R.,Rani Durgavati University | Nawange S.R.,Fungal Disease Diagnostic and Research Center | Singh K.,Banaras Hindu University | Naidu J.,Government Science College | And 2 more authors.

Naturally acquired disseminated dual infection caused by Candida famata and Candida catenulata was observed in a group of albino rats bred in an animal house for sale at Jabalpur, India. Out of 200 rats examined, 40 (20%) revealed disseminated infection from which 10 (5%) exhibited infection of the brain. Mixed colonies of C. famata and C. catenulata were isolated in culture from brain, heart, lungs, liver, kidneys, spleen and stomach of the diseased animals. Histopathology revealed the presence of necrotic lesions containing yeast cells. Epidemiological studies showed the presence of the pathogens in the soil of the animal's breeding place. It is suggested that the rats may have acquired infection from the soil either through contaminated food, drinking water or aerosol. This is the first report of the naturally acquired dual infection in albino rats caused by C. famata (Debaryomyces hansenii) and C. catenulata. © 2009 Blackwell Verlag GmbH. Source

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