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Araneda O.F.,University of Los Andes, Chile | Urbina-Stagno R.,Fundacion para la Investigacion de las Ciencias Ambientales y Humanas FICAH | Tuesta M.,Vina del Mar University | Haichelis D.,Fundacion para la Investigacion de las Ciencias Ambientales y Humanas FICAH | And 3 more authors.
Journal of Physiology and Biochemistry | Year: 2014

It is a well-established fact that exercise increases pro-oxidants and favors oxidative stress; however, this phenomenon has been poorly studied in human lungs. Pro-oxidative generation (H2O2, NO 2 -), lipid peroxidation markers (MDA), and inflammation (pH) in exhaled breath condensate (EBC) have been determined through data from 10 active subjects who ran 10 km; samples were obtained immediately before, at 20, and at 80 min post-exertion. In EBC, the concentration of H 2O2 at 80 min post-exertion was increased. NO2 - concentration showed a tendency to increase at 80 min post-exertion, with no variations in MDA and pH. No variations of NO2 - were found in plasma, while there was an increase of NO 2 - at 80 min post-exertion in the relation between EBC and plasma. NO2 - in EBC did not correlate to plasmatic NO2 -, while it did correlate directly with H 2O2 in EBC, suggesting a localized origin for the exercise-related NO2 - increase in EBC. MDA in plasma did not increase nor correlate with MDA in EBC. In conclusion, high-intensity exercise increases lung-originated pro-oxidants in non-athlete subjects with no evidence of early lipid peroxidation and changes in the pH value in EBC. © 2013 University of Navarra. Source

Tuesta M.,University of Santiago de Chile | Tuesta M.,University of Barcelona | Alvear M.,University for Development | Carbonell T.,University of Barcelona | And 3 more authors.
Journal of Physiology and Biochemistry | Year: 2016

Exercise promotes pulmonary oxidative imbalance. In this regard, some evidence has been obtained from the study of exhaled breath condensate (EBC) during urban races, in which the factors involved in the occurrence of this process are still not characterized. In this paper, under laboratory conditions, both the role of time of exercise on the generation of pro-oxidants (H2O2, NO2 −) and pH have been assessed in EBC of 16 under-trained subjects who completed three tests of cycloergometric exercise at low intensity (30 % of VO2 max) with a duration of 10, 30, and 90 min. Samples were obtained as follows: immediately before and at 80 min post exertion in each test. In the 90-min test, an increase in H2O2, NO2 − concentration in EBC at 80 min post exertion with no changes in the pH was observed. Total O2 consumption and total ventilation weakly correlated with the changes in H2O2 and NO2 −. In conclusion, the concentration of pro-oxidants in the EBC depends on the duration of the exercise when it is performed at low intensity under laboratory conditions. © 2016 University of Navarra Source

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