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Rodriguez-Carmona Y.,Metropolitan Autonomous University | Rodriguez-Carmona Y.,Instituto Nacional Of Medicina Genomica Inmegen | Perez-Rodriguez M.,National Autonomous University of Mexico | Gamez-Valdez E.,Instituto Nacional Of Medicina Genomica Inmegen | And 19 more authors.
Journal of Nutrigenetics and Nutrigenomics | Year: 2014

Background/Aim: Genetic variation in apolipoprotein E (ApoE) has a key role in lipid metabolism. However, its contribution to the amount and distribution of body fat is under investigation. The aim of this study was to analyze the association between genetic variation in ApoE and obesity-related traits in Mexican school children. Material and Methods: Anthropometric, body composition and physical activity measures were conducted using standard methods in 300 children (177 girls/123 boys) who fulfilled the inclusion criteria. DNA was isolated from saliva. ApoE genotypes were analyzed by allelic discrimination. The association between variation in ApoE and anthropometric and body composition measures was investigated using the General Linear Model. Results: The mean ± SD values for age, body mass index (BMI) and waist circumference (WC) were 9.05 ± 0.80 years, 19.01 ± 3.83 and 67.98 ± 10.97 cm, respectively. Approximately 46% of the participants were overweight or obese. A significant association between ApoE isoforms and WC was found after controlling for age, sex and the percentage of physical activity (p = 0.025). Significant main effects were found for vigorous physical activity and light physical activity influencing the adiposity-related BMI (p < 0.001) and WC (p = 0.044), respectively. Conclusions: Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children. © 2015 S. Karger AG, Basel. Source


Castaneda De La Lanza C.,Subdireccion de Planeacion | O'Shea Cuevas G.,Comisionado Nacional de Proteccion Social en Salud | Gallardo Valdes D.M.,Instituto Materno Infantil Del Estado Of Mexico Imiem | Farreras Pina D.,Instituto Materno Infantil Del Estado Of Mexico Imiem | And 2 more authors.
Gaceta Mexicana de Oncologia | Year: 2015

Developing palliative care units is necessary in healthcare systems, especially in hospitals with paediatric haematology-oncology services. It has to be acknowledged that children with life-threatening diagnoses and diseases require comprehensive management, and symptom control must be effective due to the suffering of the patient and anxiety caused to the family. In turn, it is important for paediatric palliative care teams to know and recognise the sources of suffering and their relationship with physical, psychological, social and spiritual aspects, which have to be comprehensively treated in order to control symptoms effectively. Active, continuous and total care has to be ensured, establishing a balance between the goals of the parents (legal guardians) and the patients. © 2015 Sociedad Mexicana de Oncologiá. Source

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