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Torregrosa I.,Hospital Clinico Universitario Of Valencia | Montoliu C.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Urios A.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Elmlili N.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | And 10 more authors.
Nefrologia | Year: 2012

Background: Acute kidney injury (AKI) is a common complication of cardiac surgery and coronary angiography, worsening the prognosis of these patients. The diagnosis is based on the rise in serum creatinine, which is late. It is necessary identifying and validating new biomarkers, which allow early and effective interventions. Aims: To assess the sensitivity and specificity of neutrophil gelatinaseassociated lipocalin in urine (uNGAL), interleukin-18 (IL-18) in urine and cystatin C in serum for the early detection of AKI in patients with acute coronary syndrome or heart failure, and undergoing cardiac surgery or catheterization. Methods: The study included 135 patients admitted to the intensive care unit for acute coronary syndrome or heart failure by coronary or valvular pathology and who underwent cardiac angiography or cardiac bypass surgery or valvular replacement. The biomarkers were determined 12 hours after surgery and serum creatinine was monitored during the next six days for the diagnosis of AKI. Results: The area under the ROC curve (AUC) for NGAL was 0.983, and for cystatin C and IL-18 the AUCs were 0.869 and 0.727, respectively. At a cut off of 31.9 ng/ml of uNGAL the sensitivity was 100% and the specificity was 91%. Conclusions: uNGAL is an early marker of AKI in patients with acute coronary syndrome or heart failure and undergoing cardiac surgery and cardiac angiography, with a higher predictive value than cystatin C or IL-18. Source


Martinez-Jabaloyas J.M.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Martinez-Jabaloyas J.M.,Hospital Clinico Universitario Of Valencia | March-Villalba J.A.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | March-Villalba J.A.,Hospital Clinico Universitario Of Valencia | And 3 more authors.
Expert Opinion on Biological Therapy | Year: 2013

Prostate cancer (PCa) is the second most common type of cancer among men in Western societies. Once in the castrate-resistant metastatic setting therapeutic options are limited. The importance of angiogenesis in the progression of PCa has been widely reported providing a rationale to test anti-angiogenic compounds for PCa treatment in clinical trials (CTs). However, in spite of the promising results shown in preclinical models and some anti-tumor activity observed in CTs, to date, no angiogenic inhibitor has been approved for use in PCa. This editorial outlines the latest clinical evidence regarding anti-angiogenic therapies in PCa treatment. © 2013 Informa UK, Ltd. Source


Civera M.,Hospital Clinico Universitario | Urios A.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Garcia-Torres M.L.,Hospital Clinico Universitario | Ortega J.,Hospital Clinico Universitario | And 6 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2010

Background: In obesity, insulin resistance appears frequently after activation of proinflammatory molecules. Caspase-generated cytokeratin-18 (CK-18) fragments are produced during the apoptosis of hepatic cells. The main objective in the present study is to investigate the relationship between insulin resistance and caspase-generated CK-18 fragments in patients with severe obesity. Methods: Sixty-two patients selected for bariatric surgery were clinically studied (sex, age, weight, waist diameter, body mass index, arterial pressure and type 2 diabetes mellitus) and analytic parameters were measured in blood (glucose concentration, cholesterol, triglycerides, insulin, glycosylated hemoglobin, aspartate aminotransferase, alanine aminotransferase, highsensitivity C-reactive protein, adiponectin, interleukin 6, interleukin 18 and CK-18 fragments). Patient group division was based on 70th percentile of insulin resistance as measured by homeostasis model asssessment (HOMA) and also according to liver histology. Results: Patients with greater insulin resistance (percentile >70th) showed higher values of CK-18 fragments, interleukin 6 and transaminases. A positive correlation between the HOMA score, value of CK-18 fragments and triglyceride level was found. A correlation between CK-18 fragments with interleukin 6, triglycerides and transaminases was also observed. HOMA score and value of CK-18 fragments correlated with the degree of liver fibrosis. Conclusions: Greater degree of insulin resistance induces apoptosis of hepatic cells as measured by the serum levels of CK-18 fragments. Copyright © 2010 John Wiley & Sons, Ltd. Source


Puig-Silla M.,University of Valencia | Dasi-Fernandez F.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Montiel-Company J.-M.,University of Valencia | Almerich-Silla J.-M.,University of Valencia
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2012

Objectives: The aim of this study was to determine the prevalence of the different fimA genotypes of Porphyromonas gingivalis in adult Spanish patients with chronic periodontitis, patients with gingivitis and periodontally healthy subjects, and the relationship between these genotypes and other periodontopathogenic bacteria. Study design: Samples of subgingival plaque were taken from 86 patients (33 with chronic periodontitis, 16 with gingivitis, and 37 periodontally healthy) in the course of a full periodontal examination. PCR was employed to determine the presence of the 6 fimA genotypes of Porphyromonas gingivalis (I-V and Ib) and of Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Treponema denticola. Results: Porphyromonas gingivalis fimA genotypes II and Ib were present in significantly higher percentages in periodontal patients (39.4% and 12.1% respectively) than in healthy or gingivitis subjects. The prevalence of Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis fimA genotype IV was significantly higher in the group that presented bleeding greater than 30%. A positive correlation was found between Porphyromonas gingivalis fimA genotype IV and Treponema denticola. Conclusions: A strong association between Porphyromonas gingivalis fimA genotypes II and Ib and chronic periodontitis exists in the Spanish population. The most prevalent genotype in periodontal patients is II. © Medicina Oral S. L. Source


Almerich-Silla J.M.,University of Valencia | Montiel-Company J.M.,University of Valencia | Pastor S.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | Serrano F.,Fundacion Investigacion Hospital Clinico Universitario Of Valencia | And 2 more authors.
Disease Markers | Year: 2015

Objective. To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. Methods. A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal healthy as control. Oxidative stress biomarkers (8-OHdG and MDA), total antioxidant capacity (TAOC), and the activity of two antioxidant enzymes (GPx and SOD) were determined in saliva. Subgingival plaque samples were obtained from the deepest periodontal pocket and PCR was used to determine the presence of the 6 fimA genotypes of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola. Results. Periodontal disease was found to be associated with increased oxidative stress parameter levels. These levels rose according to the number and type of different periodontal bacteria found in the periodontal pockets. The presence of different types of periodontal bacteria is predictive independent variables in linear regresion models of oxidative stress parameters as dependent variable, above all 8-OHdG. Conclusions. Oxidative stress parameter levels are correlated with the presence of different types of bacteria. Determination of these levels and periodontal bacteria could be a potent tool for controlling periodontal disease development. © 2015 Jose Manuel Almerich-Silla et al. Source

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