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Freije A.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | Molinuevo R.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | Ceballos L.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | Cagigas M.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | And 9 more authors.
Cell Reports | Year: 2014

Tumor suppressor p53 is a major cellular guardian ofgenome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to80% in squamous cell carcinoma (SCC). By adapting the small hairpin RNA (shRNA) technology, we inactivated endogenous p53 in primary epithelial cells from the epidermis of human skin. We show thateither loss of endogenous p53 or overexpressionofa temperature-sensitive dominant-negative conformation triggers a self-protective differentiation response, resulting in cell stratification and expulsion. These effects follow DNA damage and exit from mitosis without cell division. p53 preserves the proliferative potential of the stem cell compartment and limits the power of proto-oncogene MYC to drive cell cycle stress and differentiation. The results provide insight into the role of p53 in self-renewal homeostasis and help explain why p53 mutations do not initiate skin cancer but increase the likelihood that cancer cells will appear. © 2014 The Authors. Source


Ramos L.,University of Cantabria | Ramos L.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | Piedra M.,University of Cantabria | Piedra M.,Fundacion Institute Investigacion Marques Of Valdecilla Idival | And 4 more authors.
Calcified Tissue International | Year: 2014

Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it showed finely speckled subcutaneous calcifications in the high convexity of the head. Cutaneous exploration did not show any abnormality. We herein report an unusual case of late-onset scalp calcifications in a patient with PPHP. © 2014 Springer Science+Business Media. Source

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