Morillo C.A.,Hamilton Health Sciences |
Avezum A.,Instituto Dante Pazzanese Of Cardiologia |
Sosa-Estani S.,Instituto Nacional Of Parasitologia |
Rassi A.,Hospital Do Corao Anis Rassi |
And 15 more authors.
New England Journal of Medicine | Year: 2015
BACKGROUND The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed for a mean of 5.4 years. The primary outcome in the time-to-event analysis was the first event of any of the components of the composite outcome of death, resuscitated cardiac arrest, sustained ventricular tachycardia, insertion of a pacemaker or implantable cardioverter-defibrillator, cardiac transplantation, new heart failure, stroke, or other thromboembolic event. RESULTS The primary outcome occurred in 394 patients (27.5%) in the benznidazole group and in 414 (29.1%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.81 to 1.07; P = 0.31). At baseline, a polymerase-chain-reaction (PCR) assay was performed on blood samples obtained from 1896 patients; 60.5% had positive results for Trypanosoma cruzi on PCR. The rates of conversion to negative PCR results (PCR conversion) were 66.2% in the benznidazole group and 33.5% in the placebo group at the end of treatment, 55.4% and 35.3%, respectively, at 2 years, and 46.7% and 33.1%, respectively, at 5 years or more (P<0.001 for all comparisons). The effect of treatment on PCR conversion varied according to geographic region: in Brazil, the odds ratio for PCR conversion was 3.03 (95% CI, 2.12 to 4.34) at 2 years and 1.87 (95% CI, 1.33 to 2.63) at 5 or more years; in Colombia and El Salvador, the odds ratio was 1.33 (95% CI, 0.90 to 1.98) at 2 years and 0.96 (95% CI, 0.63 to 1.45) at 5 or more years; and in Argentina and Bolivia, the odds ratio was 2.63 (95% CI, 1.89 to 3.66) at 2 years and 2.79 (95% CI, 1.99 to 3.92) at 5 or more years (P<0.001 for interaction). However, the rates of PCR conversion did not correspond to effects on clinical outcome (P = 0.16 for interaction). CONCLUSIONS Trypanocidal therapy with benznidazole in patients with established Chagas' cardiomyopathy significantly reduced serum parasite detection but did not significantly reduce cardiac clinical deterioration through 5 years of follow-up. (Funded by the Population Health Research Institute and others; ClinicalTrials.gov number, NCT00123916; Current Controlled Trials number, ISRCTN13967269.). © 2015 Massachusetts Medical Society. All rights reserved.
Reyes L.M.,University of Alberta |
Garcia R.G.,Fundacion Cardiovascular de Colombia |
Ruiz S.L.,Fundacion Cardiovascular de Colombia |
Broadhurst D.,University of Alberta |
And 3 more authors.
Growth Factors | Year: 2012
Background: An imbalance between anti-angiogenic factors (e.g. soluble vascular endothelial growth factor receptor-1 (s-FLT1) and soluble endoglin (s-Eng)) and pro-angiogenic factors (e.g. placental growth factor (PlGF)) as well as increased oxidized low-density lipoprotein (ox-LDL) concentrations have been associated with preeclampsia (PE). Risk factors associated with the development of PE, however, are known to be different between developed and developing countries. The aim of the study was to determine the levels of s-FLT1, s-Eng, PIGF, and ox-LDL in women with PE from a developing country. Methods: A multi-center casecontrol study was conducted. One hundred and forty three women with PE were matched by age and parity with 143 healthy pregnant women without cardiovascular or endocrine diseases. Before delivery, blood samples were taken and serum was stored until analysis. Results: Women with PE had lower concentrations of PIGF (p < 0.0001) and higher concentrations of s-Eng (p = 0.001) than healthy pregnant women. There were no differences between the groups regarding ox-LDL or s-FLT1. Women with early onset PE had higher s-FLT1 concentrations (p = 0.0004) and lower PIGF concentrations (p < 0.0001) than their healthy pregnant controls. Women with late onset PE had higher concentrations of s-Eng (p = 0.005). Women with severe PE had higher concentrations of s-Eng (p = 0.0008) and ox-LDL (p = 0.01), and lower concentrations of PIGF (p < 0.0001). Conclusions: Women with PE from a developing country demonstrated an angiogenic imbalance and an increased rate of LDL oxidation. Findings from this study support the theory that PE is a multifactorial disease, and understanding differences in these subpopulations may provide a better target to approach future therapies. © 2012 Informa UK, Ltd.
Reyes L.M.,Fundacion Cardiovascular de Colombia |
Garcia R.G.,Fundacion Cardiovascular de Colombia |
Ruiz S.L.,Fundacion Cardiovascular de Colombia |
Camacho P.A.,Fundacion Cardiovascular de Colombia |
And 4 more authors.
PLoS ONE | Year: 2012
Background: Preeclampsia (PE) is a multi-causal disease characterized by the development of hypertension and proteinuria in the second half of pregnancy. Multiple risk factors have been associated with the development of PE. Moreover, it is known that these risk factors vary between populations from developed and developing countries. The aim of this study is to identify which risk factors are associated with the development of preeclampsia (PE) among Colombian women. Methods: A multi-centre case-control study was conducted between September 2006 and July 2009 in six Colombian cities. Cases included women with PE (n = 201); controls were aged-matched pregnant women (n = 201) without cardiovascular or endocrine diseases for a case-control ratio of 1:1. A complete medical chart, physical examination and biochemical analysis were completed before delivery. Multivariable logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) of potential risk factors associated with PE. Results: The presence of factors present in the metabolic syndrome cluster such as body mass index >31 Kg/m2 (OR = 2.18; 1.14-4.14 95% CI), high-density lipoprotein <1.24 mmol/L (OR = 2.42; 1.53-3.84 95% CI), triglycerides >3.24 mmol/L (OR = 1.60; 1.04-2.48 95% CI) and glycemia >4.9 mmol/L (OR = 2.66; 1.47-4.81 95%CI) as well as being primigravidae (OR = 1.71; 1.07-2.73 95% CI) were associated with the development of PE, after adjusting for other variables. Conclusion: Factors present in the cluster of metabolic syndrome and primigravidity were associated with a greater risk of PE among Colombian women. Understanding the role of this cluster of risk factors in the development of PE is of crucial importance to prevent PE and remains to be determined. © 2012 Reyes et al.
Torres O.A.,Institute Parasitologia y Biomedicina Lopez Neyra |
Calzada J.E.,Instituto Conmemorativo Gorgas Of Estudios Of La Salud Icges |
Beraun Y.,Institute Parasitologia y Biomedicina Lopez Neyra |
Morillo C.A.,Fundacion Cardiovascular de Colombia |
And 3 more authors.
Infection, Genetics and Evolution | Year: 2010
Genetic susceptibility to Trypanosoma cruzi infection and the development of cardiomyopathy is complex, heterogeneous, and likely involves several genes. Previous studies have implicated cytokine and chemokine genes in susceptibility to Chagas disease. Here we investigated the association between the interferon-gamma gene (IFNG) +874T/A polymorphism and Chagas disease, focusing on susceptibility and severity. This study included 236 chagasic patients (asymptomatic, n=116; cardiomyopathic, n=120) and 282 healthy controls from a Colombian population where T. cruzi is highly endemic. Individuals were genotyped for functional single nucleotide polymorphism (SNP; rs2430561; A/T) of the IFNG gene by amplification refractory mutational system PCR (ARMS-PCR). Moreover, clinical manifestations of Chagas in patients were analyzed. We found a significant difference in the distribution of the IFNG +874 "A" allele between patients and healthy controls (P=0.003; OR = 1.46, 95% CI, 1.13-1.89). The frequency of the IFNG +874 genotype A/A, which is associated with reduced production of interferon-gamma, was increased in the patients relative to controls (38.1% vs. 26.6%). We compared the frequencies of IFNG alleles and genotypes between asymptomatic patients and those with chagasic cardiomyopathy and found no significant difference. Our data suggest that the IFNG +874T/A genetic polymorphism may be involved in susceptibility but not in the progression of Chagas disease in this Colombian population. © 2010 Elsevier B.V.
Alvarado-Socarras J.L.,Neonatology Unit |
Idrovo A.J.,Industrial University of Santander |
Bermon A.,Fundacion Cardiovascular de Colombia
Jornal de Pediatria | Year: 2016
Objective: To evaluate the differences in hospital survival between modes of transport to a tertiary center in Colombia for critically ill neonates. Methods: Observational study of seriously ill neonates transported via air or ground, who required medical care at a center providing highly complex services. Data on sociodemographic, clinical, the Transport Risk Index of Physiologic Stability (TRIPS), and mode of transport were collected. Patients were described, followed by a bivariate analysis with condition (live or dead) at time of discharge as the dependent variable. A multiple Poisson regression with robust variance model was used to adjust associations. Results: A total of 176 neonates were transported by ambulance (10.22% by air) over six months. The transport distances were longer by air (median: 237.5. km) than by ground (median: 11.3. km). Mortality was higher among neonates transported by air (33.33%) than by ground (7.79%). No differences in survival were found between the two groups when adjusted by the multiple model. An interaction between mode of transport and distance was observed. Live hospital discharge was found to be associated with clinical severity upon admittance, birth weight, hemorrhaging during the third trimester, and serum potassium levels when admitted. Conclusions: Mode of transport was not associated with the outcome. In Colombia, access to medical services through air transport is a good option for neonates in critical condition. Further studies would determine the optimum distance (time of transportation) to obtain good clinical outcomes according type of ambulance. © 2016 Sociedade Brasileira de Pediatria.
Zenteno M.,National Autonomous University of Mexico |
Santos-Franco J.,IMSS Instituto Mexicano del Seguro Social |
Rodriguez-Parra V.,Fundacion Cardiovascular de Colombia |
Balderrama J.,National Autonomous University of Mexico |
And 3 more authors.
Journal of Neurosurgery | Year: 2010
Object. So-called direct carotid-cavernous fistulas (CCFs) are commonly treated by detachable balloons or coils to occlude the shunt while sparing the carotid artery. Liquid embolic agents have been rarely used, and in particular, to the authors' knowledge, the use of Onyx as the sole agent has never been reported in an indexed publication. Methods. The authors describe a case series of 5 patients with posttraumatic CCF in whom embolization with Onyx was prospectively used as the sole strategy of management. Results. Complete occlusion was obtained at the end of the procedure in 4 cases, and the lesion in the remaining patient subsequently occluded at the 6-month follow-up evaluation. Conclusions. As endovascular techniques for treatment of direct CCFs continue to evolve, this novel approach with Onyx as the sole embolic material seems promising in treating these lesions.
Overweight and obesity in Colombian college students and its association with physical activity [Sobrepeso y obesidad en estudiantes universitarios colombianos y su asociación con la actividad física]
Rangel Caballero L.G.,Santo Tomás University of Colombia |
Rojas Sanchez L.Z.,Fundacion Cardiovascular de Colombia |
Gamboa Delgado E.M.,Fundacion Cardiovascular de Colombia
Nutricion Hospitalaria | Year: 2015
Introduction: Overweight, obesity and physical activity are considered modifiable factors related to development of chronic diseases. Taking into account physical activity patterns in college students, it is necessary to establish its association with the excessive weight in order to prevent and to decrease the prevalence of future chronic diseases. Objective: The aim of this study was to determine the association between excessive weight and physical inactivity among college students. Material and methods: An analytical cross sectional study was carried out in 2013 among college students from a private university of Bucaramanga, Colombia. Students (n=306) 18 to 25 years old were included using simple random sampling. An interview was realized using a survey that included the International Physical Activity Questionnaire (IPAQ), together with socio demographic variables. An assessment of body composition was realized in order to measure height, weight, body mass index (BMI), total fat percentage, and waist and hip circumferences. A trained professional in physical activity was in charge of data collection and anthropometric measurements. This study was approved by the university research and ethics committee. Participation was both voluntary and anonymous. All data were analyzed in compliance with the Helsinki Declaration. Written consent was signed by every participant of the study. A descriptive analysis of the studied population’s general characteristics was realized. The association between excessive weight and physical inactivity was estimated using regression logistic models that allows estimate row and adjusted Odds Ratios (OR). Results: An excessive weight was observed in 26.47% of the students, among which 20.26% were overweight and 6.21% obese, according to BMI cutoff. Taking into account the total fat percentage, 12.09% of the students were in risk of becoming obese and 10.13% were already obese. 50.56% of the students practiced very little weekly physical activity. The median of daily sedentary lifestyle was 12 hours, with an interquartile range of 4 hours. A statistically significant association was found between excessive weight and sedentary behavior, according to the total fat method (adjusted OR: 1.11, CI 95%: 1.01-1.23). Conclusions: College students’ health behavior is often inadequate in terms of physical activity and dietary habits. Our study observed an association between physical inactivity and excessive weight. Physical inactivity is an important lifestyle factor related to chronic diseases. Further research should focus on determinants to increase their physical activity and to improve their daily lifestyle in order to lower the risk of future diseases. © 2015, Grupo Aula Medica S.A. All rights reserved.
Risk of malnutrition associated with poor food intake, prolonged hospital stay and readmission in a high complexity hospital in Colombia [Riesgo de malnutrición asociado a baja ingesta alimentaria, estancia hospitalaria prolongada y reingreso en un hospital de alto nivel de complejidad en Colombia]
Varela A.L.V.,Fundacion Cardiovascular de Colombia |
Delgado E.M.G.,Fundacion Cardiovascular de Colombia
Nutricion Hospitalaria | Year: 2015
Introduction: hospitalary malnutrition is highly prevalent and is related with prolonged hospital stay, increase in attention costs and associated clinic complications. Objective: to determine the risk of malnutrition in hospitalized patients in a highly specialized health center and its associated factors. Methods: questionnaires of the Nutrition Day initiative were applied to 70 adult patients of a health institution of high level of complexity in Bucaramanga, Colombia. The parameters included anthropometric and socio demographic data, clinical history, factors related to the diet, and the patients’ perception regarding their health status. Malnutrition Screening Tool (MST) was applied to assess the risk of malnutrition. To establish the reasons for prevalence (RP), binomial regression models were used. Results: age and length of hospital stay, at the time of the baseline, were in average, 61.89 ± 15.17 years old and 7.96 ± 9.79 days. The prevalence of risk of malnutrition was 52.86% (CI 95%: 40.55% - 64.91%); 40.91% for women and 58.33% for men (p = 0.175). 18.57% of the patients did not consume any food at lunch. 40.00% of the participants manifested having had an intake lower than normal, during the previous week. The variables associated to risk of malnutrition, adjusted by age and sex, were: food intake at baseline, readmission, and length of hospital stay during follow up. Conclusion: evidence about the importance of early diagnosis and of proper nutritional management of hospitalary malnutrition support the need to implement effective nutritional interventions. © 2015, Grupo Aula Medica S.A. All rights reserved.
Lujan Schierenbeck Ma.,Fundacion Cardiovascular de Colombia |
Diaz-Quijano F.A.,Fundacion Cardiovascular de Colombia |
Alvarez Camacho J.P.,Fundacion Cardiovascular de Colombia
Medicina Cutanea Ibero-Latino-Americana | Year: 2013
Aplasia Cutis Congenita is a defect characterized by localized absence of skin in one or more body areas. Small lesions health spontaneously, whereas larger lesions require medical management and/or surgery. The prognosis depends on the size, location of the defect and associated malformations. We present a case of a female newborn with isolated Aplasia Cutis Congenita and its posterior evolution to management with hydrocolloids.
Barrera J.G.,Fundacion Cardiovascular de Colombia |
Rojas K.E.,University of Texas Southwestern Medical Center |
Balestrini C.,Fundacion Cardiovascular de Colombia |
Espinel C.,Fundacion Cardiovascular de Colombia |
And 4 more authors.
Journal of Vascular Surgery | Year: 2013
Background: The optimal management of patients with combined carotid and coronary artery disease requiring cardiac surgery is still unknown. Staged carotid endarterectomy and carotid artery stenting (CAS), each followed by coronary artery bypass graft (CABG), are options frequently employed. However, for patients with severe carotid artery disease in urgent need of open cardiac revascularization, staged operations may not be the most appropriate alternative. The aim of this study was to describe our experience using a synchronous CAS-CABG method with minimal interprocedural time. We used this synchronous combination of procedures in patients with combined carotid and coronary artery disease admitted for urgent CABG. Methods: Patients with concomitant severe carotid and coronary artery disease scheduled for synchronous CAS and urgent CABG between December 2006 and January 2010 were included in the study. All procedures were performed at a single center: the Cardiovascular Foundation of Colombia, in Floridablanca, Santander, Colombia. The study cohort was characterized according to demographic and clinical characteristics, which included degree of carotid stenosis, presence/absence of preoperative neurological symptoms, and cardiac operative risk profile. All patients underwent CAS under embolic protection devices and then CABG within the next 2 hours. Patients received aspirin pre- and postprocedure but were started on clopidogrel only after CABG. The primary end point of the study was the composite incidence rate of myocardial infarction, stroke, and death 30 days after CAS-CABG. Results: Fifteen patients with concomitant severe carotid and coronary artery disease underwent synchronous CAS-CABG. Most patients (60%) were men, and mean (± standard deviation) age was 65.2 (± 8.4) years. Most patients (93%) were neurologically asymptomatic. The median (interquartile range) ejection fraction and logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE) for the cohort were 55% (36%-62%) and 9.7% (4.6%-14.8%), respectively. There were no deaths, major strokes, minor strokes, or myocardial infarctions during the procedure or within 30 days of CAS-CABG. One patient experienced neurological symptoms likely as a result of transient ischemic attack ipsilateral to the CAS procedure. None of the patients required cardiac or carotid reinterventions, and there were no cases of postoperative bleeding requiring reoperation. Conclusions: Synchronous CAS-CABG, when CABG is performed within the 2 hours of the CAS procedure, may be a viable alternative to the more generally accepted staged combination, particularly among patients for whom CABG cannot be postponed. We hope that this strategy will be further evaluated in larger prospective studies and adequately powered randomized clinical trials. © 2013 by the Society for Vascular Surgery.