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Echeverri D.,Fundacion Cardioinfantil Institute Cardiologia
Revista Colombiana de Cardiologia

Drug-eluting stents offer the best available non-surgical alternative for the treatment of coronary disease, thanks to its demonstrated efficacy. However, in terms of security, these excellent results have been overshadowed by the late or very late appearance of stent thromboses.The biological effects they have in the coronary artery after its implantation are due to the effect of the platform used, the polymer and the medication released. The vascular healing disorders induced by drug-eluting stents favor stent thrombosis and its clinical consequences. This is a review of the different biological effects of drug-eluting stents in coronary arteries that allows to understand how the rapid onset of new versions of materials, designs, polymers and medications diminish adverse coronary effects and improve its efficacy and safety. Source

Dennis R.J.,Fundacion Cardioinfantil Institute Cardiologia
Clinical evidence

About 10% of adults have suffered an attack of asthma, and up to 5% of these have severe disease that responds poorly to treatment. Patients with severe disease have an increased risk of death, but patients with mild-to-moderate disease are also at risk of exacerbations. Most guidelines about the management of asthma follow stepwise protocols. This review does not endorse or follow any particular protocol, but presents the evidence about specific interventions. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for chronic asthma? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found 54 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review we present information relating to the effectiveness and safety of the following interventions: adding anti-IgE treatment; beta(2) agonists (adding long-acting inhaled beta(2) agonists when asthma is poorly controlled by inhaled corticosteroids, or short-acting inhaled beta(2) agonists as needed for symptom relief); inhaled corticosteroids (low dose and increasing dose); leukotriene antagonists (with or without inhaled corticosteroids); and theophylline (when poorly controlled by inhaled corticosteroids). Source

Vargas M.C.,Fundacion Cardioinfantil Institute Cardiologia | Castillo M.,University of North Carolina at Chapel Hill
Dentomaxillofacial Radiology

Cavernous haemangiomas arising in the paranasal sinuses are very rare. Even though the lesion is benign in nature, its imaging features are non-specific, leading to an incorrect pre-operative diagnosis in most patients. We present a case of a maxillary sinus cavernous haemangioma in a young male. The clinical presentation and imaging characteristics of this entity are reviewed. © 2012 The British Institute of Radiology. Source

Vargas M.C.,Fundacion Cardioinfantil Institute Cardiologia | Castillo M.,University of North Carolina at Chapel Hill
Journal of Radiology Case Reports

Hirayama disease (HD) is a rare type of cervical myelopathy related to flexion of the neck characterized by progressive muscular weakness and atrophy of the distal upper limbs most frequently seen in young males. HD is thought to be secondary to an abnormal anterior displacement of the posterior dura with secondary compression of the lower cervical spinal cord and chronic injury to the anterior gray matter horns. We present two patients with HD and discuss its pathophysiology and imaging characteristics. Source

Torres A.,Fundacion Cardioinfantil Institute Cardiologia
Revista Colombiana de Cardiologia

The current evidence is that heart failure units constitute a good quality care strategy with high cost-effectiveness standards; they have an impact on quality of life, increased survival and reduced rehospitalisation and costs for a disorder which greatly affects public health. This is why this document provides a definition of the unit, its elements and strategies for its development, along with strategic objectives and how to overcome opportunity and access constraints, based on the structure of a multidisciplinary team and the physical, human and technological resources of the unit, focusing efforts on high risk patients and constructing paths of integration with primary healthcare in order to monitor stable patients and ensure them good end-of-life care. © 2016. Source

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