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Wang J.-L.,Shandong University | Wang J.-L.,Function Research Affiliated | Xu L.,Shandong University | Xu L.,Function Research Affiliated | And 7 more authors.
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | Year: 2010

Introduction. We performed a meta-analysis with the aim of assessing the association of the angiotensin II type 1 (AT1) receptor gene A1166C polymorphism with essential hypertension in Chinese case-control studies. Methods. Studies were searched from the Chinese Biomedicine Database, the China National Knowledge Infrastructure platform, Pubmed and Medline, using the search terms ĝ€̃hypertensionĝ€™, ĝ€̃ angiotensin II type 1 receptorĝ€™, ĝ€̃AT 1Rĝ€™, ĝ€̃polymorphismĝ€ ™, ĝ€̃Chinaĝ€™ and ĝ€̃ Chineseĝ€™, without limiting to any specific language. The strength of the association between the A1166C polymorphism and hypertension was evaluated by the odds ratio (OR) with the corresponding 95% confidence interval (CI). The analyses were performed with Cochrane RevMan software version 4.2. Results. Overall, the variant genotype AC/CC was associated with a statistically increased essential hypertension risk with the pooled OR 1.48 (95% CI: 1.20ĝ€"1.83). In the subgroup analyses, the association was also significant among studies using Northern populations, Southern populations, Han Chinese and hospital-based controls. The age did not influence the relationship between the AT1 receptor A1166C polymorphism and hypertension in the subgroup analyses. Conclusions. The present meta-analysis suggests that the AT1 receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population. © 2010 The Authors.

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