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Sato Y.,JCHO Funabashi Central Hospital | Ogasawara T.,JCHO Funabashi Central Hospital | Shida T.,JCHO Funabashi Central Hospital | Nomura S.,JCHO Funabashi Central Hospital | And 4 more authors.
Chiba Medical Journal | Year: 2016

An 84-year-old man with severe anemia was diagnosed with ascending colon cancer, sigmoid colon cancer, and rectal lateral spreading tumor, and simultaneously underwent laparoscopic surgery for double colon cancer. Rectal tumor was resected with ESD after 6 months of the initial surgery. Histopathological examination revealed that all lesions were adenocarcinoma and were resected completely. Three synchronous primary colorectal cancers were followed up as per the Japanese Society for Cancer of the Colon and Rectum Guidelines. After 4 years of the initial surgery, he presented with intermitted abdominal pain, vomiting, and weight loss. Abdominal compute tomography indicated an obstruction in the ileum adjacent to the staple and clip in the initial surgery. Following decompression with a long tube, laparotomy was performed and adhesion was found on the small intestine, which stuck to the staple that was used for closing the end of the ileum during the initial surgery. Inside the small intestine, we palpated a small tumor and resected it. The tumor was diagnosed as a primary small intestinal cancer. Complete endoscopic evaluation of the colon before operation and routine surveillance after resection of colorectal cancer is very important because the risk of synchronous and metachronous colon cancer is relatively high. Postoperative surveillance is more important for people who are at the risk of hereditary colon cancer. © 2016, Chiba Medical Society. All rights reserved.

PubMed | JCHO Funabashi Central Hospital
Type: Journal Article | Journal: Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2017

A 76-year-old male patient was diagnosed with progressive descending colon cancer. Since the patient had severe respiratoryfunction impairment after right pneumonectomy, the anesthesiologydepartment of our hospital determined that general anesthesia induction was too difficult. He was thus started on capecitabine plus oxaliplatin(XELOX)therapy. Three months after starting this treatment, colonoscopyshowed that the site had become scarred, and tissue examination revealed no indication of malignancy. Accordingly, the patient achieved clinical complete response. The patient had no findings of recurrence 1 year and 11 months after the start of chemotherapy. Chemotherapy for unresectable progressive recurrent colorectal cancer is based on the 5-FU anticancer agent, which exerts its antitumor effect byinhibiting DNA synthesis. The antitumor effect is reportedly high when the expression of thymidylate synthase(TS), a target agent, is low. In this patient, TS expression was low based on tissue examination. TS expression maybe an effective useful predictive factor for the efficacyof chemotherapyadministered to patients with unresectable progressive recurrent colorectal cancer.

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