Araki A.,Hokkaido University |
Kanazawa A.,Hokkaido University |
Kawai T.,Osaka Occupational Health Service Center |
Eitaki Y.,Osaka Occupational Health Service Center |
And 9 more authors.
Science of the Total Environment | Year: 2012
Microbial volatile organic compounds (MVOCs) are a type of VOCs produced by microorganisms. Exposure to 1-octen-3-ol, one of the known MVOCs, has been reported to reduce nasal patency and increase nasal lavage myeloperoxidase, eosinophil cationic proteins, and lysozymes in both experimental and field studies. We reported in a previous paper that 1-octen-3-ol exposure at home is associated with mucosal symptoms. In this study, our aim was to investigate the relationship between asthma and allergies and MVOC exposure in single-family homes. The subjects were 624 inhabitants of 182 detached houses in six regions of Japan. Air samples were collected using diffusive samplers, and the concentrations of eight selected MVOCs were analyzed using gas chromatography/mass spectrometry in selected-ion-monitoring mode. Each inhabitant of each of the dwellings was given a self-administered questionnaire. Among the 609 subjects who answered all of the questions about allergies, history of the medical treatment for asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis within the preceding two years was 4.8%, 9.9%, 18.2%, and 7.1%, respectively. A significant association between 1-octen-3-ol (per log10 unit) and allergic rhinitis odds ratio (OR): 4.10, 95% confidence interval (CI): 1.71 to 9.80 and conjunctivitis (OR: 3.54, CI: 1.17 to 10.7) was found after adjusting for age, sex, tobacco, wall-to-wall carpeting, signs of dampness, history of treatment for hay fever, and other potentially relevant environmental factors. No relationships were found between any MVOCs and asthma or atopic dermatitis after the adjustment. The levels of MVOCs and airborne fungi were only weakly correlated. These results are consistent with previous studies that have associated higher levels of 1-octen-3-ol exposure with increased irritation of nasal and ocular mucosae. Although the indoor-air concentrations of 1-octen-3-ol found in this study were relatively low, we conclude that exposure to MVOC may be related to rhinitis and conjunctivitis. © 2012 Elsevier B.V.
Takigawa T.,Okayama University of Science |
Saijo Y.,Asahikawa University |
Morimoto K.,Osaka University |
Nakayama K.,Osaka University |
And 5 more authors.
Science of the Total Environment | Year: 2012
To determine whether indoor chemicals act as possible environmental risk factors responsible for sick building syndrome (SBS)-related symptoms in new houses (< 6. years old) in Japan, we studied 871 people living in 260 single-family houses in 2004 and 2005. We measured the indoor concentrations of aldehydes and volatile organic compounds and longitudinal changes in the living rooms over two consecutive years. Participants answered standardized questionnaires on SBS symptoms and lifestyle habits. Approximately 14% and 12% of subjects were identified as having SBS in the first and second year, respectively. According to analysis adjusted for sex, age, smoking, and allergic diseases, increases in aldehydes and aliphatic hydrocarbons contributed to the occurrence of SBS. Elevated levels of indoor aldehydes and aliphatic hydrocarbons increased the possible risk of SBS in residents living in new houses, indicating that source controls against indoor chemicals are needed to counter SBS. © 2011 Elsevier B.V.
Hyodo K.,Tohoku University |
Sakuma A.,Tohoku University |
Kota Y.,Fukushima College
Physical Review B - Condensed Matter and Materials Physics | Year: 2016
We develop a first-principles procedure for the individual evaluation of the intrinsic, side-jump, and skew-scattering contributions to the anomalous Hall conductivity σxy. This method is based on the different microscopic conductive processes of each origin of σxy in the Kubo-Bastin formula. We also present an approach for implementing this scheme in the tight-binding linear muffin-tin orbital (TB-LMTO) method with the coherent potential approximation (CPA). The validity of this calculation method is demonstrated for disordered FePt and FePd alloys. We find that the estimated value of each origin of σxy exhibits reasonable dependencies on the electron scattering in these disordered alloys. © 2016 American Physical Society.
Sakatani K.,Fukushima College |
Sakatani K.,Nihon University |
Fujii M.,Yui Acupuncture Clinic |
Takemura N.,Fukushima College |
Hirayama T.,Nihon University
Advances in Experimental Medicine and Biology | Year: 2016
There is increasing evidence that acupuncture is useful in treating somatic and psychological disorders caused by stress; however, the physiological basis of the effect remains unclear. In the present study, we evaluated the effect of acupuncture on psychological conditions (i.e., anxiety) and prefrontal cortex (PFC) activity. We studied 10 patients with anxiety disorders and measured anxiety levels by means of the State-Trait Anxiety Inventory (STAI), including state anxiety (STAI-1) and trait anxiety (STAI-2). Employing a two-channel NIRS device, we measured oxy-Hb concentration in the bilateral PFC at rest, and evaluated asymmetry of the PFC activity by calculating the Laterality Index at Rest (LIR). The patients were treated by acupuncture at Yui Clinic in Osaka. The treatment significantly decreased the STAI-1 score (p<0.001), but not the STAI-2 score (p>0.05). The NIRS measurements indicated the presence of spontaneous oscillations of oxy-Hb in the bilateral PFC at rest before and after the treatment. Notably LIR decreased significantly in 7 out of the 10 subjects (p<0.01), while 3 subjects showed an increasing tendency. The present pilot study indicates that acupuncture is effective in decreasing anxiety levels in patients with anxiety disorders. Our NIRS data suggest that acupuncture may alter the balance of PFC activity at rest, resulting in relaxation effects. Our NIRS data suggest that acupuncture changes the balance of PFC activity toward left-dominant, resulting in relaxation effects on the patients. © Springer Science+Business Media, New York 2016.
Yokota O.,Fukushima College
Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C | Year: 2012
In this study, the replica of the metal processing surface was produced using the transparent silicone. The new measuring method which examined the transmission image was proposed with a scattering of the spot light in the replica. The result was summarized in the following. It was able to be classified to four patterns of the transmission image from the replica reflection plane, that is to say, point pattern, circular pattern, elliptic pattern, diffraction pattern. It is possible that these patterns estimate the shape of the reflection plane, namely shape and processing method of the machined surface. The surface roughness by the diffraction was equal to the maximum height roughness by the tracer. In circular pattern and elliptic pattern, the empirical formula which showed the relationship between maximum height roughness and radius of gyration was obtained. In the point pattern, it was not possible to show surface roughness in the measuring range of this experiment. © 2012 The Japan Society of Mechanical Engineers.
Yamauchi N.,Fukushima College |
Kurumada K.,Fukushima College
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2016
A facile method for surface hydrophobization of magnetite (Fe3O4) nanoparticles with polyhexylsilsesquioxane was proposed. The surface-hydrophobizing coating formed of polyhexylsilsesquioxane on the surface of the magnetite nanoparticles was spontaneously generated from hexylated silanol moiety dissolved in diethylamine. Due to the Lewis basicity, diethylamine worked as the catalyst for the polycondensation of the hexylated silanol. At the same time, the relatively low polarity of diethylamine was found favorable for maintaining the dispersibility of the polyhexylsilsesquioxane-coated magnetite nanoparticles. Moreover, the presence of the surface-hydrophobizing coating was effective for suppressing the transition of the magnetite phase to hematite (α-Fe2O3) even under highly oxidative condition since the polyhexylsilsesquioxane coating blocked oxygen molecules from the access to the surface of the magnetite nanoparticles as evidenced by the absence of micropores in the polyhexylsilsesquioxane coating layer. © 2016 Elsevier B.V.
Itoi T.,Tokyo Medical University |
Kawakami H.,Hokkaido University |
Katanuma A.,Teine Keijinkai Hospital |
Irisawa A.,Fukushima College |
And 9 more authors.
Gastrointestinal Endoscopy | Year: 2015
Background There are currently no prospective, controlled trials of endoscopic transpapillary gallbladder drainage in patients with acute cholecystitis. Objective We evaluated the technical success rate and efficacy of endoscopic transpapillary gallbladder drainage by using either endoscopic nasogallbladder drainage (ENGBD) or endoscopic gallbladder stenting (EGBS) for patients with acute cholecystitis. Design Randomized, controlled study. Setting Tertiary-care referral centers. Patients Seventy-three consecutive patients with acute cholecystitis were randomized. Interventions ENGBD by using a 5F or 7F tube (n = 37) or EGBS (n = 36) by using a 7F stent. Main Outcome and Measurements Technical success, clinical success, adverse events, and procedure-related pain score. Results The overall technical success rates in the ENGBD and EGBS groups were 91.9% and 86.1%, respectively (P >.05). The mean procedure times of ENGBD and EGBS were 20.3 ± 12.1 and 22.2 ± 14.5 minutes, respectively (P >.05). The overall clinical success rates by per protocol analysis were 94.1% and 90.3% in the ENGBD and EGBS groups, respectively, whereas the rates by intention-to-treat analysis were 86.5% and 77.8%, respectively (P >.05). Moderate adverse events were observed in the ENGBD (n = 2) and EGBS (n = 1) groups. The mean visual analog score of postprocedure pain in the ENGBD group was significantly higher than that in the EGBS group (1.3 ± 1.1 vs 0.4 ± 0.8, respectively; P <.001). Limitations Small sample size and the participation of multiple endoscopists who may have different levels of experience in endoscopic transpapillary gallbladder drainage. Conclusions Both ENGBD and EGBS appear to be suitable for the treatment of acute cholecystitis in patients who are poor candidates for emergency cholecystectomy. (Clinical trial registration number: UMIN000012316.) © 2015 American Society for Gastrointestinal Endoscopy.
Imai E.,Nagoya University |
Yamamoto R.,Osaka University |
Suzuki H.,Saitama University |
Watanabe T.,Fukushima College
Clinical and Experimental Nephrology | Year: 2010
Background: Use of erythropoiesis-stimulating agents (ESA) has been reported to increase the incidence of cardiovascular diseases at target Hb levels by more than 12.0 g/dl. The recent TREAT study found an increased incidence of stroke and cancer when maintaining the Hb level at 12.5 g/dl in diabetic patients. Methods: Surveillance of Epoetin-Adverse Events of Stroke and Cancer (SEASCAN) was a cross-sectional study conducted under urgent conditions by the Committee on CKD Initiatives of the Japanese Society of Nephrology. Patients who were at least 18 years old and had CKD stage 4 and 5, namely, eGFR <30 ml/min/1.73 m2, and who had visited the outpatient department of the participating facilities between December 2009 and January 2010 with at least 6 months of prior medical treatment in the participating facilities were eligible to participate in the study. Results: Of 7,415 patients with CKD stage 4 and 5, 3,653 (49.3%), 879 (11.9%) and 2,883 (38.9%) patients received no epoetin, epoetin for less than 6 months and epoetin for at least 6 months, respectively. In patients who did not use epoetin, use of epoetin for less than 6 months and use of epoetin for at least 6 months, the numbers of patients with stroke were 38 (1.0%), 8 (0.9%) and 27 (0.9%), respectively, and those with newly diagnosed or exacerbated malignancy were 88 (2.4%), 30 (3.4%) and 71 (2.5%), respectively, demonstrating insignificant associations between outcome and duration of treatment with epoetin (P for trend = 0.666 in stroke and 0.836 in malignancy). Conclusions: No significant increase in the risk of developing symptomatic stroke and cancer was observed for the use of epoetin in current clinical practice in Japan. © 2010 Japanese Society of Nephrology.
PubMed | Sumitomo Chemical, Fukushima College, RIKEN and Yokohama National University
Type: Journal Article | Journal: Langmuir : the ACS journal of surfaces and colloids | Year: 2016
Highly oriented J-aggregates of a nitroazo dye were obtained in solid thin films on aligned poly(tetrafluoroethylene) surfaces. During film deposition on a friction-transferred poly(tetrafluoroethylene) layer, a sharp peak grew in the polarized absorption spectra around 613 nm, which was red-shifted 117 nm from the peak in dilute dichloromethane solution. The peak showed remarkable optical anisotropy: dichroic ratios D of up to 22 were observed, and the intrinsic D value should substantially exceed this value. These results indicate that the peak is attributable to highly oriented J-aggregates. On glass, however, H-like aggregates grew, exhibiting an absorption peak at 410 nm. Hence, the substrate surface induced the remarkable chromism observed as a 203 nm red shift.
PubMed | Ezaki Glico Co., University of Shizuoka, Fukushima College and Kagoshima University
Type: | Journal: Carbohydrate polymers | Year: 2016
A series of multivalent sialoglyco-conjugated nanoparticles were efficiently synthesized by using highly-branched -glucuronic acid-linked cyclic dextrins (GlcA-HBCD) as a backbone. The sialoglycoside-moieties, with varying degrees of substitution, could be incorporated onto the preformed nanoparticles. These synthesized particles, which are highly soluble in aqueous solution, were shown to have a spherical nanostructure with a diameter of approximately 15nm. The interactions of the sialoglyco-nanoparticles (Neu5Ac2,6LacNAc-GlcA-HBCDs) with human influenza virus strain A/Beijing/262/95 (H1N1) were investigated using a hemagglutination inhibition assay. The sialoglyco-nanoparticle, in which the number of sialic acid substitution is 30, acted as a powerful inhibitor of virus binding activity. We show that both distance and multiplicity of effective ligand-virus formation play important roles in enhancing viral inhibition. Our results indicate that the GlcA-HBCD backbone can be used as a novel spherical nanocluster material for preparing a variety of glyco-nanoparticles to facilitate molecular recognition.