Nogami K.,Fukuoka Dental College
Journal of Oral and Maxillofacial Surgery | Year: 2015
Purpose The aim of this study was to evaluate the relative effectiveness of stellate ganglion blockade (SGB) versus xenon light irradiation (XLI) for the treatment of neurosensory deficits resulting from orthognathic surgery as determined by a comparison of prospective measurements of electrical current perception thresholds (CPTs) and ranged CPTs (R-CPTs). Materials and Methods CPT and R-CPT in the mental foramen area were measured during electrical stimulation at 98 different sites on the body in patients who had undergone orthognathic surgery. After surgery, patients were assigned to the SGB group or the XLI group. CPT and R-CPT of the 2 groups were measured at stimulation frequencies of 2,000, 250, and 5 Hz before surgery, 1 week after surgery, and after 10 treatment sessions. Furthermore, the influence of surgical factors, such as genioplasty and a surgically exposed inferior alveolar nerve (IAN), was examined in the 2 groups. Results Patients' CPT and R-CPT values indicated a considerable amount of sensory disturbance in most cases after surgery. The change in magnitude of all CPT and R-CPT values for the SGB group decreased considerably compared with that for the XLI group after treatment. There was no correlation between CPT or R-CPT values and surgical factors (eg, genioplasty and exposure of the IAN). Conclusion SGB of the IAN could be an effective method for treating neurosensory deficits after orthognathic surgery on the IAN. © 2015 American Association of Oral and Maxillofacial Surgeons.
Nishie M.,Kyushu University |
Nagao J.-I.,Fukuoka Dental College |
Sonomoto K.,Kyushu University
Biocontrol Science | Year: 2012
Bacteriocins are ribosomally synthesized antibacterial peptides produced by bacteria that inhibit the growth of similar or closely related bacterial strains. A number of bacteriocins from a wide variety of bacteria have been discovered, and their diverse structures have been reported. Growing evidence suggests that bacteriocins have diverse structures, modes of action, mechanisms of biosynthesis and self-immunity, and gene regulation. Bacteriocins are considered as an attractive compound in food and pharmaceutical industries to prevent food spoilage and pathogenic bacterial growth. Furthermore, elucidation of their biosynthesis has led to the use of bacteriocin-controlled gene-expression systems and the biosynthetic enzymes of lantibiotics, a class of bacteriocins, as tools to design novel peptides. In this review, we summarize and discuss currently known information on bacteriocins produced by Gram-positive bacteria and their applications.
Kajiya H.,Fukuoka Dental College
Advances in Experimental Medicine and Biology | Year: 2012
Calcium (Ca 2+) signaling controls multiple cellular functions and is regulated by the release of Ca 2+ from internal stores and its entry from the extracellular fluid. Ca 2+ signals in osteoclasts are essential for diverse cellular functions including differentiation, bone resorption and gene transcription. Recent studies have highlighted the importance of intracellular Ca 2+ signaling for osteoclast differentiation. Receptor activator of NF-κB ligand (RANKL) signaling induces oscillatory changes in intracellular Ca 2+ concentrations, resulting in Ca 2+/calcineurin-dependent dephosphorylation and activation of nuclear factor of activated T cells c1 (NFATc1), which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. Recently, some reports indicated that RANKL-induced Ca 2+ oscillation involved not only repetitive intracellular Ca 2+ release from inositol 1, 4, 5-triphosphate channels in Ca 2+ store sites, but also via store-operated Ca 2+ entry and Ca 2+ entry via transient receptor potential V channels during osteoclast differentiation. Ca 2+-regulatory cytokines and elevation of extracellular Ca 2+ concentrations have been shown to increase intracellular Ca 2+ concentrations ([Ca 2+] i) in mature osteoclasts, regulating diverse cellular functions. RANKL-induced [Ca 2+] i increase has been reported to inhibit cell motility and the resorption of cytoskeletal structures in mature osteoclasts, resulting in suppression of bone-resorption activity. In conclusion, Ca 2+ signaling activates differentiation in osteoclast precursors but suppresses resorption in mature osteoclasts. This chapter focuses on the roles of long-term Ca 2+ oscillations in differentiation and of short-term Ca 2+ increase in osteoclastic bone resorption activity. © 2012 Springer Science+Business Media B.V.
Shimada K.,Fukuoka Dental College
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2012
An associative classification method for incomplete database is proposed based on an evolutionary rule extraction method. The method can extract class association rules directly from the database including missing values and build an associative classifier. Instances including missing values are classified by the classifier. In addition, an evolving associative classifier is proposed. The proposed method evolves the classifier using the labeled instances by itself as acquired information. The performance of the classification was evaluated using artificial incomplete data set. The results showed that the proposed evolving associative classifier has a potential to expand the target data for classification through its evolutionary process and gather useful information itself. © 2012 Springer-Verlag.
Kawaguchi M.,Fukuoka Dental College
International journal of nanomedicine | Year: 2011
Carbon nanotubes act as a photon antenna that serves as an effective "molecular heater" around the near-infrared (NIR) region. This exothermic generation can be used as a possible heating source for hyperthermia therapy. The current study reports the dispersible and exothermic properties with NIR irradiation for single-walled carbon nanotubes (SWNTs) treated with a strong acid (acid-treated SWNTs), and the SWNTs further functionalized with double-stranded DNA (DNA-functionalized SWNTs: DNA-SWNTs). DNA-SWNTs significantly improved the dispersibility of SWNTs when compared with the acid-treated SWNTs. The binding ratio of the acid-treated SWNT and DNA was calculated to be 3.1 (DNA/SWNTs) from the phosphorous content in the DNA-SWNT. This interaction of the SWNTs and DNA would contribute to the stable dispersion of the DNA-SWNTs in a culture medium. With NIR irradiation by a halogen lamp light source, the acid-treated SWNTs and the DNA-SWNTs showed strong heat evolution in vitro (in a culture medium) and in vivo (in the subcutaneous tissue of a mouse) condition without any invasive effect on the non-SWNT area. The results of this study suggested that the functionalization with DNA was an efficient approach to improve the dispersibility of SWNTs in body fluids, and the DNA-SWNT would be a promising source for photo-induced exothermic generation.