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Egawa K.,Suntory Wellness Ltd. | Yoshimura M.,Suntory Wellness Ltd. | Kanzaki N.,Suntory Wellness Ltd. | Nakamura J.,Suntory Wellness Ltd. | And 3 more authors.
Japanese Pharmacology and Therapeutics | Year: 2012

Objectives: The objective of this study was to evaluate the effect of long-term consumption of green tea containing quercetin glucoside on body fat accumulation and the safety in obese subjects. Methods: We performed a randomized double-blind, placebo-controlled trial on subjects (81 men and 119 women) aged from 20 to 65 years old with 25≦ body mass index (BMI) <30 kg/m 2. They were randomly assigned into two groups and consumed the beverages containing 0 mg or 110 mg of quercetin glucoside for 12 weeks. Results: Both total fat area and visceral fat area were significantly reduced in test group compared with placebo group. No adverse effect related to the test beverage containg quercetin glucoside was observed in this study. Conclusions: The results of this study suggest that the long-term consumption of green tea containing quercetin glucoside reduced body fat in safe, and could be useful for prevention and amelioration of obesity and metabolic syndrome. Source


Ukawa Y.,Central Research Institute ITO EN Ltd. | Sagesaka Y.,Central Research Institute ITO EN Ltd. | Hatakeyama Y.,New Drug Research Center Inc | Noro A.,New Drug Research Center Inc | Fukuhara I.,Fukuhara Clinic
Japanese Pharmacology and Therapeutics | Year: 2013

Objective: We examined the effect of catechins with a galloyl moiety to reduce dietary lipid absorption in humans. Methods: A randomized double-blind placebo-controlled crossover study was conducted. The beverage (340 mL/bottle) contained 190.9 mg of tea catechins with a galloyl moiety. Fifteen healthy adult subjects were randomly divided into two groups. Group A was requested to consume the drinks, containing catechins with a galloyl moiety, everyday for 10 days and then the placebo for 10 days, after an 11 day interval between these intake periods. On the contrary, Group B consumed the placebo first for 10 days and then the catechin drinks for 10 days, after an 11 day interval between the periods. Each subject in the catechin group was given 3 bottles of the test beverage/day and each subject in the placebo group was given 3 bottles of the placebo beverage/day. During the treatment period, subjects were given the same menu (Male : 2244±35.6 kcal, 84±0.6 g lipids, Female : 1944±35.6 kcal, 66±0.6 g lipids) at each meal. On the last 3 days of each treatment period, feces were collected in order to measure the excretion of lipids. Results: Lipid excretion into feces was found to be significantly higher in the test beverage consumption cases than in the placebo beverage ones on third day. Serum total cholesterol and LDL cholesterol were significantly lower in the test beverage consumption cases than in the placebo beverage ones. Conclusions: Our present observations suggest that consumption of catechins with a galloyl moiety could increase lipid excretion into feces. Source


Saito S.,Kao Corporation | Fukuhara I.,Fukuhara Clinic | Osaki N.,Kao Corporation | Nakamura H.,Mitsukoshi Health and Welfare Foundation | Katsuragi Y.,Kao Corporation
Journal of Oleo Science | Year: 2016

A randomized, double-blind controlled, parallel-group designed trial was performed to investigate the effect of alpha linolenic acid (ALA)-enriched diacylglycerol (DAG) on visceral fat area (VFA) in obese subjects. One hundred eighty-four obese subjects were recruited and randomly allocated to two groups consuming either 2.5 g/d control triacylglycerol (TAG) or ALA-DAG for 12 wk. A 4-wk observation period followed the 12-wk consumption period. One hundred seventy-seven subjects (N=89 in the TAG group, N=88 in the ALA-DAG group) completed the study. The change in VFA at 12-wk from baseline, as the primary outcome, was significantly lower in the ALA-DAG group than in the TAG group. The reduction in VFA was significantly correlated with the baseline VFA. Body weight and waist circumference, as the secondary measures, were also significantly lower in the ALA-DAG group than in the TAG group. The reduction in the VFA was significantly correlated with body weight reduction, suggesting that the VFA reduction was a contributing factor preventing weight gain. Safety parameters and the incidence of adverse events did not differ significantly between groups. In conclusion, ALA-DAG could be useful for reducing VFA and concomitantly suppressing weight gain with no side effects. © 2016 by Japan Oil Chemists’ Society. Source


Fukuhara I.,Fukuhara Clinic | Ikenaga T.,Otsuka Pharmaceutical Factory Inc. | Noguchi H.,Otsuka Pharmaceutical Factory Inc. | Kohashi C.,Otsuka Pharmaceutical Factory Inc. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2013

Objectives: The aim of the present study was to investigate the effect of cooked rice with β-glucan enriched barley on postprandial glucose response and its second-meal effect. Methods: The study was conducted in randomized crossover design with twenty healthy subjects whose fasting blood glucose was normal level. Subjects consumed test meals at breakfast and blood glucose, insulin and free fatty acid were measured for 120 min after the breakfast. For a subsequent lunch, they consumed standardizes meals and blood glucose was measured for 120 min after the lunch. Results: Cooked rice with β-glucan enriched barley lowered the blood glucose and insulin incremental areas under the curve (IAUC) (0-120 min) at breakfast and the blood glucose IAUC (0-120 min) at a subsequent lunch (P<0.05). The blood free fatty acid was not changed after ingestion of the test meals at breakfast. Conclusions: These findings suggested that cooked rice with β-glucan enriched barley contributed to postprandial glucose response and its second-meal effect. The present study suggested that cooked rice with β-glucan enriched barley has potential to an advantage for diabetes care. Source


Asakura R.,Asahi Soft Drinks Co. | Kametani N.,Asahi Soft Drinks Co. | Mitsuda H.,Asahi Soft Drinks Co. | Fukuhara I.,Fukuhara Clinic | And 2 more authors.
Japanese Pharmacology and Therapeutics | Year: 2010

Objectives: We developed a carbonated beverage supplemented with indigestible dextrin. In this study, we investigated whether the beverage would suppress the postprandial elevation of blood glucose level of volunteers. Methods: We conducted a double-blinded crossover trial. 40 volunteers (39±10 years old) ingested a test meal and a 350 mL of carbonated beverage supplemented with 5 g of indigestible dextrin or a placebo. The blood glucose level and insulin level were measured before and 30, 60, 90, and 120 minutes after meal, and compared between a test beverage and a placebo beverage. Results: Concurrent ingestion of the test beverage with the test meal significantly lowered the blood glucose level at 30, 60 minutes after meal and AUC compared to concurrent ingestion of the placebo. More significantly lowered the blood glucose level at 30, 60, 90 minutes after meal and AUC was appeared in subjects with higher glycemic response. Conclusions: The data obtained through these trials suggested that the carbonated beverage supplemented with indigestible dextrin suppresses the elevation of the postprandial blood glucose level. Source

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