Hirose M.,Fujiyoshida Municipal Hospital |
Hirose M.,Showa University |
Hasegawa T.,Showa University |
Hasegawa T.,Fukushima Medical University |
And 2 more authors.
Journal of the Showa Medical Association | Year: 2016
As in the general population, peripheral artery disease (PAD) is reported to be closely associated with the onset of coronary artery disease (CAD) or stroke in hemodialysis patients. PAD has been suggested to be a strong prognostic factor of all-cause and CAD-related deaths in this population. We performed exploratory investigation of the factors associated with new-onset PAD in non-diabetic patients on hemodialysis. In our retrospective cohort study to explore the factors related to new-onset PAD. 106 non-diabetic outpatients undergoing maintenance hemodialysis with no signs of PAD at baseline (as confirmed by duplex ultrasonography examination of the lower extremity arteries) at a single dialysis unit were enrolled. Follow-up duplex ultrasonography examination of the lower extremity arteries was performed five years later to assess the presence or absence of PAD. Multivariate logistic regression analyses were employed to investigate which of the following covariates are associated with new-onset PAD: Age. sex. smoking habit, hypo- High Dense Lipoprotein (HDL) cholesterolemia. and statin use. Findings on multivariate logistic regression analyses, with adjustments for potential confounding variables, demonstrated a significant relation between hypo-HDL cholesterolemia and new-onset PAD (odds ratio 1.91. 95% CI 1.11-3.34, p = 0.02). The present study suggested a possible association between hypo- HDL cholesterolemia and new-onset PAD in patients on hemodialysis.
Kobayashi J.,Fujiyoshida Municipal Hospital |
Sato T.,Fujiyoshida Municipal Hospital |
Sato T.,National Hospital Organization Takasaki General Medical Center |
Ishikawa H.,Fujiyoshida Municipal Hospital
Kitakanto Medical Journal | Year: 2015
A 54-year-old male diagnosed with sigmoid colon cancer associated with urinary bladder invasion was referred to our department. Due to invasion into the ileum, we performed a sigmoidectomy with resection of the bladder and ileum, and reconstructed the colon using end-to-end anastomosis. The pathological diagnosis was T4b, NO, HO, P0, M0, stage II. After the operation, suture complications resulted in massive emphysema. Patient elected for conservative treatment, but we were unable to insert a central venous catheter due to subcutaneous emphysema, and so implemented nutritional management using peripheral venous nutrition and elemental diet. Total parenteral nutrition is generally required as conservative treatment for colon post-operative suture failure. However, the low-residue of the elemental diet turned nutritional management into a treatment option, its wound-healing effects have been the subject of some focus in recent years.
Ino H.,Yamanashi University |
Masamune T.,Yamanashi University |
Sato H.,Yamanashi University |
Okuyama K.,Shizuoka Childrens Hospital |
And 6 more authors.
Anesthesia and Analgesia | Year: 2015
BACKGROUND: Hyperglycemia is common in critically ill and surgical patients, as are core temperature disturbances. The effect of hyperglycemia on thermoregulatory defenses remains unknown. We determined the effect of blood glucose concentration on the shivering threshold in rabbits. METHODS: Twenty-seven rabbits lightly anesthetized with isoflurane were randomly assigned to infusions of (1) saline, (2) insulin titrated to produce blood glucose concentrations 60 to 100 mg/dL, or (3) 50% dextrose titrated to produce blood glucose concentrations 200 to 300 mg/dL. Core temperature was reduced at a rate of 2 to 3°C/h by perfusing water at 10°C through a plastic tube positioned in the colon. Cooling continued until shivering was observed by an investigator blinded to treatment or until esophageal (core) temperature reached 34°C. Core temperatures at the onset of shivering defined the threshold. All analyses were conducted using SAS version 9.3 (SAS Institute Inc., Cary, NC). RESULTS: Rabbits given saline shivered at 37.2 ± 0.5°C (mean ± SD). Rabbits given insulin shivered at 36.3 ± 1.1°C. Rabbits given dextrose shivered at 38.0 ± 0.6°C. The shivering threshold increased as a function of blood glucose concentration: shivering threshold (°C) = 0.009 [blood glucose concentration (mg/dL)] + 35.6, r2 = 0.53. The shivering threshold thus increased approximately 1°C for each 100 mg/dL increase in blood glucose concentration. CONCLUSIONS: Hyperglycemia increases the threshold for shivering, whereas hypoglycemia lowers the threshold on rabbits. © 2015 International Anesthesia Research Society.
Yamazaki T.,Fujiyoshida Municipal Hospital |
Hirayama Y.,Fujiyoshida Municipal Hospital |
Yamamoto T.,Fujiyoshida Municipal Hospital |
Takahashi S.,Fujiyoshida Municipal Hospital
Endoscopic Forum for Digestive Disease | Year: 2011
A 19-year-old male with fever, diarrhea, and vomiting was hospitalized for a gastroenteritis. He was treated and recovered, but it became clear that he could not eat solid food since his birth. Endoscopy and esophagograph revealed an esophageal web in the inferior esophagus. He was treated by endoscopic cut and dilation by using a balloon dilator twice. But about two months later he had a symptom of dysphagia again and endoscopy found that the esophageal web was recurrent. So he was treated by a third endoscopic treatment for cut and dilation again. Because another recurrent esophageal web was expected he was treated by endoscopic balloon dilation and intralesional steroid injection. He remained symptom-free for three months.
Ishiyama T.,The Surgical Center |
Shibuya K.,Yamanashi University |
Ichikawa M.,Fujiyoshida Municipal Hospital |
Masamune T.,Yamanashi University |
And 3 more authors.
Journal of Neurosurgical Anesthesiology | Year: 2010
BACKGROUND: Propofol and sevoflurane are commonly used anesthetics for neurosurgery. The aim of the study was to compare the effects of propofol with sevoflurane on cerebral pial arteriolar and venular diameters during global brain ischemia and reperfusion. METHODS: Japanese white rabbits were anesthetized with propofol (n=11), sevoflurane (n=9), or the combination of sevoflurane and intralipid (n=10). Global brain ischemia was induced by clamping the brachiocephalic, left common carotid, and left subclavian arteries for 15 minutes. Pial microcirculation was observed microscopically through closed cranial windows and measured using a digital-video analyzer. Measurements were recorded before clamping and afterward for 120 minutes. RESULTS: Plasma glucose and mean arterial blood pressure increased significantly during ischemia in the propofol-anesthetized rabbits. During ischemia, pial arteriolar and venular diameters decreased significantly in all groups. After unclamping, large and small, pial arteriolar and venular diameters increased temporarily and significant dilation was observed in both sevoflurane groups. From 10 minutes after unclamping until the end of the study, large and small arterioles returned to baseline diameters in the sevoflurane groups, but decreased significantly by 10% to 20% in the propofol rabbits. Ischemia-induced adverse effects such as pulmonary edema and acute brain swelling were observed primarily in propofol-anesthetized rabbits. CONCLUSION: Propofol and sevoflurane acted differently on pial vessels during reperfusion after ischemic insult. Pial arterioles and venules did not dilate immediately after reperfusion, and subsequently constricted throughout the reperfusion period in propofol-anesthetized rabbits. In contrast, pial arterioles and venules dilated temporarily and returned to baseline in sevoflurane-anesthetized rabbits. Copyright © 2010 by Lippincott Williams & Wilkins.
Takeyoshi I.,Gunma University |
Makita F.,National Nishi Gunma Hospital |
Tanahashi Y.,Shibukawa General Hospital |
Iwazaki S.,Tatebayashi Kosei Hospital |
And 17 more authors.
Anticancer Research | Year: 2011
Background: Paclitaxel and doxifluridine (5′-DFUR) have distinct mechanisms of action and toxicity profiles. This study evaluated the antitumor activity and toxicities of combination chemotherapy with these drugs in patients with advanced/recurrent gastric cancer (AGC). Patients and Methods: Patients with histologically confirmed AGC, which was either unresectable or metastatic, were included in this study. The treatment consisted of 80 mg/m2 paclitaxel given i.v. on days 1, 8, and 15 every 4 weeks, and 533 mg/m 2 doxifluridine given orally on days 1-5 every week. Results: One hundred and four patients were evaluated for toxicity and 93 patients were evaluated for a therapeutic response. The overall response rate was 33.3% (1st line: 41.7%, 2nd line: 25.0%), including a complete remission in two patients, a partial remission in 29, stable disease in 39, progressive disease in 17; the response was not evaluable in six patients. The median overall survival was 287 days. Commonly observed grade 3/4 adverse events were leukopenia (13.5%), anorexia (3.8%), fatigue (3.8%) and diarrhea (2.9%). Conclusion: Paclitaxel and doxifluridine combination chemotherapy is a well-tolerated and convenient treatment regimen that can be given on an outpatient basis with promising efficacy for AGC.
Sato Y.,Showa University |
Sato Y.,Fujiyoshida Municipal Hospital |
Taki K.,Fujiyoshida Municipal Hospital |
Honda Y.,Fujiyoshida Municipal Hospital |
And 3 more authors.
Thyroid | Year: 2013
Background: Lithium is widely used to treat bipolar disorders. Lithium toxicity is generally caused by inappropriately high doses of lithium or impaired lithium excretion. Most lithium is eliminated via the kidneys and, since thyroid hormone increases tubular reabsorption of lithium, thyrotoxicosis could contribute to the development of lithium toxicity. We report a case of severe lithium toxicity that was apparently precipitated by the onset of thyrotoxicosis resulting from silent thyroiditis and dehydration. Patient Findings: The patient was a 64-year-old woman who was admitted for muscle weakness in the lower extremities, diarrhea, and palpitations. She had bipolar disorder and was being treated with lithium carbonate, which she discontinued one week before admission. Her circulating lithium levels had been monitored yearly. Early in her admission she was dehydrated and had febrile episodes, paroxysmal atrial fibrillation, and muscle weakness. Initially, fluid therapy was started, but she lost consciousness and had a cardiac arrest for 2 minutes due to prolonged sinus arrest. Chest compression and manual artificial ventilation were performed, and body surface pacing was started. Serum lithium was markedly elevated to 3.81 mEq/L (therapeutic range, 0.4-1.0 mEq/L), and thyroid hormone levels were increased (free triiodothyronine, 8.12 pg/mL; free thyroxine, 4.45 ng/dL), while thyrotropin (TSH) was suppressed (<0.01 μIU/mL). Hemodialysis was performed, and a temporary pacemaker was inserted for severe sinus bradycardia. The serum thyroglobulin was 4680 ng/mL (reference range, <32.7 ng/mL). A TSH receptor antibody test was negative. Glucocorticoid therapy and inorganic iodine (100 mg) were administered and continued until day 11. However, her neurological symptoms deteriorated with floppy quadriplegia and deep coma. She gradually recovered. On day 36, she was discharged without any neurological symptoms or thyrotoxicosis. Summary: A 64-year-old woman taking lithium for bipolar disorder developed lithium toxicity in the setting of what seemed likely to be a recent onset of thyrotoxicosis due to silent thyroiditis. Conclusions: Thyrotoxicosis may be a contributing cause of lithium toxicity, particularly if it is abrupt in onset and even with cessation of lithium therapy if renal function is compromised. Thyroid function should be assessed immediately in patients with suspected lithium toxicity. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
Watanabe M.,Fujiyoshida Municipal Hospital
Nihon Hoshasen Gijutsu Gakkai zasshi | Year: 2012
We examined the two-dimensional-spiral-gradient-echo (2D-spiral-GRE) for magnetic resonance venography (MRV). In addition, five variations in patient positioning of the MRV were investigated to determine the best method of visualizing. First, flow phantom experiments were performed on a 1.5 T scanner. Using a flow phantom, the authors aimed to (1) measure the optimal TR (40, 60, 140, 190 ms), (2) measure the flip angle (20-60 degrees) and (3) determine the optimal combination of saturation pulse (S, I, A, P, R, L) and half acquisition method for MRV. Secondly, ten volunteers without vessel disease were imaged by phase contrast sequence for measured mean value of the venous area and velocity of the femoral and popliteal vein. The volunteers' MRV images were compared qualitatively on visualization. There is better demonstration of the veins under the longer repetition time (TR), resulting in a setting of 2-3 acquisitions ordering. Because the fluid or blood has been irradiated with pulsed radiofrequency multiple times, optimal FA was about 40 degrees. Combination of saturation pulse was slightly effective and the best saturation effect was seen in the half acquisition method. Volunteer study patient positioning, which involves the slight lifting up of the upper half of the body and continuous warming of the feet, has brought about a larger area and a slower velocity in the lower extremity veins. The greater veins and peripheral veins were demonstrated more accurately. 2D-spiral-GRE sequence was a useful method for lower extremity MRV. Furthermore, the most effective patient positioning for the lower extremity MRV was slightly lifting up the upper half of the body and continuously warming the feet. These enabled the best results to be obtained in the lower extremity MRV.
PubMed | Red Cross, Nara Prefectural Gojo Hospital, Tachikawa General Hospital, Fujiyoshida Municipal Hospital and 46 more.
Type: Journal Article | Journal: Gastroenterology research | Year: 2016
To examine the effects of percutaneous endoscopic gastrostomy (PEG) on quality of life (QOL) in patients with dementia.We retrospectively included 53 Japanese community and tertiary hospitals to investigate the relationship between the newly developed PEG and consecutive dementia patients with swallowing difficulty between Jan 1st 2006 and Dec 31st 2008. We set improvements in 1) the level of independent living, 2) pneumonia, 3) peroral intake as outcome measures of QOL and explored the factors associated with these improvements.Till October 31st 2010, 1,353 patients with Alzheimers dementia (33.1%), vascular dementia (61.7%), dementia with Lewy body disease (2.0%), Pick disease (0.6%) and others were followed-up for a median of 847 days (mean 805 542 days). A total of 509 deaths were observed (mortality 59%) in full-followed patients. After multivariate adjustments, improvement in the level of independent living was observed in milder dementia, or those who can live independently with someone, compared with advanced dementia, characterized by those who need care by someone: Odds Ratio (OR), 3.90, 95% confidence interval (95%CI), 1.59 - 9.39, P = 0.003. Similarly, improvement of peroral intake was noticed in milder dementia: OR, 2.69, 95%CI, 1.17 - 6.17, P = 0.02. Such significant associations were not observed in improvement of pneumonia.These results suggest that improvement of QOL after PEG insertion may be expected more in milder dementia than in advanced dementia.
PubMed | Fujiyoshida Municipal Hospital
Type: Journal Article | Journal: Nihon Hoshasen Gijutsu Gakkai zasshi | Year: 2012
We examined the two-dimensional-spiral-gradient-echo (2D-spiral-GRE) for magnetic resonance venography (MRV). In addition, five variations in patient positioning of the MRV were investigated to determine the best method of visualizing.First, flow phantom experiments were performed on a 1.5 T scanner. Using a flow phantom, the authors aimed to (1) measure the optimal TR (40, 60, 140, 190 ms), (2) measure the flip angle (20-60 degrees) and (3) determine the optimal combination of saturation pulse (S, I, A, P, R, L) and half acquisition method for MRV. Secondly, ten volunteers without vessel disease were imaged by phase contrast sequence for measured mean value of the venous area and velocity of the femoral and popliteal vein. The volunteers MRV images were compared qualitatively on visualization.There is better demonstration of the veins under the longer repetition time (TR), resulting in a setting of 2-3 acquisitions ordering. Because the fluid or blood has been irradiated with pulsed radiofrequency multiple times, optimal FA was about 40 degrees. Combination of saturation pulse was slightly effective and the best saturation effect was seen in the half acquisition method. Volunteer study patient positioning, which involves the slight lifting up of the upper half of the body and continuous warming of the feet, has brought about a larger area and a slower velocity in the lower extremity veins. The greater veins and peripheral veins were demonstrated more accurately.2D-spiral-GRE sequence was a useful method for lower extremity MRV. Furthermore, the most effective patient positioning for the lower extremity MRV was slightly lifting up the upper half of the body and continuously warming the feet. These enabled the best results to be obtained in the lower extremity MRV.