Fujita Health University Nanakuri Sanatorium

Toyoake, Japan

Fujita Health University Nanakuri Sanatorium

Toyoake, Japan
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Okano H.,Suzuka General Hospital | Nakano T.,Fujita Health University Nanakuri Sanatorium
Acta Hepatologica Japonica | Year: 2014

We compared the clinical features and laboratory data of 13 cases with acute hepatitis E and 61 cases with drug-induced liver injury (DILI) in our hospital. Out of 13 hepatitis E cases, 12 had no history of eating or undercooked raw meat/viscera and remained unknown for the origin and route of hepatitis E virus (HEV) infection. More than half of acute hepatitis E and DILI did not exhibit jaundice during the clinical course. All 13 cases of acute hepatitis E had a high score of ≥5 points by the DDW-J 2004 scale. Without HEV screening, eight cases of acute hepatitis E might have been misdiagnosed as DILI. The DDW-J 2004 scoring scale, current diagnostic scale for DILI, cannot discriminate acute hepatitis E cases from DILI cases because the scoring scale has no support for HEV infection. We propose that HEV-IgA test should be included in the current diagnostic scale for drug-induced liver injury for differential diagnosis of acute HEV infection to provide more accurate diagnosis of DILI in Japan. © 2014 The Japan Society of Hepatology.


Fujimoto S.,Kuwana West Medical Center | Ishida S.,Kuwana West Medical Center | Nakano T.,Fujita Health University Nanakuri Sanatorium | Kitagawa N.,Kuwana West Medical Center | And 9 more authors.
Acta Hepatologica Japonica | Year: 2014

We experienced a case of hepatitis E in Mie prefecture infected with genotype 4 hepatitis E virus (HEV) strain endemic in Aichi and Shizuoka prefectures (Aichi/Shizuoka strain). The HEV isolate obtained from the patient clustered with other Aichi/Shizuoka strains with 100% of bootstrap value in the phylogenetic tree, and was more than 97.8% identical to other Aichi/Shizuoka strains, in the 412-nucleotide sequence within the ORF2 region. Interestingly, the patient had no history of consuming wild animal meat although all other reported Aichi/Shizuoka strains were recovered from meat from wild animals or humans after eating wild animal meat. The finding indicated that the origin of Aichi/Shizuoka strains is confined not only to wild animal meat but also to other unknown reservoirs. © 2014 The Japan Society of Hepatology.


Okano H.,Suzuka General Hospital | Takahashi M.,Jichi Medical University | Isono Y.,Suzuka General Hospital | Tanaka H.,Suzuka General Hospital | And 10 more authors.
Hepatology Research | Year: 2014

Aim: To characterize hepatitis E in Mie prefecture and to investigate whether raw pig liver sold as food in Mie is contaminated with hepatitis E virus (HEV) strains similar to those recovered from patients. Methods: Seventeen patients with sporadic acute hepatitis E treated from 2004 to 2012 were studied. A total of 243 packages of raw pig liver from regional grocery stores were tested for the presence of HEV RNA. The partial genomic sequences of human and swine HEV isolates were determined and subjected to the phylogenetic analyses. Results: The HEV isolates recovered from the 17 patients segregated into genotype 3 (n=15) and genotype 4 (n=2), and 15 genotype 3 isolates further segregated into 3e (n=11) and 3b (n=4). Pig liver specimens from 12 (4.9%) of the 243 packages had detectable HEV RNA. All 12 swine HEV isolates were grouped into genotype 3 (3a or 3b). Although no 3e strains were isolated from pig liver specimens, two 3b swine strains were 99.5-100% identical to two HEV strains recovered from hepatitis patients, within 412-nt partial sequences. Conclusion: The 3e HEV was prevalent among hepatitis E patients. HEV RNA was detected in approximately 5% of pig liver sold as food. The presence of identical HEV strains between hepatitis patients and pig liver indicated that pigs play an important role as reservoirs for HEV in humans in Mie. Further studies are needed to clarify the source of 3e HEV in the animal and environmental reservoirs. © 2013 The Japan Society of Hepatology.


Okano H.,Suzuka General Hospital | Nakano T.,Fujita Health University Nanakuri Sanatorium | Matsusaki S.,Suzuka General Hospital | Sase T.,Suzuka General Hospital | And 7 more authors.
Acta Hepatologica Japonica | Year: 2011

From 2004 to 2010, we have seen four cases of sporadic acute hepatitis E in nothern or central district of Mie Prefecture, Japan, who contracted infection of rare genotype 3 hepatitis E virus (HEV) strains. The HEV strains recovered from the four patients were 99.3-99.5% identical to each other in the 412-nucleotide sequence within ORF2 and homologous to those circulating in European countries such as Spain, United Kingdom, and the Netherlands, suggesting the long-term maintenance of the European type genotype 3 HEV strains in a restricted area in Japan. None of these four patients had histories of consuming uncooked or undercooked meat and/or viscera from infected animals and of travel to European countries, and the source of infectious origin remains unknown. These results warrant careful observation of clinical and subclinical HEV infection in this area and implementation of infection prevention measures in the future. © 2011 The Japan Society of Hepatology.


Okano H.,Suzuka General Hospital | Akachi S.,Mie Prefecture Health and Environment Research Institute | Nakano T.,Fujita Health University Nanakuri Sanatorium | Okamoto H.,Jichi Medical University
Acta Hepatologica Japonica | Year: 2014

The source of European-type subgenotype 3e/3sp hepatitis E virus (HEV) strain that is prevalent in hepatitis E patients in Mie, Japan, remained unknown. The present analyses of stored RNA samples that had been extracted from liver tissues obtained from 85 slaughtered pigs in Mie in 2007, revealed the presence of two HEV strains (swJ-Mie07-37L and swJ-Mie07-80L). The swJ-Mie07-80L strain was classified into subgenotype 3b/3jp, while swJ-Mie07-37L belonged to 3e/3sp and shared high nucleotide sequence identities of 98.399.2% with the 3e/3sp strains recovered from hepatitis E patients in Mie during 2004-2012. These results suggest that pigs are important reservoirs for HEV infection even in Mie, although the hepatitis E patients did not recall consuming raw pig liver/intestine before the disease onset. © 2014 The Japan society Hepatology.


PubMed | Zenjyokai Rehabilitation Hospital, Fujita Health University Nanakuri Sanatorium, Comprehensive Care, Fujita Health University Hospital and Tsujimura Surgical Hospital
Type: Journal Article | Journal: Journal of physical therapy science | Year: 2015

[Purpose] The motor paralysis-improving effect on the hemiplegic lower limb was compared among mirror therapy, integrated volitional-control electrical stimulation, therapeutic electrical stimulation, repetitive facilitative exercises, and the standard training method in post-stroke hemiplegia patients. [Subjects and Methods] Eighty one stroke patients admitted to a convalescent rehabilitation ward were randomly allocated to the above 5 treatment groups. Each patient performed functional training of the paralytic lower limb for 20 minutes a day for 4 weeks, and changes in the lower limb function were investigated using the Stroke Impairment Assessment Set. [Results] The hip and knee joint functions did not significantly improve in the standard training control group, but significant improvements were observed after 4 weeks in the other intervention groups. Significant improvement was noted in the ankle joint function in all groups. [Conclusion] Although the results were influenced by spontaneous recovery and the standard training in the control group, the hip and knee joints were more markedly improved by the interventions in the other 4 groups of patients with moderate paralysis, compared to the control group.


PubMed | Hiroshima University, Health Science University, Fujita Health University Nanakuri Sanatorium and Fujita Health University Hospital
Type: Journal Article | Journal: Journal of physical therapy science | Year: 2015

[Purpose] The purpose of this study was to find whether a fast treadmill gait training speed is effective for the gait training of stroke patients in the early rehabilitation stage. [Subjects and Methods] Thirty-nine stroke patients were the subjects of our investigation. They walked on a treadmill with handrail supports at a fast speed (130% of their comfortable gait speed in the 2nd week). The treadmill gaits of the patients were recorded using a 3-dimensional analysis system at two and six weeks after their admissions. Intraclass Correlation Coefficients (ICC) of the temporal and spatial parameters of the two periods were statistically analyzed. [Results] For all of the patients, the ICCs of the measured parameters were greater than 0.58. In the case of patients whose gait speeds of the two periods were close, the ICC units were greater than 0.7. [Conclusion] The fast gait speed training allowed us to expose the patients to a gait speed that they were expected to acquire at a later stage of their rehabilitation. This training method was found to be beneficial for the mildly paralyzed patients.


Matsuo K.,Aichi University | Watanabe R.,Fujita Health University Hospital | Kanamori D.,Aichi University | Nakagawa K.,Aichi University | And 5 more authors.
Supportive Care in Cancer | Year: 2016

Purpose: Adverse oral symptoms gradually appear in advanced cancer patients as the disease progresses. We retrospectively investigated the associations between the incidence of oral problems and the days to death (DTD) in patients receiving palliative care. Methods: The dental assessment sheets and medical charts of 105 patients who had been admitted into the palliative care unit at our hospital were examined. Case data included evaluations of organic and functional oral conditions at the time of admission for all patients. The cohort was divided into two groups according to the DTD as the short group (<28 days from the time of dental assessment until death) and the long group (≥28 days). We compared the incidences of organic and functional oral problems between these groups. Results: Dry mouth, tongue inflammation, and bleeding spots were significantly more frequent in the short group than in the long group (78 vs. 54 % for dry mouth, 67 vs. 46 % for tongue inflammation, 35 vs. 14 % for bleeding spots, respectively; p < 0.05). Tongue coating and candidiasis were comparable between the two groups. Dysphagia was significantly more common in the short group (43 %) than in the long group (20 %) (p = 0.01), as was assistance with oral health care (76 vs. 50 %) (p = 0.01). Conclusions: Our findings suggest that, during palliative care, oral complications appear more frequently when the DTD period is shorter. These symptoms may be useful indicators when deciding on the proper timing of intensive oral care intervention to decrease oral problems and pain in terminally ill patients. © 2015, Springer-Verlag Berlin Heidelberg.


Sugiyama M.,Nagoya University | Hattori H.,Nagoya University | Inoue T.,Nagoya University | Wakita H.,Fujita Health University Nanakuri Sanatorium | And 2 more authors.
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | Year: 2014

Purpose: The aim of this study was to investigate the effect of stem cells from human exfoliated deciduous teeth (SHED) after permanent MCAO (pMCAO). Materials and methods: Adult male Sprague-Dawley rats were subjected to pMCAO. After pMCAO, SHED was transplanted into the brain. Motor function and infarct volume were evaluated. Neurogenesis and vasculogenesis were determined using immunochemical markers. Results: The SHED group had more positive signals for doublecortin, neurofilament, anti-neuronal nuclei (NeuN) and rat endothelial cell antigen-1 (RECA1) in the peri-infarct area than the PBS group. Migration of doublecortin-positive neural progenitor cells (NPCs) from subventricular zone (SVZ) to the peri-infarct area was observed on day 16. Transplanted SHED merged vascular endothelial growth factor (VEGF) and stromal cell-derived factor 1 (SDF-1) positive cells. Conclusion: SHED promoted migration and differentiation of the endogenous NPCs and induced vasculogenesis, and ameliorated ischemic brain injury after pMCAO in rats. © 2013 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI.


Inoue T.,Nagoya University | Sugiyama M.,Nagoya University | Hattori H.,Nagoya University | Wakita H.,Fujita Health University Nanakuri Sanatorium | And 2 more authors.
Tissue Engineering - Part A | Year: 2013

Regenerative therapy using stem cells is a promising approach for the treatment of stroke. Recently, we reported that dental pulp stem cells (DPSC) ameliorated ischemic tissue injury in the rat brain and accelerated functional recovery after middle cerebral artery occlusion (MCAO). In this study, we investigated the effects of stem cells from human exfoliated deciduous tooth (SHED)-derived conditioned medium (SHED-CM) on permanent MCAO (pMCAO). Adult male Sprague-Dawley rats were subjected to pMCAO. SHED-CM were then administered intranasally, and the motor function and infarct volume were evaluated. Neurogenesis and vasculogenesis were determined using immunochemical markers. The SHED-CM group had more positive signals than the Dulbecco's modified Eagle's medium group, with doublecortin (DCX), neurofilament H, neuronal nuclei, and rat endothelial cell antigen observed in the peri-infarct area. Migration of neuronal progenitor cells (NPC) with DCX from the subventricular zone to the peri-infarct area was observed on days 6 and 16, with migration on day 6 being the most prominent. In conclusion, SHED-CM promoted the migration and differentiation of endogenous NPC, induced vasculogenesis, and ameliorated ischemic brain injury after pMCAO as well as transplantation of DPSC. © Mary Ann Liebert, Inc.

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