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Hachioji, Japan

Patent
Fujirebio Inc. | Date: 2014-01-21

The present invention provides a method for detecting a c-MET gene amplification cell. Specifically, the present invention provides a method for detecting a c-MET gene amplification cell, comprising measuring a soluble c-MET in a sample utilizing a region specific for the soluble c-MET, wherein the soluble c-MET is formed by cleavage between the lysine residue (K) and the valine residue (V) in the partial region GKVI (SEQ ID NO:2) in a c-MET extracellular domain.


Patent
Fujirebio Inc. | Date: 2013-12-26

Means that enables an immunoassay of hemoglobin A1c in a whole blood sample without pretreatment of the sample is disclosed. The immunoassay of hemoglobin A1c in a sample according to the present invention comprises bringing latex particles into contact with a non-pretreated whole blood sample in a hypotonic solution, and then bringing hemoglobin A1c adsorbed on the latex particles into contact with an anti-hemoglobin A1c antibody. The immunoassay is preferably carried out by an agglutination method. The hypotonic solution is, for example, a buffer containing a Goods buffer at a concentration of 0.02 to 0.2 mol/L, which Goods buffer has the maximum buffer capacity in the neutral to alkaline region.


The present invention provides a detection system using a nucleic acid probe which is commonly used in a measurement system using a recombinase (e.g., nucleic acid amplification reaction). Specifically, the present invention provides a method for detecting a target nucleic acid, comprising measuring the target nucleic acid using a cleavage enzyme, a recombinase, and a probe having characteristics of the following (a) to (c): (a) being a single-stranded nucleic acid molecule comprising a pair of regions capable of complementarily binding to each other, and a region capable of complementarily binding to the target nucleic acid;


Patent
Fujirebio Inc. and Hiroshima University | Date: 2012-01-30

A method of measuring the length of a G tail sequence, characterized by hybridizing the G tail of an nondenatured chromosomal DNA in a sample with a labeled DNA probe having a sequence complementary to the telomere repeat sequence, measuring chemiluminescence from the hybridized DNA probe, and determining the length of the G tail sequence from the measured value, and a kit used for use in such a method.


The present invention provides a method for stably correcting a detection signal in an isothermal nucleic acid amplification reaction, particularly an isothermal nucleic acid amplification reaction performed at low temperature. Specifically, the present invention provides a method for detecting a target nucleic acid in an isothermal nucleic acid amplification reaction, comprising the following (1) and (2):

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