Fujirebio Inc.

Hachioji, Japan

Fujirebio Inc.

Hachioji, Japan
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Patent
Jeol Ltd. and Fujirebio Inc. | Date: 2017-08-30

An aspect of the present invention is an automatic analysis device having a BF separation process, wherein the width in a container conveyance direction of a surface facing a reaction container of a magnet for preliminary magnetic collection of a first magnetic generation part is set to have a length including a region for housing a liquid sample of the reaction container conveyed to a magnetic collection position of the first magnetic generation part. An end in the container conveyance direction of a surface facing the reaction container of a magnet for regular magnetic collection of a second magnetic generation part is designed to be close to the center of the region for housing the liquid sample of the reaction container conveyed to a magnetic collection position of the second magnetic generation part.


The present invention provides a method and means that can specifically detect a target nucleic acid containing a modified nucleobase. Specifically, the present invention provides a method for measuring a target nucleic acid containing a modified nucleobase, the method comprising:(1) incubating a nucleic acid sample and a heterologous nucleic acid probe having a property of pairing with a modified nucleobase, in a solution; and(2) measuring the modified nucleobase using an antibody against a modified nucleobase having a property of heterologous pairing, in the solution obtained at (1). The present invention also provides a kit for measuring a target nucleic acid containing a modified nucleobase, the kit comprising:(I) a heterologous nucleic acid probe having a property of pairing with a modified nucleobase; and(II) an antibody against a modified nucleobase having a property of heterologous pairing.


Patent
Jeol Ltd. and Fujirebio Inc. | Date: 2017-03-22

To clean a nozzle that is part of an automated analyzer and is provided with both a tubular discharge unit that discharges a cleaning liquid and a tubular suction unit that suctions in cleaning liquid that was discharged from the discharge unit and is running down an outer surface, first the discharge unit is made to start discharging, and then in parallel with said discharging, the suction unit is made to start suctioning. After the suction unit has suctioned in the cleaning liquid running down the aforementioned outer surface for a prescribed length of time, the suctioning is temporarily stopped. Next, after a prescribed amount of the cleaning liquid has accumulated in a cleaning tank, the discharging is stopped, and with the suction unit immersed in the cleaning liquid accumulated in the cleaning tank, the suctioning is restarted.


Patent
Jeol Ltd. and Fujirebio Inc. | Date: 2017-03-22

This invention provides a container supply unit and an automated analyzer in which anomalous orientations of containers ejected from a container (cuvette) ejection part can be prevented in advance. This container supply unit has a container storage part, a container ejection part, and a container alignment part. The container ejection part includes a circular belt, placement members provided on said circular belt, and a belt rotation mechanism. Said belt rotation mechanism rotates the circular belt in an R direction, forming an outward leg along which the placement members move upwards and a return leg along which the placement members move downwards. The placement members carry containers placed thereon on the outward leg and eject said containers to the container alignment part between the outward leg and the return leg. The top of each placement member during the outward leg comprises the following: a first inclined surface that is sloped upwards from one end, on the circular-belt side, towards the other end; and a second inclined surface that is sloped downwards from one end, which connects to the first inclined surface, towards the other end.


Patent
Jeol Ltd. and Fujirebio Inc. | Date: 2017-01-25

This reagent vessel housing unit 7 is provided with a drive unit 121, a base member 122, a first opening/closing mechanism 135, and a second opening/closing mechanism 136. By means of the driving force of the drive unit 121, the base member 122 can move to an initial position, at which the cap of a first reagent vessel and the cap of a second reagent vessel are closed, a first opening position at which the cap of the first reagent vessel is opened, and a second opening position at which the cap of the second reagent vessel is opened. The first opening/closing mechanism 135 opens the cap of the first regent vessel. The second opening/closing mechanism 136 opens the cap of the second regent vessel.


Patent
Hokkaido University, Fujirebio Inc. and SRL Inc. | Date: 2016-03-24

The present invention provides a novel marker for diagnosing fibromyalgia syndrome (FMS). More specifically, the present invention provides a method for diagnosing FMS, comprising measurement of (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human; and a diagnosis kit for FMS, comprising a means for measuring (1) the relative frequency of MAITs to the total T cells in a sample; or (2) the expression level of one or more surface antigens selected from the group consisting of CD4, CD8, CCR4, CCR7, CXCR1, NKp80, CD150, CD107a, CD8, CD44 and CXCR4 for MAITs in a sample, wherein the sample is a biological sample collected from a human.


Patent
Fujirebio Inc. and Jeol Ltd. | Date: 2016-04-13

[PROBLEMS] It is an object to provide a gripping mechanism that enables inhibition of possible static electricity and contamination in a gripping object such as a reaction container, while enabling the orientation of the gripping object to be stabilized. [MEANS TO SOLVE PROBLEMS] The gripping mechanism is a gripping mechanism for gripping a cuvette T, the gripping mechanism comprising: a sandwiching section 50 for holding the cuvette T in a laterally sandwiching manner; a pressing section 60 for pressing downward an upper end surface of the cuvette T held in a sandwiching manner by the sandwiching section 50, wherein the pressing section 60 is arranged such that, with the cuvette T being held in a sandwiching manner by the sandwiching section 50, a central axis of the cuvette T along a vertical direction coincides mutually with a central axis of the pressing section 60 in the vertical direction.


The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic acid. Specifically, the present invention provides a method for measuring a modified nucleobase including:(1) incubating a nucleic acid sample, a capture probe, and a guide probe in a solution; and(2) measuring the modified nucleobase using an antibody against the modified nucleobase in the solution obtained at (1) . The present invention also provides a kit for measuring a modified nucleobase including:(I) a guide probe; and(II) a capture probe and/or an antibody against the modified nucleobase.


Disclosed is a means for enabling reduction of non-specific reaction caused by p19 while a decrease in the measurement value is suppressed as much as possible in cases of HTLV antibody positive. A method for reducing non-specific reaction in an immunoassay for anti-HTLV antibody according to the present invention comprises allowing a modified p19 peptide(s) to be present in an antigen-antibody reaction system. The modified p19 peptide is a polypeptide which is constituted by a p19 fragment comprising the region of the 103rd to 130th amino acids in HTLV p19 and has at least one substitution mutation in the region corresponding to the 112th to 118th amino acids in p19. Typically, the modified p19 peptide is an artificial polypeptide.


The disclosure relates to use of the HE4/HE4a marker(s) together with one or more other markers to assess ovarian cancers in a patient.

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