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Amagasaki, Japan

Umemoto H.,Fujimoto Chemicals Co. | Onaka T.,Fujimoto Chemicals Co. | Miki Y.,Kinki University | Nakamura A.,Kinki University | Maegawa T.,Kinki University
Synlett | Year: 2014

The reaction of 2-[(trimethylsilyl)methyl]-2H-tetrazoles with various alkyl halides and carbonates using n-butyllithium or lithium diisopropylamide (LDA) gave 2-[1-(trimethylsilyl)alkyl]-2H-tetrazoles and (2H-tetrazol-2-yl)acetates as useful synthons of modified tetrazoles. © Georg Thieme Verlag Stuttgart. Source


Umemoto H.,Fujimoto Chemicals Co. | Onaka T.,Fujimoto Chemicals Co. | Miki Y.,Kinki University | Nakamura A.,Kinki University | Maegawa T.,Kinki University
Heterocycles | Year: 2014

2-((Trimethylsilyl)methyl)-2H-tetrazoles were treated with aldehydes and ketones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 2-(2-hydroxyethyl)-2H-tetrazoles. This simple procedure offers a valuable strategy for the preparation of 2-(hydroxyethyl)-2H-tetrazoles. © 2014 The Japan Institute of Heterocyclic Chemistry. Source


Onaka T.,Fujimoto Chemicals Co. | Umemoto H.,Fujimoto Chemicals Co. | Miki Y.,Kinki University | Nakamura A.,Kinki University | Maegawa T.,Kinki University
Journal of Organic Chemistry | Year: 2014

A mild and regioselective 2-arylation of 5-substituted tetrazoles is described. The reaction proceeds regioselectively with a variety of arylboronic acids in the presence of [Cu(OH)(TMEDA)]2Cl2 to afford 2,5-disubstituted tetrazoles. This is the first report of highly regioselective arylation of 5-alkyltetrazoles. © 2014 American Chemical Society. Source

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