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Yokohama-shi, Japan

A microchip for measuring platelet function by allowing blood to flow through a channel to induce platelet aggregation, wherein the microchip comprises a channel provided inside thereof, wherein at least a part of the channel is coated with collagen for allowing adhesion of platelets; a plurality of walls extend along the direction of the flow of blood in the channel and divide the width of the channel to form a channel dividing section; and the walls are treated to have a surface roughness (Ra) of 10 to 200 nm.

Fujimori Kogyo Co. | Date: 2014-05-20

Provided are a light-shielding sheet that has a function of shielding light of a specific wavelength and that is capable of preventing a light-shielding substance from being transferred into the contents and seeping out of a container and a container produced using the light-shielding sheet. This light-shielding sheet of the present invention has a multilayer structure of three or more layers including at least one light-shielding layer that shields a specific wavelength and/or eluate-blocking layer that blocks substances eluted from the light-shielding layer. When producing a container from the light-shielding sheet, an eluate-blocking layer A is provided at least between the light-shielding layer and an innermost layer or on the innermost layer, and an eluate-blocking layer B is provided between the light-shielding layer and an outermost layer or on the outermost layer. The light-shielding layer may further double as an eluate-blocking layer.

Fujimori Kogyo Co. | Date: 2015-11-02

A method for testing platelet function, wherein platelet function is tested by allowing anticoagulated blood, to which a weak platelet-activating reagent has been mixed, to pass through a capillary having a platelet-adhesive surface on at least a part of its inner surface, and observing or measuring the behavior of the blood in the capillary.

Fujimori Kogyo Co. | Date: 2012-12-11

The invention provides a resin composition for a sealant capable of improving non-adsorption properties and heat sealing properties with respect to an organic component in an article contained, a laminated film and a packaging bag. The resin composition for a sealant of the invention is made of a resin obtained by blending a cycloolefin polymer (COP), a cycloolefin copolymer (COC) and polyethylene (PE), and the blending ratio is 42 weight % to 98 weight % of the cycloolefin polymer (COP), 1 weight % to 49 weight % of the cycloolefin copolymer (COC) and 1 weight % to 19 weight % of the polyethylene (PE).

Ogawa S.,Kyoto Prefectural University of Medicine | Ohnishi T.,Fujimori Kogyo Co. | Hosokawa K.,Fujimori Kogyo Co. | Szlam F.,Emory University | And 2 more authors.
British Journal of Anaesthesia

Background. Blood flow patterns are important modifiers of platelet interactions with plasma coagulationfactors.However, it is not feasible to evaluate rheological effects of haemodilution on coagulation using conventional coagulation testing. Methods.We evaluated thrombusformation with amicrochip-basedflow-chamber systemusing whole blood from 12 healthy volunteers (with/without 40% dilution with saline), and 15 cardiac patients [before/after cardiopulmonary bypass (CPB)] in parallel with thromboelastometry. The in vitro additions of von Willebrand factor (vWF, 1.5 U ml-1), prothrombin complex concentrate (PCC, 0.3 U ml-1), fibrinogen (2 g litre -1), or combined PCC (0.3 U ml-1) and fibrinogen (1 g litre-1) were examined. Recalcified whole-blood samples were perfused over the microchip coated with collagen and tissue thromboplastin at flow rates of 10 and 3 μl min-1. Results. Dilution of whole blood led to delayed onset of thrombus formation (Ton), and thrombus growth (T80). Changes relative to baseline values were more extensive at 10 μl min-1 (≥85% prolongation for Ton and T 80) than at 3 μl min-1 (≥40% prolongation for Ton and T80). Adding vWF accelerated thrombus formation only at 10 μl min -1, while PCC increased thrombin generation in the thrombus at both flow rates. Fibrinogen increased mural thrombus formation at 3 μl min -1. Decreased clot strength after dilution was restored by fibrinogen, but not by vWF or PCC on thromboelastometry. Additive effects of fibrinogen and PCC in post-CPB blood were demonstrated by both flow chamber and thromboelastometry. Conclusions. Blood flow affects thrombus formation after haemodilution and subsequent haemostatic component interventions, with differential effects at low and high flow. © The Author [2013]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. Source

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