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Wang C.,National Center for Cardiovascular Diseases | Wang C.,Peking Union Medical College | Li J.,National Center for Cardiovascular Diseases | Li J.,Peking Union Medical College | And 17 more authors.
Diabetes Research and Clinical Practice | Year: 2015

Aims: To estimate the incidence of Type 2 diabetes mellitus (T2DM) and the number of those with T2DM attributable to overweight and obesity in China. Methods: We conducted a prospective cohort study among 15. 680 participants (46.4%, men) aged 35-74 years. The mean duration of follow-up was 8.0 years. We examined the relationship between overweight, obesity and risk of T2DM by Cox proportional hazards models. Population attributable risk (PAR) of overweight and obesity was also calculated. Moreover, we estimated the number of T2DM events attributed to overweight and obesity using PAR, incidence of T2DM and the population size of China in 2010. Results: During a mean follow-up of 8.0 years, the age-standardized incidence of T2DM was 9.5 per 1000 person-years in men and 9.2 in women. Overweight accounted for 28.3% (95% confidence interval [CI]: 20.1, 36.2) of incident T2DM among men and 31.3% (95% CI: 25.5, 36.9) among women. The corresponding PAR of obesity was 10.1% (95% CI: 6.0, 14.2) among men and 16.8% (95% CI: 12.0, 21.6) among women. Approximately 3.32 million (95% CI: 2.47, 4.24) incident T2DM were attributable to overweight and obesity in Chinese adults who were 35 to 74 years in 2010. Conclusion: Our results indicate that incident T2DM is mainly attributable to overweight and obesity in China. It is extremely important to advocate healthy lifestyle and prevent excessive weight gain for reducing T2DM burden in China. © 2015. Source

Zheng J.,Fujian Provincial Peoples Hospital
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2011

To explore the impacts of Yishen Jiangzhuo Granule (YJG) on peripheral blood B-cells and regulatory T-cells (Treg) in patients with chronic renal insufficiency (CRI). Fifty-three CRI patients were randomly assigned to two groups, the control group and the YJG group. Before and after treatment, the following parameters in blood were detected: the peripheral Treg, percentage (CD19+), activation rate (CD19+ CD69+) and apoptotic rate (AV) of B-lymphocyte by flow cytometry; cytokines (IL-6 and IL-10) by CBA stream protein analyzing system; high sensitivity C-reactive protein (hs-CRP) by scattering turbidimetric analysis; homocysteine (Hcy) by end-point method; hemoglobin (HGB) content by Beckman-Coulter hemo-analyser; blood contents of Ca, phosphate (P), blood urea nitrogen (BUN), creatinine (SCr) and plasma albumin (Alb) by automatic biochemical analyser; and urinary contents of creatinine (UCr) by inverse HPLC. Then the product of calcium-phosphate (Ca x P) was calculated based on blood contents of Ca2 and P and the clearance rate of endogenous creatinine (CCr) was calculated based on blood BUN and SCr. After treatment CD19+ and CCr significantly increased (P < 0.01), but AV and SCr decreased in both groups (P < 0.01), with the changes in the YJG group were more significant than those in the control group (P < 0.05); levels of CD19+ CD69+, Treg, IL-6, IL-10, CRP, BUN, P and Ca x P showed no significant change (P > 0.05); levels of Ca2+, HGB and Alb increased as well as of Hcy in both groups (P < 0.05). Correlation analysis: There were negative correlation in CD19+ with AV and Hcy; Alb with AV and Hcy; CCr with CRP, SCr and BUN, while positive correlation existed in SCr with CRP and BUN; and CRP with BUN. YJG can improve renal function, and delay the progress of renal failure, and it also shows the regulatory effect on B lymphocytes by lowering the apoptosis rate and improving the percentage of CD19+ in patients. Source

Fan S.,Peking Union Medical College | Chen J.,Peking Union Medical College | Huang J.,Peking Union Medical College | Li Y.,Peking Union Medical College | And 9 more authors.
Medicine and Science in Sports and Exercise | Year: 2014

Purpose: The objective is to examine the association between physical activity level (PAL) and incident type 2 diabetes among middle-age and older Chinese men and women in urban China. Methods: This prospective study included 6348 participants (age 35 to 74 yr) who were free of diabetes and cardiovascular disease at baseline. PAL was estimated on the basis of self-reported overall physical activity on a typical day. According to PAL, participants were classified into four groups: sedentary (PAL, 1.00-1.39), low active (PAL, 1.40-1.59), active (PAL, 1.60-1.89), and very active (PAL, 91.89). The association of PAL with incident diabetes was examined by Cox proportional hazards model. Results: During 7.9 yr of follow-up (50,293 person-years), 478 incident cases of type 2 diabetes were identified. After adjustment for age, sex, geographic region, educational level, smoking, alcohol use, and family history of diabetes, the HR (95% CI) values for type 2 diabetes across increasing categories of PAL were 1.00 (reference), 0.82 (0.62-1.09), 0.63 (0.47-0.83), and 0.47 (0.36-0.61), respectively (P for trend G0.0001). Additional adjustment for baseline body mass index or waist circumference attenuated the magnitude of risk reduction, but it remained significant. The inverse association between PAL and risk of incident diabetes was persistent in subgroup analyses according to age, sex, hypertension, smoking, body mass index, waist circumference, and fasting plasma glucose level. Conclusions: Higher PAL is associated with substantial reduction in risk of type 2 diabetes. Our findings suggest the importance of a physically active lifestyle in the prevention of diabetes. © 2014 by the American College of Sports Medicine. Source

Qiu Y.-M.,Fuzhou General Hospital of Nanjing Military Command | Du W.,Fujian Provincial Peoples Hospital | Chen Y.,Fuzhou General Hospital of Nanjing Military Command | Luo X.,Fuzhou General Hospital of Nanjing Military Command | Ouyang X.-N.,Fuzhou General Hospital of Nanjing Military Command
Chinese Journal of Cancer Prevention and Treatment | Year: 2014

CONCLUSIONS: The tumor antigen-loaded DC co-culture with CIK can effectively suppress the expression of VEGF, MMP-9 and Bcl-2, it also supress the lung adenocarcinoma xenografts in nude mice.OBJECTIVE: To investigate the in vivo killing activity and molecular mechanism of tumor antigen-loaded DC co-culture with CIK.METHODS: Peripheral blood mononuclear cells from healthy human were separated by conventional methods, and induced to DC and CIK cells in vitro. The phenotypic changes of antigen-loaded DC and CIK were detected by flow cytometry.Human lung adenocarcinoma A549 xenografts in nude mice were established and randomly divided into PBS group, CIK group and Ag-DC-CIK group.The tumor mass were removed, weighed and the inhibition rates were calculated 30 days after the treatment. HE staining and immunohistochemistry assay such as VEGF, MMP-9 and Bcl-2 were carried out with the tumor mass.RESULTS: Surface markers CD83+(45.812±6.110)%, CD86+(78.341±6.839)% and HLA-DR+(75.103±5.913)% of DC were significantly increased, with statistics value (t=5.384, P=0.009), (t=7.902, P=0.003) and (t=10.132, P<0.001) after antigen Loading, CD3+CD8+(55.417±8.428)% and CD3+CD56+(39.823±7.215)% were significantly increased after co-cultured with CIK, with statistics value (t=6.185, P=0.008) and (t=9.904, P=0.001).VEGF, MMP-9 and Bcl-2 protein expression were significantly decreased in the Ag-DC-CIK group with statistics value (t=7.630, P=0.002), (t=11.751, P<0.001) and (t=9.624, P<0.001). The VEGF and Bcl-2 expression inhibition was stronger in Ag-DC-CIK group than that in CIK group with statistics value (t=5.832, P=0.009) and (t=6.214, P<0.001). The expressions of MMP-9 were not significantly different between Ag-DC-CIK group and CIK group (t=1.022, P=0.865). ©, 2014, Chinese Journal of Cancer Prevention and Treatment. All right reserved. Source

Sun D.,Chinese Academy of Sciences | Cao J.,Chinese Academy of Sciences | Liu X.,Cardiovascular Institute | Yu L.,Fujian Provincial Peoples Hospital | And 9 more authors.
Journal of Women's Health | Year: 2010

Objectives: To quantify the combined effects of systolic blood pressure (SBP) and cigarette smoking on incident coronary heart disease (CHD) in women. Methods: Overall, 86,338 women aged ≥40 years were enrolled in 1991. The follow-up evaluation was conducted in 1999-2000, with a response rate of 92.9%. Results: A total of 829 CHD events (fatal and nonfatal) were observed among the participants who were free of cardiovascular diseases (CVD) at baseline. Higher SBP was significantly associated with more risk of CHD in both nonsmokers and current smokers (all p<0.0001 for linear trends). Comparing with never smoking, both low and high levels of cigarettes smoked per day (1-7, and ≥8 cigarettes per day) and pack-years (<10, and ≥10 pack-years) were associated with increased risk of CHD in those with normal and high SBP. The multivariate adjusted relative risks (RRs) of CHD were 2.54 (95% confidence interval [CI] 2.00-3.23), 1.28 (1.01-1.63), and 1.57 (1.33-1.86) for current smokers with high SBP, current smokers with normal SBP, and nonsmokers with high SBP, respectively, compared with nonsmokers with normal SBP. The present study identified a statistically significant additive interaction between these two factors on CHD. Conclusions: Our study indicated that the combined effects of cigarette smoking and high SBP could be expected to have extra adverse effects on CHD in women, which highlights the importance of multifactorial interventions to decrease the risk of CHD, for example, quitting smoking and treatment of high blood pressure in Chinese women. © 2010 Copyright Mary Ann Liebert, Inc. Source

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