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Hu X.,Fuzhou University | Hu X.,Fujian University of Traditional Chinese Medicine | Xia Q.-W.,Fuzhou University | Zhao Y.-Y.,Fuzhou University | And 5 more authors.
Chemical and Pharmaceutical Bulletin | Year: 2014

A rare hexacyclic oxindole alkaloid, speradine F (1), together with two novel tetracyclic oxindole alkaloids, speradines G (2) and H (3), were isolated from the marine-derived fungus Aspergillus oryzae. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. This study is the first report on cyclopiazonic acid (CPA)-type alkaloids with a hexacyclic skeleton. © 2014 The Pharmaceutical Society of Japan. Source


Wu J.,Fuzhou University | Liu H.,Fuzhou University | Ge S.,Fuzhou University | Wang S.,Fuzhou University | And 5 more authors.
Food Hydrocolloids | Year: 2015

Gelatin films containing cinnamon essential oil (CEO) nanoliposomes were prepared to enhance the antimicrobial stability by thin film ultrasonic dispersion method. The results showed the mean size of CEO nanoliposomes was about 107nm. The absolute zeta potential value was greater than 30mV and the entrapment efficiency was above 92%. A decrease of the tensile strength (TS), water soluble (WS), water content (WC) and water vapor permeability (WVP) accompanied with an increase in elongation at break (EAB) was observed for the gelatin films incorporated with CEO nanoliposomes. SEM indicated that gelatin film added with CEO nanoliposomes had a finer inner network on their cross-section and an evener structure on their surface than the control film. At the same time, the information on FT-IR reflected that the gelatin and CEO nanoliposomes (or CEO solution) were mixed together physically without any chemical reaction. Finally, an increase in antimicrobial stability along with a decrease in CEO release rate was observed for the film incorporated with CEO nanoliposomes. Our results indicated that the incorporation of CEO nanoliposomes as a natural antibacterial agent possessed sustained release effect, which had potential for using the developed film as an active packaging. © 2014 Elsevier Ltd. Source


Hu X.,Fuzhou University | Hu X.,Fujian University of Traditional Chinese Medicine | Xia Q.-W.,Fuzhou University | Zhao Y.-Y.,Fuzhou University | And 5 more authors.
Heterocycles | Year: 2014

Four novel tetracyclic oxindole alkaloids, namely, speradines B (1), C (2), D (3), and E (4) were isolated from the marine-derived fungus Aspergillus oryzae. The structures of these compounds without the absolute configurations were elucidated through 1D and 2D nuclear magnetic resonance and high-resolution mass spectrometric analyses. Among these compounds, 1 and 4 showed weak cytotoxic effects on the HeLa cell line. © 2014 The Japan Institute of Heterocyclic Chemistry. Source


Chen L.,Fuzhou University | Gong M.-W.,Fuzhou University | Peng Z.-F.,Fuzhou University | Zhou T.,Fuzhou University | And 5 more authors.
Marine Drugs | Year: 2014

Dicitrinone B, a rare carbon-bridged citrinin dimer, was isolated from the marine-derived fungus, Penicillium citrinum. It was reported to have antitumor effects on tumor cells previously; however, the details of the mechanism remain unclear. In this study, we found that dicitrinone B inhibited the proliferation of multiple tumor types. Among them, the human malignant melanoma cell, A375, was confirmed to be the most sensitive. Morphologic evaluation, cell cycle arrest and apoptosis rate analysis results showed that dicitrinone B significantly induced A375 cell apoptosis. Subsequent observation of reactive oxygen species (ROS) accumulation and mitochondrial membrane potential (MMP) reduction revealed that the apoptosis induced by dicitrinone B may be triggered by over-producing ROS. Further studies indicated that the apoptosis was associated with both intrinsic and extrinsic apoptosis pathways under the regulation of Bcl-2 family proteins. Caspase-9, caspase-8 and caspase-3 were activated during the process, leading to PARP cleavage. The pan-caspase inhibitor, Z-VAD-FMK, could reverse dicitrinone B-induced apoptosis, suggesting that it is a caspase-dependent pathway. Our data for the first time showed that dicitrinone B inhibits the proliferation of tumor cells by inducing cell apoptosis. Moreover, compared with the first-line chemotherapy drug, 5-fluorouracil (5-Fu), dicitrinone B showed much more potent anticancer efficacy, suggesting that it might serve as a potential antitumor agent. © 2014 by the authors; licensee MDPI. Source


Chen L.,Fuzhou University | Zhou T.,Fuzhou University | Zhao Y.-Y.,Fuzhou University | Gong M.-W.,Fuzhou University | And 6 more authors.
Heterocycles | Year: 2015

Six new compounds, penicitrinols L-O (1-4), penicillenols D1 (9) and D2 (10), together with six known compounds were isolated from the marine-derived fungus Penicillium citrinum. Their structures were elucidated on the basis of comprehensive spectral analysis and chemical methods. All the new compounds were evaluated for their cytotoxic effects on the A-549, HL-60 and SW-620 cell lines by the MTT method. Penicitrinols L (1) and M (2) showed weak cytotoxicities against SW-620 cell line, while penicillenols D1 (9) and D2 (10) showed weak cytotoxicities against A-549 and HL-60 cell lines, respectively. © 2015 The Japan Institute of Heterocyclic Chemistry. Source

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