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Xie W.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Xie W.,Fujian Normal University | Xie W.,Fujian Provincial Key Laboratory of Photonic Technology | Zeng Z.,Key Laboratory of Optoelectronic Science and Technology for Medicine | And 12 more authors.
Zhongguo Jiguang/Chinese Journal of Lasers | Year: 2012

Signal attenuation is highly concerned in many research fields. Imaging quality and depth in photoacoustic (PA) imaging system are often limited by the attenuation of PA signal. The PA signal attenuation is induced by many factors in PA imaging system. The factors leading to the signal attenuation and its characteristics are discussed based on tissue optics, acoustic transport and detection in a long-focal-zone PA imaging system. Considering to recover the PA signal from optical to ultrasonic attenuation, a method to compensate the detected PA signals is presented. The proposed method is evaluated by simulant sample and employed to image a thyroid tissue in vitro. The experimental results demonstrate that the method could be used to recover the PA signal and to improve the imaging depth and quality in the PA system.


Li Z.,Fujian Normal University | Li Z.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Li Z.,Fujian Provincial Key Laboratory of Photonic Technology | Chen H.,Fujian Provincial Hospital | And 7 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2011

We explore the feasibility of using photoacoustic imaging based on a focused transducer to characterizing acute myocardial ischemia at different stage. In this study, we blocked rat left anterior coronary descending artery (LAD) to induce the acute myocardial ischemia. The results show that the intensity and areas of photoacoustic images of myocardial decrease with the LAD time increasing, which suggests that photoacoustic imaging has a potential for diagnosis of acute myocardial ischemia. © 2011 SPIE.


Xie W.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Xie W.,Fujian Provincial Key Laboratory of Photonic Technology | Xie W.,Fujian Normal University | Li H.,Key Laboratory of OptoElectronic Science and Technology for Medicine | And 11 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2010

Photoacoustic imaging is a promising technique in practical medicine to image biological tissue's function and diagnose internal organs. In this paper, a new photoacoustic imaging modality for imaging internal organs was presented. A laser which wavelength is tunable was coupled into a multimode optical fiber. And the fiber was inserted into the inner tract of the samples to deliver light for exciting photoacoustic signals. The outgoing PA signal was detected by a focal ultrasound transducer with long focal length which was placed on the surface of the samples. By transducer scanning, we obtained a 2D cross-section photoacoustic image. Finally, we evaluate this system's performance and demonstrate its capabilities by imaging phantoms with complex structure. © 2010 SPIE.


Li Z.F.,Fujian Provincial Key Laboratory of Photonic Technology | Li H.,Fujian Provincial Key Laboratory of Photonic Technology | Li J.J.,Fujian Provincial Key Laboratory of Photonic Technology | Lin X.N.,Fujian Provincial Key Laboratory of Photonic Technology
Laser Physics | Year: 2011

Our purpose is to investigate the feasibility of Brownian motion in time-domain optical coherence tomography (OCT) incorporated with wavelet power spectrum to monitor glucose concentration in Intralipid solution. The results show that the standard deviation (SD) of frequency in the superficial layer of single scattering region, linearly proportional to Brownian diffusion coefficient, is independent of the depth. Our preliminary results demonstrate that average SD of frequency in the single scattering region is inversely proportional to the glucose concentration in Intralipid solution, since the Brownian diffusion coefficient is a function of concentration. Thus the average SD of frequency in OCT signal is capable of differentiating the glucose concentration. © Pleiades Publishing, Ltd., 2011.

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