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Huang R.-F.,Fujian Provincial Cancer Hospital
Chinese Journal of Pathology | Year: 2011

Objective: To study clinicopathologic and genetic features of anaplastic lymphoma kinase ( ALK )-positive large B-cell lymphoma (LBCL). Methods Light microscopy, EliVision immunohistocheimical method and fluorescence in-situ hybridization were used to evaluate three ALK + LBCL cases recently diagnosed accompanied with a literature review. Results All three cases were male adult patients (mean age =36.3 years) with nodal involvement by lymphoma. Histologic evaluation revealed a diffuse effacement of the nodal architecture by the infiltration of tumor cells. Sinusoidal infiltration was seen. The neoplastic cells were large and exhibited the immunoblastic/plasmablastic morphology. By immunohistochemistry, all the cases showed a cytoplasmic granular staining of ALK. They were positive for CD45, CD138, and epithelial membrane antigen (EMA) , but were negative for CD3, CD20, CD79a and CD30. Fluorescence in situ hybridization (FISH) demonstrated the presence of ALK gene translocation in all of the cases. Conclusions ALK + LBCL represents a distinct variant of diffuse large B-cell lymphoma, usually involving lymph node of middle-aged men. The tumor has a immunoblastic/plasmablastic morphology along with a distinct immunophenotypic profile and ALK gene rearrangement. Source


Lin D.,Fujian Normal University | Lin D.,Fujian University of Traditional Chinese Medicine | Chen G.,Fujian Normal University | Feng S.,Fujian Normal University | And 4 more authors.
Applied Physics Letters | Year: 2015

This study aims to evaluate the utility of a home-made surface-enhanced Raman spectroscopy (SERS) system for detection of nasopharyngeal cancer (NPC). A Raman spectral system with a special probe and a millimeter order excitation laser spot size was developed to acquire SERS signals of blood plasma. High quality SERS spectra can be recorded from blood plasma samples belonging to 60 healthy volunteers and 96 NPC patients, and the diagnostic sensitivity and specificity of 95.8% and 91.7%, respectively, can be achieved for classification between normal and cancer blood groups by principal component analysis combined with linear discriminant analysis (PCA-LDA). This exploratory study demonstrates that SERS based on a larger laser spot together with PCA-LDA has the potential for detection of nasopharyngeal cancer, and even for further in vivo cancer detection in the future. © 2015 AIP Publishing LLC. Source


Wu C.,Peking Union Medical College | Miao X.,Huazhong University of Science and Technology | Huang L.,Peking Union Medical College | Che X.,Chinese Academy of Sciences | And 34 more authors.
Nature Genetics | Year: 2012

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. Source


Wu S.-X.,Sun Yat Sen University | Cui T.-T.,Sun Yat Sen University | Zhao C.,Sun Yat Sen University | Pan J.-J.,Fujian Provincial Cancer Hospital | And 3 more authors.
Radiotherapy and Oncology | Year: 2010

Purpose: A multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention and treatment of chemoradiotherapy-induced acute oral mucositis. Methods and materials: Between February 2006 and May 2007, 156 evaluable patients with nasopharyngeal carcinoma were randomized to Group 1 (n = 53) for prevention, Group 2 (n = 51) for treatment, and Group 3 (n = 52) for control. All patients received concomitant chemoradiotherapy ± induction chemotherapy. Radiation technique and dose were similar among 3 groups. Intravenous Actovegin of 30 ml daily (5 days/week) was administrated from day 1 of the radiotherapy for Group 1 and from the onset of grade 2 mucositis for Group 2, until the end of the radiotherapy. Results: The incidence of grade 3 mucositis was lower in Group 1 compared with Group 3 (26.4% vs. 55.8%, P = 0.002). Group 2 had a lower progression rate of mucositis from grade 2 to 3 compared with Group 3 (39.2% vs. 60.4%, P = 0.035). There was no difference in the onset time of grade 3 mucositis among 3 groups. Actovegin was well tolerated and no treatment-related adverse events were observed. Conclusions: Actovegin is effective in the prevention and treatment of chemoradiotherapy-induced oral mucositis. © 2010 Elsevier Ireland Ltd. All rights reserved. Source


Yu J.,Southern Medical University | Hu J.,University of Sichuan | Huang C.,Fujian Medical University | Ying M.,Fujian Provincial Cancer Hospital | And 7 more authors.
European Journal of Surgical Oncology | Year: 2013

Background This study aims to evaluate the role of age and comorbidities on postoperative complications in the patients with advanced gastric cancer (AGC) following laparoscopy-assisted gastrectomy (LAG) and D2 lymphadenectomy based on the results from the Chinese Laparoscropic Gastrointestinal Surgery Study (CLASS) Group. Methodology From February 2003 and December 2009 at twenty-seven medical centers, 1184 AGC patients after LAG with D2 lymphadenectomy were entered and followed in a retrospective recorded database. The postoperative complications were recorded by using the Accordion Severity Grading System. Results Postoperative morbidity and mortality after LAG and D2 dissection in the AGC patients was 10.1% and 0.1%, respectively. Multivariable analysis identified age ≥65 years (OR = 1.72, P = 0.024) and having two or more comorbidities (OR = 2.76, P = 0.009) as the significant predictors of the development of postoperative complications. Meanwhile, age ≥65 years (OR = 1.95, P = 0.016) and having two or more comorbidities (OR = 3.62, P = 0.001) were also the significant predictors of moderate or severe complications. In stratified analysis by the number of comorbidities, age ≥65 years was significantly associated with an excess risk of postoperative complications (OR = 2.35, P = 0.033), and the moderate or severe complications (OR = 4.36, P = 0.003) when the patients had at least one comorbidity. Conclusions LAG would be a safe and technically feasible approach for the AGC patients, despite age ≥65 years and having multiple comorbidities were the potential risk factors for postoperative complications. Importantly, elderly patients with resectable gastric cancer should not be excluded from the potential benefits of LAG provided that comorbidities are fully considered. © 2013 Elsevier Ltd. All rights reserved. Source

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