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Dong H.-Y.,Fujian Key Laboratory of Transplantation Biology | Wang J.,Fujian Key Laboratory of Transplantation Biology | Huang L.-H.,Fujian Key Laboratory of Transplantation Biology | Tan J.-M.,Fujian Key Laboratory of Transplantation Biology
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Mesenchymal stem cells have tumor-targeting properties, and can be isolated easily and expand to the numbers required for application, and they can be genetically manipulated with viral vectors, which suggest the potential of mesenchymal stem cells in the clinical cancer gene therapy.OBJECTIVE: To review the characteristics of mesenchymal stem cells, the tropism of tumor, the relationships between unmodified mesenchymal stem cells and tumor, and the treatment effect of genetically modified mesenchymal stem cells on tumor.METHODS: A computer-based online search of literatures published between January 2002 to March 2012related to mesenchymal stem cells and tumor was performed in PubMed database by the first author. The key words were "mesenchymal stem cells, tropism, genetically modified, tumor, therapy". The repetitive and unrelated researches were excluded, and finally, 50 articles were included according to inclusion criteria.RESULTS AND CONCLUSION: Mesenchymal stem cells can specifically migrate to multiple kinds of tumors and their metastases. Some studies have shown that mesenchymal stem cells can promote the growth of tumor and some other studies have shown that they also inhibit the growth of tumor. The mode to modify the mesenchymal stem cells and perform the tumor gene therapy is mainly to carry the suicide gene, apoptosis genes, anti-angiogenic gene, immune-stimulating genes or oncolytic viral vectors. In vitro and in vivo experiments have confirmed the effect of this method on tumor treatment. Source

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