Fujian Key Laboratory of Cardiovascular Disease

Fuzhou, China

Fujian Key Laboratory of Cardiovascular Disease

Fuzhou, China
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Luo Z.,Xiamen University | Yan C.,Shenyang General Hospital | Zhang W.,Xiamen University | Shen X.,Fujian Key Laboratory of Cardiovascular Disease | And 7 more authors.
Clinical Chemistry and Laboratory Medicine | Year: 2014

Background: The small conductance calcium-activated potassium, subfamily N, member 3 (KCNN3) gene rs13376333 and rs1131820 have been shown to be strongly associated with lone atrial fibrillation (AF), while replication association studies between rs13376333 in KCNN3 gene and risk of AF showed conflicting results. The current study tried to validate the impact of SNP rs13376333 and rs1131820 of KCNN3 gene on the risk of AF in the Chinese Han population. Methods: A total of 889 AF patients and 1015 controls were enrolled. Two hundred and seventy-eight cases of AF were lone AF. KCNN3 gene SNP rs13376333 and rs1131820 were genotyped by allele-specific MALDI-TOF mass spectrometry. Results: The genotype distribution and allele frequency of rs13376333 polymorphism were not different between total AF patients and controls. However, the genotype distribution of rs13376333 polymorphism was significantly different between lone AF and control group (p<0.001); and T allele frequency was significantly higher in lone AF group than that in controls (7.6% vs 3.6%, p<0.001). Multivariable logistic regression analysis showed that T allele carriers of rs13376333 was significantly associated with lone AF (OR=2.31, 95% CI 1.41-3.78, p=0.001). No relationship between rs1131820 polymorphism and total AF or lone AF was found in this study. Conclusions: KCNN3 rs13376333 polymorphism was associated with lone AF in the Chinese Han population and the T allele carriers may be an independent predictive factor for lone AF. © by De Gruyter 2014.


Luo Z.,Fujian Medical University | Yan C.,Shenyang General Hospital | Yu P.,Fujian Medical University | Bao W.,Fujian Medical University | And 8 more authors.
International Journal of Cardiology | Year: 2015

Abstract Background Caspase-3 plays an important role in the initiation and maintenance of atrial fibrillation (AF), but little is known about the role of CASP3 variants in the susceptibility to atrial fibrillation (AF). The purpose of this study was to comprehensively investigate the association between common genetic variants of CASP3 gene and AF in Chinese Han population. Methods and results We investigated the association of five variants in CASP3 and the risk of AF in 889 AF patients and 1015 controls. The genotype distribution of the rs4647602 was significantly different between patients with AF and controls (p < 0.001), and the A allele frequency was significantly higher in AF patients than in controls (61.0% vs 53.2%; p < 0.001). Compared with CC genotype carriers, subjects with AA genotype had significantly increased susceptibility to AF (OR = 1.84, p < 0.001). Multivariable logistic regression analysis showed that the rs4647602 polymorphism was significantly associated with risk of AF under dominant, recessive and additive genetic model (OR, 1.44-1.64; all p < 0.001). There was no association between the other four SNPs (rs6948, rs2696056, rs4647602 and rs4647610) and risk of AF. Conclusion The rs4647602 polymorphism is independently associated with the risk of AF in Chinese Han population. © 2015 Elsevier Ireland Ltd. All rights reserved.


PubMed | Fujian Medical University, Shenyang General Hospital and Fujian Key Laboratory of Cardiovascular Disease
Type: | Journal: International journal of cardiology | Year: 2015

Caspase-3 plays an important role in the initiation and maintenance of atrial fibrillation (AF), but little is known about the role of CASP3 variants in the susceptibility to atrial fibrillation (AF). The purpose of this study was to comprehensively investigate the association between common genetic variants of CASP3 gene and AF in Chinese Han population.We investigated the association of five variants in CASP3 and the risk of AF in 889 AF patients and 1015 controls. The genotype distribution of the rs4647602 was significantly different between patients with AF and controls (p<0.001), and the A allele frequency was significantly higher in AF patients than in controls (61.0% vs 53.2%; p<0.001). Compared with CC genotype carriers, subjects with AA genotype had significantly increased susceptibility to AF (OR=1.84, p<0.001). Multivariable logistic regression analysis showed that the rs4647602 polymorphism was significantly associated with risk of AF under dominant, recessive and additive genetic model (OR, 1.44-1.64; all p<0.001). There was no association between the other four SNPs (rs6948, rs2696056, rs4647602 and rs4647610) and risk of AF.The rs4647602 polymorphism is independently associated with the risk of AF in Chinese Han population.


Li H.-R.,Fujian Provincial Hospital | Chen Y.-S.,Fujian Provincial Hospital | Shao H.,Fujian Provincial Hospital | Han L.-L.,Fujian Key Laboratory of Cardiovascular Disease | Zhang X.-E.,Fujian Provincial Hospital
Chinese Journal of Medical Genetics | Year: 2012

Objective: To assess the association between polymorphisms of insulin-like growth factor receptor (IGF-1R and IGF-2R) and genetic susceptibility and non-small-cell lung cancer (NSCLC). Methods: A case-control study of 260 patients with NSCLC and 258 cancer-free subjects from Fujian was carried out. Genotypes of polymorphisms of IGF-1R +1013 and IGF-2R + 1619 were determined by DNA sequencing and polymerase chain reaction-restrictive fragment length polymorphism. Results: (1) Significant differences in allele frequency and genotypes distribution of IGF-1R + 1013 (G/A) were found between the two groups (P<0.05). On multivariate analysis after controlling age and gender, compared with GG genotype of the IGF-1R + 1013 (G/A), the risk of lung cancer for individuals with GA genotype was increased by 0.80 times (95%CI: 1.24-2. 59, P = 0.002), those with AA genotype was increased by 2.56 times (95%CI: 1.78-7.26, P = 0.000), and those with the polymorphic A variant (GA or AA) was increased by 0.98 times (95%CI: 1.39-2.83, P = 0.000). No significant differences in genotypic or allelic frequencies of IGF-2R +1619 (G/A) were found between the two groups (P> 0.05). (2) After stratification of the clinical status, the IGF-1R + 1013 A allele increased the risk of lung squamous cell carcinoma (OR=3.20, 95%CI: 1.75-5.84, P = 0.000), lung adenocarcinoma (OR= 1.55, 95%CI: 1.00-2.41, P = 0.049) and other types of lung cancer (OR=1.96, 95% CI: 1.10-3.49, P = 0.023), but no association was found between the two SNPs and other clinical features. (3) IGF-1R + 1013(G/A) and IGF-2R +1619(G/A) polymorphisms showed a synergic effect (P = 0.003). Conclusion: The common IGF-1R gene polymorphism G1013A may influence the risk of lung cancer. The polymorphisms of IGF-1R + 1013 (G/A) and 1GF-2R +1619 (G/A) have synergistic influence on the risk of lung cancer.

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