Fujian Institute of Medical science

Fuzhou, China

Fujian Institute of Medical science

Fuzhou, China
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Lin J.,Fujian Medical University | Peng H.-Y.,Fujian Institute of Medical science
Chinese Pharmacological Bulletin | Year: 2010

Aim: To investigate the mechanism of induction of cell apoptosis of berberine α-hydroxy-β-decanoylethyl sulfonate (HB). Methods: MTT assay was employed to determine the cytotoxicity of HB in B16 cells. Through Rhodamine 123 staining, agarose gel electrophoresis, Hoechst 33258 staining, activity of caspase-3 and caspase-8 was detected, and B16 cell apoptosis induced by HB was observed. Results: HB inhibited the B16 cell proliferation in vitro. The inhibitory effect was dose and time dependent, and the IC50 was 16.59, 9.29 and 6.22 mg·L-1 when B16 cell was exposed to HB for 24, 48 and 72h , respectively. B16 cells treated with HB showed typical characteristics of apoptosis; decreased Rhodamine 123 fluorescence intensity, karyopyknosis and DNA Ladder. Caspase-3 and caspase-8 might be involved in this process. Conclusion: HB could inhibit cell growth and induce apoptosis of B16 cells.


Zhou B.,CAS Shanghai Institute of Materia Medica | Yang Y.,CAS Shanghai Institute of Materia Medica | Lin S.,Fujian Institute of Medical science | Li Y.,CAS Shanghai Institute of Materia Medica
Advanced Synthesis and Catalysis | Year: 2013

The rhodium-catalyzed addition of indole C-H bonds to a range of aryl- and alkyl-N-sulfonylaldimines is reported. The reaction proceeds with high functional group compatibility and provides easy and rapid access to a wide variety of 2-indolylmethanamine derivatives under mild reaction conditions. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhou B.,CAS Shanghai Institute of Materia Medica | Luo Z.,CAS Shanghai Institute of Materia Medica | Lin S.,Fujian Institute of Medical science | Li Y.,CAS Shanghai Institute of Materia Medica
Synlett | Year: 2012

A synthesis of (+)-valienamine was achieved starting from Garner's aldehyde in ten steps and 23% overall yield. A unique feature of the synthetic route is that an acyclic precursor was constructed, using diastereoselective antireductive coupling reaction of alkyne and Garner's aldehyde as the key step, which was then cyclized in an intramolecular aldol reaction to form the valienamine skeleton. © Georg Thieme Verlag Stuttgart · New York.


Lin S.,Fujian Institute of Medical science | Que H.-Q.,Fujian Institute of Medical science | Peng H.-Y.,Fujian Institute of Medical science | Qian L.-P.,Fujian Institute of Medical science | And 2 more authors.
Yaoxue Xuebao | Year: 2011

In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2α-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).


PubMed | Fujian Institute of Medical science
Type: Journal Article | Journal: Yao xue xue bao = Acta pharmaceutica Sinica | Year: 2011

In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).

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