Entity

Time filter

Source Type


Zhou B.,CAS Shanghai Institute of Materia Medica | Yang Y.,CAS Shanghai Institute of Materia Medica | Lin S.,Fujian Institute of Medical science | Li Y.,CAS Shanghai Institute of Materia Medica
Advanced Synthesis and Catalysis | Year: 2013

The rhodium-catalyzed addition of indole C-H bonds to a range of aryl- and alkyl-N-sulfonylaldimines is reported. The reaction proceeds with high functional group compatibility and provides easy and rapid access to a wide variety of 2-indolylmethanamine derivatives under mild reaction conditions. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Zhou B.,CAS Shanghai Institute of Materia Medica | Luo Z.,CAS Shanghai Institute of Materia Medica | Lin S.,Fujian Institute of Medical science | Li Y.,CAS Shanghai Institute of Materia Medica
Synlett | Year: 2012

A synthesis of (+)-valienamine was achieved starting from Garner's aldehyde in ten steps and 23% overall yield. A unique feature of the synthetic route is that an acyclic precursor was constructed, using diastereoselective antireductive coupling reaction of alkyne and Garner's aldehyde as the key step, which was then cyclized in an intramolecular aldol reaction to form the valienamine skeleton. © Georg Thieme Verlag Stuttgart · New York. Source


Lin S.,Fujian Institute of Medical science | Que H.-Q.,Fujian Institute of Medical science | Peng H.-Y.,Fujian Institute of Medical science | Qian L.-P.,Fujian Institute of Medical science | And 2 more authors.
Yaoxue Xuebao | Year: 2011

In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2α-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells). Source

Discover hidden collaborations