Fujian Institute of Chinese Medicine

Fujian Institute of Chinese Medicine

SEARCH FILTERS
Time filter
Source Type

Su L.,Chinese Academy of Sciences | Li Y.,Chengdu University of Traditional Chinese Medicine | Lv B.,Chengdu University of Traditional Chinese Medicine | Ji H.,Shaanxi Provincial Peoples Hospital | And 6 more authors.
Zhongguo Zhongyao Zazhi | Year: 2011

Objective: To study the efficacy and safety of Naoxintong capsule treatment of stroke recovery with Qi-deficiency and blood-stasis syndrome (cerebral infarction), and to compared the non-inferiority analysis with the positive drug Tongxinluo capsule. Method: Taking Tongxinluo capsules as control, randomized, double-blind, controlled, multi-center clinical experiments were studied. The evaluating indexes included the decrease of integral value of stroke patients, changes in traditional Chinese medicine, the improvement of the patient viability status (disability level), Chinese stroke scale (CSS), activities of daily living (DAL) scale and barthel index (BI) points. Result: The total effect of the two groups, Chinese and other symptoms, showed no significant statistical significance. Conclusion: Naoxintong capsule stroke recovery, with Qi-deficiency and blood-stasis syndrome (cerebral infarction) has a therapeutic effect, and more secure.


Ke X.,Fujian University of Traditional Chinese Medicine | Zhou F.,Fujian Institute of Chinese Medicine | Gao Y.,Fujian University of Traditional Chinese Medicine | Xie B.,Fujian University of Traditional Chinese Medicine | And 5 more authors.
International Journal of Molecular Medicine | Year: 2013

The activation of the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway has been implicated as a key mediator in the pathogenesis of ulcerative colitis (UC); therefore, it has become an attractive target for the treatment of UC. Qing Hua Chang Yin (QHCY) is a traditional Chinese formula, which has been used for many years to clinically treat conditions associated with inflammatory bowel diseases, such as UC. However, the precise mechanisms behind its anti-inflammatory effects remain largely unknown. In this study, using the dextran sulfate sodium (DSS)-induced colitis mouse model, we evaluated the therapeutic effects of QHCY against UC and elucidated the possible underlying molecular mechanisms. We found that the administration of QHCY profoundly ameliorated DSS-induced clinical manifestations, colon shortening and histological damage in the mice with colitis. In addition, treatment with QHCY significantly decreased the DSS-induced secretion of serum amylase. Moreover, QHCY significantly inhibited the DSS-induced expression of TLR4 and myeloid differentiation primary response gene 88 (MyD88), the phosphorylation of IκB and the nuclear translocation of NF-κB. Taken together, our findings suggest that the suppression of the TLR4/NF-κB signaling pathway may be one of the mechanisms involved in the therapeutic effects of QHCY against UC.


Zheng S.X.,Fujian Institute of Chinese Medicine
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] | Year: 2012

To observe the difference of the microcirculatory blood perfusion between acupoints and non-acupoints of the Stomach Meridian and its bilateral control points and to analyze the effect of electroacupuncture (EA) on subcutaneous microcirculatory perfusion in healthy volunteers. A total of 21 healthy adult volunteers were recruited in the present study. Subcutaneous microcirculatory blood perfusion units (BPU) of Shangjuxu (ST 37), Liangqiu (ST 34), Yinshi (ST 33), Futu (ST 32) and non-acupoint (the midpoint between ST 33 and ST 32) of the Stomach Meridian and their bilateral on-meridian points were measured by using Laser Doppler Flowmetry (LDF, PeriFlux 5000). EA (0.5 Hz,duration 0.2 ms, 3-4 V) was applied to Zusanli (ST 36) for 10 min. The subcutaneous microcirculatory perfusion was detected under room temperature of (28 +/- 1) degree C and humidity of about 60% after inserting a single-use syringe needle into the subcutaneous tissues (about 1 cm in depth). In comparison with the bilateral control points, the subcutaneous microcirculatory BPU values of Shangjuxu (ST 37), Liangqiu (ST 34), Yinshi (ST 33), Futu (ST 32) and non-acupoint regions of the Stomach Meridian were significantly higher (P < 0.01). In comparison with pre-EA, the cutaneous microcirculatory BPU was increased mildly after EA of ST 36 (P > 0.05). Following EA for 5 to 10 min, the waveforms of LDF of the Stomach Meridian got regular and smooth. The microcirculatory blood perfusion of acupoints and non-acupoint of the Stomach Meridian in the deeper subcutaneous tissues are significantly higher than that of their bilateral corresponding control points, suggesting that subcutaneous microvascular blood flow may be the heat source for forming infrared radiation trace along the meridian in the human body observed in our past studies.


Huang J.S.,Fujian Institute of Chinese Medicine
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2011

To analyze the correlation between changes of thyroid hormone (TH), dopamine (DA) and Chinese medicine syndrome types by detecting contents of serum TH and DA in insomnia, thus to explore objective indices of Chinese medicine syndrome types. Insomnia patients were assigned to four Chinese medicine syndrome types groups, covering depressed Gan transforming into fire, internal disturbance by phlegm-heat, excessive fire due to yin deficiency, and Xin-Pi deficiency. One healthy control group was set up. Each group consisted of 30 patients or subjects. Serum DA content was determined using spectrophotofluorometry. Serum levels of 3,5,3'-triiodothyronine (T3) and tetraiodothyronine (T4) were detected using radioimmunoassay (RIA). The serum levels of DA and TH showed difference among groups at various levels. The serum DA level was sequenced from high to low as the control group > the depressed Gan transforming into fire group > the excessive fire due to yin deficiency group > the internal disturbance by phlegm-heat group > the Xin-Pi deficiency group. The serum TH level was sequenced from high to low as the excessive fire due to yin deficiency group > the depressed Gan transforming into fire group > the internal disturbance by phlegm-heat group > the control group > the Xin-Pi deficiency group. Serum DA levels in insomnia patients were in line with the disease course and the dynamic change from sthenia to asthenia in Chinese syndrome types. Serum DA levels, as one of pathological factors constituting the sthenia syndrome or the asthenia syndrome, may be taken as an objective indicator in Chinese medicine syndrome typing.


Lin J.Y.,Fujian Institute of Chinese Medicine
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] | Year: 2010

To observe the effect of Spleen-Meridian-acupoint injection of Lentinan on the immunologic function in spleen-deficiency rabbits. A total of 54 Newzealand rabbits were randomly divided into normal (n = 10), model (n = 8), intramuscular injection (n = 10), Sanyinjiao (SP6, n = 10), Diji (SP8, n = 8) and Xuehai (SP 12, n = 8) groups. Spleen-qi deficiency model was established by intragastric administration of 100% crude Radix et Rhizoma Rhei decoction (15 mL/kg/day x 10 d), and then Lentinan (LNT, 0.025 mg/kg/2 day x 5) was injected into the aforementioned acupoints of the Spleen Meridian. The erythrocyte immunologic function (RBC-C3 bR, RBC-IC), hemolysin (lgM) and changes of physical signs of the rabbits were observed. In comparison with the control group, the rabbits' body weight, rectal temperature, RBC-C3 bR% and serum IgM level were decreased significantly in model group (P < 0.05); while in comparison with the model group, the body weight in SP 8 group,retal temperature in SP 9 and SP 8 groups, RBC-C3 bR% in SP 9 and SP 12 groups, and serum IgM levels in SP 9, SP 8 and SP 12 groups increased considerably (P < 0.05, P < 0.01). Comparison among the 4 treatment groups showed that the effect of SP 12 was superior to that of intramuscular injection group in upregulaing RBC-C3 bR%, and the effects of SP 9, SP 8 and SP 12 groups were significantly superior to those of intramuscular injection group in upregulating serum IgM level (P < 0.05). The Spleen-Meridian-acupoint injection of LNT is superior to that of intramuscular injection of LNT in improving the spleen-qi deficiency rabbits' symptoms and immunologic function.


Xie L.-H.,Fujian Institute of Chinese Medicine | Ni C.-B.,Fujian Institute of Chinese Medicine | Li S.-Q.,Fujian Institute of Chinese Medicine | Chen J.,Fujian Institute of Chinese Medicine | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Studies have shown the bone mineral density of postmenopausal women is closely related to parathyroid hormone. But there are differences in different areas. Objective: To investigate the association between BstBI polymorphism of parathyroid hormone gene with bone mineral density in postmenopausal women from Fuzhou area. Methods: The bone mineral densities of the lumbar spine, femoral neck, trochanter and Ward's triangle were measured in 150 postmenopausal women by dual energy X-ray absorptiometry. The genotype of parathyroid hormone gene was determined by polymerase chain reaction-restriction fragment length polymorphism. Results and Conclusion: (1) The distribution of parathyroid hormone genotypes were BB genotype 68.8%, Bb 24.1%, and bb 7.1%. The B allelic gene frequencies reached 81%, while b was 19%. The distribution followed the Hardy-Weinberg equilibrium. (2) Analysis of the relationship between the genotypes and bone mineral density: There was no significant difference in the bone mineral densities of the lumbar spine, femur, neck, trochanter and Ward's triangle among the three genotypes (P > 0.05). BstBI gene polymorphism of parathyroid hormone gene is not correlated to bone mineral density, and there is no enough evidence to support genotype of parathyroid hormone gene as a genetic marker in predicting the risk of developing osteoperosis in Fuzhou postmenopausal women.


Zhang X.,Fujian University of Traditional Chinese Medicine | Ke X.,Fujian University of Traditional Chinese Medicine | Chen J.-T.,Fujian University of Traditional Chinese Medicine | Gao Y.-L.,Fujian University of Traditional Chinese Medicine | Zhou F.,Fujian Institute of Chinese Medicine
Journal of Xi'an Jiaotong University (Medical Sciences) | Year: 2015

Objective: To study the expressions of serum interleukin-1β (IL-1β) and interleukin-4 (IL-4) in ulcerative colitis (UC) rats with damp-heat syndrome and explore their significance in assessing inflammatory severity. Methods: We randomly divided 50 healthy Wistar rats of SPF grade (half males and half females) into normal group, and damp-heat syndrome model of UC I (3 days), II (7 days), III (14 days) and IV (21 days) groups, with 10 in each group. Rats in normal group were raised in the natural environment of breeding, while those UC model groups with damp-heat syndrome were fed with high-sugar and high-fat food in the high-temperature and high-humidity environment for 4 weeks. The rat model of damp heat syndrome UC was established by using TNBS-ethanol enema. Then we detected the changes of disease activity index (DAI), colonic mucosa damage index (CMDI), IL-1β and IL-4 in each group. Results: Compared with those in normal control group, DAI, CMDI and IL-1β levels in damp heat syndrome UC model I, II, III groups were significantly increased (P<0.01, P<0.05), with model group II having the most obvious increase (P<0.01). Serum IL-4 level decreased significantly (P<0.01, P<0.05), with model group II having the most significant decrease (P<0.01). The above indexes did not significantly differ in model group IV (P>0.05). Conclusion: Inflammatory cytokines IL-1β and IL-4 are involved in the pathogenesis of damp-heat syndrome UC. The increased IL-1β and decreased IL-4 levels are consistent with the time of inflammatory severity; therefore, they can be regarded as markers for assessing inflammatory severity in UC. ©, 2015, Xi'an Medical University. All right reserved.


PubMed | Fujian Institute of Chinese Medicine
Type: Comparative Study | Journal: Zhen ci yan jiu = Acupuncture research | Year: 2012

To observe the difference of the microcirculatory blood perfusion between acupoints and non-acupoints of the Stomach Meridian and its bilateral control points and to analyze the effect of electroacupuncture (EA) on subcutaneous microcirculatory perfusion in healthy volunteers.A total of 21 healthy adult volunteers were recruited in the present study. Subcutaneous microcirculatory blood perfusion units (BPU) of Shangjuxu (ST 37), Liangqiu (ST 34), Yinshi (ST 33), Futu (ST 32) and non-acupoint (the midpoint between ST 33 and ST 32) of the Stomach Meridian and their bilateral on-meridian points were measured by using Laser Doppler Flowmetry (LDF, PeriFlux 5000). EA (0.5 Hz,duration 0.2 ms, 3-4 V) was applied to Zusanli (ST 36) for 10 min. The subcutaneous microcirculatory perfusion was detected under room temperature of (28 +/- 1) degree C and humidity of about 60% after inserting a single-use syringe needle into the subcutaneous tissues (about 1 cm in depth).In comparison with the bilateral control points, the subcutaneous microcirculatory BPU values of Shangjuxu (ST 37), Liangqiu (ST 34), Yinshi (ST 33), Futu (ST 32) and non-acupoint regions of the Stomach Meridian were significantly higher (P < 0.01). In comparison with pre-EA, the cutaneous microcirculatory BPU was increased mildly after EA of ST 36 (P > 0.05). Following EA for 5 to 10 min, the waveforms of LDF of the Stomach Meridian got regular and smooth.The microcirculatory blood perfusion of acupoints and non-acupoint of the Stomach Meridian in the deeper subcutaneous tissues are significantly higher than that of their bilateral corresponding control points, suggesting that subcutaneous microvascular blood flow may be the heat source for forming infrared radiation trace along the meridian in the human body observed in our past studies.


PubMed | Fujian Institute of Chinese Medicine
Type: Journal Article | Journal: Zhen ci yan jiu = Acupuncture research | Year: 2010

To observe the effect of Spleen-Meridian-acupoint injection of Lentinan on the immunologic function in spleen-deficiency rabbits.A total of 54 Newzealand rabbits were randomly divided into normal (n = 10), model (n = 8), intramuscular injection (n = 10), Sanyinjiao (SP6, n = 10), Diji (SP8, n = 8) and Xuehai (SP 12, n = 8) groups. Spleen-qi deficiency model was established by intragastric administration of 100% crude Radix et Rhizoma Rhei decoction (15 mL/kg/day x 10 d), and then Lentinan (LNT, 0.025 mg/kg/2 day x 5) was injected into the aforementioned acupoints of the Spleen Meridian. The erythrocyte immunologic function (RBC-C3 bR, RBC-IC), hemolysin (lgM) and changes of physical signs of the rabbits were observed.In comparison with the control group, the rabbits body weight, rectal temperature, RBC-C3 bR% and serum IgM level were decreased significantly in model group (P < 0.05); while in comparison with the model group, the body weight in SP 8 group,retal temperature in SP 9 and SP 8 groups, RBC-C3 bR% in SP 9 and SP 12 groups, and serum IgM levels in SP 9, SP 8 and SP 12 groups increased considerably (P < 0.05, P < 0.01). Comparison among the 4 treatment groups showed that the effect of SP 12 was superior to that of intramuscular injection group in upregulaing RBC-C3 bR%, and the effects of SP 9, SP 8 and SP 12 groups were significantly superior to those of intramuscular injection group in upregulating serum IgM level (P < 0.05).The Spleen-Meridian-acupoint injection of LNT is superior to that of intramuscular injection of LNT in improving the spleen-qi deficiency rabbits symptoms and immunologic function.

Loading Fujian Institute of Chinese Medicine collaborators
Loading Fujian Institute of Chinese Medicine collaborators