Lin Z.,Nanjing University |
Lin Z.,Fujian University of Traditional Chinese Medicine |
Fang Y.,Fujian University of Traditional Chinese Medicine |
Huang A.,Fujian University of Traditional Chinese Medicine |
And 4 more authors.
Pharmaceutical Biology | Year: 2014
Context: Sedum aizoon L. (Crassulaceae) (SA) is widely used to treat various hemorrhages in folk medicine. However, its hemostatic constituents are not yet clear.Objective: The chemical constituents of EtOAc fraction from SA and their hemostatic activity were investigated to provide a basis for the application in folk use.Materials and methods: The chemical constituents were isolated from the aerial parts of SA by column chromatography and identified by IR, MS, and NMR, then tested for hemostatic activity using the capillary method and coagulation assays including blood clotting time in vivo, and prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT) in vitro at concentrations of 300.0, 100.0, and 30.0g/mL.Results: Eleven compounds were identified as p-hydroxybenzoic acid (1), gallic acid (2), protocatechuic acid (3), vallinic acid (4), thymine (5), caffeic acid (6), 5,7-dihydroxy chromone (7), pyrogallol (8), quercetin (9), kaempferol (10), and luteolin (11). This is the first report of compounds 3-8 being isolated from this plant. Compounds 2 (300.0 and 100.0g/mL), 4 (100.0g/mL), and 11 (100.0 and 30.0g/mL) significantly reduced the clotting time (p<0.01) with inhibition rates of 34.7, 24.5, 30.3, 25.9, and 36.6%, respectively. For further mechanism study, they also reduced PT (3.5, 2.5, 3.5, 3.5, and 3.8%, respectively), APTT (4.5, 3.3, 11.4, 8.5, and 11.1%, respectively), and TT (20.3, 3.8, 7.6, 6.1, and 10.3%, respectively).Discussion and conclusion: SA produced hemostatic activity possibly related to the presence of gallic acid, vallinic acid, and luteolin, which may be potent candidates of hemostatic drug. © 2014 Informa Healthcare USA, Inc. All rights reserved.
Yang C.,Fujian Agriculture and forestry University |
Ma J.,Wuhan University |
Zhang M.,Fujian Health College |
Zheng S.,China Three Gorges University |
Tian X.,Wuhan University
Infrared Physics and Technology | Year: 2014
In this paper, we proposed a new robust infrared small target detector that is more suitable for complex background with low signal-to-clutter ratio. The original image is decomposed into sub-bands in different orientations by using the directional second-order directional derivative (DSODD) filters deduced from the facet model. The multiscale facet model (MFM) analysis is developed by using a series of multiscale DSODD filters, which are obtained by filling zeros in the basic DSODD filter. Based on MFM, an MFM matrix is constructed, and the normalized determinant of this matrix is then defined as the target measure. The corresponding multiscale correlations of the target measures are computed to enhance the target signal and suppressing the background clutter. The experimental results on a set of real infrared images demonstrate that the proposed approach is effective and is superior to the traditional small target detection methods in terms of the pertained quantitative detection evaluation indexes, such as the signal-to-clutter ratio gain and the background suppression factor. © 2014 Elsevier B.V. All rights reserved.
Li Y.,Fuzhou University |
Li Y.,Fujian Health College |
Wu H.,Fuzhou University |
Guo L.,Fuzhou University |
And 3 more authors.
Food Chemistry | Year: 2012
The determination of citrinin (CIT) by a microsphere-based flow cytometric immunoassay (MFCI) has been developed. In the method, the carboxyl-modified microspheres were conjugated with CIT-Ovalbumin (OVA) antigen. CIT competed with the CIT-OVA antigen on the surface of the microspheres for the anti-CIT McAb. Under the optimised conditions, IC50 value was 1.0 ng/mL and the limit of detection reached 0.005 ng/mL. The cross-reactivity was less than 0.01% against each of the four mycotoxins such as aflatoxin B1 (AFB 1), ochratoxin A (OTA), zearalenone (ZEA), deoxynilvalenol (DON). In the work, the MFCI could accurately determine CIT in the real red yeast rice. The systematic error was low with the coefficient of variation (CV) from 5.24% to 8.16% by the MFCI. The mean recovery of CIT from artificially contaminated red yeast rice was from 89% to 94%, with CV from 7.2% to 8.7%. The experimental data showed that the precision, sensitivity and specificity of the developed MFCI method for the determination of CIT were satisfactory. © 2012 Elsevier Ltd. All rights reserved.
Tian J.,Fujian Medical University |
Jia L.N.,Fujian Health College |
Cheng Z.C.,Fujian Tumor Hospital
Current Oncology | Year: 2015
Aim We aimed to assess the relationships of patient education with the severity of treatment-induced side effects, daily calorie and protein intake, psychological status, and performance status in patients with lung cancer. Methods The study patients were divided into an intervention (n = 62) and a control group (n = 110). The patients in the intervention group were provided with information about treatment, diet, and rehabilitation during chemotherapy. The patients in the control group were not specially provided with that information. Results We observed significant differences between the intervention and control groups with respect to low daily protein intake (54.84% vs. 70.00%, p = 0.046), prevalence of depression (51.61% vs. 70.91%, p = 0.011), prevalence of severe side effects of treatment (14.52% vs. 37.27%, p = 0.002), and good performance status (75.81% vs. 55.45%, p = 0.008). Conclusions Our results suggest that educating patients about cancer treatment and rehabilitation can lead to increased protein intake, a lower prevalence of depression, lesser side effects from cancer treatments, and improved performance status. © 2015 Multimed Inc.
Zhao B.,Fuzhou University |
Zhuang N.,Fuzhou University |
Li T.,Shandong University |
Guo F.,Fuzhou University |
And 3 more authors.
Journal of Crystal Growth | Year: 2011
A new Nd: Lu0.141Y0.855VO4 mixed laser crystal had been successfully grown by the Czochralski method. The reason of the crystal boule appearing additionally yellowish at the bottom was discussed. The X-ray powder diffraction analysis showed that the as-grown mixed crystal possesses the ZrSiO4 structure. The effective segregation coefficients of Nd3 and Lu3 ions in the crystal were measured to be about 0.51 and 0.76, respectively. The room temperature fluorescence spectrum of the mixed crystal showed that the FWHM (full-width at half-maximum) of the 1064.9 nm fluorescence band was 5.1 nm, broader than that of Nd: YVO4. A continuous-wave (CW) laser output was achieved with the Nd: Lu0.141Y0.855VO4 crystal at 1.06 μm using laser diode pumping. The maximum CW output power of 1.7 W was obtained with the pump power of 7.6 W, higher than the 1.38 W achieved with the 0.5 at% Nd: LuVO4 crystal under the same experimental conditions. All the results above show that the Nd: Lu0.141Y0.855VO 4 crystal is a promising laser material. © 2011 Elsevier B.V. All Rights Reserved.