Hanamaki, Japan
Hanamaki, Japan

Fuji University is a private university in Hanamaki, Iwate, Japan, established in 1965. Wikipedia.

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Yoshida J.,Iwate Medical University | Uesugi S.,Iwate University | Kawamura T.,Iwate University | Kimura K.-I.,Iwate University | And 5 more authors.
Lipids | Year: 2017

Many uncommon non-methylene-interrupted fatty acids (NMI FA) are present in limpet gonads, but their biological properties remain unknown. To investigate new biological effects of naturally occurring NMI FA in eukaryotic cells, the biological activities of structurally analogous (4Z,15Z)-octadecadienoic acid (1), (9Z,20Z)-tricosadienoic acid (2), and (12Z,23Z)-hexacosadienoic acid (3) were examined by using a yeast-based drug-screening system using the Ca2+-sensitive mutant strain, Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ). Among 1–3, 1 showed restored growth activity at a dose of 80 µg/disc in the mutant yeast strain. This phenotype suggests that 1 suppresses Ca2+-signaling of the mutant yeast through inhibition of glycogen synthase kinase-3β (GSK-3β) or calcineurin pathways or both. From this result, the inhibitory activity of 1–3 against GSK-3β was further determined. 1–3 showed potent inhibitory activity against GSK-3β with IC50 values ranging from 8.7 to 21.9 µM. Inhibition of GSK-3β reduces gene expression of the gluconeogenic key enzymes in liver, so we analyzed glucose production in rat hepatoma H4IIE cells to assess GSK-3β inhibitory activity of 1–3. Acid 1 inhibited glucose production at 25 µM in H4IIE cells. Our results would open up new possibilities for an anti-diabetic effect of 1 and might provide important insights into understanding the biological properties of naturally occurring NMI FA. © 2017 AOCS


Shimazaki K.-I.,Fuji University | Kawai K.,Azabu University
Biochemistry and Cell Biology | Year: 2017

Lactoferrin is a multifunctional, iron-binding glycoprotein found in milk and other exocrine secretions. Lactoferrin in milk plays vital roles in the healthy development of newborn mammals, and is also an innate resistance factor involved in the prevention of mammary gland infection by microorganisms. Inflammation of the udder because of bacterial infection is referred to as mastitis. There have been many investigations into the relationships between lactoferrin and mastitis, which fall into several categories. The main categories are fluctuations in the lactoferrin concentration of milk, lactoferrin activity against mastitis pathogens, elucidation of the processes underlying the onset of mastitis, participation of lactoferrin in the immune system, and utilization of lactoferrin in mastitis treatment and prevention. This minireview describes lactoferrin research concerning bovine mastitis. In the 1970s, many researchers reported that the lactoferrin concentration fluctuates in milk from cows with mastitis. From the late 1980s, many studies clarified the infection-defense mechanism in the udder and the contribution of lactoferrin to the immune system. After the year 2000, the processes underlying the onset of mastitis were elucidated in vivo and in vitro, and lactoferrin was applied for the treatment and prevention of mastitis. © 2017 Published by NRC Research Press.


Nakamura M.,Juntendo University | Takami Y.,Seiwa University | Nakano M.,Juntendo University | Ito K.,Fuji University | And 2 more authors.
Archives of Budo | Year: 2014

Background & Study Aim: Female kendo practitioners' technical and tactical abilities have steadily improved since the 10th World Kendo Championship held in 1997, when a dedicated women's competition class was created. However, exercise methodologies and injury prevention techniques have not evolved in tandem. The current study is meant to provide kendo practitioners, coaches, and managers with information essential to tailoring their exercise and injury prevention programs to female kendo practitioners. The aim of the study is to assess whether women differ from men in terms of technical and tactical aspects of competition outcomes. Material & Methods: Sixty matches from the 50th All Japan Women's Kendo Championship and 60 men's matches from the 45th All Japan Men's Kendo Championship were analyzed using DVDs. Specifically, the following aspects were analyzed: technique categories, spatial distance, counter attack, datotsu-bui (target points), body and shinai (bamboo sword) movement, and ratio of points awarded based on the total number of attacks. These data were analyzed by three kendo experts who hold 7th,5th,4th dan. Results: Point scoring attacks were comparatively fewer in women's competitions than in men's. Female competitors also attacked in closer spatial distance relative to their male counterparts. Finally, women attacked primarily by stepping forward in a defensive stance while waving the shinai side to side in close proximity to the opponent's body. Conclusions: Women's tactics differed markedly from that of men's. It is recommended that female kendo practitioners employ an exercise regimen that accounts for the fundamental differences between the male and female physique. © ARCHIVES OF BUDO.


Ito K.,Fuji University | Hirose N.,Juntendo University | Maekawa N.,International Budo University | Tamura M.,Teikyo University | Nakamura M.,Juntendo University
Archives of Budo | Year: 2015

Background & Study Aim: Significant changes in kumite tactics could be expected following the 2013 International Judo Federation rule revision, which mandated that competitors initiate sparring immediately at match outset. The research contained in this paper focused on the specific areas of kumite that were likely to be affected by this rule revision. Material & Methods: In total, 396 men’s contests were selected from All Japan Judo Federation DVDs. Throws resulting in scores were identified and the preceding kumite was analyzed. Chi-square tests were performed to determine variations in the number of scored throws between the 2012 and 2013 contests based on predetermined criteria and comparisons of kumite efficacy were made using the resulting score ratios. Results: Re-gripping resulted in a higher score rate in aiyotsu, kenkayotsu and the total of both stances. (P=0.022, P=0.033, P=0.002; respectively). The score rate increased when both hands were used for throwing in the aiyotsu stance and the total of both stances (P=0.017, P=0.002; respectively). The score rate increased in cases where the competitor grabbed their opponents in places other than the collar or sleeve with both hands or in a place other than the collar or sleeve with one hand and the collar or sleeve with the other hand when the competitors sparred in the kenkayotsu stance and in the total of both stances combined (P=0.007, P=0.010, respectively). Conclusions: Re-gripping the opponent and targeting locations other than the collar and sleeves for grabbing might facilitate scoring. This should be considered by trainers and competitors when preparing for competitions. © ARCHIVES OF BUDO.


Yang Y.,Hiroshima University | Nirmagustina D.E.,Hiroshima University | Kumrungsee T.,Hiroshima University | Okazaki Y.,Fuji University | And 2 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2017

Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta. Fecal mucins and cecal propionate were significantly elevated by both extracts, and fecal IgA was significantly elevated by WGL, but not by AWGL. These results suggest that the reishi extracts have an impact on colon luminal health by modulating secondary bile acids, microflora, mucins, and propionate that related to colon cancer. © 2017 Japan Society for Bioscience, Biotechnology, and Agrochemistry.


Kawashima H.,Iwate Prefectural University | Ohnishi M.,Fuji University
Lipids | Year: 2017

Our previous study characterized highly diverse dienoic fatty acids (FA), in particular an uncommon non-methylene-interrupted (NMI) FA, in the ovaries of the Japanese limpet Cellana toreuma belonging to the archaeogastropods, but many minor chemically unidentified FA remain. In this study, among previously unidentified FA (less than 0.1% of total FA), four novel NMI FA with a terminal double bond [7,18-nonadecadienoic (19:2Δ7,18), 11,18-nonadecadienoic (19:2Δ11,18), 7,20-heneicosadienoic (21:2Δ7,20), and 11,20-heneicosadienoic (21:2Δ11,20) acids] were found, along with known 14-pentadecenoic (15:1Δ14), 16-heptadecenoic (17:1Δ16), and 9,18-nonadecadienoic (19:2Δ9,18) acids, based on capillary GC–MS of their methyl esters, 3-pyridylcarbinol derivatives, and argentation thin-layer chromatography. From our findings, possible biosynthetic pathways for the novel FA are discussed. © 2017 AOCS


Komatsu E.,Fuji University | Morita M.,Hokkaido University of Education | Okamura S.,Hokkaido University of Education | Yahata M.,Geological Survey of Japan | Ikuno H.,Tokyo Gakugei University
Sen'i Gakkaishi | Year: 2011

We dyed cotton fabric samples using colored clay pigments, which can be recovered from dyehouse effluent and be reused. The Lab color space (CIE L*a*b*) values of both the clay pigments and the fabric samples after dying were measured. The compounds in the pigments, and the compounds adhering to the dyed fabrics, were analyzed using XRF, XRD, SEM and EDS. We then determined which minerals affected the color of the clay pigments and the dyed fabrics and discussed their interrelationships in our analyses.


Osaki A.,Hiroshima University | Okazaki Y.,Fuji University | Kimoto A.,Hiroshima University | Izu H.,Japanese National Research Institute of Brewing | Kato N.,Hiroshima University
Journal of Nutritional Science and Vitaminology | Year: 2014

This study investigated the effects of the consumption of 1% or 2% (v/v) ethanol in drinking water for 12 wk on rats fed a high-fat diet. Body weight gain, food intake, and fluid intake were unaffected by ethanol intake. Adipose tissue weight, and serum glucose and lipids were unaffected. Compared to the control (no ethanol), 1% ethanol intake significantly reduced serum levels of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ammonia (p<0.05), whereas 2% ethanol intake did so to a lesser extent. Serum urate was significantly lower in both the 1% and 2% ethanol groups than that in the control group (p<0.05). The results suggest a low dose of ethanol has beneficial effects on liver function and serum urate in rats fed a high-fat diet. © 2014, Center for Academic Publications Japan. All Rights Reserved.


Okazaki Y.,Fuji University | Sekita A.,Fuji University | Chiji H.,Fuji University | Kato N.,Hiroshima University
Food Science and Biotechnology | Year: 2016

It has been recently suggested a high ratio of fecal Firmicutes and reduction in the Bacteroidetes in obese animals. This study investigated the effect of dietary lily bulb (LB) on fecal Firmicutes and Bacteroidetes in rats fed a high-fat (HF) diet. In experiment 1, rats were fed an HF diet with or without 7% raw (R) or steamed (S) LB. In experiment 2, rats were fed the HF diet with or without 7% RLB, 0.9% ethanol extract of LB, or 6.1% ethanol extract residue of LB. In experiment 1, fecal Firmicutes was reduced and Bacteroidetes was increased in both the RLB and SLB groups. In experiment 2, the fecal Firmicutes/Bacteroidetes ratio was not affected by the ethanol extract or ethanol extract residue of LB. These results suggest that LB in its entirety modulates colonic microflora, regardless of heat treatment. © 2016, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.


Mueller C.M.,Fuji University | Jacobsen N.D.,George Washington University
ReCALL | Year: 2015

Qualitative research focusing primarily on advanced-proficiency second language (L2) learners suggests that online corpora can function as useful reference tools for language learners, especially when addressing phraseological issues. However, the feasibility and effectiveness of online corpus consultation for learners at a basic level of L2 proficiency have been relatively unexplored. The current study of Japanese-L1 (first language) learners in an EFL (English as a foreign language) context (N=117) addresses these gaps in research. A preliminary investigation (Experiment 1) examined EFL learners (n=78) as they used the Corpus of Contemporary American English (COCA: Davies, 2008–) to revise essays. Experiment 2 (n=39) used a within-subjects comparison to determine whether participants attained greater accuracy in supplying the missing word in a gap-fill test when using an electronic dictionary or COCA. The survey results from the two experiments revealed that participants generally found using an online corpus difficult. In Experiment 2, a paired-samples t-test showed that participants, at an alpha of p=.05 two-tailed, were marginally better able to answer test questions when using the online corpus than they were when using an electronic dictionary, p=0.030. The implications of the study within the context of previous research are discussed along with pedagogical recommendations and possible avenues for future research. Copyright © European Association for Computer Assisted Language Learning 2015

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