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Nishi-Tokyo-shi, Japan

Inoue M.,Aichi Gakuin University | Tanabe H.,Aichi Gakuin University | Matsumoto A.,Aichi Gakuin University | Matsumoto A.,Kaken Co. | And 4 more authors.
Biochemical Pharmacology | Year: 2012

Astaxanthin (ASX), an oxygenated carotenoid (xanthophyll), has previously been shown to exert ameliorative effects on obesity and insulin resistance, but the underlying mechanisms were not clearly elucidated. In the present study, we investigated whether ASX serves as a novel selective peroxisome proliferator-activated receptor (PPAR) γ modulator. Analyses of PPARγ binding by CoA-BAP assays revealed that ASX bound to PPARγ in a dose-dependent manner. However, ASX was unable to activate transcription in PPARγ reporter assays, although it antagonized transcriptional activation by the PPARγ agonist rosiglitazone (RGZ). When the molecular interactions between PPARγ and three coactivators were examined, ASX increased the interactions of PPARγ with transcriptional intermediary factor 2 (TIF2) and steroid receptor coactivator-1 (SRC-1), but not cAMP responsive element-binding protein (CREB)-binding protein (CBP). In addition, ASX effectively blocked the increase in CBP recruitment to PPARγ mediated by RGZ. ASX alone did not stimulate 3T3-L1 cell differentiation, although it antagonized 3T3-L1 cell differentiation and lipid accumulation induced by RGZ, similar to the PPARγ antagonist GW9662. When the effects of cotreatment of 3T3-L1 cells with ASX and RGZ were determined based on the mRNA levels of PPARγ target genes, ASX effectively reduced the mRNA levels of aP2 and lipoprotein lipase, but not CD36. Intriguingly, ASX was capable of inducing PPARγ target genes such as liver X receptor, CD36 and ABCA1 in thioglycollate-elicited peritoneal macrophages. Collectively, the present findings indicate that ASX is a novel selective PPARγ modulator that acts as an antagonist or agonist depending on the cell context. © 2012 Elsevier Inc. All rights reserved. Source

Fuji Chemical Industry Co. | Date: 2010-12-07

There is provided pet food comprising astaxanthin and/or an ester thereof as an active component and having an effect of deodorizing excrement such as urine and feces, effects of improving sleep, sensibility such as perception and cognition, and visual sense, and an effect of treating, improving or preventing diabetes and diabetic complications. The pet food can deodorize excrement such as urine and feces, improve sleep, sensibility such as perception and cognition, and visual sense, and treat, improve or prevent diabetes and diabetic complications.

Fuji Chemical Industry Co. | Date: 2015-11-02

Skin care preparations; cosmetic creams; cosmetic creams for skin care; cosmetic hand creams; cosmetic masks; cosmetic massage creams; cosmetic milks; cosmetic nourishing creams; cosmetic oils; cosmetic preparations for skin renewal; cosmetic preparations for body care; cosmetic preparations, namely, firming creams, firming lotions, skin balsams; cosmetic preparations for skin care; cosmetic skin fresheners; cosmetics; cosmetics in the form of milks, lotions and emulsions; skin and body topical lotions, creams and oils for cosmetic use; skin clarifiers; skin cleansers; skin conditioners; skin creams; skin emollients; skin fresheners; skin lotions; skin moisturizer; skin moisturizing gel; skin softeners; skin texturizers; skin toners; skin whitening preparations. Dietary supplements; nutritional supplements; dietary food supplements, namely, processed food products in the form of powder, granule, tablet, pill, capsule, or liquid made from principal ingredient of astaxanthin; dietary food supplements, namely, processed food products in the form of powder, granule, tablet, pill, capsule, or liquid made from principal raw material of dehydrated haematococcus algae powder or dehydrated haematococcus algae.

[Subject Matter] A rapidly disintegrating compression-molded material has been demanded, which exhibits good taking feeling and taste in the oral cavity, has a sufficient hardness for prevent the material from causing problems such as cracking or dusting during the preparation or distribution process, also has a good disintegrating property in the oral cavity, and can be taken in a large amount. [Means to Solve] A disintegrating particle composition is prepared by wet-granulating a starch, a water-soluble binding agent, and if needed a molding agent/an effective ingredient. By incorporating this disintegrating particle composition, a rapidly disintegrating compression-molded material can be prepared which has an excellent taking feeling, taste, hardness and disintegrating property and can be taken without limitation in quantity.

Fuji Chemical Industry Co. | Date: 2010-10-20

The present invention provides rapid disintegrating tablets in oral cavity having a shortened disintegration time in oral cavity as well as a sufficient hardness with compared to rapid disintegrating tablets of the prior art. The above objective is solved by a composition for rapid disintegrating tablets in oral cavity, wherein components (a) to (c) are contained in such manner that

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