Fu Dan University

Huashan, China

Fu Dan University

Huashan, China

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Qi C.,Guangdong Pharmaceutical University | Chen L.,Guangdong Pharmaceutical University | Wei H.,Fu Dan University | Zhang R.,Guangdong Pharmaceutical University | And 2 more authors.
Journal of Solution Chemistry | Year: 2016

Abstract: Molecular dynamic simulations and 2D-NMR spectroscopy were performed to study the conformations and hydrogen-bonding interactions of ACE-inhibitory valine–isoleucine–proline (VIP) tripeptide in aqueous solution. Intra-molecular distance, solvent-accessible surface, radius of gyration and root-mean-square deviations were used to describe the properties of the VIP in aqueous solution. MD results showed that the VIP molecule is highly flexible in water and the conformations can change from extended state to folded states. The VIP molecule exists in the extended state most of the time, which is in good agreement with the 2D-NMR spectra. Graphical Abstract: Molecular dynamic simulations revealed that the ACE-inhibitory tri-peptide VIP is highly flexible in aqueous solution. The conformations can change from extended states to folded states. At most of the time, the VIP molecule exists in the extended state. Findings in simulations have been confirmed by 2D-NOESY spectrum.[Figure not available: see fulltext.] © 2016, Springer Science+Business Media New York.


Li R.,Shanghai JiaoTong University | Cai Y.,Shanghai JiaoTong University | Wang Y.,Shanghai JiaoTong University | Sun Z.,Shanghai JiaoTong University | And 4 more authors.
Health Psychology | Year: 2016

Objective: We intended to verify the syndemic effect of psychosocial health conditions on suicidal ideation among men who have sex with men (MSM) in Shanghai, China; design a comprehensive framework for the identification of the MSM with suicidal ideation; and provide suggestion for suicidality intervention among MSM. Method: A cross-sectional study was conducted among 547 MSM in 4 districts in Shanghai. Sociodemographic, psychosocial, and suicidal ideation information of the participants was collected. Logistic regressions were performed to assess the relationship between psychosocial variables and suicidal ideation and to verify the syndemic effect of psychosocial factors. Results: Of the MSM sample, 10.6% reported suicidal thoughts in the past year. In univariate analysis, depression, anxiety, loneliness, impulsivity, involuntary subordination (IS), social support, and risky sex were associated with suicidal ideation. Multivariate analysis found that IS (ORm = 2.92, 95% confidence interval [CI] = 1.55-5.51) and risky sex (ORm = 3.79, 95% CI = 1.44 -9.97) remained significant. The MSM with more than 5 psychosocial health problems were nearly 4 times more likely (adjusted odds ratio = 4.68, 95% CI = 2.23-9.80) to have had suicidal ideation in the past year. Conclusions: The study confirmed the syndemic effect of psychosocial health problems in magnifying the risk of suicidality among MSM. More integrated and holistic approaches in the identification of high-risk groups and intervention of suicidality among MSM are needed. © 2015 American Psychological Association.


Kong L.,Shanghai JiaoTong University | Wang J.,Fu Dan University | Lu J.-L.,Shanghai JiaoTong University | Wu M.-Y.,Shanghai JiaoTong University
International Journal of Advancements in Computing Technology | Year: 2012

Capacity is one fundamental problem in wireless Ad hoc networks. Deploying directional antennas to wireless networks can reduce interference among concurrent transmissions and increase spatial reuse, while the technology of multi-channel can separate concurrent transmissions. Therefore, combining these two technologies into one wireless network is capable of great improvement on the network capacity. Recent studies proposed a multi-channel network architecture that equips each wireless node with multiple directional antennas, which is called MC-MDA network. The capacity in MC-MDA network is derived under arbitrary and random placements. However, they only used a simplified directional antenna model. For approaching the more accurate capacity in real scenario, we consider a hybrid antenna model, which takes the effect of side lobe into account. We derive the capacity upper-bounds of MC-MDA networks in arbitrary and random network with the hybrid model to find the effect of side lobe. We show that the network capacity is closely related to the ratio of the radiuses of side lobe to main lobe. The capacity decreases when the ratio increases. Moreover, we compare the network capacity of MC-MDA using the simplified antenna model with our results.


Zhao L.,Shanghai JiaoTong University | Dong B.,Shanghai JiaoTong University | Zhou Y.,Shanghai JiaoTong University | Lu L.,Shanghai JiaoTong University | And 7 more authors.
Life Science Journal | Year: 2013

The study analyzed the status of diabetes education at community in a developed city. A community with sixteen health clinics was enrolled in the study. Questionnaires were used and qualitative interview applied to four clinics and their physicians in the area. Investigation focused on the plan, educator, program, costs, evaluation, obstacles, and satisfaction in diabetes education. The survey was based on the National Diabetes Education Practice Survey (AADE 2008) and Chinese Diabetes Prevention and Care Guideline (CDA 2004). In the survey community, there were inconsistencies in the diabetes educator training curriculum, education method and evaluation. The frequency of education and the percentage of educated patients with diabetes differed depending on the staff to patient ratio. No dietician enrolled in diabetes education at community. The education courses were mainly developed by clinic with different method. The sessions mainly included basic information of disease, nutrition, treatment and complications, but little emphasis on behavioral supporting. Investment of financial and human resource for diabetes education still is a major challenge at community. The results indicate the areas for improvement of diabetes education at community in China, especially in evaluation and standardization. It is an important and necessary step to promote the effect of diabetes control for China in the future.


PubMed | Fu Dan University and Shanghai JiaoTong University
Type: Journal Article | Journal: Health psychology : official journal of the Division of Health Psychology, American Psychological Association | Year: 2016

We intended to verify the syndemic effect of psychosocial health conditions on suicidal ideation among men who have sex with men (MSM) in Shanghai, China; design a comprehensive framework for the identification of the MSM with suicidal ideation; and provide suggestion for suicidality intervention among MSM.A cross-sectional study was conducted among 547 MSM in 4 districts in Shanghai. Sociodemographic, psychosocial, and suicidal ideation information of the participants was collected. Logistic regressions were performed to assess the relationship between psychosocial variables and suicidal ideation and to verify the syndemic effect of psychosocial factors.Of the MSM sample, 10.6% reported suicidal thoughts in the past year. In univariate analysis, depression, anxiety, loneliness, impulsivity, involuntary subordination (IS), social support, and risky sex were associated with suicidal ideation. Multivariate analysis found that IS (ORm = 2.92, 95% confidence interval [CI] = 1.55-5.51) and risky sex (ORm = 3.79, 95% CI = 1.44-9.97) remained significant. The MSM with more than 5 psychosocial health problems were nearly 4 times more likely (adjusted odds ratio = 4.68, 95% CI = 2.23-9.80) to have had suicidal ideation in the past year.The study confirmed the syndemic effect of psychosocial health problems in magnifying the risk of suicidality among MSM. More integrated and holistic approaches in the identification of high-risk groups and intervention of suicidality among MSM are needed.


Xu G.,Fu Dan University | Hou C.-R.,CAS Shanghai Institutes for Biological Sciences | Jiang H.-W.,Fu Dan University | Xiang C.-Q.,Centers for Disease Control and Prevention | And 4 more authors.
Indian Journal of Geo-Marine Sciences | Year: 2010

Diagnostic biomarkers for early detection of renal cell carcinoma (RCC) are in great need. In the present study, we compared the serum protein profiles of patients with small RCC to those of healthy individuals to identify the differentially expressed proteins with potential to serve as biomarkers. Serum samples were collected from 10 patients with small RCC and 10 healthy individuals. The serum protein expression profiles were analyzed by two-dimensional (2-D) gel electrophoresis. Twenty-seven proteins with differences in expression levels between RCC patients and healthy volunteers were identified. Of these, 19 were expressed at different levels and eight were expressed in serum from the RCC group, but not from the control group. Six differentially expressed proteins identified by using mass spectrometry included coagulation factor XIII B, complement C3 and its precursor, misato homolog 1 (isoform CRA_b), hemopexin, and alpha-1-Bglycoprotein. Some of these serum proteins are known regulators of tumor progression in human malignancies. In conclusion, we successfully applied 2-D gel electrophoresis and identified six serum proteins differentially expressed between patients with small RCC and healthy volunteers. These proteins may provide novel biomarkers for early detection and diagnosis of human RCC. © 2010, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.


PubMed | Fu Dan University
Type: Journal Article | Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2016

4741 Background: An herbal combination PC-SPES was available in US for prostate cancer treatment and withdrawn in 2002 due to contamination. In China, the number of Prostate cancer recurrence after surgical castration has increased recently. There is an urgent need to find an effective therapy for these patients. We therefore investigated the effect of the seven Chinese herbal extract in PC- SPES on androgen insensitive prostate cancer (AIPC) cell lines and in nude mice inoculated with the cancer cells.LC-MS was used to detect any synthetic drug contamination. Flow cytometry was used to measure cell cycle and apoptosis. Western blot was used to measure p16, p-RB, p21, Bax, Bad, bcl-2 and Bcl-X, Caspase and PARP protein expressions. IL-6 was detected by the method of ELISA. Each group of 40 nude mice was inoculated with PC-3 and DU-145 separately. Oral administration of the herbal extract continued for 8 weeks. After sacrifice, various tissues were examined for pathological toxicity and the tumors were studied for molecular targets.The extract, found free of drug contamination, prolonged G1 and G2/M phase in PC-3 and DU-145 respectively, and induced apoptosis in both cell lines. At concentrations of 125, 250, 500 mg/kg/d, the extract inhibited the tumor growth by 27.6%, 44.15%, 53.2% in PC-3 (p<0.05) and 29.8%, 44.2%, 66.2% in DU-145 (p<0.05) when compared to the control group (N=10 each). No toxicity was found in all tissues including liver, heart and kidney. Furthermore, p16 was elevated and the phosphorylated RB protein was decreased in both cell lines and animal tumors. The proapoptic proteins Bad and Bax were increased while the antipropotic proteins Bcl-XL and Bcl-2 were decreased. These alterations resulted in the activation of caspase-3 (in cell lines) and PARP (in mice) and finally led to apoptosis. Lastly, IL-6 was found depleted in both animal tumors.Our results demonstrate the activity and mechanism of the herbal extract in suppressing AIPC both in vitro and in mice. We will further investigate its therapeutic benefit in human. No significant financial relationships to disclose.


PubMed | Fu Dan University
Type: Journal Article | Journal: Indian journal of biochemistry & biophysics | Year: 2010

Diagnostic biomarkers for early detection of renal cell carcinoma (RCC) are in great need. In the present study, we compared the serum protein profiles of patients with small RCC to those of healthy individuals to identify the differentially expressed proteins with potential to serve as biomarkers. Serum samples were collected from 10 patients with small RCC and 10 healthy individuals. The serum protein expression profiles were analyzed by two-dimensional (2-D) gel electrophoresis. Twenty-seven proteins with differences in expression levels between RCC patients and healthy volunteers were identified. Of these, 19 were expressed at different levels and eight were expressed in serum from the RCC group, but not from the control group. Six differentially expressed proteins identified by using mass spectrometry included coagulation factor XIII B, complement C3 and its precursor, misato homolog 1 (isoform CRA_b), hemopexin, and alpha-1-B-glycoprotein. Some of these serum proteins are known regulators of tumor progression in human malignancies. In conclusion, we successfully applied 2-D gel electrophoresis and identified six serum proteins differentially expressed between patients with small RCC and healthy volunteers. These proteins may provide novel biomarkers for early detection and diagnosis of human RCC.

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