Friedrich Miescher Institute for Biomedical Research
Friedrich Miescher Institute for Biomedical Research | Date: 2017-08-02
The present invention relates to a method for treating breast cancer in a subject having a breast cancer of the estrogen receptor (ER) negative type, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the Large Tumor Suppressor Kinase (LATS). Also provided are a si RNA decreasing or silencing the expression of the Large Tumor Suppressor Kinase (LATS), and an antibody specifically binding to the Large Tumor Suppressor Kinase (LATS), for use to treat breast cancer of the estrogen receptor (ER) negative type.
Friedrich Miescher Institute for Biomedical Research | Date: 2017-04-19
The present application provides a method for treating an influenza virus infection in a subject characterised in that a therapeutically effective amount of a modulator of the ubiquitin-binding property of HDAC6 is administered to said subject. The present application also provides an antibody binding to HADC6 and decreasing or blocking its ubiquitin-binding properties for use in treating an influenza virus infection.
Friedrich Miescher Institute for Biomedical Research and University of Basel | Date: 2017-01-04
The application relates to a method for predicting a risk for preeclampsia in a subject, said method comprising analysing a sample from the subject for the level of expression of miR455 and comparing the level of expression of miR455 in the sample from the subject to the levels of miR455 in a control sample, wherein a significantly lower expression of miR455 as compared to the expression of miR455 in the control is indicative of a risk for preeclampsia.
Friedrich Miescher Institute for Biomedical Research | Date: 2017-04-26
The present application relates to a method for the targeted formation of heterochromatin and/or induction of epigenetic gene silencing in a cell using a small RNA, said method comprising the step of inhibiting the Paf1 complex in said cell and the step of contacting said cell with a small RNA targeted to a region of the genome of the cell, said region being the region where heterochromatin formation and/or induction of epigenetic gene silencing should be induced.
Friedrich Miescher Institute for Biomedical Research | Date: 2017-06-07
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 200 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
Friedrich Miescher Institute for Biomedical Research | Date: 2017-05-10
The invention relates to a pharmaceutical combination which comprises (a) a compound inhibiting BRAFV600E and (b) a compound which inhibits MerTK activation; for simultaneous, separate or sequential use; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
Friedrich R.W.,Friedrich Miescher Institute for Biomedical Research
Annual Review of Neuroscience | Year: 2013
The main olfactory system encodes information about molecules in a combinatorial fashion by distributed spatiotemporal activity patterns. As activity propagates from sensory neurons to the olfactory bulb and to higher brain areas, odor information is processed by multiple transformations of these activity patterns. This review discusses neuronal computations associated with such transformations in the olfactory system of zebrafish, a small vertebrate that offers advantages for the quantitative analysis and manipulation of neuronal activity in the intact brain. The review focuses on pattern decorrelation in the olfactory bulb and on the readout of multiplexed sensory representations in the telencephalic area Dp, the homolog of the olfactory cortex. These computations are difficult to study in larger species and may provide insights into general information-processing strategies in the brain. Copyright ©2013 by Annual Reviews. All rights reserved.
Genoud C.,Friedrich Miescher Institute for Biomedical Research
Nature Neuroscience | Year: 2016
The dense reconstruction of neuronal circuits from volumetric electron microscopy (EM) data has the potential to uncover fundamental structure–function relationships in the brain. To address bottlenecks in the workflow of this emerging methodology, we developed a procedure for conductive sample embedding and a pipeline for neuron reconstruction. We reconstructed ∼98% of all neurons (>1,000) in the olfactory bulb of a zebrafish larva with high accuracy and annotated all synapses on subsets of neurons representing different types. The organization of the larval olfactory bulb showed marked differences from that of the adult but similarities to that of the insect antennal lobe. Interneurons comprised multiple types but granule cells were rare. Interglomerular projections of interneurons were complex and bidirectional. Projections were not random but biased toward glomerular groups receiving input from common types of sensory neurons. Hence, the interneuron network in the olfactory bulb exhibits a specific topological organization that is governed by glomerular identity. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Schubeler D.,Friedrich Miescher Institute for Biomedical Research |
Schubeler D.,University of Basel
Nature | Year: 2015
Cytosine methylation is a DNA modification generally associated with transcriptional silencing. Factors that regulate methylation have been linked to human disease, yet how they contribute to malignances remains largely unknown. Genomic maps of DNA methylation have revealed unexpected dynamics at gene regulatory regions, including active demethylation by TET proteins at binding sites for transcription factors. These observations indicate that the underlying DNA sequence largely accounts for local patterns of methylation. As a result, this mark is highly informative when studying gene regulation in normal and diseased cells, and it can potentially function as a biomarker. Although these findings challenge the view that methylation is generally instructive for gene silencing, several open questions remain, including how methylation is targeted and recognized and in what context it affects genome readout. © 2015 Macmillan Publishers Limited.
Schubeler D.,Friedrich Miescher Institute for Biomedical Research
Science | Year: 2012
Mammalian methylomes reveal how DNA methylation is infl uenced by the underlying nucleotide sequence.