French National Institute for Agricultural Research, French National Conservatory of Arts, Crafts, Institute Science Industries Vivant Et Environnement Agroparistech, Brodart and French National Center for Scientific Research | Date: 2015-03-04
The use of a composition including at least one saturated free fatty acid and at least one unsaturated free fatty acid as additive, for modifying the mechanical properties of a thermoplastic polymer material. An additivated thermoplastic polymer material and a process for producing same are also described.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.3 | Award Amount: 15.21M | Year: 2011
VISION: By 2015, novel service-oriented management methodologies and the Future Internet universal business infrastructure will enable European virtual factories and enterprises to self-organize in distributed, autonomous, interoperable, non-hierarchical innovation ecosystems of tangible and intangible manufacturing assets, to be virtually described, on-the-fly composed and dynamically delivered as a Service, end-to-end along the globalised value chain.\nThe first Grand Challenge for MSEE project is to make SSME (Service Science Management and Engineering) evolve towards Manufacturing Systems and Factories of the Future, i.e. from a methodological viewpoint to adapt, modify, extend SSME concepts so that they could be applicable to traditionally product-oriented enterprises; from an implementation viewpoint to instantiate Future Internet service oriented architectures and platforms for global manufacturing service systems.\nThe second Grand Challenge for MSEE project is to transform current manufacturing hierarchical supply chains into manufacturing open ecosystems, i.e. on the one side to define and implement business processes and policies to support collaborative innovation in a secure industrial environment; on the other side to define a new collaborative architecture for ESA (Enterprise Software and Applications), to support business-IT interaction and distributed decision making in virtual factories and enterprises.\nThe synthesis of the two Grand Challenges above in industrial business scenarios and their full adoption in some European test cases will result in new Virtual Factory Industrial Models, where service orientation and collaborative innovation will support a new renaissance of Europe in the global manufacturing context.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.4.1 | Award Amount: 4.29M | Year: 2011
ARtSENSE tackles a very important problem in the modern usage of ICT in cultural heritage domain: bridging the gap between the digital world with the physical in a highly flexible way in order to enable a novel, adaptive cultural experience.\nARtSENSE aims to develop an active assistants which looks over the users shoulder (physical world) and react on any change in a visitors state of interests (users world) by adapting the guide (digital world) accordingly.\nBesides introducing novel wearable technologies for sensing continuously and non-intrusively the users context (visual eye-tracking, audio, physiological biosensing) in order to determine the users current interest (mental engagement), ARtSENSE will revolutionize the way how adaptive assistance will be realized: using cutting-edge technology (low weight bidirectional see-through displays) that enables overlaying reality with digital information transparently, including gaze-and gesture-controlled interaction, so that visitors have the feeling that physical objects are directly responding to them. In that way artworks become active artefacts that react on users attention and emotions and provide more information about them! This leads to the new generation of mobile museum guides based on the novel concept we call Adaptive Augmented Reality (A2R).\nThe realization of such an ambitious result will be based on the prior work of partners in the domain of Augmented Reality for Cultural Heritage, Affective Computing and Complex Event Processing, which ensures the quality and reliability of generated outcomes and it will be driven by the three complementary use cases from Cultural Heritage domain, which ensures the usefulness and reusability of results.\nVery rigorous and comprehensive evaluation and exploitation plans ensures that this work will produce exploitable research results and influence the selected research areas, as well as the usage of advance ICT in the CH domain in general.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 4.15M | Year: 2012
The EMPhAtiC objective is to develop, evaluate and demonstrate the capability of enhanced multicarrier techniques to make better use of the existing radio frequency bands in providing broadband data services in coexistence with narrowband legacy services. The project will address the Professional Mobile Radio (PMR) application, especially the evolution of the Public Protection & Disaster Relief (PPDR) service currently using TETRA systems for voice and low-speed data services. Both cell-based and ad-hoc networking solutions are needed for PPDR and will be developed.Our main emphasis is on filter bank based multicarrier (FB-MC) and single-carrier (FB-SC) waveforms for utilizing effectively the available fragmented spectrum in such heterogeneous environments. The core idea is to develop a multi-mode radio platform, based on variable filter-bank processing, which is able to perform modulation/detection functions simultaneously for different signal formats with adjustable center frequencies, bandwidths and subchannel spacings. SC-FDMA waveforms are included in the study in order to relax the transmitter power amplifier requirements of mobile terminals. Also enhanced OFDM solutions are considered as alternatives aiming at minimal modifications to the 3GPP LTE standard, which serves as the reference system in the studies. In addition to the basic physical layer functionalities, the project develops also MIMO and MAC-layer techniques, as well as relay networking solutions which are compatible and maximize the benefits of the waveform level solutions.The EMPhAtiC consortium has a strong expertise in the design of practical TETRA and ETSI BRAN systems. We believe that the design of FB-MC schemes facilitating flexible and efficient multi-access spectrum usage, along with a proof of concept implementation, form the necessary basis for proposing better next generation broadband data solutions for the PMR evolution and other applications, including the 3GPP LTE evolution.
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2011.2.2.1-1 | Award Amount: 3.15M | Year: 2011
ENGINEER will support the widespread adoption in Europe of innovative methods of science teaching and provide extensive teacher training on inquiry-based methods. It will be based on the proven Engineering is Elementary (EiE) program developed by Bostons Museum of Science (BMOS) since 2003-04 and now widely used in primary schools throughout the U.S. Evaluations of EiE have found that incorporating engineering in science teaching, using inquiry-based pedagogic methods, results in highly desirable impacts on students and teachers, raising students interest in science and engineering. BMOS will play an instructional and advisory role in ENGINEER. ENGINEER will develop 10 engineering design challenge units suited to European environments using EiEs Engineering Design Plan model. Each unit will focus on one engineering field and will use inexpensive materials for student-led design problem-solving. ENGINEER will adapt and enhance EiE teacher training materials. Project materials will be tested in pilot applications and refined before use in outreach. Science museums will lead the outreach effort that targets schools, teachers and science museums. Teachers trained in using ENGINEERs materials will incorporate the units into science teaching in their classes. Museums will offer programs for student groups as well as for the general public. Training will be provided to 1,000 teachers, and trained teachers and school/museum activities will reach 27,000 students during outreach. Dissemination activities will increase awareness of ENGINEER and help promote participation. An advocacy program is specifically aimed at influencing education policy makers throughout Europe. Its major goal is to promote the much more widespread future deployment of ENGINEERs tools after the project formally ends. ENGINEERs consortium features 10 science museums and 10 schools, as well as universities and other organizations that will contribute expertise to project tasks.
Breban R.,Institute Pasteur Paris |
Riou J.,Institute Pasteur Paris |
Fontanet A.,Institute Pasteur Paris |
Fontanet A.,French National Conservatory of Arts and Crafts
The Lancet | Year: 2013
Background The new Middle East respiratory syndrome coronavirus (MERS-CoV) infection shares many clinical, epidemiological, and virological similarities with that of severe acute respiratory syndrome (SARS)-CoV. We aimed to estimate virus transmissibility and the epidemic potential of MERS-CoV, and to compare the results with similar findings obtained for prepandemic SARS. Methods We retrieved data for MERS-CoV clusters from the WHO summary and subsequent reports, and published descriptions of cases, and took into account 55 of the 64 laboratory-confirmed cases of MERS-CoV reported as of June 21, 2013, excluding cases notified in the previous 2 weeks. To assess the interhuman transmissibility of MERS-CoV, we used Bayesian analysis to estimate the basic reproduction number (R0) and compared it to that of prepandemic SARS. We considered two scenarios, depending on the interpretation of the MERS-CoV cluster-size data. Results With our most pessimistic scenario (scenario 2), we estimated MERS-CoV R0 to be 0·69 (95% CI 0·50- 0·92); by contrast, the R0 for prepandemic SARS-CoV was 0·80 (0·54-1·13). Our optimistic scenario (scenario 1) yielded a MERS-CoV R0 of 0·60 (0·42-0·80). Because of recent implementation of effective contact tracing and isolation procedures, further MERS-CoV transmission data might no longer describe an entire cluster, but only secondary infections directly caused by the index patient. Hence, we calculated that, under scenario 2, eight or more secondary infections caused by the next index patient would translate into a 5% or higher chance that the revised MERS-CoV R0 would exceed 1 - ie, that MERS-CoV might have pandemic potential. Interpretation Our analysis suggests that MERS-CoV does not yet have pandemic potential. We recommend enhanced surveillance, active contact tracing, and vigorous searches for the MERS-CoV animal hosts and transmission routes to human beings. Funding Agence Nationale de la Recherche (Labex Integrative Biology of Emerging Infectious Diseases), and the European Community's Seventh Framework Programme project PREDEMICS. © 2013 Elsevier Ltd.
Delaneau O.,French National Conservatory of Arts and Crafts |
Delaneau O.,University of Oxford |
Marchini J.,University of Oxford |
Zagury J.-F.,French National Conservatory of Arts and Crafts
Nature Methods | Year: 2012
Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes. © 2012 Nature America, Inc. All rights reserved.
Meunier F.,French National Conservatory of Arts and Crafts
Applied Thermal Engineering | Year: 2013
A review of the state of the art of adsorption heat powered heat pumps is presented. Interesting results on solar cooling, advanced cycles and consolidated materials were obtained in early developments until 1995 but, at that time, commercialization was not successful. Recently, breakthroughs were achieved on materials (including composite ones) and on coated surfaces but no obvious progresses have been obtained on advanced cycles and this is a gap to be completed. In parallel, commercialization has improved with the perspectives of the boiler new market. A promising future for those components exists if the recent and ongoing innovation yields more efficient commercialized products. © 2013 Elsevier Ltd. All rights reserved.
Legay A.,French National Conservatory of Arts and Crafts
International Journal for Numerical Methods in Engineering | Year: 2013
Noise reduction for passengers' comfort in transport industry is now an important constraint to be taken into account during the design process. This process involves to study several configurations of the structures immersed in a given acoustic cavity in the context of an optimization, uncertainty, or reliability study for instance. The finite element method may be used to model this coupled fluid-structure problem but needs an interface conforming mesh for each studied configuration that may become time consuming. This work aims at avoiding this remeshing step by using noncompatible meshes between the fluid and the structures. The immersed structures are supposed to be thin shells and are localized in the fluid domain by a signed distance level-set. To take into account the pressure discontinuity from one side of the structures to the other one, the fluid pressure approximation is enriched according to the structures positions by a Heaviside function using a partition of unity strategy (extended finite element method). The same fluid mesh of the empty cavity is then used during the whole parametric study. The method is implemented for a three-dimensional fluid and tested on academic examples before being applied to an industrial-like case. © 2012 John Wiley & Sons, Ltd.
Agency: Cordis | Branch: H2020 | Program: ERC-STG | Phase: ERC-StG-2014 | Award Amount: 1.50M | Year: 2015
The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life. Since the first resolution of protein structures by X-ray crystallography and NMR, structural biology seeks to provide this picture of biological phenomena at the molecular and atomic level by analyzing 3D structures. In the present proposal, we propose to change this paradigm by changing the mode of representation of protein surfaces to 2D maps. That will open new avenues for 1. the development of innovative high-throughput computation of protein interactions and relationships and 2. the emergence of new forms of visualization and analysis of protein structures and properties. We will apply this powerful tool of conformal mapping to structural biology by representing protein surfaces that are complex 3D surfaces in 2D conformal maps that we will call positive conformal maps. We will extend this representation by also generating the 2D conformal maps of the negatives of the 3D surface of the proteins. These positive and negative 2D conformal maps of the surface of proteins will constitute a new representation of the protein surfaces that will be the basis for innovative high-throughput and/or interactive simulation methods, visualization methods and more generally that will give an other insight on the structure of proteins. The major impact of this proposal lies in the fact that it will at last open the gates of the long awaited proteome docking. Using a simplified representation of protein surfaces will allow to perform faster complete cross docking calculations and create a new classification of the protein structures based on their surficial similarity.