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Janin Y.L.,Institute Pasteur Paris | Janin Y.L.,French National Center for Scientific Research
Chemical Reviews | Year: 2012

A pyrazole nucleus halogenation, if possible regioselective, is often the first step of many syntheses of more elaborated derivatives. Concerning the preparation of 3/5-halogenated derivatives with electrophilic reagents, this usually requires the 4 position to be substituted. Otherwise, halogenation will first take place on position 4 and then on the other ones, usually at higher temperature and/or using stronger reaction conditions. One approach to avoid the faster 4-halogenation of pyrazoles is to undertake C-5 halogenation of suitably N-substituted pyrazole anions. Dehydroxyhalogenation of 3/5-hydroxypyrazoles is probably one of the most obvious preparations of 3/5-chloro- or 3/5- bromopyrazoles using reagents such as phosphorus oxychloride or phosphorus oxybromide. Preparation of 1-substituted 3-halogenopyrazoles by the Sandmeyer reaction is also possible. Cycloaddition between sydnones and halogenated dipole leads to 3-halogenopyrazoles. Source


Armijo J.,French National Center for Scientific Research
Physical Review Letters | Year: 2012

We report the first direct observation of collective quantum fluctuations in a continuous field. Shot-to-shot atom number fluctuations in small subvolumes of a weakly interacting, ultracold atomic 1D cloud are studied using in situ absorption imaging and statistical analysis of the density profiles. In the cloud centers, well in the quantum quasicondensate regime, the ratio of chemical potential to thermal energy is μ/k BT 4, and, owing to high resolution, up to 20% of the microscopically observed fluctuations are quantum phonons. Within a nonlocal analysis at variable observation length, we observe a clear deviation from a classical field prediction, which reveals the emergence of dominant quantum fluctuations at short length scales, as the thermodynamic limit breaks down. © 2012 American Physical Society. Source


Narison S.,French National Center for Scientific Research
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

We reconsider the extraction of the gluon condensates {left double angle bracket;αsG2{right double angle bracket}, {left double angle bracket;g3fabcG3{right double angle bracket} and the MS running quark masses mc,b from different Mn(Q2) moments and their ratios by including PT corrections to order αs3, NPT terms up to {left double angle bracket;G4{right double angle bracket} and using stability criteria of the results versus the degree n (number of Q2-derivative). We explicitly show that the spectral part of the lowest moment M1(0) depends strongly (as expected) on its high-energy (continuum) contribution, which is minimized for Mn≥3-4(0). Using higher moments and the correlations of {left double angle bracket;αsG2{right double angle bracket} with {left double angle bracket;g3fabcG3{right double angle bracket} and {left double angle bracket;G4{right double angle bracket}, we obtain {left double angle bracket;αsG2{right double angle bracket}=(7.0±1.3)×10-2GeV4 and {left double angle bracket;g3fabcG3{right double angle bracket}=(8.8±5.5)GeV2×{left double angle bracket;αsG2{right double angle bracket}, while our analysis favours a modified precise factorisation for {left double angle bracket;G4{right double angle bracket}. Using the previous results, we re-determine mc(mc) and find that the commonly used M1(0) lowest moment tends to overestimate its value compared to the ones from higher moments where stable values of mc(mc) versus the variations of n and the continuum models are reached. These features can indicate that the quoted errors of mc,b from M1(0) may have been underestimated. Our best results from different high-n moments and their ratios are: mc(mc)=1261(16)MeV and mb(mb)=4171(14)MeV, in excellent agreement with results obtained in Narison (2010) [1] using some judicious choices of ratios of moments. © 2011 Elsevier B.V. Source


Narison S.,French National Center for Scientific Research
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

We test the convergence of the QCD exponential sum rules by including PT corrections to order αs3 and the NP contributions up to dimension D=8 condensates. Then, using the ratio of exponential sum rules where the QCD PT series is more convergent, we study the correlation between the gluon condensates 〈α sG 2〉 and 〈g 3f abcG 3〉. From charmonium systems and using the charm quark mass as input, we deduce: 〈g 3f abcG 3〉=(8.2±1.0)GeV 2×〈α sG 2〉 corresponding to 〈α sG 2〉=(7.5±2.0)×10 -2GeV 4. Using these results for the bottomium systems, we obtain: m̄b(m̄b)=4212(32)MeV, which is slightly higher but consistent within the errors with the ones from Q 2-moments and their ratios m̄b(m̄b)=4172(12)MeV. We are tempted to consider as a final result from the sum rules approaches, the average m̄b(m̄b)=4177(11)MeV of the two previous determinations. © 2011 Elsevier B.V. Source


Berthier L.,CNRS Charles Coulomb Laboratory | Biroli G.,CEA Saclay Nuclear Research Center | Biroli G.,French National Center for Scientific Research
Reviews of Modern Physics | Year: 2011

A theoretical perspective is provided on the glass transition in molecular liquids at thermal equilibrium, on the spatially heterogeneous and aging dynamics of disordered materials, and on the rheology of soft glassy materials. We start with a broad introduction to the field and emphasize its connections with other subjects and its relevance. The important role played by computer simulations in studying and understanding the dynamics of systems close to the glass transition at the molecular level is given. The recent progress on the subject of the spatially heterogeneous dynamics that characterizes structural relaxation in materials with slow dynamics is reviewed. The main theoretical approaches are presented describing the glass transition in supercooled liquids, focusing on theories that have a microscopic, statistical mechanics basis. We describe both successes and failures and critically assess the current status of each of these approaches. The physics of aging dynamics in disordered materials and the rheology of soft glassy materials are then discussed, and recent theoretical progress is described. For each section, an extensive overview is given of the most recent advances, but we also describe in some detail the important open problems that will occupy a central place in this field in the coming years. © 2011 American Physical Society. Source


Albertin W.,French National Center for Scientific Research
Proceedings. Biological sciences / The Royal Society | Year: 2012

Polyploidy is a major evolutionary process in eukaryotes-particularly in plants and, to a less extent, in animals, wherein several past and recent whole-genome duplication events have been described. Surprisingly, the incidence of polyploidy in other eukaryote kingdoms, particularly within fungi, remained largely disregarded by the scientific community working on the evolutionary consequences of polyploidy. Recent studies have significantly increased our knowledge of the occurrence and evolutionary significance of fungal polyploidy. The ecological, structural and functional consequences of polyploidy in fungi are reviewed here and compared with the knowledge acquired with conventional plant and animal models. In particular, the genus Saccharomyces emerges as a relevant model for polyploid studies, in addition to plant and animal models. Source


Narison S.,French National Center for Scientific Research
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

Using recent values of the QCD (non-)perturbative parameters given in Table 1 and an estimate of the N3LO QCD perturbative contributions based on the geometric growth of the PT series, we re-use QCD spectral sum rules (QSSR) known to N2LO PT series and including all dimension-six NP condensate contributions in the full QCD theory, for improving the existing estimates of m̄c,b and fD(s),B(s) from the open charm and beauty systems. We especially study the effects of the subtraction point on "different QSSR data" and use (for the first time) the Renormalization Group Invariant (RGI) scale-independent quark masses in the analysis. The estimates [rigourous model-independent upper bounds within the SVZ framework] reported in Table 8: fD/fπ=1.56(5) [≤1.68(1)], fB/fπ=1.58(5) [≤1.80(3)] and fDs/fK=1.58(4) [≤1.63(1)], fBs/fK=1.50(3) [≤1.61(3.5)], which improve previous QSSR estimates, are in perfect agreement (in values and precisions) with some of the experimental data on fD, Ds and on recent lattice simulations within dynamical quarks. These remarkable agreements confirm both the success of the QSSR semi-approximate approach based on the OPE in terms of the quark and gluon condensates and of the Minimal Duality Ansatz (MDA) for parametrizing the hadronic spectral function which we have tested from the complete data of the J/ψ and Υ systems. The values of the running quark masses m̄c(mc)=1286(66) MeV and m̄b(mb)=4236(69) MeV from MD,B are in good agreement though less accurate than the ones from recent J/ψ and Υ sum rules. © 2012 Elsevier B.V. Source


Faure V.,French National Center for Scientific Research
Molecular cell | Year: 2010

Lagging-strand and leading-strand synthesis of chromosomes generates two structurally distinct ends at the telomeres. Based on sequence bias of yeast telomeres that contain a 250-300 bp array of C(1-3)A/ TG(1-3) repeats, we developed a method allowing us to distinguish which of the two daughter telomeres chromosome end-binding proteins bind to at the end of S phase. The single-stranded DNA-binding protein Cdc13 and the telomerase subunits Est1 and Est2 can bind to the two daughter telomeres, but only their binding to the leading-strand telomere depends on the Mre11/Rad50/Xrs2 (MRX) complex involved in both telomeric 5' nucleolytic resection and telomerase recruitment at short telomeres. Consistently, the MRX complex is mainly found to bind to the leading-strand telomere. Our results indicate that Cdc13 can bind to the telomeric template for lagging-strand replication. Since mre11-deficient strains have markedly short telomeres, telomere elongation by telomerase is likely to occur mainly at the leading-strand telomere. Copyright (c) 2010 Elsevier Inc. All rights reserved. Source


Barboiu M.,French National Center for Scientific Research
Angewandte Chemie - International Edition | Year: 2012

Going through the channels: Synthetic scaffolds mimicking natural protein functions have been developed that allow water/proton or only water translocation pathways in bilayer membranes (see picture). The ion-exclusion behaviors of the synthetic systems are based on hydrophobic or dimensional steric effects, while hydrodynamic effects appear to be less important. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Changeux J.-P.,French National Center for Scientific Research
Nature Reviews Molecular Cell Biology | Year: 2013

The concept of indirect or 'allosteric' interaction between topographically distinct sites, and the subsequent 1965 Monod-Wyman-Changeux (MWC) model for the conformational change mediating them, arose around 50 years ago. Many classic regulatory proteins (including haemoglobin, Asp transcarbamylase and nicotinic acetylcholine receptor) follow the central paradigm of the MWC model, which has been expanded and challenged as a result of novel technologies. Importantly, the concept of allosteric interaction has aided our understanding of human diseases and drug design. © 2013 Macmillan Publishers Limited. All rights reserved. Source


Kroymann J.,French National Center for Scientific Research
Current Opinion in Plant Biology | Year: 2011

Technological advances in metabolomics, transcriptomics and genomics have facilitated the detection of genes that contribute to diversification in plant secondary metabolism. Statistical tools from molecular population genetics may help in evaluating whether the corresponding genes or genomic regions carry a signature of selection and answering the question of whether novel compounds are 'adaptive'. Gene duplication fuels diversification in plant secondary metabolism and the evolutionary mechanism for adaptation may follow a path of neofunctionalization subsequent to gene duplication, or gene duplication may occur subsequent to - and resolve - an adaptive conflict present in a single ancestral gene sequence. © 2011 Elsevier Ltd. Source


Abergel C.,French National Center for Scientific Research
Acta Crystallographica Section D: Biological Crystallography | Year: 2013

Molecular replacement is the method of choice for X-ray crystallographic structure determination provided that suitable structural homologues are available in the PDB. Presently, there are ∼80000 structures in the PDB (8074 were deposited in the year 2012 alone), of which ∼70% have been solved by molecular replacement. For successful molecular replacement the model must cover at least 50% of the total structure and the Cα r.m.s.d. between the core model and the structure to be solved must be less than 2Å. Here, an approach originally implemented in the CaspR server (http://www.igs.cnrs-mrs.fr/ Caspr2/index.cgi) based on homology modelling to search for a molecular-replacement solution is discussed. How the use of as much information as possible from different sources can improve the model(s) is briefly described. The combination of structural information with distantly related sequences is crucial to optimize the multiple alignment that will define the boundaries of the core domains. PDB clusters (sequences with ≥30% identical residues) can also provide information on the eventual changes in conformation and will help to explore the relative orientations assumed by protein subdomains. Normal-mode analysis can also help in generating series of conformational models in the search for a molecular-replacement solution. Of course, finding a correct solution is only the first step and the accuracy of the identified solution is as important as the data quality to proceed through refinement. Here, some possible reasons for failure are discussed and solutions are proposed using a set of successful examples. Source


Chami L.,French National Center for Scientific Research
Molecular neurodegeneration | Year: 2012

Alzheimer's disease (AD) is a complex age-related pathology, the etiology of which has not been firmly delineated. Among various histological stigmata, AD-affected brains display several cellular dysfunctions reflecting enhanced oxidative stress, inflammation process and calcium homeostasis disturbance. Most of these alterations are directly or indirectly linked to amyloid β-peptides (Aβ), the production, molecular nature and biophysical properties of which likely conditions the degenerative process. It is particularly noticeable that, in a reverse control process, the above-described cellular dysfunctions alter Aβ peptides levels. β-secretase βAPP-cleaving enzyme 1 (BACE1) is a key molecular contributor of this cross-talk. This enzyme is responsible for the primary cleavage generating the N-terminus of "full length" Aβ peptides and is also transcriptionally induced by several cellular stresses. This review summarizes data linking brain insults to AD-like pathology and documents the key role of BACE1 at the cross-road of a vicious cycle contributing to Aβ production. Source


Wurger A.,French National Center for Scientific Research
Physical Review Letters | Year: 2011

We show that thermal creep is at the origin of the recently discovered Leidenfrost ratchet, where liquid droplets float on a vapor layer along a heated sawtooth surface and accelerate to velocities of up to 40cm/s. As the active element, the asymmetric temperature profile at each ratchet summit rectifies the vapor flow in the boundary layer. This mechanism works at low Reynolds number and provides a novel tool for controlling gas flow at nanostructured surfaces. © 2011 American Physical Society. Source


Perrot-Rechenmann C.,French National Center for Scientific Research
Cold Spring Harbor perspectives in biology | Year: 2010

The phytohormone auxin is a major regulator of plant growth and development. Many aspects of these processes depend on the multiple controls exerted by auxin on cell division and cell expansion. The detailed mechanisms by which auxin controls these essential cellular responses are still poorly understood, despite recent progress in the identification of auxin receptors and components of auxin signaling pathways. The purpose of this review is to provide an overview of the present knowledge of the molecular mechanisms involved in the auxin control of cell division and cell expansion. In both cases, the involvement of at least two signaling pathways and of multiple targets of auxin action reflects the complexity of the subtle regulation of auxin-mediated cellular responses. In addition, it offers the necessary flexibility for generating differential responses within a given cell depending on its developmental context. Source


De Massy B.,French National Center for Scientific Research
Annual Review of Genetics | Year: 2013

Meiotic recombination is essential for fertility in most sexually reproducing species. This process also creates new combinations of alleles and has important consequences for genome evolution. Meiotic recombination is initiated by the formation of DNA double-strand breaks (DSBs), which are repaired by homologous recombination. DSBs are catalyzed by the evolutionarily conserved SPO11 protein, assisted by several other factors. Some of them are absolutely required, whereas others are needed only for full levels of DSB formation and may participate in the regulation of DSB timing and frequency as well as the coordination between DSB formation and repair. The sites where DSBs occur are not randomly distributed in the genome, and remarkably distinct strategies have emerged to control their localization in different species. Here, I review the recent advances in the components required for DSB formation and localization in the various model organisms in which these studies have been performed. © 2013 by Annual Reviews. All rights reserved. Source


Bronner C.,French National Center for Scientific Research
Science Signaling | Year: 2011

Inheritance of DNA methylation patterns is a key mechanism involved in epigenetic cell memory transmission from mother cell to daughter cell. This occurs due to cooperation between the DNA methyltransferase DNMT1 and the ubiquitin ligase UHRF1 (ubiquitin-like, containing plant homeo domain and RING finger 1) in a macromolecular complex. Newly identified members of this complex are the acetyltransferase Tip60 (Tat-interactive protein) and the deubiquitinase HAUSP (herpes virus-associated ubiquitin specific protease), which exert tight regulation of DNMT1 abundance through a ubiquitylation-dependent process. It is important to determine how all of these actors communicate with each other and what signals coordinate their communication. In the case of DNMT1, the balance of UHRF1 and HAUSP activities might be influenced by the local environment, such as histone code, cell-cycle status, and local DNA methylation status. Source


Drane P.,French National Center for Scientific Research
Genes and Development | Year: 2010

The histone variant H3.3 marks active chromatin by replacing the conventional histone H3.1. In this study, we investigate the detailed mechanism of H3.3 replication-independent deposition. We found that the death domain-associated protein DAXX and the chromatin remodeling factor ATRX (α-thalassemia/mental retardation syndrome protein) are specifically associated with the H3.3 deposition machinery. Bacterially expressed DAXX has a marked binding preference for H3.3 and assists the deposition of (H3.3-H4) 2 tetramers on naked DNA, thus showing that DAXX is a H3.3 histone chaperone. In DAXX-depleted cells, a fraction of H3.3 was found associated with the replication-dependent machinery of deposition, suggesting that cells adapt to the depletion. The reintroduced DAXX in these cells colocalizes with H3.3 into the promyelocytic leukemia protein (PML) bodies. Moreover, DAXX associates with pericentric DNA repeats, and modulates the transcription from these repeats through assembly of H3.3 nucleosomes. These findings establish a new link between the PML bodies and the regulation of pericentric DNA repeat chromatin structure. Taken together, our data demonstrate that DAXX functions as a bona fide histone chaperone involved in the replication-independent deposition of H3.3. © 2010 by Cold Spring Harbor Laboratory Press. Source


Hapiot P.,French National Center for Scientific Research
Journal of the American Chemical Society | Year: 2010

A global strategy to prepare a versatile and robust reactive platform for immobilizing molecules on carbon substrates with controlled morphology and high selectivity is presented. The procedure is based on the electroreduction of a selected triisopropylsilyl (TIPS)-protected ethynyl aryldiazonium salt. It avoids the formation of multilayers and efficiently protects the functional group during the electrografting step. After TIPS deprotection, a dense reactive ethynyl aryl monolayer is obtained which presents a very low barrier to charge transfer between molecules in solution and the surface. As a test functionalization, azidomethylferrocene was coupled by "click" chemistry with the modified surface. Analysis of the redox activity highlights a surface concentration close to the maximum possible attachment considering the steric hindrance of a ferrocenyl group. © 2010 American Chemical Society. Source


Gertner-Dardenne J.,French National Center for Scientific Research
Blood | Year: 2013

Vγ9Vδ2 cells, the major γδ T-cell subset in human peripheral blood, represent a T-cell subset that displays reactivity against microbial agents and tumors. The biology of Vγ9Vδ2 T cells remains poorly understood. We show herein that the interaction between B- and T-lymphocyte attenuator (BTLA) and herpesvirus entry mediator (HVEM) is a major regulator of Vγ9Vδ2 T-cell proliferation control. BTLA was strongly expressed at the surface of resting Vγ9Vδ2 T cells and inversely correlated with T-cell differentiation. BTLA-HVEM blockade by monoclonal antibodies resulted in the enhancement of Vγ9Vδ2 T-cell receptor-mediated signaling, whereas BTLA-HVEM interaction led to a decrease in phosphoantigen-mediated proliferation by inducing a partial S-phase arrest. Our data also suggested that BTLA-HVEM might participate in the control of γδ T-cell differentiation. In addition, the proliferation of autologous γδ T cells after exposition to lymphoma cells was dramatically reduced through BTLA-HVEM interaction. These data suggest that HVEM interaction with BTLA may play a role in lymphomagenesis by interfering with Vγ9Vδ2 T-cell proliferation. Moreover, BTLA stimulation of Vγ9Vδ2 T cells appears as a new possible mechanism of immune escape by lymphoma cells. Source


Mechali M.,French National Center for Scientific Research
Nature Reviews Molecular Cell Biology | Year: 2010

At each cell division in humans, 30,000-50,000 DNA replication origins are activated, and it remains unclear how they are selected and recognized by replication factors. DNA replication in multicellular organisms must accommodate variations in growth conditions and DNA damage. It must also adapt to changes in chromatin organization associated with cell differentiation and development. The selection of replication origins in metazoans seems to involve multiple choices, with the appropriate answers depending on the identity of the cell or the conditions of growth. This suggests that during evolution, the use of replication origins became more controlled by epigenetic mechanisms affecting chromosome dynamics and expression than by DNA synthesis per se. © 2010 Macmillan Publishers Limited. All rights reserved. Source


Cavalli G.,French National Center for Scientific Research
Science | Year: 2012

A transcriptional repressor switches to an activator function in an aggressive form of prostate cancer. Source


Laperrousaz B.,French National Center for Scientific Research
Blood | Year: 2013

Leukemic stem cells in chronic phase chronic myelogenous leukemia (CP-CML) are responsible for disease persistence and eventual drug resistance, most likely because they survive, expand, and are sustained through interactions with their microenvironment. Bone morphogenetic proteins 2 (BMP2) and 4 (BMP4) regulate the fate and proliferation of normal hematopoietic stem cells, as well as interactions with their niche. We show here that the intrinsic expression of members of the BMP response pathway are deregulated in CML cells with differences exhibited in mature (CD34(-)) and immature (CD34(+)) compartments. These changes are accompanied by altered functional responses of primitive leukemic cells to BMP2 and BMP4 and strong increases in soluble BMP2 and BMP4 in the CML bone marrow. Using primary cells and a cell line mimicking CP-CML, we found that myeloid progenitor expansion is driven by the exposure of immature cells overexpressing BMP receptor Ib to BMP2 and BMP4. In summary, we demonstrate that deregulation of intracellular BMP signaling in primary CP-CML samples corrupts and amplifies their response to exogenous BMP2 and BMP4, which are abnormally abundant within the tumor microenvironment. These results provide new insights with regard to leukemic stem cell biology and suggest possibilities for the development of novel therapeutic tools specifically targeting the CML niche. Source


Dupeux F.,French National Center for Scientific Research
The EMBO journal | Year: 2011

Abscisic acid (ABA) is a key hormone regulating plant growth, development and the response to biotic and abiotic stress. ABA binding to pyrabactin resistance (PYR)/PYR1-like (PYL)/Regulatory Component of Abscisic acid Receptor (RCAR) intracellular receptors promotes the formation of stable complexes with certain protein phosphatases type 2C (PP2Cs), leading to the activation of ABA signalling. The PYR/PYL/RCAR family contains 14 genes in Arabidopsis and is currently the largest plant hormone receptor family known; however, it is unclear what functional differentiation exists among receptors. Here, we identify two distinct classes of receptors, dimeric and monomeric, with different intrinsic affinities for ABA and whose differential properties are determined by the oligomeric state of their apo forms. Moreover, we find a residue in PYR1, H60, that is variable between family members and plays a key role in determining oligomeric state. In silico modelling of the ABA activation pathway reveals that monomeric receptors have a competitive advantage for binding to ABA and PP2Cs. This work illustrates how receptor oligomerization can modulate hormonal responses and more generally, the sensitivity of a ligand-dependent signalling system. Source


Mondin M.,French National Center for Scientific Research
The Journal of neuroscience : the official journal of the Society for Neuroscience | Year: 2011

The mechanisms governing the recruitment of functional glutamate receptors at nascent excitatory postsynapses following initial axon-dendrite contact remain unclear. We examined here the ability of neurexin/neuroligin adhesions to mobilize AMPA-type glutamate receptors (AMPARs) at postsynapses through a diffusion/trap process involving the scaffold molecule PSD-95. Using single nanoparticle tracking in primary rat and mouse hippocampal neurons overexpressing or lacking neuroligin-1 (Nlg1), a striking inverse correlation was found between AMPAR diffusion and Nlg1 expression level. The use of Nlg1 mutants and inhibitory RNAs against PSD-95 demonstrated that this effect depended on intact Nlg1/PSD-95 interactions. Furthermore, functional AMPARs were recruited within 1 h at nascent Nlg1/PSD-95 clusters assembled by neurexin-1β multimers, a process requiring AMPAR membrane diffusion. Triggering novel neurexin/neuroligin adhesions also caused a depletion of PSD-95 from native synapses and a drop in AMPAR miniature EPSCs, indicating a competitive mechanism. Finally, both AMPAR level at synapses and AMPAR-dependent synaptic transmission were diminished in hippocampal slices from newborn Nlg1 knock-out mice, confirming an important role of Nlg1 in driving AMPARs to nascent synapses. Together, these data reveal a mechanism by which membrane-diffusing AMPARs can be rapidly trapped at PSD-95 scaffolds assembled at nascent neurexin/neuroligin adhesions, in competition with existing synapses. Source


Patent
University of Franche Comte and French National Center for Scientific Research | Date: 2012-10-05

A piezoelectric and ferroelectric bulk wave transducer operating at a predetermined frequency includes a block of substrate, having a first thickness and in a first material, and a piezoelectric and ferroelectric transduction plate, having a length, a width and a second thickness, and in a second piezoelectric material, first and second metal electrodes covering the plate in the direction of the length thereof. The plate has first and second ferroelectric domains with alternating polarizations, distributed along the length of the plate according to a periodic pattern of pitch. The plate is attached perpendicularly to the block so that the width of the plate and the first thickness of the block are the same direction. The first and second material, the first thickness of the block, the length, the width, the second thickness, the pitch of the plate are configured for generating and trapping bulk waves at the operating frequency of the transducer, guided between both electrodes.


Patent
Deinove, French National Center for Scientific Research and Montpellier University | Date: 2015-10-16

The present invention relates to composition and methods of producing bioenergy. More specifically, the invention relates to the use of bacterium of the genus


Patent
Viessmann Faulquemont, French National Center for Scientific Research and University of Lorraine | Date: 2014-03-13

The invention concerns a multilayer material comprising at least: Application to the production of thermal solar panels having a low stagnation temperature and high performance.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2014-05-15

The invention relates to a matrix device for measuring characteristics of an X-ray beam. The device includes a first set of detection cells of a size different from the cells of at least one second set of detection cells. Each cell corresponds to an ionization chamber including a detection electrode. The detection electrodes of all the cells have the same effective surface for collecting charges.


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2014-04-28

This invention relates to a two-dimensional detection system for neutron radiation comprising a means (


Patent
Silmach Inc., University of Franche Comte and French National Center for Scientific Research | Date: 2013-11-26

The subject matter here is an actuation device (


Patent
Électricité de France and French National Center for Scientific Research | Date: 2014-08-07

The invention relates to the use of a ceramic of formula Ba


A method is provided for inserting a digital watermark in an image by an insertion device. Inserting includes: applying a Fourier transform to the image, delivering a 2D Fourier spectrum; inserting the watermark in the Fourier spectrum delivering a modified Fourier spectrum; and applying an inverse Fourier transform to the modified Fourier spectrum delivering a watermarked image. The watermark includes a set of watermarking coefficients each associated with a distinct determined position of a given quadrant among the quadrants of the Fourier domain, the spectral coordinates u and v of which, measured along the two axes of coordinates of the given quadrant and starting from the continuous component and expressed in percentage of the dimensions U and V of the given quadrant, are such that: u>66%U and v>66%V. The set of positions associated with the watermarking coefficients defines a convex pattern in the given quadrant.


Patent
French National Center for Scientific Research | Date: 2012-08-24

The invention relates to a method for the isomerisation of glucose into fructose in water in the presence of a solid base catalyst characterised by its reversibility of CO


Patent
French National Center for Scientific Research | Date: 2014-03-25

According to one aspect, the invention relates to a device for detecting a resonant non-linear optical signal of Stimulated Raman Scattering (SRS) type induced in a sample. The device comprises electro-optical means for making interact in the sample, at a first modulation frequency, trains of light pulses of angular frequencies


Patent
French National Center for Scientific Research, University of Paris Descartes, French Institute of Health and Medical Research | Date: 2014-04-18

The present Inventors demonstrated that the RelB subunit of NFB plays a crucial role in promoting cell migration. More precisely, they identified that this pro-migratory activity is mediated by the activation of the NFB pathway through RelB phosphorylation at serine 472. In a first aspect, the present invention proposes to monitor the activation of the NFB pathway by following the phosphorylation status of said serine. Also, the present invention discloses methods and kits for prognosing the evolution of a disease involving cell migration in a subjecttreated or notsuffering thereof, based on the detection of said RelB-S472 phosphorylation.


Patent
French National Center for Scientific Research | Date: 2012-09-27

The invention relates to novel peptidase substrates of formula (I): wherein R0, R1, R2, R3, R4, R5 and n are as defined in claim 1, and a method for detecting the presence of a catalytically active peptidase, by means of one of these substrates.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2014-02-12

The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.


Patent
University of Paris 13 and French National Center for Scientific Research | Date: 2014-10-28

The invention relates to a cyclic peptide increasing the fusiogenic capacity of the oocyte arising from the disintegrin loop of fertilin beta, to a pharmaceutical composition comprising said cyclic peptide and to the use thereof, particularly in order to supplement culture media used to carry out in vitro fertilization.


Patent
Dna Therapeutics, Institute Curie and French National Center for Scientific Research | Date: 2015-10-27

The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules facilitating endocytosis, in particular for use in the treatment of cancer.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2013-07-10

The disclosure includes a glow-discharge lamp including: an elongate casing transparent to illuminating radiation and containing a plasma gas; a device for applying an electric field for maintaining a plasma in the so-called positive column region of the casing, the device including two electrodes forming an anode and a cathode located in the casing at each end thereof; and a radio-frequency or microwave cathode plasma source arranged in the casing in relation to the cathode-forming electrode, such as to generate a high-frequency discharge located on the surface of the electrode in order to generate the plasma. The disclosure also includes a lighting method of such a glow-discharge lamp.


Patent
Vivatech, French National Center for Scientific Research, University Paris Diderot and Mohammed V University | Date: 2013-03-29

The present invention relates to a method and kit for the classification and prognosis of wounds of mammalian, in particular in human. The method defines a molecular signature that enables one to characterize a pathological wound healing such as chronic or non-healing wound.


Patent
French Atomic Energy Commission, Institute Curie and French National Center for Scientific Research | Date: 2013-10-18

The present invention concerns a new family of 2,3-dihydroquinazolin-4(1H)-one compounds of general formula (I), and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as ricin or Shiga toxin, for example, using retrograde transport to intoxicate cells.


Patent
University Pierre, Marie Curie, French National Center for Scientific Research and Koelis | Date: 2012-09-28

The invention relates to a device for guiding a medical instrument (


Patent
University of Franche Comte and French National Center for Scientific Research | Date: 2012-05-15

The present invention relates to electronic power converter suitable, in a first mode, for receiving electrical voltage and/or current magnitudes from a first device as input, for processing them using processing means capable of measuring said electrical magnitudes and servocontrolling said electrical magnitudes based on said measurements and constraints specific to a second device, and for providing the adapted voltage and/or current magnitudes to said second device.


Patent
University Paul Sabatier, Ecole Superieure Des Beaux Arts De La Reunion, Institute National Des Science Appliquees Of Toulous and French National Center for Scientific Research | Date: 2012-03-07

A colloidal dispersion of a metal chalcogenide material in divided state in an aqueous liquid phase selected from the group consisting of aqueous solutions and solutions including a mixture of water and at least one solvent that is miscible with water, wherein the carbon element of the material is present in a proportion of less than 2.5 wt. % as determined by elemental analysis, the concentration of the material in the colloidal dispersion is more than 40 g/l, and the colloidal dispersion has a charge potential value which is negative and the absolute value of which is higher than 20 mV.


Patent
French National Center for Scientific Research, Aix - Marseille University and Assistance Publique Des Hopitaux De Marseille | Date: 2013-12-30

The present invention relates to a method of assessing proprioceptive status by calculating a proprioceptive score Sp from absolute and variable errors between target angles and angles estimated and joint motion detection by the person tested, and/or between measured time of perceived movement of the joint of the tested person these proprioceptive scores of a person being associated with an assessment date and then stored with a date so as to serve as a reference when said person is monitored or when there is a comparison of said person with at least another person. The present invention also concerns an apparatus for the proprioceptive assessment of at least one joint, this apparatus having two movable parts (


Patent
French National Center for Scientific Research, Montpellier University and Montpellier SupAgro | Date: 2013-06-06

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-06-27

The present invention relates to a method for determining the presence or absence of a microorganism, said method including the steps of: 1) providing an enclosure containing a liquid or semi-solid phase consisting of a biological medium capable of containing a living form of said microorganism, nutritional elements, and an enzymatic substrate which is specific to said microorganism and which can be metabolised into at least one VOC metabolite, and a gaseous phase adjacent to said liquid or semi-solid phase; 2) exposing at least said liquid or semi-solid phase to conditions that are propitious for said microorganism to metabolise said enzymatic substrate into a molecule of said VOC metabolite; and 3) determining, by optical transduction, the presence or absence of said VOC metabolite, characterised in that the latter interacts with a nanoporous matrix, said matrix being implemented in a form that is separate from said enzymatic substrate, and in that the detection, by optical transduction, of a change in the optical properties of said matrix indicates an interaction of said matrix with said metabolite.


Patent
Institute Curie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2014-09-05

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein:


Patent
Rhodia and French National Center for Scientific Research | Date: 2013-12-20

The present invention concerns a process to obtain primary, secondary or tertiary amines, via a direct amination reaction of alcohols in presence of bis(perfluoroalkylsulfonimide) acid or salts thereof catalysts, and derivatives.


Patent
Aix - Marseille University and French National Center for Scientific Research | Date: 2012-10-26

The invention relates to a method for the decontamination of contaminated liquid, as well as a reactor for implementing a decontamination method. The method comprises a step of mixing the contaminated liquid under stirring with at least one persulphate ion with the exception of ammonium persulphate, and at least iron, an iron atom or an iron ion in its ferrous or ferric form at a concentration between 50 M and 600 M, preferably between 100 M and 400 M, a second step in which the mixture obtained is subjected for a sufficient time to at least one UV/visible irradiation having a narrow wavelength spectrum comprised between 153 nm and 560 nm.


Patent
French National Center for Scientific Research | Date: 2012-12-21

The invention relates to a method for improving the mechanical strength of a ceramic matrix composite material of the SiC/SiC type, this composite material being obtained by (a) forming a fiber preform from 3


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2012-12-19

The invention relates to a miniature linear vibrotactile actuator comprising: a first element


Patent
University of Lorraine and French National Center for Scientific Research | Date: 2013-06-13

The method for obtaining a nano-capsule structure includes at least one layer of resin deposited on a layer of substrate. The capsule nanometric in size is capable of enabling the encapsulation of a compound. The layer of resin is structured, by low voltage electron lithography, or by optical lithography or by nanoimprinting in such a way as to obtain at least one cavity in the thickness of the layer of resin. The cavity has a depth smaller than the thickness of the layer of resin. At least one layer of an encapsulating material is isotropically deposited by sputtering the material under vacuum. The cavity is sealed with a sealing material. The layer of resin is dissolved by soaking in a suitable solvent.


Patent
French National Center for Scientific Research | Date: 2013-06-26

A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I).


Patent
Lille University of Science, Technology and French National Center for Scientific Research | Date: 2012-04-25

An intervertebral disc prosthesis comprises a structure having a rigid upper plate, a rigid lower plate, and a core inserted between said plates, the structure being made from thermoplastic material, the core further comprising a thermoplastic monomaterial having graduated elastic and damping properties. According to one alternative, the core is composed of an elastomeric central nucleus surrounded by one or more rings which are referred to as rings having ranks j relative to the core, and which are more rigid.


Patent
French National Center for Scientific Research | Date: 2013-07-12

A micromagnetometry system for detecting the presence of very small quantities of magnetic particles comprises a first magnetic hybrid AMR/PHR multi-ring sensor using a Wheastone bridge electrical configuration, a first current source, a first voltage measurement device, a set of at least one magnetic particles deposited on the first magnetic sensor and a processing unit for detecting from a set of different measured differential voltages a magnetic flux shift representative of the presence of a least one deposited magnetic particle. The micromagnetometry system comprises means for creating a magnetic excitation field H


Patent
French National Center for Scientific Research and University of Rennes 1 | Date: 2014-01-15

This deals with a luminescent salt comprising a metal cluster anion and an organic cation, wherein the metal cluster anion comprises a metal cluster with at least two metal atoms, and ligands, the metal atoms being chosen from the group consisting of molybdenum, rhenium, tungsten, thallium, niobium, and mixtures thereof, wherein the organic cation comprises a cationic head substituted by at least one substituent including a polymerisable functional group. It also deals with a polymeric material comprising a polymer matrix which has polymerised with this luminescent salt.


Patent
Montpellier University and French National Center for Scientific Research | Date: 2013-12-06

Disclosed are specific antibodies against the protein Trio, their method of production, and their use in in vitro cancer prognostic method. Also described are the antigens enabling production of the antibodies.


Patent
French Atomic Energy Commission, French National Center for Scientific Research and Institute Curie | Date: 2013-11-19

The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.


Patent
Lafarge, National Polytechnic Institute of Toulouse and French National Center for Scientific Research | Date: 2012-05-11

A process for decarbonation of particles of raw meal, to be burnt in a clinkering kiln at a cement plant, the process includes: a) decarbonation of particles of raw meal, in a fluidised bed heat exchanger, the particles being suspended in a rising carrier gas including carbon dioxide, the fluidised bed heat exchanger having a solid heat carrier circulating counter-current relative to the carrier gas, to provide an effluent gas including carbon dioxide and decarbonated raw meal; b) separating the effluent gas and the decarbonated raw meal c) separating the effluent gas into a first and second part; cooling the first part of the effluent gas and recycling to provide carrier gas, d) isolating the second part of effluent gas e) recovering and re-heating the heat carrier and recirculating to step (a).


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2012-06-28

A method for turning off routers, operating according to a link-state protocol, in a communications network, said network linking a plurality of devices, said method being executed simultaneously over a plurality of routers of the network, includes: a step of initializing; a step of monitoring verifying a list of predefined conditions to be met to allow the turning off of the router; a step of waiting; a step of turning off, including the transmission of a message destined for other routers executing said method to signal the turning off of said router to them; the waiting step being carried out before the turning-off step, the turning-off step being carried out only if no turning-off message originating from other routers is received during the waiting step, if a turning-off message coming from other routers is received during the waiting step then the return to the monitoring step.


Patent
French National Center for Scientific Research and Montpellier University | Date: 2014-12-18

The present application relates to polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of Primate T-cell leukemia virus (PTLV), or fragments or variants thereof named receptor binding domain ligands (RBD) selected for their ability to bind specifically to the nutrient transporter GLUT1.


Patent
French National Center for Scientific Research and University Paul Sabatier | Date: 2013-09-20

A method for preparing a composition including silicate mineral particles that have colouring properties in which a talcose composition, including phyllosilicate mineral particles chosen from the group formed: from the particles having the chemical formula: ((Si


The invention relates to a method for labelling at least one material comprising an organic or inorganic, solid or liquid matrix, comprising at least one step consisting in incorporating therein, during the manufacturing thereof, at least one compound based on at least one luminescent rare earth element according to a concentration which makes this compound detectable under UV irradiation in said material. According to the invention, said compound comprises at least one hexanuclear complex corresponding to formula (I): [Ln


Patent
French National Center for Scientific Research | Date: 2014-01-24

The invention relates to a method for the production of a light-emitting diode, characterised in that the method comprises a step of preparing a light-emitting layer (


Patent
French National Center for Scientific Research | Date: 2014-02-28

The present invention relates to novel vitroceramic or lens compositions that are nanostructured and transparent or translucent, including at least 97%, such as 97% to 100%, preferably 99% to 100%, by weight, relative to the total weight of the material, of a composition having the following formula I: (GeO


Patent
University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2012-09-26

The invention relates to a method for determining a predictive function for discriminating patients according to their disease activity status, comprising steps of: ameasuring values of biological markers for each patient of a first group of patients having a first known disease activity status, and for each patient of a second group of patients having a second known disease activity status, the measured values forming a dataset banalyzing the dataset for identifying biological markers which are differentially expressed between the first group of patients and the second group of patients, camong the biological markers identified at step b, determining correlated markers as markers which are correlated with other markers above a predetermined significance level, dremoving from the dataset, values measured for a biological marker identified as correlated marker, eanalyzing the dataset obtained at step d for determining a predictive function that predicts a disease activity status of a patient as a combination of values of biological markers, fevaluating an accuracy index associated with the predictive function determined at step e, grepeating steps d to f by selectively removing from the dataset, values measured for one or several biological marker(s) identified as correlated marker(s), so as to gradually decrease the number of biological markers in the combination of value until the accuracy index reaches an expected level.


Patent
Idenix Pharmaceuticals, Luniversite Montpellier Ii, French National Center for Scientific Research and University of Cagliari | Date: 2014-01-02

2 and/or 3 prodrugs of 1, 2, 3 or 4-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.


Patent
University Pierre, Marie Curie, French National Center for Scientific Research and Ariel University | Date: 2013-07-10

A method is provided for inspecting a zone, termed the zone of interest, whose characteristics are known at least partially, to detect at least one element included in the zone of interest, the method including: a first detection providing, through a time reversal method, a first signal relating to the position of the element for a first emission point, and at least one second detection providing, through a time reversal method, at least one second signal relating to the position of the element for a second emission point different from the first emission point. The method furthermore includes a multiplication of the first detection signal with the second detection signal to provide a third detection signal which is more accurate than the first and the second detection signal. A system implementing this method is also provided.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2013-02-07

The present invention relates to a method for preparing three-dimensional actin structures having a well-defined shape and displaying improved mechanical rigidity. This method comprises the steps of (a) providing a polymerization solution comprising actin monomers, a branching agent and a capping agent, (b) providing at least one surface having thereon a pattern which is coated with a nucleating agent, and (c) contacting the at least one surface of step (b) with the polymerization solution of step (a) so as to induce the polymerization of actin and obtain the said desired three-dimensional actin structure. Applications of the present invention in various technological fields such as microelectronics are also provided.


Patent
French National Center for Scientific Research, Institute Regional Du Cancer Of Montpellier and Montpellier University | Date: 2013-02-26

The present invention relates to an association of poly (N-acryloyl glycinamide) with at least one active principle and/or at least one product which is visible in medical imaging, in a physiologically acceptable aqueous medium.


Patent
French Atomic Energy Commission, French National Center for Scientific Research and National Graduate School of Chemistry, Montpellier | Date: 2011-02-02

The invention relates to a fluorocarbon polymer material comprising a backbone with the following unit: wherein: m is an integer comprised between 0 and 10, preferably between 0 and 3;


Patent
University of Lyon, Nano H, French National Center for Scientific Research and Joseph Fourier University | Date: 2013-04-12

The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.


Patent
Viroxis S.A.S., Institute Gustave Roussy, University Paris - Sud and French National Center for Scientific Research | Date: 2012-12-07

A pharmaceutical composition includes, as active substance a mutated lentiviral ENV protein, substantially devoid of immunosuppressive properties or a variant of the mutated lentiviral ENV protein or a fragment of the above proteins, in association with a pharmaceutically acceptable carrier.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2013-10-04

The invention concerns a multi-view imaging system for laparoscopic surgery comprising: A tubular member; A first imaging device having a longitudinal body and an active end for acquiring images, intended to be inserted through the tubular member, and movable in the tubular member in translation along the longitudinal axis and/or in rotation about the longitudinal axis; A second imaging device comprising at least two cameras each mounted on a support member and movable relative to the tubular member between: a stowed position in which the cameras are positioned inside the tubular member, and a deployed position in which the cameras are positioned outside the tubular member at the distal end, the cameras being arranged on either side of the longitudinal axis of the tubular member and being held secure relative to the tubular member by holding means, so as to follow any movement of the tubular member.


Patent
Soitec, Ommic and French National Center for Scientific Research | Date: 2012-06-28

The invention relates to a method for manufacturing, by means of epitaxy, a monocrystalline layer of GaN on a substrate, wherein the coefficient of thermal expansion is less than the coefficient of thermal expansion of GaN, comprising the following steps: (b) three-dimensional epitaxial growth of a layer of GaN relaxed at the epitaxial temperature, (c1) growth of an intermediate layer of B


Patent
French National Center for Scientific Research and Umicore AG | Date: 2011-10-06

The invention relates to crystalline nanometric olivine-type LiFe


Patent
French National Center for Scientific Research and Montpellier University | Date: 2013-02-19

An inclinometer for measuring a change in the inclination of a structure from a given initial position. The inclinometer comprises a frame, a pendulum and at least three distance-measuring device. The frame is rigidly connected to the structure such that the inclination of the frame has the same changes in inclination as the structure. The pendulum is freely suspended from the frame and comprises a first end attached to the frame and a freely moving opposite end. The distance-measuring devices at the frame have respective coplanar measuring axes converging at a single point. Each measuring device measures a change in the distance separating same from the pendulum.


Patent
French National Center for Scientific Research | Date: 2014-01-15

The present invention relates to methods for verifying the integrity of data blocks and for accessing the blocks and relates more particularly to a method for verifying the integrity of a digital data block, the method comprising steps of: searching for a digital fingerprint in a data block of a reference point, calculating a digital fingerprint by applying a fingerprint calculation function to the data block, the fingerprint calculated having a value which depends on each of the bits of the data block excluding the bits of a fingerprint found in the data block, and verifying the fingerprint found in the data block by comparing it with the fingerprint calculated.


Patent
French National Center for Scientific Research, University Paris Diderot, Ecole Normale Superieure de Lyon, University Pierre and Marie Curie | Date: 2012-03-21

This method comprises bringing drops to be separated into contact with an interface (


Patent
French National Center for Scientific Research, University of Versailles and Électricité de France | Date: 2011-02-07

The invention relates to a method for determining the maximum open circuit voltage and the power that can be output by a photoconverter material subject to a measurement light intensity, the method including the following steps: measuring the photoluminescent intensity of the material, measuring the absorption rate of the photoconverter material at a second wavelength substantially equal to the photoluminescent wavelength of the photoconverter material, determining the maximum open circuit voltage of the photoconverter material with the measurement light intensity by means of the absorption rate and the photoluminescent intensity measured at substantially the same wavelength; said invention being characterised in that the light source and the photoconverter material are arranged such that the angular distributions of the rays incident on and emitted by the lit surface of the material and collected by the detector are substantially identical.


Patent
University of Burgundy and French National Center for Scientific Research | Date: 2011-06-24

The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.


Patent
L'Oréal, French National Center for Scientific Research and Institute Curie | Date: 2011-02-28

The present invention concerns various compositions comprising the essential oil of


Patent
French Institute of Health, Medical Research, University of Strasbourg and French National Center for Scientific Research | Date: 2012-11-22

The present invention relates to agent selected from the group consisting of an anti-S100B antibody, an anti-S100B aptamer or an inhibitor of S100B gene expression for use in a method for reducing airway hyperresponse in a subject in need thereof. The present invention also relates to a method for determining whether a subject is at risk of having or developing an airway hyperresonse comprising determining the level of S100B protein in a biological sample obtained from said subject.


Patent
Center Leon Berard, University Claude Bernard Lyon 1, Hospices Civils De Lyon, French Institute of Health, Medical Research and French National Center for Scientific Research | Date: 2012-12-17

A method for selecting in vitro compounds is capable of potentiating the effect of a DNA damage inducing chemotherapy agent for the treatment of cancer, and includes selecting compounds inhibiting the interaction between MyD88 and ERK MAP KINASE.


Patent
Bayer Sas, French National Center for Scientific Research and French National Institute for Agricultural Research | Date: 2011-07-28

The present invention relates to synthetic compounds that are active on plants, especially as legume nodulation factors, and also as plant growth stimulators, and to methods for preparing such compounds, which are of formula (I).


Patent
National Graduate School of Chemistry, Rennes and French National Center for Scientific Research | Date: 2013-04-19

A process for enzymatically converting a furanoside substrate in a product of interest, includes contacting the substrate with an enzyme in presence of an alcohol acceptor, wherein the enzyme is preferably Araf51, and wherein the product is preferably an alkyl furanoside. The mutant Araf51 enzyme showing improved transglycosylation activity in comparison with the native wild-type (wt) Araf51 enzyme, and a method for screening the mutants are also described.


Patent
Arkema, Montpellier University and French National Center for Scientific Research | Date: 2014-03-27

The subject matter of the invention is a copolymer obtained by free-radical copolymerization of vinylidene fluoride with trifluoroethylene and of at least a third monomer, the third monomer having a molar mass greater than 0 g/mol and corresponding to the formula: in which R


Patent
French Institute of Health, Medical Research, Linstitut Paoli Calmette, Aix - Marseille University and French National Center for Scientific Research | Date: 2012-10-04

The present invention relates to compounds of formula (I), wherein R


Patent
French National Center for Scientific Research | Date: 2013-10-15

Cork stoppers are treated by subjecting the cork to an electrochemical dehalogenation by electrolysis.


Patent
University of Lorraine, Imerys and French National Center for Scientific Research | Date: 2011-01-06

A flotation process for recovering feldspar from a feldspar containing feed material, comprising the following steps: (1) forming an aqueous suspension of a feldspar containing feed material, in the absence of hydrofluoric acid, wherein the suspension comprises from 0.004 to 0.3% wt. of a flotation reagent comprising: (a) one or more amines, containing at least one aliphatic hydrocarbon chain, linear or branched, saturated or unsaturated, comprising 8 to 50 carbon atoms, or a salt thereof; and (b) one or more primary, secondary or tertiary alcohols, containing at least one aliphatic hydrocarbon chain, linear or branched, saturated or unsaturated, comprising 8 to 50 carbon atoms; the ratio of (a) to (b) ranging from 500:1 to 1:40 by weight; (2) agitating the obtained suspension to produce a feldspar containing fraction, and (3) separating the feldspar containing fraction.


Patent
French Atomic Energy Commission, Lille University of Science, Technology and French National Center for Scientific Research | Date: 2013-03-05

A device for converting transverse spatial profile of intensity of a light beam, using a microstructured optical fiber. Transverse dimensions of the fiber vary longitudinally and both its ends have opto-geometrical parameters such that at the wavelength of the beam the fiber has a fundamental mode having two different profile shapes at its two ends. Thus by introducing the beam with one of the profiles through one of the two ends, the beam emerges through the other end with the other profile, whose shape is different from that of the profile of the introduced beam.


Patent
French National Center for Scientific Research | Date: 2013-11-15

The invention relates to a digital holography method for detecting the vibration amplitude of an object (


Z

Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-09-12

The transistor comprises first and second source/drain electrodes formed in a semiconductor film by N-doped and P-doped areas, respectively. A polarization voltage is applied between the two source/drain electrodes in order to impose to the P-doped electrode a potential higher than that of the N-doped electrode. The transistor comprises first and second devices for generating a potential barrier in the semiconductor film. The two potential barriers are opposed to the passage of the charge carriers emitted by the first and second source/drain electrodes, respectively. The two potential barriers are shifted with respect to an axis connecting the two source/drain electrodes. The two devices for generating a potential barrier are configured to generate a potential barrier having a variable amplitude and it are electrically connected to the gate and to the counter electrode.


Patent
Societe Nationale Des Chemins De Fer Francais Sncf, Montpellier University, University Blaise Pascal and French National Center for Scientific Research | Date: 2013-10-28

The method for evaluating the compactness of a layer of railroad ballast near a railroad tie includes at least one step of taking at least two measurements ( Also provided are a device for implementing such a method and a method for predicting the settlement of the ballast of a railroad track including a step of evaluating the compactness of a ballast near a railroad tie.


Patent
French Institute of Health, Medical Research, Nantes University Hospital Center, University of Nantes, French National Center for Scientific Research and University of Angers | Date: 2013-05-14

The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.


Patent
French National Center for Scientific Research and Ecole Normale Superieure de Cachan | Date: 2012-11-02

The present invention relates to a human mast cell line corresponding to deposit number CNCM I-4551 and also to the lines derived therefrom, in particular the derived lines corresponding respectively to deposit numbers CNCM I-4552 and CNCM I-4553, and to the uses thereof, in particular for screening for compounds of therapeutic interest.


Patent
French National Center for Scientific Research, University of Angers and Wroclaw University of Technology | Date: 2013-10-23

A method for assessing turbulence parameters of a medium comprises the following steps: the illumination, by a laser beam being propagated in said medium, of a film of photochromic organic material that can comprise molecules of azobenzene, or of spyropyrane, or of stilbene, or of coumarin, or of fulgide, said illumination creating a surface grating in said film comprising scratches, the deformations of which are a function of the turbulence parameters; a step of acquisition of images comprising individual areas of structures linked to said scratches, more or less reduced and representative of the turbulence parameters of said medium; a step of processing of said images that makes it possible to assess the turbulence parameters of said medium. A device is also provided.


Patent
Solvay Group and French National Center for Scientific Research | Date: 2013-04-22

The invention pertains to a process for manufacturing a fluoropolynner film comprising a fluoropolymer hybrid organic/inorganic composite, said process comprising the following steps: (i) providing a mixture of:at least one fluoropolymer [polymer (F)];at least one metal compound [compound (M)] having formula: X


Patent
Céramiques Techniques Industrielles, French National Center for Scientific Research and Montpellier University | Date: 2013-09-26

A supported membrane is provided comprising an inorganic, solid porous filtration membrane supported by an inorganic, solid porous support, said supported membrane comprising nanoparticles of a metal coordination polymer with CN ligands comprising M


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2013-05-22

A method for producing a film including a non-magnetic matrix and a plurality of three-dimensional magnetic microstructures arranged within the matrix according to a predetermined pattern. The method includes providing a master substrate with a magnetically structured face formed from a plurality of magnetic field micro-sources, having a magnetic field gradient of between 10


Patent
Clariant and French National Center for Scientific Research | Date: 2014-01-03

A process for preparing an at least partially lithiated transition metal oxyanion-based lithium-ion reversible electrode material, which includes providing a precursor of said lithium-ion reversible electrode material, heating said precursor, melting same at a temperature sufficient to produce a melt including an oxyanion containing liquid phase, cooling said melt under conditions to induce solidification thereof and obtain a solid electrode that is capable of reversible lithium ion deinsertion/insertion cycles for use in a lithium battery. Also, lithiated or partially lithiated oxyanion-based-lithium-ion reversible electrode materials obtained by the aforesaid process.


Patent
French National Center for Scientific Research and University of Liverpool | Date: 2011-09-13

A structure for bending transversal elastic waves around a zone to isolate of a plate, has an anisotropic Youngs modulus and/or a heterogeneous mass density. The wavelengths of the elastic waves to bend are large with respect to the thickness of the plate and small with respect to the other dimensions of the plate. The structure is made by defining a meshing of a peripheral zone surrounding the zone to isolate; dividing the peripheral zone into several elementary rings and several elementary angular sectors; and forming, in each mesh delimited by an elementary angular sector and an elementary ring, a structural element in a material having a Youngs modulus and/or a mass density different than those of the material forming the plate, the dimensions of the meshes and of the structural elements in the plane of the plate being less than half the wavelengths of the elastic waves to bend.


Patent
Institute Pasteur Paris, University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2012-10-11

The application provides products, which may trigger pro-apoptotic or pro-death effects on neoplastic cells and/or tissues of the human nervous system, more particularly on neoplastic cells and/or tissues of the human CNS. The products of the application can be used as anti-proliferative or tumoricid agents in the treatment and/or palliation and/or prevention of neoplasms of the human nervous system, more particularly of glioblastoma or brain stem glioma. Therefore, the application also relates to compositions, such as pharmaceutical compositions or drugs, which comprise at least one of said products, as well as to the biotechnological and medical applications of said products and compositions.


Patent
French National Center for Scientific Research and University of Granada | Date: 2012-10-04

A memory cell formed of a semiconductor nanorod having its ends heavily doped to form source and drain regions and having its central portion comprising, between the source and drain regions, an N-type region surrounded on a majority of its periphery with a quasi-intrinsic P-type region, and wherein the P-type region itself is surrounded with an insulated gate.


Patent
French National Center for Scientific Research and Lille University Hospital Center | Date: 2013-02-06

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.


Patent
French National Center for Scientific Research and Idenix Pharmaceuticals | Date: 2014-02-14

Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.


The invention relates to a method which comprises emitting ultrasound into a liquid mixture containing first and second reagents in separate phases initially separated by a liquid precursor-gas barrier, the ultrasound having a high enough energy level to vaporise the precursor gas, such as to contact the reagents and thus to activate a chemical reaction therebetween.


Patent
French National Center for Scientific Research | Date: 2013-03-14

A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: -m 1=1, 2, 3, 4, 5 or 6; -m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative. Formula (I)


Patent
French National Center for Scientific Research, University of Strasbourg, French Institute of Health and Medical Research | Date: 2013-03-14

The present invention relates to methods and devices for observing eukaryotic cells devoid of cell wall, in particular for observing the cytokinetic ring, the device comprising a plurality of wells suitable for containing only one single eukaryotic cell and characterized in that the dimensions of the wells constrain the cells into an oblong shape with a long axis parallel to the depth of the wells.


Patent
Labinal Power Systems and French National Center for Scientific Research | Date: 2013-11-26

A DC-DC voltage converter including a main switch formed by a normally ON switch element connected in series with a normally OFF switch element including a control circuit, a load in series with the main switch, the main switch and the load being configured to be connected to terminals of a DC voltage source. A voltage source, that can be used for controlling is obtained by connecting a main peak detector circuit to the mid-point of the main switch. The control circuit of the normally OFF switch element can be supplied with the DC voltage that makes the entire device self-supplied. Such a converter can, for example, find application in aeronautics.


Patent
École Centrale Lille and French National Center for Scientific Research | Date: 2012-07-12

The invention relates to a miniaturised sensor having a heating element, and to an associated production method. The sensor includes a substrate, a cavity and a heat-insulating structure suspended above the cavity by areas connecting to the substrate. The heat-insulating structure includes at least two bridges extending above the cavity, the heating element being supported by said bridges, extending transversely thereto.


Patent
Thales Alenia, French National Center for Scientific Research and University Paris - Sud | Date: 2013-07-19

The invention relates to a device (


Patent
French National Center for Scientific Research | Date: 2012-07-19

A method of processing data for comparing at least two images using data processing elements, includes extracting a first sample of coordinate values (X


Patent
French Institute for Research in Computer Science, Automation, French Natural History Museum and French National Center for Scientific Research | Date: 2012-06-11

The invention relates to a method for generating control commands for coordinating displacement members of a moving platform, so as to make said moving platform progress between an initial speed and a final speed according to at least two locomotive situations. The method of the invention is characterized in that each locomotive situation is associated with an elementary module corresponding thereto for generating commands for controlling coordination between a predetermined module start speed and a predetermined module end speed, and in that domains of application of these elementary modules are represented in the form of a predetermined charts for concatenating adjoining modules, covering at least partially, by juxtaposition of their start and end speeds, the spectrum of possible initial and final speeds of displacement of the platform, so as to allow determination of a series of elementary modules to be concatenated to pass from the initial speed to the final speed and the concatenation of the modules of this series so as to derive therefrom a series of corresponding control commands for the displacement members of the moving platform.


Patent
Montpellier University and French National Center for Scientific Research | Date: 2012-01-19

The invention concerns a memory device comprising at least one memory cell comprising: a first transistor (


Patent
Montpellier University and French National Center for Scientific Research | Date: 2012-01-19

The invention concerns a memory device comprising at least one memory cell comprising: a first transistor (


Patent
French National Center for Scientific Research and Montpellier University | Date: 2012-04-19

A laser device for emitting waves in a frequency range belonging to the terahertz range, includes the following, in combination: a wave guide extending longitudinally along an axis A-A; a superconducting coil arranged coaxially to the wave guide and arranged at a first end of the wave guide; a p-Ge p-doped germanium crystal arranged inside the coil such that the turns of the superconducting coil at least partially surround the p-Ge crystal; a cooling device containing a coolant, the superconducting coil and the p-Ge crystal being arranged in the cooling device, and the wave guide partially extending outside the cooling device; and removing the coolant from the wave guide.


Patent
University of Bordeaux Segalen and French National Center for Scientific Research | Date: 2012-11-15

Antibodies for molecular imaging of vulnerable plaques in atherosclerosis Antibody specifically binding to atherosclerosis lesions for in vivo imaging and methods for in vivo imaging of atherosclerosis lesions in a patient.


Patent
Regentis International, University of Reims Champagne Ardenne and French National Center for Scientific Research | Date: 2013-01-31

The bifunctional peptide is capable of activating collagen synthesis and inhibiting the production of matrix metallo-proteinases. The peptide has a sequence including three peptide parts A, B and C. The first peptide part A corresponds to a hexapeptide repeated at least three times, the part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis. The second peptide part B corresponds to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease. The third peptide part C corresponds to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to enable inhibition of the proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2012-11-23

The invention relates to a method for coating, by means of a chemical vapour deposition (CVD) technique, a part with a coating (PAO) for protecting against oxidation. The method enables the preparation of a refractory coating for protecting against oxidation, having a three-dimensional microstructure, which ensures the protection against oxidation at a high temperature, generally at a temperature above 1200 C., for materials that are sensitive to oxidation, such as composite materials, and in particular carbon/carbon composite materials.


Patent
Syntivia, French National Center for Scientific Research and University Paul Sabatier | Date: 2012-12-14

The use of a compound of general formula (I), where: R


Patent
Arkema, University of Rennes 1 and French National Center for Scientific Research | Date: 2014-06-06

A method to synthesize a fatty nitrile/ester aldehyde comprising the following steps:


Patent
University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2012-03-28

A method for employing certain cobalt complexes as electron donors and in combination with an electron acceptor is provided for preparing an active layer in a photovoltaic conversion cell, as well as to the photovoltaic conversion cell in which the electron donor of the active layer includes such cobalt complexes.


Patent
Électricité de France and French National Center for Scientific Research | Date: 2014-05-12

A method for fabricating a photosensitive device, comprising: a first step of preparing, on a substrate, at least a first photosensitive portion, active within a range of wavelengths, the first portion being surrounded by a second portion that is inactive. A material, covering the first portion, is selectively arranged into a hydrophilic layer by an electrochemical process. The second portion comprises a hydrophobic material on an upper surface opposite the substrate. The method further comprises the following steps: spraying on the upper surfaces of the first and second portions a liquid comprising a transparent material, and forming a converging lens containing the material, above the first portion.


Patent
Consejo Superior De Investigaciones Cientificas, French National Center for Scientific Research and University Paris - Sud | Date: 2013-12-23

The invention concerns an aerosol charger having electrical discharge comprising: a body (


Patent
French National Institute for Agricultural Research and French National Center for Scientific Research | Date: 2014-01-31

A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa[Tz]Xaa2-Xaa3-Xaa4-NH


Patent
Sanofi S.A., University Pierre, Marie Curie, French National Center for Scientific Research, French Institute of Health and Medical Research | Date: 2014-09-30

The present invention concerns a neuroglobin agonist for use in the treatment or prevention of a mitochondrial disease associated with respiratory chain complex I (RCCI) deficiency and/or respiratory chain complex III (RCCIII) deficiency.


Patent
Institute Pasteur Paris, French National Center for Scientific Research, University of Paris Descartes and Assistance Publique Hopitaux De Paris | Date: 2014-04-16

The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B The present invention also relates to the polypeptides encoded by said polynucleotides, as well as to antibodies directed or raised against said polypeptides. The present invention also relates to kits and methods for the specific detection of Group B


Patent
French National Center for Scientific Research, University Paris Est Creteil, University Pierre, Marie Curie, Icm Institute Du Cerveau Et Of Moelle Epiniere, Otr3 and Assistance Publique Hopitaux Paris | Date: 2012-10-15

The present invention relates to a method of diagnosis, prognostic or treatment of neurodegenerative diseases, in particular Alzheimers disease.


Patent
French National Center for Scientific Research | Date: 2012-09-14

The present invention relates in particular to proteins, coding nucleic acid sequences for same, vectors comprising said coding sequences, a method for producing said proteins, and an oligosaccharide hydrolysis method using same. In particular, the invention relates to the protein of sequence SEQ ID no. 1. The present invention can be applied to the recycling of bio-natural resources formed by organisms and microorganisms including ulvans, in particular green algae.


Patent
French National Center for Scientific Research and Biokinesis | Date: 2013-12-06

The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.


Patent
Abivax, French National Center for Scientific Research, Institute Curie and Montpellier University | Date: 2015-07-01

A compound having the following formula or a pharmaceutically acceptable salt thereof: where:


Patent
French National Center for Scientific Research | Date: 2012-10-16

Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. Kits for applying this synthesis method as well as test and/or diagnostic kits are also described.


Patent
Mitologics, French National Center for Scientific Research and University of Versailles | Date: 2014-06-05

ANT-ligands having a substituted nitrogeneous heterocycle A wherein wherein wherein wherein,


Patent
French National Center for Scientific Research | Date: 2012-09-03

The invention relates to a process which enables optimal aggregation of cells, typically of stem cells, promoting the organisation thereof and advantageously the differentiation thereof, in particular in the context of the formation of a tissue substitute. This process comprises exposing pretreated cells to a magnetic field and makes it possible to obtain large cell aggregates, even prepared in the absence of support matrix and/or of growth factor. The invention also relates to the cell aggregates that can be obtained using such a process and also to the uses thereof as tissue initiators with a view to obtaining a tissue structure of interest in vitro, ex vivo or in vivo. Moreover, it relates to the resulting tissue structures and to the uses thereof in research or in therapy as tissue substitutes. The present application also provides a method which advantageously makes it possible to monitor the development of the tissue of interest in vivo.


Patent
University Paris - Sud and French National Center for Scientific Research | Date: 2013-09-20

The invention concerns an electromagnetic absorbent comprising: a metal earth plane, an insulating dielectric substrate, disposed on said metal earth plane, a set of metal resonant elements disposed on said insulating dielectric substrate, the electromagnetic resonant frequency of a resonant element being adjusted by adapting the dimensions of the resonant element, the set of resonant elements comprising resonant elements with different dimensions so as to enable the production, by juxtaposition of different electromagnetic resonant frequencies, of a predetermined electromagnetic absorption band. An elementary pattern formed by a plurality of metal resonant elements can be replaced periodically.


Patent
Compiègne University of Technology, Ineris, Ecole Normale Superieure de Lyon and French National Center for Scientific Research | Date: 2011-05-12

The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose.


Patent
French National Center for Scientific Research | Date: 2012-09-14

The invention relates to a material composed of nanoparticles essentially comprising a spin transition compound. The compound corresponds to the formula in which L represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; X is an anion having the valency x, 1x2; Y is an anion other than X having the valency x, 1x2; R is an alkyl group or an R


Patent
Phostech Lithium Inc. and French National Center for Scientific Research | Date: 2012-09-14

A process for preparing an at least partially lithiated transition metal oxyanion-based lithium-ion reversible electrode material, which includes providing a precursor of said lithium-ion reversible electrode material, heating said precursor, melting same at a temperature sufficient to produce a melt including an oxyanion containing liquid phase, cooling said melt under conditions to induce solidification thereof and obtain a solid electrode that is capable of reversible lithium ion deinsertion/insertion cycles for use in a lithium battery. Also, lithiated or partially lithiated oxyanion-based-lithium-ion reversible electrode materials obtained by the aforesaid process.


Patent
University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2012-12-21

A computer receives asynchronous information originating from a light sensor (


Patent
French Institute of Health, Medical Research, Association Francaise Contre Les Myopathies, University of Strasbourg and French National Center for Scientific Research | Date: 2012-08-29

The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.


Patent
French National Center for Scientific Research | Date: 2012-12-05

A medical or therapeutic application of a composite material of ruthenium with a nitrosyl ligand. Application for a medical or therapeutic treatment of a composite material of ruthenium with a nitrosyl ligand irradiated in a spectral range capable of releasing the nitrosyl ligand, i.e., the ultraviolet or visible or near-infrared spectral range.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, University Paris Est Creteil and Assistance Publique Hopitaux De Paris | Date: 2012-10-04

The present invention relates to a method for screening a compound capable of inhibiting the Notch1 transcriptional activity. The present invention also relates to compounds useful in the prevention or treatment of cell proliferative diseases and disorders associated with overexpression and/or activation of Notch1.


Patent
Herakles and French National Center for Scientific Research | Date: 2012-11-22

A part made of ceramic matrix composite material has fiber reinforcement of carbon or ceramic fibers and a majority-ceramic sequenced matrix having first matrix layers made of crack-deflector material alternating with second matrix layers made of ceramic material. An interphase coating is interposed between the fibers and the matrix, and the interphase coating adheres to the fibers and to the matrix, and is formed of at least one sequence constituted by a first elementary layer made of carbon, possibly doped with boron, surmounted by a second elementary layer made of ceramic. The outer elementary interphase layer of the coating is a ceramic layer having an outer surface formed by ceramic grains of size lying essentially in the range 20 nm to 200 nm, with the presence of grains of size greater than 50 nm conferring roughness on the outer surface ensuring mechanical attachment with the adjacent matrix phase.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2015-01-30

A method and system are provided for etching a layer to be etched in a plasma etching reactor, including: forming a reactive layer by injection of at least one reactive gas to form a reactive gas plasma, which forms, together with the layer to be etched, a reactive layer which goes into the layer to be etched during etching of said layer to be etched, wherein the reactive layer reaches a steady state thickness upon completion of a determined duration of said injection; said injection being interrupted before said determined duration has elapsed so that, upon completion of the forming of the reactive layer, the thickness of the reactive layer is smaller than said steady state thickness; and removing the reactive layer by injection of at least one inert gas to form an inert gas plasma, which makes it possible to remove only the reactive layer.


Patent
French National Center for Scientific Research and University of Lyon | Date: 2014-05-05

The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions.


Patent
University of Paris Descartes, French National Center for Scientific Research, Assistance Publique Hopitaux De Paris and Institute Curie | Date: 2014-02-06

The present invention relates to a composition comprising a) a B subunit of Shiga toxin or a functional equivalent thereof which is able to bind the Gb3 receptor, complexed with an antigen and b) at least one ligand of CDl capable of stimulating NK T cells; and to a pharmaceutical composition and a medicament comprising said composition.


Patent
Chanel Parfums Beaute, French National Center for Scientific Research and University Paul Sabatier | Date: 2015-06-11

Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.


Patent
French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2014-02-21

The invention concerns a compound formed by functionalised micro- or nanoparticles covalently associated with rheology-modifying polymers. The invention is characterised in that the functionalised micro- or nanoparticles are functionalised inorganic or metal oxide micro- or nanoparticles, in particular aluminium oxide (Al


Patent
French National Center for Scientific Research and Institute Pasteur Paris | Date: 2012-03-16

The present invention relates to a method for preparing carbohydrate T cell epitope conjugates of formula (I): M(T-B)


Patent
French National Center for Scientific Research, University of Strasbourg, French Institute of Health and Medical Research | Date: 2013-03-28

The present invention relates to methods and devices for observing or studying cells having a cell wall or invertebrate embryos with an oblong eggshell, the devices comprising wells having a conical or frustoconical shape.


Patent
University of Rennes 1 and French National Center for Scientific Research | Date: 2013-04-10

The present invention relates to a fuel cell device with electrolytes flowing by means of percolation through electrodes (


Patent
Rhodia, University Claude Bernard Lyon 1, French National Center for Scientific Research and Fonds De Developpement Des Filieres Des Oleagineux Et Proteagineux Fidop | Date: 2013-07-10

The invention relates to a method for producing a compound of fonnula (I), comprising the reaction, in the presence of a catalytic system comprising a single rare earth oxide or a mixture of rare earth oxides, of an alkyl carbonate or an alkylene carbonate with a polyol of fonnula (II), wherein p is a whole number between 2 and 10.


Patent
University of Western Brittany and French National Center for Scientific Research | Date: 2013-01-09

An electromagnetic system for exploring the seabed in a marine environment includes a current injection module with two electrodes spaced apart from one another, said injection electrodes being capable of injecting a current at a predetermined voltage into the marine environment close to the seabed, said injection electrodes having a contact surface with the marine environment. The system includes a data acquisition module with at least two measuring sensors for measuring electrical or magnetic data at at least two points of the marine environment close to the seabed, and a power supply module for supplying power to the current injection module. Each electrode includes one or more separate conductive elements that are electrically connected to each other and arranged in such a way as to form a conductive network or a multilayer conductive assembly having a large contact surface with the marine environment.


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2012-05-31

The invention relates to a system comprising an oculometer for measuring movements of at least one eye of an operator, wherein it comprises furthermore a display for displaying, for the eye, a frame of at least one point performing a blinking, so that the operator can perform at least one smooth tracking movement of the eye while looking at the display while operating. The invention also relates to a method implemented on such a system, and a corresponding computer program product.


Patent
University of Strasbourg and French National Center for Scientific Research | Date: 2015-02-02

The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).


Patent
French National Center for Scientific Research, University of Versailles and University Paris - Sud | Date: 2013-05-30

The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.


Patent
Idenix Pharmaceuticals, Luniversite Montpellier Ii Umii, French National Center for Scientific Research and University of Cagliari | Date: 2013-08-02

2 and/or 3 prodrugs of 1, 2, 3 or 4-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.


Patent
French National Center for Scientific Research | Date: 2015-02-12

A method of vaccination against a viral, bacterial or non-infectious disease includes administering an effective dose of a prime vaccine and then an effective dose of a boost vaccine. Each one of the prime vaccine and the boost vaccine includes an active principle. The prime vaccine includes, as the active principle, a colloidal synthetic bioresorbable vector that includes at least one protein substance. The boost vaccine includes, as the active principle, a viral vector that includes at least one nucleotide sequence which codes for a protein substance corresponding to the at least one protein substance of the synthetic vector.


Patent
University of Lorraine and French National Center for Scientific Research | Date: 2013-08-27

A method for producing polyHIPE porous monoliths, of the polyHIPE type or in the form of a rigid foam, by hardening solutions of condensed tannins in the presence of oil and/or air or in the presence of a non-water-miscible volatile solvent and/or air. Also disclosed is the use of these materials in the areas of catalysis, chromatography, heat and sound insulation, tissue engineering and medication release and as a floral foam.


Patent
Bayer CropScience and French National Center for Scientific Research | Date: 2013-08-28

A new process for the preparation of 3,5-bis(haloalkyl)-pyrazole derivatives of the general formula (I) is described, resulting from the reaction of 3,5-bis(haloalkyl)-pyrazole-4-carboxylic acid derivatives of the general formula (Ha) with a copper compound and a base at elevated temperature


Patent
Ivs Institute Des Vaisseaux Et Du Sang and French National Center for Scientific Research | Date: 2011-06-29

A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the proliferation and migration of pericytes and smooth muscle cells. Pharmaceutical formulations containing the peptide and/or the nucleic acids can be used to treat a variety of tumoral and non-tumoral pathologies.


Patent
French National Center for Scientific Research and University of Burgundy | Date: 2013-11-13

The present invention embodiments relate to a compound with formula (V) The invention also relates in certain embodiments to the synthesis method for compound (V) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.


Patent
French National Center for Scientific Research | Date: 2012-07-10

Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.


Patent
Vib Vzw, Ghent University, French National Center for Scientific Research, Montpellier University, Montpellier University Hospital Center and University of Osnabrück | Date: 2013-01-17

This disclosure relates to a modified -helical bundle cytokine, with reduced activity via an -helical bundle cytokine receptor, wherein the -helical bundle cytokine is specifically delivered to target cells. Preferably, the -helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified -helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified -helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.


Patent
University of Reims Champagne Ardenne, Center Valorisation Glucides Prod National, French National Center for Scientific Research, Vandeputte Oleochemicals and University of Rouen | Date: 2014-04-24

The method for producing a mixture of neutral oligosaccharides extracted from flaxseed includes oligosaccharides having high molar masses generated by fractionation by ultrafiltration at a cut-off of between 15,000 and 50,000 Da and between 5,000 and 15,000 Da. The mixture of oligosaccharides produced as a result of the implementation of the method, and to the applications of the mixture can be used for skin repair and skin aging control.


Patent
Institute Curie, French National Center for Scientific Research, University Pierre, Marie Curie and University of Nice Sophia Antipolis | Date: 2013-11-29

The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques


Patent
Thales Alenia, French National Center for Scientific Research and Institute National Des Science Appliquees Of Renne | Date: 2012-09-14

A radiating phase-shifting cell is designed to favour the excitation of an equivalent resonance of the slot type in a first part of the phase cycle, and to favour an equivalent resonance of the microstrip type in a second part of the phase cycle. This property notably allows the bandwidth of the phase-shifting cells to be optimized. A phase range of 360 can in effect be segmented into two sub-ranges of around 180. This segmentation into two sub-ranges is made possible by the complementarity of the resonant modes of the slot or microstrip type. The radiating phase-shifting cell is notably applicable to reflector arrays for an antenna designed to be installed on a space craft such as a telecommunications satellite or on a terrestrial terminal for satellite telecommunications or broadcasting systems.


Patent
French National Center for Scientific Research | Date: 2013-01-16

The present invention concerns a method for labeling specifically living bacteria of a given category in a sample, the method including: a) incubating said bacteria of said sample with at least one analog of a monosaccharide compound, and b) contacting the bacteria with a labeling molecule having a second reactive group.


Patent
University of Lyon and French National Center for Scientific Research | Date: 2013-09-25

An installation for spectroscopic measurement includes a focusing system (


Patent
French National Center for Scientific Research, Montpellier University and Institute Curie | Date: 2012-10-29

A process of diagnostic, prognostic and therapeutic monitoring of solid tumors, and new biological markers of tumor.


Patent
University Paris Diderot and French National Center for Scientific Research | Date: 2013-10-04

The present invention relates to catalysts for the production of CO gas through electrochemical CO


Patent
French National Center for Scientific Research | Date: 2014-10-30

The present invention relates to a novel


Patent
Ethnodyne and French National Center for Scientific Research | Date: 2015-12-17

The invention relates to a method for obtaining a composition from a plant extract, to assist in the treatment or prevention of disorders or diseases related to neovascularisation.


Patent
French Atomic Energy Commission, French National Center for Scientific Research, University of Versailles and University Paris - Sud | Date: 2015-10-08

A process for preparing a porous solid with an outer surface modified by at least one polymer; the polymer being simultaneously synthetized in solution and grafted on the outer surface of the solid, includes contacting:


Patent
University of Strasbourg and French National Center for Scientific Research | Date: 2012-11-14

The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms of length. Pharmaceutical compositions and therapeutic uses thereof are also provided.


The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.


Patent
French National Center for Scientific Research | Date: 2013-07-18

The present invention concerns fluorescent boron thienyldipyrromethene type compounds, their preparation process, as well as their use as an electron donor in the field of organic electronics, in particular for the production of a photoactive layer in photovoltaic cells of the bulk heterojunction type or for the production of field effect transistors.


Patent
French National Center for Scientific Research | Date: 2013-03-06

The invention relates to a method for producing a pressure sensor, comprising the following steps: assembling a support substrate with a deformable membrane on which strain gauges have been deposited, wherein the deformable membrane comprises a thinned area at the centre thereof, the support substrate is disposed on top of the deformable membrane, the support substrate comprises an upper surface and a lower surface in contact with the deformable membrane, and the support substrate also comprises lateral recesses arranged on top of the strain gauges and a central recess arranged on top of the thinned area of the membrane, so as to obtain a micromechanical structure; and, once the assembly has been obtained, depositing, in a single step, at least one conductive material on the upper surface of the support and in the lateral recesses of the support, said conductive material extending into the recesses in order to be in contact with the strain gauges so as to form electrical contacts in contact with the strain gauges.


Patent
Solvay Group, French National Center for Scientific Research, University Pierre, Marie Curie and University Claude Bernard Lyon 1 | Date: 2012-12-18

Process for the preparation of a vinylidene chloride polymer comprising polymerizing vinylidene chloride and optionally at least one ethylenically unsaturated monomer copolymerizable therewith under the control of a RAFT agent of formula (II).


Patent
ImmuPharma and French National Center for Scientific Research | Date: 2014-12-05

The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more post-translational modifications.


Patent
Saint - Gobain and French National Center for Scientific Research | Date: 2013-04-15

Sintered product exhibiting a relative density of greater than 97% and composed of:


Patent
French National Center for Scientific Research | Date: 2014-05-05

A composition of a female germinal cell (egg) extract of pluricellular organisms in M-phase of the cell cycle, the extract being used for a mitotic remodeling of chromosomes of donor cells of pluricellular organisms, wherein the mitotic remodeling confers to the nucleus of the donor cells the ability to adapt themselves to the early embryonic development, in particular to the replication phases, in order to carry out the embryonic development or to obtain stem cells.


Patent
French National Center for Scientific Research | Date: 2012-10-09

A cell includes at least two semiconductor structures of the same nature, these two structures both employing voltages and currents that are unidirectional, each structure having an anode (


Patent
French National Center for Scientific Research, University of Paris Descartes, French Institute of Health, Medical Research and Assistance Publique Hopitaux De Paris | Date: 2014-10-16

The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof.


Patent
French National Center for Scientific Research | Date: 2012-05-22

The present invention relates to a novel bilirubin oxidase from


Patent
University Pierre, Marie Curie, Australian National University, Mohammed V University and French National Center for Scientific Research | Date: 2011-12-21

A method and a system is provided for configuring a device for correcting the effect of a medium on a light signal having propagated through the medium, the device including at least one optical element whose phase profiles are individually adjustable. The configuring system and method include propagating a reference signal and a disordered signal obtained at the output of the medium through the correcting device. An interference parameter is measured and optimized by modifying the phase profile of each of the optical elements of the correcting device. A method and a system is also provided for correcting the effect of a medium on a light signal having propagated through the medium.


Patent
Givaudan, Luniversite Pierre Et Marie Curie and French National Center for Scientific Research | Date: 2013-10-25

A method of encapsulation of an active comprising The method allows the precise tailoring of polymeric shells, allowing capsules walls to be much thinner without a loss of strength. The technique is especially useful for the encapsulation of fragrances and flavours.


Patent
Institute Polytechnique Of Grenoble and French National Center for Scientific Research | Date: 2014-06-23

The present invention relates to a printing or spray deposition method for preparing a supported flexible electrode and to a method for manufacturing a lithium-ion battery.


Patent
French National Center for Scientific Research | Date: 2013-05-06

The invention concerns a method of forming a graphene layer involving: heating a support layer in a reaction chamber; and forming the graphene layer on a surface of the support layer by: a) during a first time period, introducing into the reaction chamber an organic compound gas to cause a formation of carbon atoms on the surface; b) during a second time period after the first time period, reducing a rate of introduction of the organic compound gas into the reaction chamber and introducing into the reaction chamber a further gas, wherein the further gas is a carbon etching gas; and repeating a) and b) one or more times.


Patent
Montpellier University and French National Center for Scientific Research | Date: 2012-01-09

A method is provided for manufacturing near-field optical probes including at least one organo-mineral material with an organic part and a mineral part, the method including steps of irradiating at least partially the organo-mineral material with a radiation beam to polymerize the organic part in the irradiated areas, and polycondensing the mineral part by sol-gel process. Also disclosed are near-field optical probes and AFM and SNOM systems using the probes.


Patent
bioMerieux, French National Center for Scientific Research and Institute Curie | Date: 2015-04-30

A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4+SEQ ID No.5, SEQ ID No.6+SEQ ID No.7 and SEQ ID No.8. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer.


Patent
Adisseo France S.A.S., French National Center for Scientific Research and University Claude Bernard Lyon 1 | Date: 2014-02-04

The invention relates to a method for preparing an olefine, a diene or a polyene, by catalytic conversion of at least one alcohol having a carbon chain of at least three carbon atoms and different from propan-2-ol, in the presence of at least one catalyst based of at least one phosphate of a metal or several metals M, M being chosen from among the 15 lanthanides (Lanthanum, Cerium, Praseodymium, Neodymium, Promethium, Samarium, Europium, Gadolinium, Terbium, Dysprosium, Holmium, Erbium, Thulium, Ytterbium, Lutetium), Yttrium, Scandium and Boron, and the applications of this method.


An element for processing solar radiation includes means for processing solar radiation forming a layer of the solar radiation processing element and includes a layer of radiation-emitting material, especially infrared radiation, covering the layer of the processing means. A sun tracker includes at least one processing element and a solar farm includes a series of sun trackers, each comprising a processing element.


Patent
French National Center for Scientific Research and Montpellier University | Date: 2015-08-21

A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.


Patent
Galderma Research & Development, Aix - Marseille University and French National Center for Scientific Research | Date: 2013-08-08

A method of characterizing specific microbiota associated with


Patent
French National Center for Scientific Research, French Institute of Health and Medical Research | Date: 2013-06-04

Device for focusing pulses comprising at least emitting means comprising a network of transducers, these emitting means being adapted to make the network of transducers emit, into a reflective cavity, at least one wave focused onto at least one target point of a target medium. The reflective cavity comprises a multi-scattering medium adapted to cause multiple scattering of said wave.


Patent
French National Center for Scientific Research | Date: 2013-04-05

Microparticles and nanoparticles of hydrophobized polysaccharide and an alpha-cyclodextrin, obtained by self-association in an aqueous medium, the hydrophobized polysaccharide being obtained by grafting of alkyl chains derived from fatty acids, by an acylation reaction. These microparticles and nanoparticles constitute systems used for encapsulating substances of interest, in particular in the pharmaceutical field, and vectorization thereof for therapeutic purposes.


Patent
French National Center for Scientific Research and Les Laboratoires Servier | Date: 2012-07-12

Compounds of formula (I) in which: >R is a linear or branched (C


Patent
Ecole Normale Superieure de Lyon, University of Lyon and French National Center for Scientific Research | Date: 2013-07-31

The invention concerns novel glycosidase substrates of formula (I): where R0, R1, R2, R3, and R4 are such as defined in claim 1; and a method for detecting the presence of a catalytically active glycosidase using one of these substrates.


Patent
INSA Rouen, French National Center for Scientific Research, University of Rouen and Vfp Therapies | Date: 2014-01-24

A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; R


Patent
French National Center for Scientific Research and Bordeaux Polytechnic Institute | Date: 2014-01-23

A swinging system includes two gear trains each having two pinions, a first drive train and a second train driven by the first train, a first pinion of the first train engaging a first pinion of the second train, the second pinion of the first train engaging the second pinion of the second train, each pinion including a disk such that the disk of the first pinion of the second gear train is off-axis relative to the other pinion of the first gear train and one of the two disks includes a slug which fits into a groove arranged in the second disk. Thus, the speed of rotation of the first pinion of the second train varies relative to the speed of rotation of the first pinion of the second train.


Patent
French National Center for Scientific Research, University of Picardie Jules Verne, University Of Technology Of Varsovie and University of Rome La Sapienza | Date: 2014-12-01

A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m (1m3) and m anions corresponding to the formula (I) in which R


Patent
Abivax, French National Center for Scientific Research, Institute Curie and Montpellier University | Date: 2013-09-30

The present invention relates to a compound of formula (I): wherein A and A independently represent a phenylene group or a pyridylene group; R


Patent
National Graduate School of Chemistry, Rennes and French National Center for Scientific Research | Date: 2013-12-11

The invention relates to a ruthenium alkylidene complex comprising a 1-aryl-3-cycloalkyl-imidazolin-2-ylidene ligand, the cycloalkyl group of said 1-aryl-3-cycloalkyl-imidazolin-2-ylidene ligand being a cyclic secondary aliphatic alkyl.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2014-09-11

A method for fabricating patterns of III-V semiconductor material on a semiconductor substrate based on oriented silicon or germanium comprises: production of a growth mask on the surface of the substrate, defining masking patterns Mi with R being determined to be greater than tan().


Patent
French National Center for Scientific Research | Date: 2013-01-07

The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of said patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, said signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the said expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness and from the said comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.


A subject-matter of the present invention is a material in the form of solid particles with a diameter varying from 1 m to 1 cm which are composed of a continuous shell comprising at least one silicon oxide, said shell imprisoning an aqueous phase, said material being characterized in that said aqueous phase includes at least one hydrophilic substance of interest S The invention also relates to a process for the preparation of said material, to its use for the thermostimulated delivery of active substances, and also to the compositions including it.


Patent
French National Center for Scientific Research | Date: 2013-11-29

The present invention concerns a method for preparing glass having bimodal macroporous and mesoporous porosity, whereby macroporous glass is subjected to pseudomorphic transformation. The present invention also concerns the said glass thus prepared, optionally functionalised, and the different uses thereof.


Patent
Rhodia and French National Center for Scientific Research | Date: 2013-05-10

A process for the preparation of an ether compound is disclose, wherein the ether compound is prepared via a reaction from at least an alcohol (I) and an alcohol (II), optionally using a catalyst X, wherein alcohol (I) and alcohol (II) are forming a biphasic liquid system when mixed together; comprising at least the following steps: a) Producing an alcohol (I)/alcohol (II) emulsion by using as stabilizing species amphiphilic solid particles of nanometric dimension; optionally comprising a catalyst X; b) Proceeding to the reaction of the ether compound by setting temperature, and c) Isolating the ether compound.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, Genethon, University of Paris Descartes, École Nationale Supérieure de Chimie de Paris, University of Évry Val d'Essonne and Assistance Publique Hopitaux De Paris | Date: 2014-11-18

The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2291+1655 A>G CEP290 mRNA


Patent
French National Center for Scientific Research, University of Poitiers and Valagro Carbone Renouvelable Poitou Charentes | Date: 2014-06-18

The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.


Patent
French National Center for Scientific Research, Mohammed V University, University Pierre and Marie Curie | Date: 2014-01-22

The present invention relates to a method for determining whether a protein binds to a specific DNA sequence. This method is useful in particular for identifying modifications to the DNA sequence (e.g. methylations) via the binding of proteins that specifically recognize those modifications (e.g. antibodies), but also to identify the binding sequence on DNA of a variety of proteins.


Method for analyzing, using nuclear magnetic resonance, at least one sample including at least one species to be characterized and a reference species having a content, in the sample, that is more than twice greater than the content of the species to be characterized, the method includes:


Patent
French National Center for Scientific Research | Date: 2012-12-07

The invention relates to a hydrophobic thermoplastic copolymer which is in particular of use for manufacturing and/or coating medical devices, in particular implantable medical devices, characterized in that it is obtained by copolymerization, and in that it comprises at least one first monomer unit and at least one second monomer unit onto which is grafted a paramagnetic-ion-chelating ligand which can complex with such a paramagnetic ion or a paramagnetic-ion-chelating ligand which is complexed with such a paramagnetic ion, wherein the second monomer unit is grafted in sufficient amount for the copolymer to be visible in magnetic resonance imaging when it is complexed with said paramagnetic ion. The invention also relates to a method for obtaining said hydrophobic thermoplastic copolymer.


Patent
University Of Nates and French National Center for Scientific Research | Date: 2012-05-10

The invention relates to compounds comprising a redox group, to the use thereof as an additive to an electrolyte composition, to an electrolyte composition including such an additive, and to electrochemical systems including such an electrolyte composition, in particular lithium or sodium batteries and supercapacitors having a double electric layer.


Patent
French National Center for Scientific Research | Date: 2012-10-10

The invention relates to an electrode for an electrochemical cell which exhibits good electron conductivity and good chemical conductivity, as well as good cohesion with the solid electrolyte of the electrochemical cell. To do this, this electrode is made from a ceramic, which is a perovskite doped with a lanthanide having one or more degrees of oxidation and with a complementary doping element taken from the following group: niobium, tantalum, vanadium, phosphorus, arsenic, antimony, bismuth.


Patent
Saint - Gobain and French National Center for Scientific Research | Date: 2012-12-14

Catalyst system suitable especially for the removal of CO compounds, comprising or consisting of an oxide, preferably of fluorite crystalline structure, conforming to the following molar formulation: wherein Ce is cerium, A represents at least one element possessing a plurality of oxidation states and selected from Ti, Ga, In, V, Cr, Mn, Fe, Sn, Co, Ni, Cu, M represents at least one element selected from Gd, Y, Sc, Sm, Nd, Pr, Zn, D represents at least one element other than A and selected from Pt, Pd, Rh, Ru, Cu, Fe, Ag, and Au, u is between 0.05 and 0.45, y is between 0.01 and 0.4, Z is greater than 0 and less than 0.4, v is between 0.001 and 0.4, and x is greater than 0.


Patent
French National Center for Scientific Research and Électricité de France | Date: 2013-03-28

Thin-layer photovoltaic cell structure with mirror layer. The invention relates to a photovoltaic cell structure intended for solar panel applications. The thin layer photovoltaic cell structure comprises at least one I-III-VI2 alloy layer (CIGS) with photovoltaic properties for the conversion of illuminating light into electricity. In particular, the structure comprises at least: one mirror layer (MR) comprising a surface reflecting (FR) a part of the illuminating light, where said reflecting surface (FR) is facing a first face (F1) of the I-III-VI2 alloy layer for receiving reflected illuminating light on said first face; and one or more first layers (CA, ENC) transparent to the illuminating light for receiving transmitted illuminating light on a second face (F2) of the I-III-VI2 alloy layer opposite to the first face (F1).


Patent
Ecolee Polyechnique and French National Center for Scientific Research | Date: 2012-12-03

A nonlinear optical microscope is provided, including source of a pulsed laser beam; a spatial light modulator for modulating the spatial profile of the pulsed laser beam; an objective for guiding the modulated beam towards a slide intended to carry a specimen; and a detector for collecting signals originating from the specimen, wherein the spatial light modulator is designed to modulate the intensity and/or the phase of the pulsed laser beam on the rear pupil of the objective to produce a beam that is axially extended and confined in one or two lateral directions after focusing by the objective, and wherein the slide is placed on a motorized stage of a histology slide scanner assembly.


Patent
Institute Pasteur Of Lille and French National Center for Scientific Research | Date: 2013-10-01

The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with iNKT cell agonists.


Patent
French National Center for Scientific Research, Lille University of Science and Technology | Date: 2014-01-09

The present invention relates to a process for production of hydrogen at low temperature starting from alcohols without formation of carbon using an oxyhydride material based on cerium and nickel and to the use of such a material as catalyst for transformation of alcohols to hydrogen.


Patent
French National Center for Scientific Research | Date: 2013-12-23

The invention concerns a device for controlling the charge of an aerosol comprising: an aerosol inlet area; a discharge area having dielectric barriers, in which charged species are generated, the discharge area and the aerosol inlet area being arranged relative to one another in such a way that the aerosol introduced in this way does not flow via the discharge area; a mixing area for mixing the aerosol with a portion of the charged species from the discharge area; a post-discharge area linked to the discharge area, the aerosol inlet area and the mixing area being arranged in such a way that at least a portion of a stream flowing in the post-discharge area drives at least a portion of the charged species formed in the discharge area and expelled from the discharge area by electrostatic repulsion towards said mixing area.


A composite material consisting of a matrix made of at least one aluminosilicate notably selected from barium aluminosilicate BAS, barium and strontium aluminosilicate BSAS, strontium aluminosilicate SAS, and mixtures thereof, reinforced by reinforcements made of at least one metal or metalloid oxide, the expansion coefficient of which is close to that of said at least one aluminosilicate. A method for preparing said composite material. A composite material according to the invention notably finding its application in the aeronautical or aerospace field, for example for the manufacture of radomes.


Patent
Rhodia and French National Center for Scientific Research | Date: 2013-02-15

The present invention relates to a process for hydroxylation of a compound of formula (I) by reacting the compound of formula (I) with an oxidizing agent, in the presence of a titanium silicalite zeolite prepared by crystallization preceded by a maturing step. The present invention also relates to a titanium silicalite zeolite and to the process for preparing same.


Patent
University Paul Sabatier and French National Center for Scientific Research | Date: 2012-07-06

A process for preparing a composition including synthetic mineral particles, in which a hydrogel which is a precursor of the synthetic mineral particles is prepared via a coprecipitation reaction between at least one compound including silicon, and at least one compound including at least one metal element, characterized in that the coprecipitation reaction takes place in the presence of at least one carboxylate salt of formula R


Patent
Lille University of Science, Technology and French National Center for Scientific Research | Date: 2012-02-15

Method for preparing a peptide assembly of n fragments and n1 amino acids bearing a thiol function, represented by the formula: in which A


Patent
French National Center for Scientific Research | Date: 2015-04-20

A method is provided for modifying a surface of a solid conducting material, which includes applying a potential difference between this surface and a surface of another conducting solid material positioned facing it, and wherein, simultaneously, the surface (S) is put into contact with a liquid medium comprising in solution triarylamines (I): while subjecting these triarylamines (I) to electromagnetic radiation, at least partly converting them at into triarylammonium radicals. Also provided is a conducting device which includes two conducting metal materials, the surfaces of which, (S) and (S) respectively, are electrically interconnected through an organic material comprising conducting fibrillar organic supramolecular species comprising an association of triarylamines of formula (I).


Patent
French National Center for Scientific Research | Date: 2013-11-20

A method for the in vitro production of DNA minicircles includes steps of: a) providing nicked double-stranded oligodeoxynucleotides bunt-ended substrates having at least one phosphorylated 5 end, b) performing a ligase-mediated circularization on a reaction mixture including the nicked double-stranded oligodeoxynucleotides substrates and a DNA bending protein, and c) obtaining DNA minicircles.


A transparent glass or ceramic or glass-ceramic substrate, coated with a functional layer or with a stack of at least two functional layers, the functional layer or at least one of the functional layers of the stack being porous and made of an inorganic material M1, wherein the or at least one of the porous functional layer(s) of inorganic material M1 has, at the surface of at least one portion of the pores thereof, at least one inorganic material M2 different from M1.


Patent
French National Center for Scientific Research and Institute Pasteur Paris | Date: 2013-05-08

The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.


Patent
French National Center for Scientific Research | Date: 2012-09-28

The invention relates to a method for forming a graphene layer (


Patent
French National Center for Scientific Research and University of Nantes | Date: 2013-10-31

Method of assembling a first thin copper part and a second thin aluminum part, each to be welded using heterogeneous welding, includes placing the ends of the parts so that they face one another and pressing the ends against one another so as to constitute a welding zone extending therebetween; and applying an aluminum alloy by way of filler metal to the welding zone using a low energy welding method in which the electric arc and the meltable filler wire are wider than the combined thickness of the parts, the parts being held so as to maintain the welding zone at the top using a fixing element including at least two rigid blocks of a conductive material whose thickness is between 1 and 2 mm, whose length is greater than that of the parts and whose width is sufficient to hold the parts, and a pressure fixing system.


Patent
French National Center for Scientific Research, University of Abderrahmane Mira de Béjaïa and Odyssee Environement | Date: 2013-03-07

This invention concerns the process for the manufacture of an anti-lime scaling product, that is, a product designed to inhibit the formation of lime scale in elements such as pipes or hoses that could be subject to deterioration over time due to lime scale deposits. Specifically, the process of the invention is for an ecological anti-lime scale product. For this, the process according to the invention comprises a preparation step (


The invention relates to a method for coating an organic or metallic material by covalent grafting of at least one organic compound A having at least one aromatic group substituted with a diazonium function, on a surface of said material, characterized in that the material is porous or fibrillar having a geometric surface area of at least 10 cm


Patent
Espci Innov and French National Center for Scientific Research | Date: 2013-12-06

Polymer network composition having a semi-crystalline covalently crosslinked polymer network including exchangeable covalent bonds and crosslinking bonds and at least an exchange reaction catalyst, wherein the number of crosslinking bonds is sufficient for the polymer network to be beyond the gel point and the number of exchangeable bonds is sufficient for the network to relax stresses and/or flow when conditioned at an appropriate temperature. Such compositions are characterized by the fact that the network is able to reorganize by exchange reactions that allow it to relax stresses and/or flow while maintaining network connectivity.


Patent
French National Center for Scientific Research | Date: 2014-06-03

An image sensor having photosites forming an array (KL) of K rows and L columns, including a first set of integrator circuits, with a first regulation by analog weighting in blocks of nn photosites, said photosites belonging to n adjacent columns and to n adjacent rows, and a second set of integrator circuits, with a second regulation by analog weighting in blocks of mm photosites, said photosites belonging to m adjacent columns and to a adjacent rows, n adjacent columns of a first set of columns of the array being connected to nn integrator circuits of the first set, on adjacent columns of a second set of columns of the array being connected to mm integrator circuits of the second set, n columns of the first set alternating with on columns of the second set to form the array of photosites.


Patent
University of Strasbourg and French National Center for Scientific Research | Date: 2013-03-08

A motorized, modular instrumentation device and an endoscopy system including such device. The motorized, modular instrumentation device includes at least one operational unit mounted on at least one support structure and integrating a motorized medical instrument module including, first, an elongated medical instrument with a tool arranged on one distal end, it being possible to bend the corresponding end portion of the instrument, and second, at least one electrical actuating element controlling the operation of the tool and/or the bending of the distal end portion, via transmission elements extending within the elongated body of the instrument. The actuating element(s) is/are installed in a hollow body connected to the proximal end of the instrument and the hollow body is itself arranged, with rotational guiding, within a reception housing adapted to move, at least translationally, on the support structure, the movements of the hollow body and the reception housing being motorized.


Patent
French Atomic Energy Commission and French National Center for Scientific Research | Date: 2013-06-11

A device for fractionation of a fluid containing particles and extraction of a particle-lean volume and a particle-rich volume, including: a cylindrical reservoir including an inlet orifice to supply the reservoir with fluid in a pumping direction from first to second ends of the reservoir; a fractionation body extending along a central axis of the reservoir, an upstream end positioned in vertical alignment above the inlet orifice, a cross section of the fractionation body reducing sharply at its downstream end; the fractionation body defining, with the reservoir, a first passage opening at the downstream end onto a recirculation zone with a geometric singularity; and an extraction mechanism downstream of the fractionation body to separate and extract the lean and rich volumes, including a partition delimiting an extraction volume configured, as fluid circulates in the pumping direction, to receive the particle-lean phase formed in the recirculation zone.


Patent
French National Center for Scientific Research and Genethon | Date: 2012-07-31

Inhibitors of the endoplasmic reticulum associated degradation (ERAD) pathway, particularly inhibitors of mannosidase I, are used for the preparation of a medicinal product intended to treat sarcoglycanopathies.


Patent
Air Liquide, French National Center for Scientific Research and University of Limoges | Date: 2012-06-08

Device for the purification of exhaust gases from a thermal combustion engine comprising: one or several ceramic catalyst carriers comprising an arrangement of crystallites of the same size, same isodiametric morphology and same chemical composition, or approximately the same size, same isodiametric morphology and same chemical composition in which each crystallite is in point or quasi-point contact with the surrounding crystallites, and one or several active phases for chemical destruction of impurities in the exhaust gas comprising metallic particles having chemical interactions with said ceramic catalyst carrier and mechanical anchoring in said catalyst carrier such that coalescence and mobility of each particle are limited to a maximum volume corresponding to the volume of a crystallite of said ceramic catalyst carrier.


Patent
French National Center for Scientific Research | Date: 2012-02-07

A method is provided for coating a sample with the help of a coating material, where the method includes coating material being obtained from a mixture of a polysaccharide powder as a gelling polymer and of a reinforcing powder that is a powder of a complex intermetallic alloy or a powder comprising a complex intermetallic alloy and at least one compound selected from a ceramic compound and a polymeric compound. The volume fraction of the reinforcing powder not exceeding 60% of the total volume of the mixture.


Patent
Air Liquide, French National Center for Scientific Research and University of Limoges | Date: 2012-06-08

Device for purifying exhaust gases from a thermal combustion engine, comprising a catalytic ceramic carrier comprising an arrangement of crystallites of the same size, same isodiametric morphology and same chemical composition or substantially the same size, same isodiametric morphology and same chemical composition, wherein each crystallite is in contact at a singular or almost singular point with surrounding crystallites, and whereon at least one active phase is deposited for the chemical destruction of impurities in the exhaust gas.


Patent
Alveole and French National Center for Scientific Research | Date: 2013-03-14

The invention relates to a device for the microstructured grafting of a plurality of proteins onto a substrate, which includes a substrate (


Patent
Center Europeen Detude Du Diabete 30 Partial Interest and French National Center for Scientific Research | Date: 2013-12-24

A vector for the oral administration of at least one pharmacologically active substance enabling the active substance to move from the intestinal lumen to the blood, optionally via interstitial liquid, without any substantial degradation of the substance, includes an essentially hydrophilic matrix having an outer surface which is modified by one or several chemical species providing the vector with an essentially lipophilic quality and containing one or several active substances. The vector is associated with a gastroresistant vehicle enabling it to pass into the stomach without any denaturation and/or degradation of the active substance. The invention also relates to pharmaceutical compositions containing the vector. The vectors can be used to produce medicaments used in human or veterinary medicine.


Patent
French National Center for Scientific Research and Ecole Polytechnique - Palaiseau | Date: 2011-07-12

A method is provided for exciting at least one electrode of a capacitively coupled reactive plasma reactor containing a substrate. The electrode is excited by applying a RF voltage with a trapezoidal waveform comprising a ramp-up, a high plateau, a ramp-down and a low plateau. The plasma density can be controlled by adjusting the duration of the ramp-up, the duration of the ramp-down, the amplitude and the repetition rate of the trapezoidal waveform. The ion energy distribution function at the substrate can be controlled by adjusting the amplitude and the relative duration between the high plateau and the low plateau of the trapezoidal waveform.


Patent
Seb S.A., French National Center for Scientific Research and University of Lorraine | Date: 2011-02-10

Provided is a food-cooking surface for a culinary article or domestic electrical cooking appliance, consisting in depositing Zr and/or Nb and/or Ti on a substrate, the production process including a step of carburizing and/or nitriding at least one of the aforementioned elements, characterized in that the cooking surface also includes depositing Si so as to produce (Zr/Nb/Ti)Si(N/C) coatings. Also provided is a culinary article or domestic electrical or gas cooking appliance comprising such a cooking surface.


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2011-06-01

The present invention is directed to a rhenium complex of general Formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is Se; Y is NH, O or S or is a methylene group; Z is halogen; m=0, 1, or 2 and p=0, 1, or 2, provided that m and p are both different from zero when Y is NH, O or S; n=3; R is a phenyl group or a group of general Formula (CH


Patent
French Institute of Health, Medical Research, University of Strasbourg, French National Center for Scientific Research and Stichting Dienst Landbouwkundig Onderzoek | Date: 2012-05-04

The present invention provides materials and methods for DNA amplification, in particular linear amplification methods using RNA polymerase. These methods permit high-throughput sequencing of pictogram amounts of DNA and are of use in a range of applications including genome-wide profiling of transcription factors and epigenetic DNA and histone modifications, global transcript profiling, mapping of chromatin conformations, as well as for forensic use and archaeological studies.


Patent
Saint - Gobain and French National Center for Scientific Research | Date: 2014-09-30

A polycrystalline ceramic scintillator body includes a ceramic scintillating material comprising an oxide of gadolinium (Gd) and a second rare earth element (Re). The ceramic scintillating material has a composition, expressed in terms of molar percentage of oxide constituents, that includes greater than fifty-five percent (55%) Gd


Patent
Peugeot Citroen Automobiles S.A. and French National Center for Scientific Research | Date: 2014-09-04

The invention relates to a monomer (6, 14) carrying an imidazole-type heterocycle (3). According to the invention, the chemical structure of said monomer (6, 14) comprises at least one unit of formula (I) wherein R1 comprises an alkenyl grouping and R2 comprises a grouping for protecting one of the nitrogen atoms of the heterocycle. The invention also relates to a monomer carrying a benzimidazole-type heterocycle, and to protected polymers obtained from said monomers, deprotected polymers produced by the protected polymers, a proton exchange membrane based on deprotected polymers, and a fuel cell provided with said membrane. Furthermore, the invention relates to methods for producing the above-mentioned monomers and polymers.


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2012-09-17

The present invention relates to a method for diagnosing a neurodegenerative disease in a subject, wherein the level of each of at least two catecholamines is measured in a sample of biological fluid from said subject.


Patent
French National Center for Scientific Research, University Pierre, Marie Curie and Mohammed V University | Date: 2012-12-06

The method according to the invention includes choosing a reaction presumed reaction mechanism; selecting, for said mechanism, at least one first function characteristic of a thermokinetic property that is invariant with the periodic variation frequency of a control parameter influencing said reaction, the first characteristic function being calculated at least from first-order oscillation amplitudes of the concentration of at least one of the species involved in said reaction. The method includes calculating a plurality of values of the first characteristic function from first-order oscillation amplitudes obtained experimentally and analyzing the calculated values of the first characteristic function to determine whether the first characteristic function is constant based on the calculated values, and if the first characteristic function is constant, assigning the presumed mechanism to said reaction.


Patent
Institute Pasteur Paris, French National Center for Scientific Research and University of Paris Descartes | Date: 2014-06-20

The present invention relates to compounds derived from sugars which reproduce the epitopes of


Patent
Ecole Polytechnique - Palaiseau and French National Center for Scientific Research | Date: 2013-06-14

A matching circuit is provided to adapt electrical impedance simultaneously for at least one pair of a higher and a lower frequencies between a plasma reactor and a generator; said matching circuit comprises at least a load and tune L-type stage, and includes


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research and University of Angers | Date: 2012-05-22

The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.


Patent
Thales Alenia, French National Center for Scientific Research and French National Center for Space Studies | Date: 2014-12-17

A frequency tunable microwave bandpass filter comprises a resonator, including: a cavity with conducting wall substantially cylindrical with axis Z having height H, and partially closed at both ends; and a dielectric element inside the cavity. The resonator resonates at two perpendicular polarizations having distributions of electromagnetic field in the cavity deduced from each other by 90 rotation. The element rotates about an axis substantially perpendicular to axis Z, between a first and second position. The element comprises a first end wherein: in a first position the element is disposed substantially in a plane perpendicular to axis Z and the centre of the first end is disposed at a height in the cavity corresponding substantially to an electric field minimum; and in a second position the element is substantially parallel to Z and the first end is disposed in a plane corresponding to an electric field maximum within 30%.


Patent
IntegraGen, French Institute of Health, Medical Research, French National Center for Scientific Research, Assistance Publique Hopitaux De Paris and University of Paris Descartes | Date: 2012-11-23

The present invention relates to a method for predicting whether a patient with a cancer is likely to respond to an epidermal growth factor receptor (EGFR) inhibitor, which method comprises determining the expression level hsa-miR-31-3p miRNA in a sample of said patient. The invention also relates to therapeutic uses of an EGFR inhibitor in a patient predicted to respond to said EGFR inhibitor.


Patent
French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2012-12-06

The present invention relates to isolated antibodies against human sPLA2-X and uses thereof.


Patent
French National Center for Scientific Research | Date: 2013-09-18

The invention relates to a calcium channel blocker selected from the group of the calcium channel blockers of the phenylalkylamine family, the calcium channel blockers of the amino acid family, and the calcium channel blockers of the benzofuran family, for the use thereof in the treatment of a motor neuronopathy.


Patent
French National Center for Scientific Research and DuPont Company | Date: 2012-11-14

Disclosed herein is a crosslinked fluoropolymer network formed by the free radical initiated crosslinking of a diacrylate fluoropolymer The diacrylate copolymer is of formula CH


Patent
Idenix Pharmaceuticals, Luniversite Montpellier Ii and French National Center for Scientific Research | Date: 2011-06-27

This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2-deoxy--L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2-deoxy--L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2-deoxy--L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2-deoxy--L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.


Patent
Total S.A. and French National Center for Scientific Research | Date: 2012-12-20

A thermoreversibly cross-linked graft polymer, which may be used in bituminous asphalt, includes: a main polymer chain P consisting of conjugated diene units; at least one side graft G having the following general formula (1): R(OCH


Patent
French National Center for Scientific Research | Date: 2012-03-23

The present invention concerns constructs based on sequences derived from the partitioning system of plasmid and chromosomal DNA of bacteria, such as eukaryotic expression vectors, fusion proteins and polynucleotides encoding the same and also eukaryotic cells transformed with or expressing such constructs. The present invention also concerns the use thereof in the regulation of gene expression and/or in the detection and control of the dynamics, localization or metabolism of genomic DNA loci of interest in eukaryotic cells.


Patent
French National Center for Scientific Research, Montpellier University and Institute Curie | Date: 2013-11-04

The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.


Patent
French Atomic Energy Commission, Montpellier University and French National Center for Scientific Research | Date: 2014-03-14

A method for automatic detection of defects in TSV vias formed in a layer of semiconductor material, this detection taking place before stacking this layer with a plurality of other layers of semiconductor material for the design of a multilayer chip integrated circuit, comprising: measurement on each of said TSV vias of at least one parameter derived from an electrical characteristic of the TSV vias; detection of defects in said TSV vias according to a comparison of the parameters measured with at least one reference parameter, and calculation of said at least one reference parameter using the measured parameters. The parameter measured on each of the TSV vias comprises an oscillation frequency value derived from a capacitive characteristic of the TSV vias.


Patent
French National Center for Scientific Research | Date: 2012-10-26

New chimeric molecules involving in their structure, a combination of the extracellular domain (EC) of the FasL protein and a domain enabling oligomerisation of this Fas Ligand (FasL) EC domain, such as the Ig-like (so-called Ig in the following pages) domain of the gp190 receptor for the Leukemia Inhibitory Factor (LIF), or involving in their structure variants of the domains. Also, compositions including the chimeric molecule defined herein and the use of these chimeric molecules especially to trigger cytotoxic activity toward cells sensitive to FasL.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, Jean Monnet University, University Claude Bernard Lyon 1 and Hospices Civils De Lyon | Date: 2013-06-28

The present invention relates to the diagnosis of acquired sensory neuronopathies (SNN), and to the treatment of these disorders.


Patent
French National Center for Scientific Research and University of Rennes 1 | Date: 2012-06-18

An analysis system comprises a transmitting device (


Patent
French National Center for Scientific Research and Montpellier University | Date: 2013-06-26

The method comprises the following steps: The analysis step consists of seeking an amplitude distribution P(G


Patent
French National Center for Scientific Research | Date: 2012-08-17

The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.


Patent
Sicat Catalysts Inc., French National Center for Scientific Research and University of Strasbourg | Date: 2013-06-24

Catalysts supports and catalysts capable of being used in heterogeneous catalysis. The catalyst support belongs to the porous supports based on silicon carbide (SiC), in particular, based on -SiC, modified by a surface deposit of TiO


Patent
French National Center for Scientific Research and University Paris Sub Paris 11 | Date: 2014-02-21

Process for treating a magnetic structure, wherein it comprises the following steps: providing a magnetic structure comprising one first layer of magnetic material comprising a CoFeB alloy; irradiating the magnetic structure with light low-energy ions; and simultaneously holding the magnetic structure with a preset temperature profile and for a preset time.


Patent
Merial Limited, French National Center for Scientific Research, Institute Gustave Roussy and University Paris - Sud | Date: 2014-10-06

The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.


Patent
Institute Pasteur Paris, French National Center for Scientific Research, French Institute of Health and Medical Research | Date: 2015-02-04

The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo.


Patent
French National Center for Scientific Research, Institute Curie, University Pierre and Marie Curie | Date: 2013-07-02

The present invention concerns a method of detecting macroions in a liquid medium contained in a space, the method including: a) submitting the liquid medium to a stimulating electrical field to induce formation of aggregates of macroions, the formed aggregates of macroions preferably not including any additional labeling agent, and b) measuring, in a detection zone of the space, spatial and/or temporal fluctuations within the liquid medium of at least one variable depending on the concentration of the macroions in the liquid medium, and c) determining, based on these fluctuations, the presence of the macroions, step c) preferably including processing by a time-dependent or space dependent analysis, more preferably by wavelet analysis, or by autocorrelation the fluctuations measured at step b).


Patent
Ecole Polytechnique - Palaiseau and French National Center for Scientific Research | Date: 2014-01-13

The present invention relates to a multimode local probe microscope having a resonator (


Patent
Institute Curie and French National Center for Scientific Research | Date: 2012-08-08

The present invention relates to novel pharmaceutical or cosmetic compositions comprising at least one inhibitor of a sub-unit of AP-1 adaptor complex, of a kinesin interacting with AP-1, in particular Kif13A, or of the interaction between a sub-unit of AP-1 adaptor complex and said kinesin, as well as the use of same to manufacture a drug intended for the treatment of pigmentary disorders and as a depigmentation agent.


The present invention relates to a material in the form of solid particles with a diameter varying from 1 m to 1 cm which are composed of a continuous shell E The invention also relates to a process for the preparation of said material, to its use for the thermostimulated delivery of active substances, and also to the compositions including it.


Patent
Institute Gustave Roussy and French National Center for Scientific Research | Date: 2012-07-17

A method for determining the benign or malignant state of a breast tumor in a biological sample is presented. The benign or malignant state is determined by measuring the variation of expression of twelve genes and at least one variant of each of the twelve genes when the variants exist, using a combination of 50 polynucleotide probe sets. An expression profile of the sample is then compared with reference expression profiles of control benign and malignant breast tissues. The probe sets can be arranged in a microarray.


Patent
Arjowiggins Security, Jean Monnet University and French National Center for Scientific Research | Date: 2013-09-11

A method for authenticating a security element by superimposing N shared colour images in order to obtain at least one target colour may include a phase of constructing an authenticator system that includes a step of selecting a target colour; a step of selecting a series of N decomposition colours which, by means of superimposition, together enable the target colour to be obtained; and a step of recording the N shared images each with a decomposition colour from the series. A security element comprising at least one shared image may be obtained according to the method.


Patent
French National Center for Scientific Research | Date: 2012-04-06

A method of diagnosing depression in a subject, comprising analyzing a biological sample from a subject in need of diagnosis of depression for the expression of spadin, detecting and measuring the amount of spadin in the sample, and diagnosing depression in the subject if an increase or a decrease in spadin expression in the biological sample is detected compared to a control, is described as are methods for monitoring treatment, remission and the course of the disease. Related kits are also described. Also described is a method for identifying candidate compounds for treating depression.


Patent
French National Center for Scientific Research and Dow Corning | Date: 2012-11-02

An apparatus for plasma treating a substrate comprises a high voltage source of frequency 3 kHz to 30 kHz connected to at least one needle electrode (


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-10-22

A memory cell is provided with a transistor which includes source and drain electrodes formed in a semiconductor film by respectively N-doped and P-doped areas. The transistor includes first and second devices for generating a potential barrier in the semiconductor film. The two potential barriers are shifted laterally and are opposed to the passage of the charge carriers emitted by the nearest source/drain electrode. One of the devices for generating the potential barrier is electrically connected to the gate. The other of the devices for generating the potential barrier is electrically connected to the counter-electrode. The writing of a high state is carried out by imposing on the P-doped electrode a potential higher than that of the N-doped electrode and charging the capacitor formed between the gate and the semiconductor film. The resetting of the memory cell is obtained by discharging the capacitor.


Patent
Imabiotech, Lille University of Science, Technology and French National Center for Scientific Research | Date: 2014-02-17

The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.


An HBAR resonator comprises, on a substrate, a piezoelectric transducer, said transducer comprising at least one piezoelectric layer, at least two series of electrodes and exhibiting resonance frequencies Fi corresponding to wavelengths i, characterized in that it comprises an amplification structure comprising at least one resonant cavity arranged on the substrate between said transducer and said substrate or in said substrate, this amplification structure being suitable for mechanically resonating at least one of the resonance frequencies Fi of said transducer corresponding to said wavelength i, so as to amplify the amplitude of the electrical resonance generated at said frequency.


Patent
Institute Pasteur Paris, Theravectys and French National Center for Scientific Research | Date: 2014-03-05

The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique administration or for iterative administration in a host, and to their medicinal application (such as vaccination against Immunodeficiency Virus, especially suitable in human hosts). Gene transfer vectors can be either integrative or non-integrative vectors. The invention encompasses prophylactic, therapeutic, symptomatic, and curative treatments of animals, including humans, as well as gene therapy and vaccination in vivo.


Patent
Idenix Pharmaceuticals, Montpellier University and French National Center for Scientific Research | Date: 2014-03-03

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-08-29

The invention relates to a method for preparing a hydrogel type matrix comprising at least two contiguous zones with distinct stiffnesses, comprising a step to photopolymerize a solution comprising one or several polymerizable compounds and a photopolymerization initiator, by application of light onto the entire solution and at a different intensity in at least two zones of the solution, as a result of which a hydrogel matrix is obtained comprising at least two contiguous zones with distinct stiffnesses, characterized in that the photopolymerization step is done in the presence of a polymerization catalyst.


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-05-04

A method for making semi-conductor nanocrystals, including at least the steps of:


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-05-04

A method for making a semi-conductor nanocrystals, including at least the steps of:


Patent
University of Burgundy and French National Center for Scientific Research | Date: 2012-05-18

A thermoelectric component comprises integrated into the component: a plasmonic waveguide, an exciter element for the guided plasmonic mode, a device for measuring the power dissipated during propagation along the plasmonic waveguide, characterized in that the measurement device comprises, associated with the plasmonic guide, a thermocouple junction with two electrodes, one of the electrodes including the plasmonic waveguide.


Patent
French National Institute for Agricultural Research, French National Center for Scientific Research and University Paris - Sud | Date: 2013-05-23

A compound of general formula (I): in which X represents O, S, NH or an N-alkyl radical, R


Patent
French National Center for Scientific Research | Date: 2015-01-29

The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moeities of the gangliosides GM3, GD3, and GT3.


Patent
French National Center for Scientific Research | Date: 2011-05-24

The invention relates to a method for manufacturing a microfluidic chip, wherein said method comprises the steps of: providing a plate combined with a layer of inorganic silica gel of formula: (HsiO


Patent
French National Center for Scientific Research, University of Poitiers and University of Bordeaux Segalen | Date: 2011-12-16

The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the ade1-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates.


Patent
University of Picardie Jules Verne, French National Center for Scientific Research and Agencia Estalal Consejo Superior De Investigaciones Cientifcas | Date: 2012-07-02

The present invention relates to a negative electrode material for a sodium ion battery, and to a method for producing it. The active material of the electrode material is composed of an oxide with a structure corresponding to the layered structure of the compound Na The electrode material is obtained by electrochemical reduction of an oxide Na


Patent
French National Center for Scientific Research | Date: 2012-11-30

A field effect transistor (


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2013-10-14

A magneto-optic surface includes a support; at least two moving elements; each of the moving elements including at least one anchoring point to the support and at least one moving part movable with respect to the support, the moving part including at least one magnetic part; the support and the moving elements being laid out in such a way that under the effect of an external magnetic field, at least one of the moving elements moves with respect to the support such that the optical properties of the magneto-optic surface are modified.


Patent
French National Center for Scientific Research, CNRS Le Mans Institute of Molecules and Materials | Date: 2013-10-28

A system for recording a digital hologram of an object comprises: a coherent source intended to illuminate the object and thus produce a wave diffracted by the object; and a digital sensor intended to record the digital hologram of the object. It furthermore comprises a spatial phase modulating assembly able to produce in the plane of the sensor a plurality of duplicates of the wave diffracted by the object, the duplicates being offset from each other but overlapping partially, these duplicates forming on the sensor a digital hologram of the object, this hologram being what is referred to as a self-reference hologram.


Patent
French National Center for Scientific Research and Institute Doptique Graduate School | Date: 2013-11-27

A source of directional radiation in an IR band comprises at least a substrate and an external layer comprising controllable cells made of a metal insulator transition material that changes phase depending on its temperature relative to a temperature at which the corresponding wavelength is located in the IR band and that possesses a crystalline phase and an amorphous phase, and control means for controlling the phase change of the cells so as to form in this external layer a diffraction grating when the cells are controlled to the amorphous phase, in order thus to obtain a switchable directional source.


Patent
French National Center for Scientific Research | Date: 2013-11-05

A method for scheduling tasks with deadline constraints, based on a model of independent periodic tasks and carried out in the user space by means of API POSIX is provided.


Patent
Thales Alenia, Aix - Marseille University, French National Center for Space Studies and French National Center for Scientific Research | Date: 2012-09-14

Optical devices can comprise a deformable mirror and a system for deforming said mirror. A deformation system comprises a first mechanical structure comprising a first surround, one or more electromechanical actuators attached to the first mechanical structure, a second mechanical structure comprising a substantially planar bottom and a second surround, both deformable, the bottom being attached to the first surround, the second surround being attached to the surround of the mirror, a rigid stud being attached to the bottom, substantially planar and centred on the bottom, the electromechanical actuator or actuators exerting predetermined forces or bending moments on the stud so as to generate a particular distribution of the bending moments on the surround of the mirror, deforming it according to a geometrical form representative or of one or more predetermined geometrical aberrations.


Particles having a core based on at least one biodegradable organosoluble polymer. At least a part of the surface of the particles is coated with at least one hyaluronan or a derivative thereof, the hyaluronan being a water-soluble, amphiphilic hyaluronan of which the carboxylic functions are in part transformed to form hydrophobic groups.


Patent
French National Center for Scientific Research | Date: 2011-03-15

A method of forming a pattern on the surface made of a hydrophobic macromolecular material of a substrate is provided, the method having a step of immersing at least said surface of the substrate in a solution that having at least 50% by volume of water and, optionally, one or more polar solvents having a dielectric constant greater than 30 and contains less than 0.0001 mol/L of dissolved gases and on source. The invention is particularly applicable in the electronics field.


Patent
French National Center for Scientific Research and Saint - Gobain | Date: 2011-04-01

Product formed from a ceramic material, at least part of the product not being formed from amorphous silica, having pores and satisfying the following criteria: (a) at least 70% by number of the pores are tubular pores extending substantially parallel to each other in a longitudinal direction; (b) in at least one cross-section plane, at least 30% by number of the pores have a section of convex hexagonal shape, these pores being known hereinbelow as hexagonal pores, at least 80% by number of the hexagonal pores having a roundness index of greater than 0.70, the roundness index being equal to the ratio SA/LA of the lengths of the small and long axes of the ellipse in which the section is inscribed; the mean size of the cross sections of the pores is greater than 0.15 m and less than 25 m.


Patent
STMicroelectronics and French National Center for Scientific Research | Date: 2014-08-04

The invention relates to an IC with an electrostatic discharge protection device. There is a buried insulant layer 50 nm or less in thickness and first and second bipolar transistors on the insulant layer, one being an npn transistor and the other a pnp transistor. The base of the first transistor is merged with the collector of the second transistor and the base of the second transistor is merged with the collector of the first transistor. The first and second bipolar transistors are configured to selectively conduct a discharge current between two electrodes of the protection device. There is a first semiconductor ground plane under the insulant layer, being electrically biased, extending until it is plumb with the base of the first bipolar transistor, exhibiting a first type of doping identical to that of the base of the first bipolar transistor with a doping density at least ten times greater.


Patent
University of Savoy and French National Center for Scientific Research | Date: 2011-07-20

The invention relates to a module for the circulation of fluids (A,B), comprising:at least one fluid distribution plate (


Patent
French National Center for Scientific Research, Mohammed V University, University Pierre and Marie Curie | Date: 2012-12-21

The present invention relates to a fast method for the detection and the quantification of a nucleic acid, DNA or RNA. Specifically, the invention provides a method for detecting and quantifying the presence of a specific nucleic acid molecule which is based on physical and electronic treatments. The method of the invention is particularly useful for applications as diverse as detection of chromosomal abnormal distributions or gene expression analysis.


Patent
French National Center for Scientific Research | Date: 2014-02-24

The method for producing a stack of films provided with at least one 3D-structured pattern including providing a first mould having a textured front face including a first 3D pattern, depositing a first layer of the stack on the textured front face so as to cover the first 3D pattern by a continuous layer, the first layer having a first face in contact with the front face of the mould, removing the first mould so as to release the first face of the first layer having a second 3D pattern complementary to the first 3D pattern and depositing a second layer of the stack on the first face of the first layer so as to cover the second 3D pattern by a continuous layer.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2014-03-04

A supercapacitor to be submerged in a medium containing a biological material and an oxidant, wherein the anode comprises a first enzyme that can catalyse the oxidation of the biological material and the cathode comprises a second enzyme that can catalyse the reduction of the oxidant, and wherein each of the anode and cathode electrodes consists of a solid agglomerate of a conductive material mixed with the first or the second enzyme, said agglomerate having a specific surface that is larger than or equal to 20 m


Patent
French National Center for Scientific Research | Date: 2012-08-02

The invention relates to a method and device for controlling a physical parameter of an optical signal. According to the invention, a portion of the initial optical signal (SE) having passed through an optical waveguide from the input (


The invention relates to an electronic management system ( cell connection terminals to be connected to n associated electricity generating cells ( outputs to be connected to m associated static converters ( an energy routing module ( an electronic control unit (


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, Aix - Marseille University and University of Navarra | Date: 2014-06-05

The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, University of Rennes 1, University Paris Diderot, University Pierre and Marie Curie | Date: 2011-04-04

A method for treating and/or ameliorating and/or preventing a disease or a disorder, the method comprising administering to an individual in need thereof at least one nitrogen heterocycle derivative of formula (I): The at least one nitrogen heterocycle derivative may also be used as a proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.


Patent
French National Center for Scientific Research and Aix - Marseille University | Date: 2012-03-02

The invention relates to a method and a system for estimating the resemblance between two images of optionally different modalities. More particularly, the invention makes it possible to characterize a similarity between two binary images formula (I): it allows in particular registration of images acquired in the fields of teledetection, medical imaging, industrial vision.


Patent
University of Southern Brittany and French National Center for Scientific Research | Date: 2013-02-13

The invention concerns a method for transmitting symbols of non binary error correcting code words via a transmission channel. The method comprises a first modulation associating each code word symbol of p bits with a sequence of at leas 2p chips from 2p possible sequences a second modulation to modulate the phase or amplitude of a carrier signal with the sequences associated with the code words, and a step of transmitting the modulated carrier signal via said transmission channel. According to the invention the first modulation is a spread spectrum modulation of the cyclic code shift keying type using a basic pseudo-random sequence of at least 2p chips, the possible 2p sequences being obtained by a circular shift of the basic pseudo-random sequence and a cyclic prefix is inserted into each symbol to be transmitted.


Patent
French National Center for Scientific Research | Date: 2011-12-12

The invention relates to compounds which are agonists of at least one receptor selected from S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5 receptors, for use in methods for treating HIV infections in humans or animals.


Patent
French Institute of Petroleum and French National Center for Scientific Research | Date: 2012-11-09

A process for capturing sulphur impurities present in gas feeds containing H a. desulphurisation with a retaining material containing an active phase, b. optionally, rendering the sulphurised retaining material inert, c. oxidative regeneration of the retaining material, d. optionally, rendering the regenerated retaining material inert, and e. desulphurisation with the retaining material that has been regenerated and rendered inert, and regenerating the retaining material.


Patent
French National Center for Scientific Research and Center Leon Berard | Date: 2014-09-15

The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells.


Patent
French Institute of Health, Medical Research, University of Paris Descartes, French National Center for Scientific Research and University Paris Diderot | Date: 2013-01-25

Novel antibodies and peptides relating to HIV are disclosed, as are vaccine compositions containing such antibodies and peptides. The compounds and compositions of the invention are of use in prevention and treatment of HIV, and in particular for inducing mucosal immunity to HIV.


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2012-11-26

The invention relates to a method for diffusing metal particles included in a composite layer previously deposited on a substrate, said composite layer further including at least one dielectric matrix. According to this method, the diffusion of said metal particles towards said substrate is achieved by means of a plasma treatment.


Patent
French National Center for Scientific Research, University of Santiago de Compostela and Institute Pasteur Paris | Date: 2012-01-24

The prsent invention relates to a method for manufacturing an analysis device including torpdo membrane fragments immobilized at the surface thereof, to the resulting analysis device, and to the use of said device for detecting, purifying, and characterizing molcules acting on nicotinic acetylcholine receptors. The prsent invention is useful in the field of monitoring seafood, monitoring neurotoxic phytoplankton for the shellfish industry, monitoring the quality of bathing waters along tourist beaches, the field of monitoring fresh water reserves, the field of mdical research, the field of the biological analysis and characterization of molcules, e.g., non-radioactive assays of the movement of the ligand-receptor bond on an ELISA-type microplate, thereby enabling comptitive agonists and antagonists of targets to be detected, e.g., of highly sensitive receptors.


Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.


Patent
Aix - Marseille University, University of Lorraine, French National Center for Scientific Research, University of Barcelona and Oreste Piccolo Studio Di Consulenza Scientifica | Date: 2012-11-28

Novel amino acids derivatives, in particular some amino acid amides derivatives, their process of preparation and their use for inhibiting Met-triggered disorders, in particular cancer.


Patent
Aix - Marseille University and French National Center for Scientific Research | Date: 2012-02-23

The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.


Patent
Total Research & Technology Feluy and French National Center for Scientific Research | Date: 2014-11-25

The present invention discloses new catalyst systems based on complexes of divalent metals supported by chelating phenoxy ligands for immortal ring-opening polymerisation of cyclic esters and cyclic carbonates.


Patent
French Institute for Research in Computer Science, Automation, University of Nantes, French National Center for Scientific Research, Thinking Lens LLC and University of Udine | Date: 2012-11-29

Method for shooting and editing a film comprising at least one image of a 3D computer-generated animation created by a cinematographic software according to mathematical model of elements that are part of the animation and according to a definition of situations and actions occurring for said elements as a function of time, said method being characterized by comprising the following: computing of alternative suggested viewpoints by the cinematographic software for an image of the 3D computer-generated animation corresponding to a particular time point according to said definition; and instructing for displaying on a display interface, all together, images corresponding to said computed alternative suggested viewpoints of the 3D computer-generated animation at that particular time point.


Patent
Ecole Normale Superieure de Lyon, University of Lyon and French National Center for Scientific Research | Date: 2014-04-07

A method for depositing a photocatalytic coating on a support, the method having the steps: a) providing an aqueous and/or alcoholic suspension of nanoparticles of a semiconducting material, b) providing a sol in an aqueous and/or alcoholic solution of a hydrolyzed organosilane, c) mixing the suspension and the sol and proceeding with deposition of the obtained mixture on the support to be covered, d) performing a drying operation, e) and optionally producing an illumination of the obtained coating after drying at one wavelength at least causing activation of the semiconducting material, so as to remove at least 3% of the organic groups initially present in the coating and bound to the silicon atoms through a SiC bond; as well as coatings with photocatalytic properties, materials, notably textiles, covered with such a coating and the use of such coatings and materials for photocatalysis.


Patent
French National Center for Scientific Research and STMicroelectronics | Date: 2012-08-07

In one or more embodiments, the disclosure relates to a method of setting a photolithography exposure machine, comprising: forming on a photolithography mask test patterns and circuit patterns, transferring the patterns to a resin layer covering a wafer, measuring a critical dimension of each test pattern transferred, and determining a focus setting error value of the photolithography machine from the measure of the critical dimension of each pattern, the test patterns formed on the mask comprising a first reference test pattern and a second test pattern forming for a photon beam emitted by the photolithography machine and going through the mask, an optical path having a length different from an optical path formed by the first test pattern and the circuit patterns formed on the mask.


Patent
French National Center for Scientific Research | Date: 2011-01-11

The present invention relates to isolated human cells that are precursors of endothelial cells other than embryonic stem cells, to isolated murine cells that are precursors of endothelial cells, and to methods using same, In particular, the present invention relates to established cell lines of isolated human cells that are precursors of endothelial cells other than embryonic stem cells and established cell lines of isolated murine cells that are precursors of endothelial cells. The present invention can be used in particular in the medical and/or veterinary fields, in particular in the field of therapeutics and/or in the field of studies of cellular mechanisms.


Patent
French National Center for Scientific Research, École Centrale Marseille and Aix - Marseille University | Date: 2014-03-24

A method for locating at least one target, in an electromagnetically absorbent environment, includes: emitting at least one electromagnetic excitation signal from a source; receiving, by an acoustic sensor, an acoustic signal from emission of the excitation signal; detecting, in the received acoustic signal, a first time of receipt of a first response to the excitation signal from an acoustic disturbance caused by electromagnetic heterogeneity of the target in the environment; estimating a first distance between the target and the acoustic sensor using the first time of receipt; detecting, in the same received acoustic signal, a second time of receipt of a second response to the excitation signal from an acoustic disturbance caused by acoustic heterogeneity of the target in the environment; estimating a second distance between the source and target using the second time of receipt; obtaining a location of the target from the first and second estimated distances.


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2013-11-06

Polymer composition comprising a mixture of PBA modified HA polymer grafted on at least a hydroxyl with a group comprising phenylboronic acid and Cis-diol modified HA polymer grafted on at least a hydroxyl with a group comprising a cis-diol. Injectable or implantable glucose-sensitive hydrogels comprising a this polymer composition.


Patent
Societe Financiere Cormouls Houles, University Paul Sabatier and French National Center for Scientific Research | Date: 2013-02-01

A method for preparing a food that is less allergenic from a particulate solid food matrix that is more allergenic and contains allergenic proteins, in particular a peanut and/or tree-nut matrix. The method comprises the step of processing dispersion of the solid food matrix in an aqueous medium by high-pressure homogenization to obtain a homogenate consisting of a dispersion of allergenic proteins initially contained in the matrix mixed with solid particles of the matrix. The homogenization step can be preceded by a step of grinding the matrix, and followed by a step of processing the homogenate with a protein-degrading agent, in particular with a probiotic microorganism.


Patent
Antia Therapeutics S.A. and French National Center for Scientific Research | Date: 2015-07-08

A method of embolizing an area of treatment includes providing a composition that includes a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a poly(vinyl alcohol) (PVA) having covalently grafted thereon iodinated benzyl groups comprising from 1 to 4 iodine atoms per benzyl group as the only substituents wherein a grafted repeating unit has formula (I) wherein n is from 1 to 4: and introducing the composition into the area of treatment.


Patent
Givaudan, Luniversite Pierre Et Marie Curie and French National Center for Scientific Research | Date: 2013-10-25

Core-shell capsules comprising a fragrance-containing core and a shell formed around said core, wherein the shell is formed of polycarboxylic acid having a molecular weight of 1,000 to 10,000,000 Daltons


Patent
French National Center for Scientific Research | Date: 2012-10-04

A system for transferring electrical energy to thermal energy which comprises two electrodes separated by a distance along the axis joining them and able to create field lines defining a zone of influence when subjected to a potential difference, an electrical power supply device for these electrodes, which is able to provide the potential difference, and a device for triggering an electric arc between these two electrodes. The triggering device comprises a device for emitting a laser pulse, a device for focusing the pulse at N focusing points situated in the zone of influence of the two electrodes, with a peak power density of the pulse per focusing point of greater than 1 GW/cm


Patent
Merial Limited, University Paris - Sud, Institute Gustave Roussy and French National Center for Scientific Research | Date: 2015-02-06

The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against FeLV, compositions comprising said vectors and/or FeLV polypeptides, methods of vaccination against FeLV, and kits for use with such methods and compositions.


Patent
French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2013-03-22

The present invention relates to antibodies anti-sPLA2-IIA and uses thereof.


Patent
French National Center for Scientific Research | Date: 2014-10-02

A method for monitoring a reaction and a reaction system are provided. The reaction system includes at least one vessel for the reaction medium, which is in fluid communication with an injection tube; at least one vessel for a carrier fluid that is immiscible with the reaction medium, which is in fluid communication with a reaction tube; the injection tube being mounted so as to lead into the reaction tube such that individual drops of the reaction medium can be injected into the reaction tube and into the immiscible carrier fluid, so as to form a train of reaction chambers; at least one detector for monitoring a reaction; a means for classifying the reaction chambers; and at least one means for recirculating reaction chambers in front of at least one detector for monitoring a reaction.


Patent
Montpellier University and French National Center for Scientific Research | Date: 2013-10-24

An epoxy resin is provided that is cross-linkable at room temperature, including the product of a reaction of a mixture including at least one epoxy function carrier derivative, chosen from the group consisting of non-polymeric, non-bio-sourced reagents and carriers of at least 3 epoxy end functions and biosourced, epoxidized lipidic derivatives, and at least one crosslinking agent, the ratio between the number of epoxy functions being kept constant independently of the composition of the mixture, the method for manufacturing same, and the use thereof in composite parts for the mechanical engineering or for building construction and in structural parts.


Patent
French National Center for Scientific Research | Date: 2013-04-24

The invention relates to a reprogrammable logic device comprising a plurality of elementary patches, each patch comprising: at least one logic block configurable by one or more volatile memory cells storing configuration data; and a memory comprising: a plurality of non-volatile memory cells storing refresh data, each non-volatile memory cell comprising first and second resistance-switching elements, each being programmable so as to have one of a first and of a second resistance value representative of the refresh data; and a read-write circuit adapted for periodically refreshing the configuration data on the basis of the refresh data.


Patent
French National Center for Scientific Research | Date: 2014-03-06

The invention relates to an electrochromic device comprising: a working electrode (


Patent
French National Center for Scientific Research and University Paris Est Creteil | Date: 2013-11-19

The invention concerns the use of pyridinium furosemide or one of the derivatives, analogues, salts, metabolites, or prodrugs thereof in the preparation of a chemical model of a neurodegenerative disease, preferably Parkinsons disease. The invention also concerns the corresponding chemical model and the uses of same, in particular in screening tests for identifying drug candidates.


Patent
French National Center for Scientific Research and Hydro - Quebec | Date: 2015-07-24

A method for preparing a ceramic from an inorganic base material in the form of a powder with a high boiling point, including a step in which the powder of the inorganic base material is mixed with a second inorganic component which is also in powder form and which serves as a dopant for the inorganic base material. The dopant comprises a single inorganic material or a mixture of at least two inorganic materials that have a dopant effect on the inorganic base material. The method also includes a sintering step performed at a high temperature. Owing to the high density thereof, the resulting ceramics are suitable for use as a target element. The films and electrodes obtained from said ceramics have particularly beneficial properties.


Patent
Saint - Gobain and French National Center for Scientific Research | Date: 2013-12-06

Preparation of a slip including more than 4% and less than 50% of ceramic particles and including more than 1% of orientable ceramic particles made of a material including an oriented function, as volume percentage on the basis of the set of ceramic particles, wherein the fraction of non-orientable ceramic particles has a median length less than ten times the median length of the orientable ceramic particles if the set of ceramic particles includes less than 80%, as volume percentage, of orientable ceramic particles, oriented freezing of the slip by movement of a solidification front at a speed less than the speed of encapsulation of the ceramic particles; elimination of the crystals of solidified liquid phase of said block, optionally, sintering.


Patent
Vivatech, French National Center for Scientific Research, University Paris Diderot and Mohammed V University | Date: 2013-03-29

The invention relates to methods of diagnosis or prognosis of a tissue or organ fibrosis (e.g., skin fibrosis, hypertrophic scar or a keloid) in a reparative or reactive process comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a tissue or organ from a mammalian, wherein different genes markers are studied.


Patent
French National Center for Scientific Research | Date: 2015-04-02

A device (


Patent
French National Center for Scientific Research | Date: 2013-11-15

The invention concerns a composition made from at least one sulphated polysaccharide, in particular from an algae, and combined with at least one food ingredient. This composition can be used, in particular, in the field of food or in the treatment or prevention of an infection caused by microsporidia in humans or animals. It has useful properties as an antiparasitic agent in humans or animals; for the treatment or prevention of an infection caused by at least one microsporidia in humans or animals; in particular for the treatment or prevention of an infection caused in bees by the microsporidia


Patent
Institute Curie, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2013-11-19

A method of conferring modified properties, e.g. modified physical and/or biochemical properties, to a metallic substrate surface, including at least two steps being (i) a first step including at least exposing the substrate surface to a hetero-bifunctional anchoring molecule carrying at least a silane group and at least a A


Patent
Ecole Polytechnique - Palaiseau, Ecole Nationale Superieure De Techniques Avancees and French National Center for Scientific Research | Date: 2013-04-11

A method for producing electromagnetic radiation comprising: firing a first laser pulse and generating a plasma region, the first laser pulse penetrating at least partially into the plasma region to create a plasma density wake in the plasma region; providing a group of charged particles in the plasma region arranged so as to be accelerated in the plasma density wake of the first laser pulse; reflecting the first laser pulse after the first laser pulse has penetrated into the plasma region, to give a reflected laser pulse; and arranging the reflected laser pulse to interact with the group of charged particles to generate an electromagnetic radiation.


Patent
Snecma, University Paul Sebatier Toulose Iii Ups, National Polytechnic Institute of Toulouse and French National Center for Scientific Research | Date: 2012-03-07

A method for producing a thermal barrier in a multilayered system for protecting a metal part made of superalloy, by producing a thermal treatment by flash sintering protection materials in layers superposed on the metal part in an SPS machine enclosure. The layers contain, on a superalloy substrate, at least two layers of zirconium-based refractory ceramics. A metal part is produced according to a SPS flash sintering method and contains a superalloy substrate, a metal sub-layer, a TGO oxide layer and the thermal barrier formed by the method. A first ceramic is an inner ceramic designed to have a substantially higher expansion coefficient. An outer ceramic is designed to have at least lower thermal conductivity, and at least one of a sintering temperature or maximum operating temperature that is substantially higher. The thermal barrier has a composition and porosity gradient from the metal sub-layer to the outer ceramic.


Patent
French National Center for Scientific Research and Institute Pasteur Paris | Date: 2015-01-07

The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.


Patent
University of Lyon, French National Center for Scientific Research and ETH Zurich | Date: 2013-08-02

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each others via siloxy bonds, the amount of radical ranging from 0.50 to 0.03 mmol of radical per gram of material, and in that the network is formed with a sol-gel step using an organosilane for the introduction of the organic molecules allowing their regular distribution within the porous structured material. The invention also concern a process for the preparation of such material and a method of analysis by Nuclear Magnetic Resonance (NMR) of an analyte wherein it uses dynamic nuclear polarization generated with a material according to the invention.


Patent
French National Center for Scientific Research, Air Liquide and Institute Polytechnique Of Grenoble | Date: 2013-06-24

The present invention relates to hollow platinum nanoparticles with a diameter comprised between 3 and 20 nm which comprise a first central cavity and optionally at least one second cavity at the periphery of the first cavity, the shell of which is dense and single-crystal with a thickness comprised between 0.2 and 5 nm. The invention also relates to a method for manufacturing such nanoparticles, as well as to their use as an electrocatalyst in fuel cells.


Patent
French National Center for Scientific Research, National Graduate School of Chemistry, Montpellier and Montpellier University | Date: 2013-07-08

The invention concerns a mono- or polyfunctional polysilylated organosilane compound, and the method for preparing same.


Patent
Seb S.A., Upper Alsace University and French National Center for Scientific Research | Date: 2012-08-27

The present invention relates to a cooking article a substrate having a contact surface at least partially made of metal and coated with a non-stick coating comprising at least one layer including at least one fluorocarbon resin alone or mixed with a thermostable coupling binder that is heat-resistant up to at least 200 C., the fluorocarbon resin and, if necessary, the thermostable coupling binder forming a sintered network. According to the invention, the contact surface comprises an interface layer consisting of a polymer layer formed by plasma polymerization from a precursor selected from among unsaturated carboxylic acids, the salts or esters thereof, saturated carboxylic acid vinyl esters, unsaturated dicarboxylic acids, the salts, esters, hemiesters or anhydride esters thereof, and unsaturated epoxides. The present invention also relates to a method for manufacturing such an article.


Patent
French National Center for Scientific Research and French Atomic Energy Commission | Date: 2011-06-10

A solar power tower solar receiver absorber including: an enclosure; at least one panel configured to be illuminated by solar flux; a core made of at least one material with heat conductivity at least partially encompassed by the enclosure; and a plurality of tubes passing through the core and extending substantially in a parallel direction with respect to the panel configured to be illuminated. The tube is configured for circulation of a fluid to be heated, for example a gas for operating a gas turbine.


Patent
French National Center for Scientific Research | Date: 2011-05-31

A photovoltaic component including a set of layers suitable for producing a photovoltaic device is disclosed. The component has at least one first layer made of a conductive material forming a back electrical contact, a second layer made of a material that is absorbent in the solar spectrum, and a third layer made of a transparent conductive material forming a front electrical contact, and an electrically insulating layer arranged between said back electrical contact and said front electrical contact. The third layer is discontinuous in order to allow said layers of said set of layers to be stacked in one or more zones to form, in each of these zones, an active photovoltaic zone, and a fourth layer made of a conductive material, making electrical contact with said third layer made of a transparent conductive material, to form a peripheral electrical contact for each of said photovoltaic microcells.


Patent
Institute Pasteur Paris and French National Center for Scientific Research | Date: 2013-10-15

The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single-stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated Schwarz measles virus and various recombinant Schwarz measles-based viruses expressing heterologous sequences. Such rescued viruses can be used, after amplification, as vaccines for immunization against measles and/or against the heterologous peptides or proteins expressed.


Patent
French National Center for Scientific Research | Date: 2012-09-07

The present invention relates to mutants of the


Patent
French National Center for Scientific Research | Date: 2011-09-16

A method of characterizing viscoelastic properties of a sample of a substance, includes the application (


Patent
University Pierre, Marie Curie, Endocontrol, Mauna Kea Technologies and French National Center for Scientific Research | Date: 2012-06-25

The invention relates to an endoscopic instrument (


Patent
University of Nantes and French National Center for Scientific Research | Date: 2011-09-13

The invention relates to a photoreactor (


Patent
Montpellier University and French National Center for Scientific Research | Date: 2012-06-14

The invention concerns a non-volatile memory element comprising: first and second transistors (


Patent
French National Center for Scientific Research | Date: 2013-12-20

A catalytic system which is a suspension in glycerol of metal nanoparticles in at least one transition metal. The suspension also includes at least one compound stabilizing the metal nanoparticles, soluble in glycerol. The suspensions are obtained directly in glycerol. These are stable systems that can catalyse a reaction from an organic substrate, with high yields and activity, and excellent selectivity. Additionally, the use of the catalytic system for performing organic transformations such as hydrogenation or coupling reactions (formation of CC, CN, CO, CS . . . bonds), and for synthesizing polyfunctionnal molecules, in a single reactor, by multi-step, sequential or cascade reactions.


Patent
Societe Dexploitation De Produits Pour Les Industries Chimiques Seppic, French National Center for Scientific Research and Institute Curie | Date: 2014-03-21

A straight, branched or cross-linked polymer, including, per 100 mol %: a) a mole fraction from 75% to 99.95% of monomer units from an N,N-dialkyl acrylamide; b) a mole fraction from 0.05% to 1% of monomer units from a monomer of formula (I): CH2=C(Ri)-C(=0)-0-[(CH2-CH(R2)-0]n-R3 (I); c) optionally a mole fraction higher than 0% to 24% either of monomer units from a monomer including a free strong acid function, partially or totally salified, or of monomer units from a monomer of formula (II): CH2=C(R4)-C(=0)-Y-(CH2)m-N(R5)(R6) (II); d) optionally a mole fraction higher than 0% to 1% of a diethylene or polyethylene cross-linking monomer. Also, a method for treating a surface made of a hydrophobic material, using the polymer, and an aqueous, hydro-organic or organic solution including the polymer for modifying interactions between the species contained the solution and the hydrophobic surface.


Patent
Électricité de France and French National Center for Scientific Research | Date: 2014-05-12

A method for fabricating a photovoltaic device with light concentration, comprising: a first step of fabricating, on a substrate, a first array of photovoltaic cells from a stack of layers deposited on the substrate, the cells of the first array being connected to a first group of electrical connectors, a second step of forming a light concentration system above the cells of the first array. It further comprises: a third step, prior to at least the second step, of forming on the substrate a second array of photovoltaic cells from a stack of layers deposited on the substrate, the cells of the second array being interspersed with the cells of the first array and connected to a second group of electrical connectors, and being without a light concentration system.


Patent
French National Center for Scientific Research | Date: 2011-01-18

The invention relates to a method and a device for detecting a resonant non-linear optical signal induced in a sample (


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2012-05-04

The invention relates to the use of at least one chelating agent, including an iron chelating agent, in order to stimulate the growth of magnetotactic bacteria.


Patent
Idenix Pharmaceuticals, Montpellier University and French National Center for Scientific Research | Date: 2014-03-13

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R


Patent
Nanobiotix, French National Center for Scientific Research and University of Bordeaux Segalen | Date: 2015-10-19

The present application relates to a method of monitoring the membrane permeabilization of liposome and the incidental release of a compound of interest.


Patent
University of Strasbourg and French National Center for Scientific Research | Date: 2013-04-15

A method for manufacturing a spin injector device, comprising the following steps of:


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, University of Rouen and University of Reims Champagne Ardenne | Date: 2015-10-21

The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.


Patent
Technofan, National Polytechnic Institute of Toulouse and French National Center for Scientific Research | Date: 2014-02-21

An electronic temperature sensor for measuring the junction temperature of an electronic power switch (


Patent
Rhodia, French National Center for Scientific Research and Fonds De Developpement Des Filieres Des Oleagineux Et Proteagineux Fidop | Date: 2013-03-25

The present invention concerns a method for preparing glycerol ether or glycol ether comprising the reaction of a compound of formula (II) with a compound of formula (III) in the presence of a heterogeneous acid catalyst of formulas (II) and (III).


Patent
French National Center for Scientific Research | Date: 2013-12-19

An electrically conducting talc composition may include synthetic talc particulate coated with an electrically conducting coating agent, wherein the coating agent may include carbon nanotubes or an electrically conductive polymeric material, such as a nanocarbon material, such as, for example, carbon nanotubes. A method of making an electrically conducting talc composition may include forming electrically conducting coating agent on or about particles of the talc particle.


Patent
Rhodia, Fonds De Developpement Des Filiers Des Oleagineux Et Proteagineux Fidop, University Claude Bernard Lyon 1 and French National Center for Scientific Research | Date: 2012-01-11

Disclosed is a method for preparing, by transcarbonation, a compound of formula (I), including reacting a polyol of formula (II) with an alkyl carbonate or an alkylene carbonate in the presence of a catalytic system consisting of a catalytic entity selected from among the rare earth oxides or the mixtures thereof, and optionally an inert substrate.


Patent
French Atomic Energy Commission, Institute Polytechnique Of Grenoble and French National Center for Scientific Research | Date: 2013-10-15

An energy harvester includes a circuit for collecting an excess of electrical charges on a first connection terminal, wherein the circuit is equipped with a first controllable mechanical switch, and a control device for the first switch. There is a transducer suitable for directly transforming, without consuming the excess of electrical charges present on the first connection terminal, the variation of the energy to be harvested into a mechanical deformation which displaces the first switch from its open position to its closed position.


Patent
Pierre Fabre, French National Center for Scientific Research and CIRAD - Agricultural Research for Development | Date: 2014-01-24

The present invention relates to a compound of the following formula (I) or to a salt, hydrate, or pharmaceutically acceptable solvate thereof, in which R is a monosaccharide or disaccharide residue. The hydroxyl functions of the monosaccharide or disaccharide residue are, independently, optionally substituted for a (C


Patent
French National Center for Scientific Research and Montpellier University | Date: 2014-02-21

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.


Patent
Vect Horus, French National Center for Scientific Research and Aix - Marseille University | Date: 2014-05-14

The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorise molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).


Patent
University Of Tourville and French National Center for Scientific Research | Date: 2012-06-27

A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.


Patent
Proteus, French Institute of Petroleum and French National Center for Scientific Research | Date: 2013-09-04

The invention relates to a polypeptide which has enhanced beta-glucosidase activity at a temperature of between about 30 C. and about 35 C.


Patent
Air Liquide, French National Center for Scientific Research and University of Lorraine | Date: 2014-02-04

Process for depositing a coating on a substrate having at least one cavity, comprising a step of mixing ground powders of an activating agent and a powder of the metal or of the alloy to be deposited on the substrate that were ground in step a) and a liquid so as to form a suspension, and a step of applying the suspension to the portion of the substrate to be coated.


Patent
University of Southern Brittany and French National Center for Scientific Research | Date: 2013-02-22

A device for interleaving/deinterleaving digital data delivered by processing elements (P0 . . . Pn-1) suitable for being used both with turbo-codes and with LDPC codes. The device includes memory banks (B0 . . . Bm-1) for storing data coming from or going to the processing elements, an interconnection network (INT) for directing the data between the processing elements and the memory banks, and a control unit (CTRL) for controlling the interconnection network and the memory banks. The control unit (CTRL) includes a calculation circuit (CAL) capable of the online generation of command words for the interconnection network and addressing and control sequences of the memory banks, ensuring conflict-free memory access on the basis of the interleaving rule to be applied, the size of the digital data frames, the number of processing units and memory banks, and the interconnection network.


Patent
Aircelle and French National Center for Scientific Research | Date: 2014-05-23

A method of detecting bubbles during operations for injecting resin for the manufacture of fibre composite components, is noteworthy in that the electrical capacitance or conductivity of at least one part of the medium formed by the fibres and the liquid is measured.


Patent
Idenix Pharmaceuticals, Montpellier University and French National Center for Scientific Research | Date: 2014-03-04

Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.


Patent
Genethon, Institute National Of La Sainte Et Of La Recherche Madicale and French National Center for Scientific Research | Date: 2012-06-28

The invention relates to peptides and functional derivatives thereof and their use for improving transduction efficiency of viruses into target cells.


Patent
Institute Pasteur Paris and French National Center for Scientific Research | Date: 2012-12-12

The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.


Patent
University Paul Sabatier, French National Center for Scientific Research and Mecaprotec Industries | Date: 2012-10-12

An anticorrosion treatment process in which applied to an oxidizable surface of a solid metal substrate is a liquid solution, referred to as treatment solution, including: at least one alkoxysilane, and at least one cerium (Ce) cation; in a liquid aqueous-alcoholic composition, the treatment solution being suitable for being able to form, at the surface of the solid metal substrate, a hybrid matrix by hydrolysis/condensation of each alkoxysilane(s) and of each cerium (Ce) cation; the treatment solution having a molar ratio (Si/Ce) of silicon element of the alkoxysilane(s) with respect to the cerium (Ce) cation(s) of between 50 and 500; characterized in that the cerium (Ce) cation(s) has(have) a concentration between 0.005 mol/L and 0.015 mol/L in the treatment solution.


Patent
French National Center for Scientific Research and University of Angers | Date: 2012-07-16

There is provided (i) a method of analysing small molecules that may have a mass of <800 Da, in particular alkaloids, said method being generally referred to as MALDI-TOF-MS (or MALDI time-of-flight mass spectrometry), which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Also provided is (ii) a molecule according to formula (I) and the use of the molecule as a matrix in the analysis method.