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Patent
French National Center for Scientific Research, Bordeaux Polytechnic Institute and Institute Technologique Fcba | Date: 2016-06-22

The present invention concerns a compound of formula (I):- n is an integer comprised between 1 and 7;- X_(1) is in particular a radical of formula -CH_(2)-S-(CH_(2))_(k)-S-;- A_(1) is in particular a linear or branched alkylene radical comprising from 2 to 30 carbon atoms, and- X_(2) is in particular an alkoxy group of formula OR_(a), wherein R_(a) is a linear or branched alkyl group comprising from 1 to 10 carbon atoms.


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2015-04-09

The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.


Patent
Laboratoire Francais Du Fractionnement Et Des Biotechnologies, French National Center for Scientific Research and University Paris - Sud | Date: 2015-05-28

Disclosed is a copolymer of following formula (I): in which:x is an integer between 10 and 250, preferably between 40 and 120, y is an integer between 4 and 100, preferably between 10 and 100, preferably between 19 and 60, z is an integer between 0 and (100y), preferably equal to 0, R represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan or an affinity ligand, and R represents a hydrogen, the CH_(2)CCH group, a CH_(2)-1H-1,2,3-triazole group, a CH_(2)CH_(2)CH_(2)SR group, in which R represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan, an affinity ligand or an imaging probe, and the uses of same.


Patent
French National Center for Scientific Research | Date: 2014-11-26

The invention relates to a surfactant composition including at least one compound of formula (I): in which each of the radicals Z is a hydrogen atom or (Z_(1)); at least one compound of formula (IV); one compound of formula (V); and one compound of formula (VI). The invention also relates to a method for preparing said composition and to the use thereof in cosmetics.


Patent
Societe Dexploitation De Produits Pour Les Industries Chimiques Seppic and French National Center for Scientific Research | Date: 2014-11-26

The invention relates to a composition (C_(1)) including: (a) at least one compound of formula (I) in which each of the radicals Z is a hydrogen atom or a monovalent radical (Z_(1)); (b) at least one compound of formula (IV); (c) a compound of formula (V). The invention also relates to a method for preparing said composition and to the use thereof in cosmetics.


Patent
Institute Curie, French National Center for Scientific Research, French Institute of Health, Medical Research, Assistance Publique Hopitaux De Paris and University of Paris Descartes | Date: 2016-07-29

A composition that can be used as a vaccine containing means for targeting at least one antigen to dendritic cells and as adjuvants a granulocyte macrophage colony stimulating factor and a CpG oligodeoxynucleotide and/or a CpG-like oligodeoxynucleotide. This composition can used to treat cancers, infectious diseases caused by bacterial, viral, fungal, parasitic or protozoan infections, allergies and/or autoimmune diseases.


Patent
Ecole Normale Superieure de Lyon and French National Center for Scientific Research | Date: 2015-05-15

The invention relates to a pharmaceutical or probiotic composition comprising at least one Lactobacillus strain with intestinal tropism, especially selected from the species Lactobacillus plantarum, Lactobacillus fermentum and Lactobacillus casei, used to stimulated juvenile growth in cases of malnutrition especially characterised by a protein deficiency. The strains can be selected from a vinegar fly model and/or a mouse model. The invention also relates to a method for probiotic treatment using said composition.


Patent
French National Center for Scientific Research and Mohammed V University | Date: 2016-09-29

The disclosure provides a method of delivering a polypeptide molecule to an Otx2 target cell, including contacting the target cell with a chimeric polypeptide having (i) a targeting peptide consisting of SEQ ID NO: 2 and (ii) the polypeptide molecule.


Patent
University of Nantes and French National Center for Scientific Research | Date: 2015-03-18

Disclosed are magnetic and fluorescent nanoassemblies having reverse architectures. Especially, the nanoassemblies include an organic fluorescent inner core and magnetic nanoparticles contacting the surface of the fluorescent core. The nanoassemblies may further be coated by a polymer adsorbed at its surface, the polymer being optionally functionalized. Also described is a process for manufacturing the nanoassemblies, as well as use of the nanoassemblies, especially for multimodal imaging; in vitro and/or in vivo diagnostics through multimodal imaging; ex vivo sensing and/or extraction; and/or therapy.


Patent
Medincell and French National Center for Scientific Research | Date: 2015-01-27

Compositions, pharmaceutical compositions and biodegradable pharmaceutical compositions containing at least one analog of spadin or at least one analog of a propeptides of spadin or mixtures thereof are described. Methods for treating depression using the analogs of spadin or analogs of propeptides of spadin or mixtures thereof, as well as methods for blocking TREK-1 channel activity are also disclosed.


Patent
Vib Vzw, Ghent University, French National Center for Scientific Research, Montpellier University, Montpellier University Hospital Center and University of Osnabrück | Date: 2016-09-28

This disclosure relates to a modified -helical bundle cytokine, with reduced activity via an -helical bundle cytokine receptor, wherein the -helical bundle cytokine is specifically delivered to target cells. Preferably, the -helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified -helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified -helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.


Patent
Lille University of Science, Technology and French National Center for Scientific Research | Date: 2015-04-27

The present invention relates to a method for dry reforming of at least one alkane carried out in at least one reaction chamber, preferably with a catalytic bed, having a stream of gas passing through same. According to the invention, said at least one reaction chamber comprises a catalytic solid which is cyclically and alternatively exposed to a stream of at least one alkane and a stream containing carbon dioxide, such that said catalytic solid is used as an oxidation vector.


Patent
French National Center for Scientific Research and University Paul Sabatier | Date: 2015-04-13

A process for preparing phyllomineral synthetic particles formed from constituent chemical elements in stoichiometric proportions including at least one chemical element selected from the group formed from silicon and germanium, and at least one chemical element selected from the group formed from divalent metals and trivalent metals, by a continuous solvothermal treatment at a pressure above 1 MPa and at a temperature between 100 C. and 600 C., by making the reaction medium circulate continuously in a solvothermal treatment zone of a continuous reactor (15) with a residence time of the reaction medium in the solvothermal treatment zone that is suitable for continuously obtaining, at the outlet of the solvothermal treatment zone, a suspension including the phyllomineral synthetic particles.


Patent
Arkema, French National Center for Scientific Research and ESPCI ParisTech | Date: 2015-04-23

The present invention relates to a composition containing, besides a thermosetting resin of epoxy type and a hardener of anhydride type, at least one catalyst comprising an organometallic titanium complex. This composition enables the manufacture of vitrimer resins, that is to say resins that can be deformed in the thermoset state. It also relates to a kit for manufacturing this composition, an object obtained from this composition and a kit for manufacturing this object. Another subject of the invention relates to an organometallic titanium complex corresponding to the structure titanium bis(3-phenoxy-1,2-propane dioxide) (Ti(PPD)_(2)), and the use thereof as vitrimer effect catalyst in systems based on epoxy resin and on hardener of anhydride type.


Patent
University Paris - Sud, French Atomic Energy Commission and French National Center for Scientific Research | Date: 2015-04-03

Complexes including a solid support and a material with a matrix structure containing domains complexing rare earth or strategic metals, preparation process thereof and use thereof for extracting or separating the rare earth or strategic metals in an aqueous or organic medium.


Patent
French National Center for Scientific Research | Date: 2015-03-04

The present invention relates to a new method of light induced photopolymerization under mild irradiation conditions, copper initiator complexes to be used in such method and a polymers obtained by such method.


Patent
Ecole Normale Superieure de Lyon, University of Lyon and French National Center for Scientific Research | Date: 2014-04-29

The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding as isomeric forms, either by irradiation or spontaneously. The invention also concerns compounds with a azoaryl structure for use in studying the cytoskeleton and/or its associated processes, or in the treatment of a disease for which a tubulin polymerisation inhibition activity has a beneficial effect, wherein the compound is administered to the cell, organism or patient in need of such treatment in the trans form of the diazenyl bond, and where this trans form is inactive as regards a tubulin polymerisation inhibition effect, and where after photoisomerisation in vitro, in cellulo or in vivo to an azoaryl compound in its cis isomeric form of the diazenyl bond by the application of light, optionally with modification in vitro, in cellulo or in vivo of one or more substituents, the resultant cis form is active as regards a tubulin polymerisation inhibition effect.


Patent
Polytechnic University of Turin, INSA Lyon, Doceram Medical Ceramics Gmbh, University of Lyon and French National Center for Scientific Research | Date: 2015-02-13

A process is described, for producing zirconia-based multi-phasic ceramic composite materials, comprising the steps of: providing at least one ceramic suspension by dispersing at least one ceramic zirconia powder in at least one aqueous medium to obtain at least one matrix for such composite material; providing at least one aqueous solution containing one or more inorganic precursors and adding such aqueous solution to such ceramic suspension to surface modify such ceramic zirconia powder and obtain at least one additived suspension; quickly drying such additived suspension to obtain at least one additived powder; heat treating such additived powder to obtain at least one zirconia powder coated on its surface by second phases; and forming such zirconia powder coated on its surface by second phases.


Patent
University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2015-02-12

A surface coating method includes the steps of preparing a solution containing a solvent and a material or its precursor, intended to cover a surface to be coated, which is non-volatile, film-forming and soluble or can be in suspension or dispersed in a solvent; and generating an aerosol of the solution. The method further includes generating an aerosol flow from a first end of a tube towards a second end of the tube, wherein the second end pre-determined cross-section (Se) and provided with a spray nozzle having an outlet with a cross-section (S) smaller than the cross-section (Se) of the second end of the tube, such that the ratio R1=F/S is greater than 4 metres per second. The method also includes the steps of directing the outlet of the nozzle towards the surface to be coated and spraying the aerosol onto the surface to be coated.


Patent
University of Strasbourg and French National Center for Scientific Research | Date: 2015-05-18

The subject matter of the present invention concerns the preparation of a coated solid surface wherein the coating contains at least one in-plane oriented layer of anisotropic shaped objects through a specific spraying method, and the device enabling this method.


Patent
French Institute of Health, Medical Research, French National Center for Scientific Research, Genethon, University of Paris Descartes, École Nationale Supérieure de Chimie de Paris, University of Évry Val d'Essonne and Assistance Publique Hopitaux De Paris | Date: 2016-09-16

The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2291+1655 A>G CEP290 mRNA


Patent
French National Center for Scientific Research | Date: 2015-04-08

Selective inhibitor of c-Fos and their antiproliferative properties The invention relates to selective inhibitor of c-Fos for use in the prevention and/or treatment of cancers and restenosis.


Patent
University of Rennes 1 and French National Center for Scientific Research | Date: 2015-04-17

The invention relates to a material consisting of a preparation made from a mixture of ferrocene and an inert flameproof material such as plaster, the material being presented in the form of granules and being suitable for spreading over a hydrocarbon fire in a simple and rapid manner such that, under the effect of the heat from the fire, the ferrocene contained in the granulated material is diffused progressively and homogeneously in a vapour phase over the base of the flames, so as to optimise the combustion of the hydrocarbon and to reduce the emission of smoke and unwanted particles.


Patent
French National Center for Scientific Research and University Paris Diderot | Date: 2015-05-04

The present invention relates to porphyrins of formula (I): wherein R^(1 )to R^(6), R^(1) to R^(6), X, X Y and Y are as described in claim 1. The invention also relates to complexes of said porphyrins with transition metals, in particular iron, preferably as Fe(III) or Fe(0) complex, and salts thereof, use thereof as catalysts for the selective electrochemical reduction of CO_(2 )into CO, electrochemical cells comprising said complexes, and a method for selectively reducing electrochemically CO_(2 )into CO using said complexes.


Patent
French National Center for Scientific Research, University of Valenciennes and Hainaut‑Cambresis | Date: 2015-05-19

A wheelchair having two drive wheels, each provided with a rotary drive motor wherein the value of the drive torque applied by each motor is controlled such as to stabilize the wheelchair, while in motion on the two drive wheels and occupied by a user, in an inclined balance position.


Patent
Ecole Polytechnique - Palaiseau and French National Center for Scientific Research | Date: 2015-04-14

A device for forming a quasi-neutral ion-electron beam, including: a chamber; a set of means for forming an ion-electron plasma in the chamber; and means for extracting and accelerating charged particles from the plasma out of the chamber. The particles are capable of forming the beam and the extraction and acceleration means that include a set of at least two grids located at one end of the chamber.


Patent
University of Missouri and French National Center for Scientific Research | Date: 2015-02-23

Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.


Patent
French Institute of Health, Medical Research, University of Paris Descartes, Fondation Imagine, Assistance Publique Hopitaux De Paris Aphp, French National Center for Scientific Research, University Grenoble Alpes, French Atomic Energy Commission and University of Burgundy | Date: 2015-02-18

The present invention relates to methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway. In particular, the present invention relates to a method for treating a disease selected from the group consisting of cancers, obesity and obesity related diseases, anorexia, autoimmune diseases and infectious diseases in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of the NRP-1/OBR signaling pathway.


Patent
Idenix Pharmaceuticals, University of Cagliari, French National Center for Scientific Research and Montpellier University | Date: 2016-12-14

2 and/or 3 prodrugs of 1, 2, 3 or 4-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.


Patent
French National Institute for Agricultural Research, French National Conservatory of Arts, Crafts, Institute Science Industries Vivant Et Environnement Agroparistech, Brodart and French National Center for Scientific Research | Date: 2015-03-04

The use of a composition including at least one saturated free fatty acid and at least one unsaturated free fatty acid as additive, for modifying the mechanical properties of a thermoplastic polymer material. An additivated thermoplastic polymer material and a process for producing same are also described.


Patent
Association Institute Of Myologie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2015-04-14

The present invention relates to compositions and methods for treating myotonic dystrophy.


Patent
Rhodia, French National Center for Scientific Research and University of Poitiers | Date: 2014-02-28

Providing a catalytic process for preparing 1,4-diketone compounds from furanic compounds and their precursors in a liquid medium, using an acid catalytic system and optionally in the presence of hydrogen and a hydrogenation catalyst, wherein the acidic catalytic system comprises a solid acid catalyst or a mixture of water and CO_(2).


Patent
University of Strasbourg, French National Center for Scientific Research and French Atomic Energy Commission | Date: 2015-05-15

The present invention relates to a process for the preparation of a first compound of interest C1 functionalized with a sydnone compound and to the corresponding functionalized C1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest C1 and C2 implying a sydnone compound and to the obtained conjugate. The present invention also relates to a process for preparing a compound of interest C2 comprising a strained alkyne moiety functionalized with a sydnone and to the corresponding functionalized compound of interest C2. It also relates to novel sydnone compounds substituted in position 4, which may be used in the above processes.


Patent
Thales Alenia and French National Center for Scientific Research | Date: 2015-05-15

This circuit (100) includes: an intermediate layer (103), made from a conductive material and configured according to a pattern; a first electrode and a plurality of electrodes, which includes at least second and third electrodes (126, 127, 128), each electrode including: A polarizer, made from a ferromagnetic material, placed at a particular point of the pattern of the intermediate layer, and having a magnetization; A superconducting layer, made of a superconducting material, arranged on the polarizer; and a control means (112) able to modify the magnetization of the polarizer of the second electrode; another control means (122) able to modify the magnetization of the polarizer of the third electrode; bias terminals for applying a bias signal; and, terminals for measuring an output signal, a level of the output signal being correlated with a mutual orientation of the first, second and third magnetizations.


Patent
Thales Alenia, French Atomic Energy Commission, University of Limoges and French National Center for Scientific Research | Date: 2015-04-17

A power switching cell with normally on field-effect transistors comprises a current switch receiving the control input signal over an activation input and a power transistor for switching a high voltage VDD applied to its drain, to its source that is connected to the output port of the cell. The control of the gate of the power transistor whose source is floating, according to the input signal, is provided by a self-biasing circuit connected between its gate and source. The current switch is connected between the self-biasing circuit and a zero or negative reference voltage. The self-biasing circuit comprises a transistor whose source or drain is connected to the gate or source of the power transistor. The gate of this transistor is biased by a resistor connected between its gate and source, and between the current switch and the source. The transistors are HEMT transistors using GaN or AsGa technology.


Patent
French National Center for Scientific Research and University of Nice Sophia Antipolis | Date: 2015-05-19

Antenna system comprising at least two radiating elements, a first line for neutralising electromagnetic coupling between the at least two radiating elements, at least one radiofrequency power supply line for each radiating element and at least one short-circuiting line to a ground plane of the antenna system per radiating element, characterised in that the antenna system further comprises: at least one second line for neutralising electromagnetic coupling between said at least two radiating elements; elements for activating at least some of the neutralisation lines; and in that the activation elements are configured to selectively activate or deactivate at least some of the neutralisation lines, in such a way that depending on the activation/deactivation thereof the neutralisation lines provide a maximum neutralisation of the electromagnetic coupling of the radiating elements for a plurality of different frequencies.


Patent
French National Center for Scientific Research | Date: 2015-05-20

The present invention relates to a method for manufacturing a semiconductor material including a semi-polar III-nitride layer from a semi-polar starting substrate including a plurality of grooves periodically spaced apart, each groove including a first inclined flank of crystallographic orientation C (0001) and a second inclined flank of different crystallographic orientation, the method comprising the phases consisting in:


Patent
French National Center for Scientific Research | Date: 2015-05-19

A platform for a parallel robot, for acting on an object, including: The base is connected to each bridge respectively by at least one hinge which is oriented along a connection axis which is substantially parallel to the axial direction.


Patent
Menapic and French National Center for Scientific Research | Date: 2015-04-24

The present invention relates to a device (1) for characterizing an interface of a structure (6), said structure (6) comprising a solid first material and a second material, the materials being separated by said interface. The device (1) comprises: The invention also relates to a corresponding method of characterization.


Patent
French National Center for Scientific Research and Aix - Marseille University | Date: 2015-04-09

A device for quantifying a useful thermal energy available in a tank for storing a heated or cooled fluid or solid includes: a plurality of thermoelectric converters configured to be distributed in plural locations of the storage tank; an electric circuit interconnecting the thermoelectric converters; a device measuring a single electrical variable of the electric circuit; and a converter converting a single measurement of the single electrical variable into a value for quantification of the useful thermal energy available in the storage tank.


Patent
Institute Pasteur Paris, French National Center for Scientific Research, University of Paris Descartes and Assistance Publique Hopitaux De Paris | Date: 2016-10-12

The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B Streptococcus highly-virulent ST-17 clones. The present invention also relates to the polypeptides encoded by said polynucleotides, as well as to antibodies directed or raised against said polypeptides. The present invention also relates to kits and methods for the specific detection of Group B Streptococcus highly-virulent ST-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.


Patent
Joseph Fourier University and French National Center for Scientific Research | Date: 2015-04-22

The present invention relates to novel NADPH oxidase, or Nox, proteins, to the use thereof, to a method for preparing same and to a method for identifying same.


Patent
French National Center for Scientific Research | Date: 2016-10-14

A kit for labeling bacteria, the kit including:


Patent
French National Center for Scientific Research and Joseph Fourier University | Date: 2015-02-26

Multimenic lectins having a -propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.


Patent
Institute Jean Paoli & Irene Calmettes and French National Center for Scientific Research | Date: 2015-05-07

The present invention relates to an in vitro method for predicting the survival time of a subject suffering from acute myeloid leukemia (AML) comprising determining, in a biological sample from the subject, the epigenetic profile of the H3K27.


Patent
French National Center for Scientific Research | Date: 2016-09-07

The invention concerns a method of forming a graphene layer involving: heating a support layer in a reaction chamber; and forming the graphene layer on a surface of the support layer by: a) during a first time period, introducing into the reaction chamber an organic compound gas to cause a formation of carbon atoms on the surface; b) during a second time period after the first time period, reducing a rate of introduction of the organic compound gas into the reaction chamber and introducing into the reaction chamber a further gas, wherein the further gas is a carbon etching gas; and repeating a) and b) one or more times.


Patent
Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-11-03

Replication-defective lentiviral vectors are described. Using this vector, methods of directing evolution of a target polynucleotide of interest for obtaining variants of the target polynucleotide, methods to generate genetic variability by preparing a cell library, and methods to isolate and/or screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.


Patent
French National Center for Scientific Research and Institute Doptique Graduate School | Date: 2015-05-19

According to one aspect, the invention relates to a frequency conversion cell (10) comprising:


Patent
French National Center for Scientific Research, Montpellier University and Toulouse 1 University Capitole | Date: 2015-01-22

The invention relates to a method for the in vitro diagnosis of prostate cancer in a patient, characterised in that it comprises a step of measuring the expression level of the gene of the cation-independent mannose-6-phosphate receptor (CI-M6PR) in a sample of prostate tissue of the patient, the determination of overexpression of said CI-M6PR gene indicating the presence of prostate cancer in said patient.


Patent
French National Center for Scientific Research, University of Bordeaux 1, University of Pau and Pays de l'Adour | Date: 2015-04-01

The invention relates to a method for manufacturing macroscopic fibres of titanium dioxide (TiO_(2)) by continuous extrusion in a one-way flow, to the macroscopic fibres of TiO_(2 )that can be obtained by such a method, to the use of said fibres in heterogeneous photocatalysis for decontamination of organic pollutants from gaseous environments, and to a method for decontaminating gaseous environments, in particular air, using such fibres.


Patent
French National Center for Scientific Research | Date: 2016-11-29

Method for observing an emission of light (14, 15) from a sample (10) in a medium (11) of refractive index n_(L )disposed against a surface (20a) of a transparent support (20) of refractive index n_(s), greater than n_(L), the emission of light comprising luminous components oriented toward the support and forming an angle with a direction (20b) perpendicular to the surface (20a), said components including supercritical luminous components and critical or subcritical luminous components, the method implementing an observation device (100) capable of collecting at least part of the emission of light, of applying filters (170) to the luminous signal collected; and of transforming the filtered luminous signal into an image zone of the sample (6a, 6b); the method being characterized in that:


Patent
French National Center for Scientific Research | Date: 2014-12-23

Method for analyzing a sample including a species to be characterized and a reference species, includes:


Patent
Kallistem, French National Center for Scientific Research, French National Institute for Agricultural Research and Ecole Normale Superieure de Lyon | Date: 2014-12-19

The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.


Patent
Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single-stranded nucleic acid molecule; renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.


A device including a wire element and a winding element to wind the wire element. The winding element is configured to change from a first stable state to a second stable state. A change in the state occurs either naturally or by changing an environment parameter so as to result in the wire element being wound on the winding element. In the naturally occurring state change, the energy of interaction between the wire element and the environment is higher than the energy of interaction between the wire element and the winding element. The environment parameter change results in the wire element being wound on the winding element during the change from the first state to the second state.


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2015-04-24

Asynchronous information is provided by a sensor having a matrix of pixels disposed opposite the scene. The asynchronous information includes, for each pixel of the matrix, successive events originating from this pixel, that may depend on variations of light in the scene. A model representing the tracked shape of an object is updated after detecting events attributed to this object in the asynchronous information. Following detection, the updating of the model includes an association of a point of the model with the event detected by minimizing a criterion of distance with respect to the pixel of the matrix from which the detected event originates. The updated model is then determined as a function of the pixel of the matrix from which the detected event originates and attributed to the object and of the associated point in the model, independently of the associations performed before the detection of this event.


Patent
Aix - Marseille University and French National Center for Scientific Research | Date: 2015-05-11

The present invention relates to a method for displaying a graphical interface having display areas including a reference area, wherein each file of a file set is displayed in the form of an icon in one of the display areas, and each file of the file set contains a unique identifier identifying the file, and processing a command for inserting into the file set a selected pre-existing file which does not belong to the file set, the processing of the insertion command including the steps of: generating a new file in the file set, from the content of the selected pre-existing file, generating a unique identifier identifying the new file, and inserting into the new file the generated unique identifier and a reference link generated from a file identifier corresponding to each icon located in the reference area.


Patent
University of Western Brittany and French National Center for Scientific Research | Date: 2016-10-13

An electromagnetic system for exploring the seabed in a marine environment includes a current injection module with two electrodes spaced apart from one another, said injection electrodes being capable of injecting a current at a predetermined voltage into the marine environment close to the seabed, said injection electrodes having a contact surface with the marine environment. The system includes a data acquisition module with at least two measuring sensors for measuring electrical or magnetic data at least two points of the marine environment close to the seabed, and a power supply module for supplying power to the current injection module. Each electrode includes one or more separate conductive elements that are electrically connected to each other and arranged in such a way as to form a conductive network or a multilayer conductive assembly having a large contact surface with the marine environment.


Patent
French National Center for Scientific Research | Date: 2016-07-19

An all-solid-state Li-ion battery comprising a monolithic body formed by at least three superposed layers, including: at least one layer of a negative-electrode composite comprising at least one active negative-electrode material, at least one solid electrolyte, and at least one electron-conductivity providing agent. The at least one layer of a positive-electrode composite has at least one active lithium-based positive-electrode material, at least one solid electrolyte, and at least one electron-conductivity providing agent. The at least one intermediate solid-electrolyte layer separating the composite negative- and positive-electrode layers from one another. The solid-electrolyte content in each of the composite electrode layers independently varies from 10 to 80 wt %. The content of the electron-conductivity providing agent in each of the composite electrode layers independently varies from 2 to 25 wt %. The active electrode material content in each of the composite electrode layers independently varies from 20 to 85 wt %. The thickness of each of the electrode layers varies, independently from one another, from 30 to 1400 m.


Patent
Thomson Licensing and French National Center for Scientific Research | Date: 2017-01-18

A recommendation system (200) can provide recommendations based on clustering that takes into account user data and latent behavioral functions. In various embodiments, user data can be obtained. User data can be, for example, movie ratings, prior movie category selections, age, location, etc. The user data can be clustered based on one or more latent behavioral functions. Likelihood parameters of a user preference can be determined based on the clustering, and a recommendation can be determined based on the likelihood parameters.


Patent
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-01-11

The present invention relates to a compound of formula (I) or (II) and its use for detecting and/or quantifying a solvent S_(1) in a solvent S_(2), S_(1) and S_(2) being distinct:_(1), R_(2), R_(3), R_(4), R_(5), R_(6), X, Y and n are as defined in claim 1.


The invention relates to an adaptation device (21) for adapting an UV-Vis cuvette (17) to perform in-situ spectroanalytical characterization of redox processes using gas species or solutes in a controlled atmosphere, said device being configured so as to fit the open end of a UV-Vis cuvette (17) intended to contain products to be measured during achievement of spectroanalytical measurements. The device comprises a main body (22) configured to form a lid covering the opened end (18) of the cuvette (17), said main body having a first part (23) and a second part (24); a working (13), a counter (14) and a reference (15) electrode with removable parts (132, 142, 152) at the respective ends of three conductors (131, 141, 151) coming from outside and passing through the main body (22); a gas inlet (16) intended to allow introduction of a gas said gas inlet having one aperture (162) directed to the working electrode (13) and second aperture (163) directed to the bottom of the cuvette, a gas outlet (27) intended to let the oxidation gas in excess to flow out of the cuvette (17) and an solution inlet tube (28) for titration measurements.


Patent
French National Center for Scientific Research | Date: 2017-01-18

The present invention relates to the cloning of the nicotinic acetylcholine receptors (nAChR) subunits in species from the phylum arthropoda and in particular a pollinator insect such as Apis mellifera and their uses thereof.


Patent
University of Bordeaux 1, Bordeaux Polytechnic Institute, French National Center for Scientific Research and Institute National Of Recherche En Informatique Et En Automatique | Date: 2017-01-04

The invention concerns a hybrid simulator (100) for teaching optics or for training adjustment of an optical device. According to the invention, the hybrid simulator (100) comprises at least one dummy optical component (10) physically simulating an optical device, at least one actuator device (30) for generating or simulating an adjustment of said dummy optical component (10), a sensor configured for detecting an adjustment signal representative of operating said actuator device (30), a digital processing system (90) comprising a numerical model for simulating an output numerical optical beam resulting from interaction between an input numerical optical beam and a numerical optical component representing said optical device as a function of said adjustment signal and a display system (2, 95) for displaying a visual signal (51, 52) representative of said output optical beam and/or augmented reality signals (60, 61, 62, 63).


Patent
French National Center for Scientific Research | Date: 2017-01-04

The present invention relates to a method using two-photon stereolithography for preparing molecularly imprinted polymers, notably 3D-structured molecularly imprinted polymers.


Patent
Total S.A. and French National Center for Scientific Research | Date: 2017-03-01

The invention concerns a plasma generating apparatus, for manufacturing devices having patterned layers, comprising a first electrode assembly (1) and a second electrode assembly (2) placed in a plasma reactor chamber, an electrical power supply (6) for generating a voltage difference between the first electrode assembly (1) and the second electrode assembly (2). According to the invention, the second electrode assembly (2) is configured for receiving a substrate (5), and the first electrode assembly (1) comprises a plurality of protrusions (11) and a plurality of recesses (12, 13, 14, 15, 16, 17, 18), the protrusions (11) and recesses (12, 13, 14, 15, 16, 17, 18) being dimensioned and set at respective distances (D1, D2) from the surface (51) of the substrate (5) so as to generate a plurality of spatially isolated plasma zones (21, 22) located selectively either between said surface (51) of the substrate (5) and said plurality of recesses (12, 13, 14, 15, 16, 17, 18) or between said surface (51) of the substrate (5) and said plurality of protrusions (11).


Patent
Dna Therapeutics, Institute Curie and French National Center for Scientific Research | Date: 2017-03-01

The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules facilitating endocytosis, in particular for use in the treatment of cancer.


Patent
University of Nantes, French National Center for Scientific Research and University Los Andes | Date: 2017-01-11

The invention relates to a system for assessing chloride concentration at one predetermined area of a porous or composite material, such as a reinforced concrete structure, comprising a sensor (1) embedded in the predetermined area of the material, an analyser (2) connected to the sensor, and a processing module (4) connected to the analyser. The sensor (1) comprises two facing or coplanar electrodes (11), called electrodes, an intermediate layer (13) arranged between said electrodes, said intermediate layer being in contact with the material of the first area of the structure and comprising calcium aluminates. The analyser (2) is configured to apply an alternate current between the electrodes and output an impedance value or capacitance value of the intermediate layer. The processing module (4) is configured to compute a chloride concentration assessment in the predetermined area of the material based on the impedance value or capacitance value outputted by the analyser.


Patent
French National Center for Scientific Research | Date: 2017-01-18

The invention concerns an antenna apparatus having a selectively orientable directivity comprising a first face (101) and a second face (102). The first face (101) comprises at least a first radiating element (200) and a first set of at least three parasitic elements (301, 302, 303), the second face (102) comprises at least a second radiating element (250) and a second set of at least three parasitic elements (351, 352, 353), the apparatus being configured to selectively activate at least some of the parasitic elements (301, 302, 303, 351, 352, 353). The apparatus comprises at least a first electrically-conductive wire (400) and a feed point (500) connected to the electrically-conductive wire (400), the first (200) and second (250) radiating elements being connected together by said electrically-conductive wire (400), said electrically-conductive wire (400) and feed point (500) feeding the first (200) and second (250) radiating elements according to a differential mode.


Patent
Synthopetrol, French National Center for Scientific Research, School of Chemistry, Physics and Electronics, Lyon | Date: 2017-03-08

The present invention relates to the use of a heterogeneous solid catalyst comprising or consisting of a metal complex linked by covalent bonds and / or by Van der Waals type interactions on a magnetic carrier for the implementation of a hydrotreatment reaction of gas derived from the pyrolysis of a substrate, the said hydrotreatment reaction being carried out with hydrogen and with said gas in the presence of said catalyst and leading to a gaseous phase, said gaseous phase leading by a step of cooling to the production of a liquid phase formed of liquid biofuel.


Patent
French National Center for Scientific Research and Moscow State University | Date: 2017-02-01

This invention relates to dye-sensitive light absorbing species and, more particularly, to trans-disubstituted benzodiazaporphyrins useful in dye-sensitive light absorbing applications especially active in the long wavelength spectrum range.


Patent
French National Center for Scientific Research, Bordeaux Polytechnic Institute and The Regents Of The University Of California | Date: 2017-02-01

The present invention concerns the use of a thioether alkylation process for modulating the lower critical solution temperature of an elastin-like polypeptide comprising at least one methionine residue. It also concerns derivatives of elastin-like polypeptides and their preparation process.


Patent
French National Center for Scientific Research and Institute Curie | Date: 2017-01-25

A fluidic device comprising at least:a/ a solid matrix 5,b/ a textile component 4, embedded in said matrix and mechanically cohesive with said matrix,c/ at least one channel 6 embedded in said matrix and entangled with said textile component 4, said channel 6 being at least partly open. A method for making a fluidic device comprising providing a textile component 4 comprising support fibers 1.1, 1.2 and at least a movable fiber 2 entangled with said textile 4, embedding at least part of said textile 4 and part of said movable fiber 2, in a matrix precursor material 5, applying a treatment in order to obtain a solid matrix 5.


Patent
French National Center for Scientific Research and Institute Curie | Date: 2017-01-25

A minifluidic device comprising a matrix, an elongated guiding duct 109 embedded at least in part in said matrix, with at least one port to the outside of the matrix, a movable fiber 104 at least partly contained in said guiding duct 109, and able to undergo within said guiding duct 109, and at least along some part of said fiber 104, at least one action selected among a sliding, or a deformation, or a rotation, at least one zone in fluidic connection with said guiding duct 109, said zone being selected from: a fluid drop area, a reservoir, or a chamber 107.


Patent
French National Institute for Agricultural Research and French National Center for Scientific Research | Date: 2017-03-15

The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.


Patent
French National Center for Scientific Research | Date: 2017-03-08

The invention concerns a Thickness Shear Mode (TSM) biosensor (1) which comprises an ex vivo living skin explant (2), the skin explant (2) comprising at least one of the skin layers among: hypodermis, dermis (2A), epidermis (2B) and the stratum corneum (2C), a TSM transducer (3) which comprises: an AT cut quartz resonator 3C which has two opposite exterior surfaces (3A,3B), and two conducting electrodes (4A, 4B), each conducting electrode being deposited on one of the two exterior surfaces (3A,3B), the TSM transducer (3) allowing to determine micro rheological characteristics of the living skin explant (2) by piezoelectric transducing using shear waves, the TSM transducer (3) presenting: measuring means (30), monitoring and calculating means (31) which monitor an evolution in time of an electrical response of the living skin explant (2), and which calculate in time, from the electrical response, micro rheological characteristics of the living skin explant (2), a bottom surface of the skin explant (2) being in contact with the TSM transducer (3), a top surface of the skin explant (2) being in contact with air.


Patent
French National Center for Scientific Research, École Centrale Lille, Japan National Institute of Advanced Industrial Science and Technology | Date: 2017-02-01

The present invention relates to the use of an alumina-supported rhenium oxide catalyst for the deoxydehydration of glycerol to allyl alcohol, as well as to a process for the production of allyl alcohol from glycerol in the presence of such a heterogeneous catalyst.


Patent
French National Center for Scientific Research and Synthelor SAS | Date: 2017-04-05

The present invention relates to novel P-chirogenic organophosphorus compounds of general formula (I). The present invention also provides a process for the synthesis of said compounds of formula (I). The present invention also relates to intermediate products of general formulae (II), (III) and (IV), as shown below, which are involved in the synthesis of compounds (I). Further, the invention relates to metal complexes comprising compounds (I) as ligands. The novel compounds and complexes of the present invention are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.


Patent
French National Center for Scientific Research and UREKA Sarl | Date: 2017-03-08

The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.


Patent
University of Nantes and French National Center for Scientific Research | Date: 2017-03-08

The present invention relates to a method and a device for encoding a current frame of a video sequence, said current frame being encoded block by block. According to the invention, a current block of the current frame is encoded by performing the following steps:- applying (S1) a texture synthesis to said video sequence in order to generate a set of n candidate blocks for replacing the current block, said n candidates blocks. being similar to the current block according to a predefined criterion,- encoding (S3) the candidate blocks in order to generate encoded candidate blocks and computing a coding cost for each encoded candidate block, and- selecting (S4) as encoded block for the current block the encoded candidate block having the lowest coding cost.


Patent
French National Center for Scientific Research, University of Bordeaux 1 and Bordeaux Polytechnic Institute | Date: 2017-01-25

The invention relates to a method for manufacturing a miniaturized electrochemical cell and to a miniaturized electrochemical cell. The method of the invention comprises preparing at least one inner electrode (1) made of an electron conducting or semi-conducting material M_(1), providing a hollow support (4) made of an electrically insulating material M_(6), this support (4) having at least one internal hollow channel, depositing on the external surface of the support (4) a layer of an electrically conducting material M_(2), forming a template (5) of colloidal particles made of an electrically insulating material M_(3), on the layer of electrically conducting material M_(2), depositing a layer of an electrically conducting material M_(4) on the layer of electrically conducting material M_(2), depositing a layer L_(1) of an electron conducting or semi-conducting material M_(5) on the layer of electrically conducting material M_(4), introducing the at least one inner electrode (1) into the at least one internal hollow channel of the obtained structure, stabilizing the obtained structure at its two open ends with an electrically insulating material M_(7), removing the materials M_(2), M_(3), M_(4) and M_(6). The invention finds applications in the field of electrochemistry, in particular.


Patent
French National Center for Scientific Research | Date: 2017-01-25

The present invention relates to a method for processing asynchronous signals generated by a light sensor, the sensor having a matrix (100) of pixels, the method comprising:- receiving the asynchronous signals (401), each signal being associated with a pixel in a group of pixels (101 a, 102a, 101 b, 102b) in the matrix, each signal comprising successive events issued by the associated pixel ;- upon an occurrence of an event in one of the asynchronous signals, updating (405) an integration value associated to said group by adding an additive value to the integration value;- if the integration value is greater than a predetermined threshold (406), generating (408) an event in an outputted asynchronous signal.


The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasites variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.


Patent
French National Center for Scientific Research | Date: 2017-04-19

The present invention relates to TRPV2, a cation channel, whose expression at the mRNA level and at the protein levels, correlates with melanoma and with aggressive/invasive or metastatic melanoma. More specifically, the invention provides methods and kits for the diagnosis of melanoma and of aggressive/invasive or metastatic melanoma, and for the treatment of melanoma and the prevention of melanoma metastasis formation in melanoma patient.


Patent
French National Center for Scientific Research and Aix - Marseille University | Date: 2017-04-19

The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.


Dubois A.,French National Center for Scientific Research
Applied Optics | Year: 2017

Full-field optical coherence microscopy (FFOCM) is an optical technique, based on low-coherence interference microscopy, for tomographic imaging of semi-transparent samples with micrometer-scale spatial resolution. The differences in refractive index between the sample and the immersion medium of the microscope objectives may degrade the FFOCM image quality because of focus defect and optical dispersion mismatch. These phenomena and their consequences are discussed in this theoretical paper. Experimental methods that have been implemented in FFOCM to minimize the adverse effects of these phenomena are summarized and compared. © 2017 Optical Society of America.


Rodriguez-Martinez M.,French National Center for Scientific Research
Nature Structural and Molecular Biology | Year: 2017

Although some features underlying replication-origin activation in metazoan cells have been determined, little is known about their regulation during metazoan development. Using the nascent-strand purification method, here we identified replication origins throughout Caenorhabditis elegans embryonic development and found that the origin repertoire is thoroughly reorganized after gastrulation onset. During the pluripotent embryonic stages (pregastrula), potential cruciform structures and open chromatin are determining factors that establish replication origins. The observed enrichment of replication origins in transcription factor–binding sites and their presence in promoters of highly transcribed genes, particularly operons, suggest that transcriptional activity contributes to replication initiation before gastrulation. After the gastrula transition, when embryonic differentiation programs are set, new origins are selected at enhancers, close to CpG-island-like sequences, and at noncoding genes. Our findings suggest that origin selection coordinates replication initiation with transcriptional programs during metazoan development. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.


Patent
SYRAL Belgium NV and French National Center for Scientific Research | Date: 2017-04-19

The invention relates to a composition of isomers of mono-alkyl ethers of monoanhydro-hexitol having an alkyl ether radical (OR) at C-3, C-5 or C-6 of the monoanhydro-hexitol, in which the alkyl group (R) is a linear or branched, cyclic or non-cyclic hydrocarbon group comprising between 4 and 18 carbon atoms. The invention also relates to the method for producing such a composition, as well as to the use thereof as a non-ionic surfactant, an emulsifier, a lubricant, an antimicrobial agent or a dispersing agent.


Patent
French National Center for Scientific Research | Date: 2017-01-04

A luminescent hybrid nanomaterial comprising: at least one inorganic nanomaterial comprising an inorganic first compound; and at least one second compound comprising a first aggregation-induced emission moiety, wherein the at least one second compound is grafted on at least part of a surface of the inorganic first compound.


Patent
French National Center for Scientific Research | Date: 2017-02-08

The invention relates to a method for manufacturing macroscopic fibres of titanium dioxide (iO2) by continuous extrusion in a one-way flow, to the macroscopic fibres of iO2 that can be obtained by such a method, to the use of said fibres in heterogeneous photocatalysis for decontamination of organic pollutants from gaseous environments, and to a method for decontaminating gaseous environments, in particular air, using such fibres.


Patent
Paris Science Et Lettres Quartier Latin and French National Center for Scientific Research | Date: 2017-02-08

A method for producing a metal fluoride ceramic, comprising: providing a sedimented compound comprising metal fluoride particles having an average particle size lower than 30 nm and a solvent, partially drying the sedimented compound at a temperature lower than 65C until the partially dried compound comprises from 5 wt% to 45 wt% of the solvent, and sintering, for example in air, the partially dried and sedimented compound.


Patent
French National Center for Scientific Research | Date: 2017-03-29

The present invention relates to a pod (55) for a parallel robot, for controlling an object, including: at least two frames (80, 82) comprising at least two pairs of swivels (96, 98, 100, 102, 108, 110, 112, 114); at least two bridges (84, 86) that are connected to each of the frames respectively by four hinges (116, 118, 120, 122) which are substantially parallel to an axial direction (V) and define a parallelogram (ABCD) in a plane (P) perpendicular to the axial direction, the parallelogram being movable between a plurality of configurations in which the two sides (AD, BC) corresponding to the two frames are substantially parallel to an orientation direction (DI); and a base (88) which is mounted on the pod and is intended to be connected to an effector (60) which is suitable for controlling the object. The base is connected to each bridge respectively by at least one hinge (124, 126) which is oriented along a connection axis which is substantially parallel to the axial direction, the two connection axes of the base defining, in said plane, a segment (EF) which is parallel to the orientation direction in all the configurations of the parallelogram.


Patent
French National Center for Scientific Research, French National Institute for Agricultural Research and Toulouse 1 University Capitole | Date: 2017-02-15

The present invention relates to ex vivo method for producing outer membrane vesicles (OMVs) by expression or overexpression of the hemolysin F gene (hlyF) in gram-negative bacterium.


The invention relates to a braking system capable of being mounted in an electrically powered wheelchair, comprising at least: two hydraulic brakes each capable of being mounted on a respective driving wheel of said wheelchair, said brakes being activatable by an electric signal and by manual control; a control device (36) which can be controlled by a user and provides said electric signal; a manual control unit (42) for activating and deactivating said brakes independently of said electric signal; a module (31) for controlling the brakes, which generates a signal for controlling said brakes on the basis of said electric signal provided by the control device and on the basis of the set point for controlling the speed of the wheelchair; said brakes being actuated by means of an electromagnetic actuator (41) which is controlled by an activation signal which is a function of the control signal generated by said control module (31).


Patent
French National Center for Scientific Research | Date: 2017-02-01

The present invention relates to a method for predicting the survival time of a patient suffering from acute myeloid leukemia (AML) comprising i) determining in a sample obtained from the patient the expression level of NKp46 ii) comparing the expression level determined at step i) with its predetermined reference value and iii) providing a good prognosis when the expression level determined at step i) is higher than its predetermined reference value, or providing a bad prognosis when the expression level determined at step i) is lower than its predetermined reference value.


Patent
Rhodia and French National Center for Scientific Research | Date: 2017-02-08

The invention relates to a material comprising at least one compound having formula Bi1-xMxCu1-y-MyOS1-zMz, the methods for producing said material and the use thereof as a semiconductor, such as for photovoltaic or photochemical use and, in particular, for supplying a photocurrent. The invention further relates to photovoltaic devices using said compounds.


Patent
French National Institute for Agricultural Research, French National Conservatory of Arts, Crafts, Institute Des Science Et Industries Du Vivant Et Of Lenvironnement and French National Center for Scientific Research | Date: 2017-01-11

The present invention relates to the use of a composition comprising at least one saturated free fatty acid and at least one unsaturated free fatty acid as additive, for modifying the mechanical properties of a thermoplastic polymer material. The present invention also relates to an additivated thermoplastic polymer material and to the process for producing same.


Patent
Arkema and French National Center for Scientific Research | Date: 2017-03-01

The present invention relates to a composition containing, besides a thermosetting resin of epoxy type and a hardener of anhydride type, at least one catalyst comprising an organometallic titanium complex. This composition enables the manufacture of vitrimer resins, that is to say of resins that can be deformed in the thermoset state. It also relates to a kit for manufacturing this composition, an object obtained from this composition and a kit for manufacturing this object. Another subject of the invention relates to an organometallic titanium complex corresponding to the structure titanium bis(3-phenoxy-l,2-propane dioxide) (Ti(PPD)2), and the use thereof as vitrimer effect catalyst in systems based on epoxy resin and on hardener of anhydride type.


Patent
University of Nantes and French National Center for Scientific Research | Date: 2017-03-29

The present invention relates to methods for determining whether a patient will achieve a response after radiation therapy. In particular, the present invention relates to a method for determining whether a patient suffering from a cancer will achieve a response after radiation therapy comprising the steps of i) determining the level of ceramide in a first blood sample obtained from the patient before radiation therapy, ii) determining the level of ceramide in a second blood sample obtained from the patient during or just after radiation therapy, iii) comparing the level determined at step i) with the level determined at step ii) and iv) concluding that the patient will achieve response when the level determined at step ii) is higher than the level determined at step i) or concluding that the patient will not achieve a response when the level determined at step ii) is lower than the level determined at step i).


Patent
Aria Energie Developpement Environnement, French National Institute for Agricultural Research and French National Center for Scientific Research | Date: 2017-01-18

The invention relates to a device for separating a first gas component and a second gas component which are contained in a gas mixture, comprising: a liquid/gas absorption separation column (10), comprising a lower tank (12) and an upper separation area (11); means for placing the gas mixture in contact, with a liquid solution capable of selectively absorbing the second gas component, via counter-flow circulation in the separation area (11); and means (19) for recovering the first gas component, separate from the second gas component. The tank (12) stores a volume (16) of absorbing solution. The transverse cross-sectional surface of the tank (12) of the absorption column (10) is no lower than twice the transverse cross-sectional surface of the separation area (11) of the absorption column (10).


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2017-02-15

The invention relates to compounds which are inhibitors of the polymerisation of tubulin, to the methods for the production thereof, and to the uses of same.


Patent
French National Center for Scientific Research | Date: 2017-04-12

A photovoltaic device comprising: a plurality of photovoltaic cells, distant from one another; a holder (6) receiving the cells; and a light guide (10) making contact with said cells and comprising a primary guide (18) having a face (22) that is proximal to the cells, the proximal face (22) being oriented toward the cells (8) and the holder (6). The photovoltaic device comprises, between the cells, zones located between the holder and the primary guide and containing a material (24) of refractive index lower than that of the proximal face, the material making contact with said proximal face.


Patent
Peugeot Citroen Automobiles S.A., French National Center for Scientific Research and Céramiques Techniques Industrielles | Date: 2017-04-12

The invention relates to a process for producing a membrane filter comprising the steps of selecting a honeycomb monolith with a network of channels separated by porous channel walls and the deposition on these walls of a membrane that adheres to the wall, obtained by a coating operation during which some of the walls of the monolith are placed in contact with an aqueous suspension of a sinterable powder of a constituent material of the monolith then by drying and finally by calcining the coated monolith. The membrane is obtained by repeating the coating operation, the weight concentration of sinterable powder in the aqueous suspension being reduced at each new operation, and the calcination is carried out at a temperature below 1000C.


Pixel comprising three adjacent sub-pixels (P1, P2, P3), formed by respective stacks of semiconducting layers, said pixel being characterized in that: - each said sub-pixel comprises a first active layer (32), adapted to emit a light at a first wavelength (1) when it is traversed by an electric current; - another sub-pixel (P2) also comprises a second active layer (52, 52), adapted to emit a light at a second wavelength (2) greater than said first wavelength; - another of said sub-pixels (P3) also comprises a third active layer (22, 6), adapted to emit a light at a third wavelength (3) greater than said first wavelength and different from said second wavelength; at least one out of said second and third active layer being adapted to emit said light when it is excited by the light of the first wavelength emitted by said first active layer of the same sub-pixel. Semi-conducting structure and methods for the fabrication of such a pixel.


Patent
French National Center for Scientific Research | Date: 2017-02-01

The invention relates to a process for preparing a high-performance composite part that is electrically conductive at the surface, to said high-performance composite part that is electrically conductive at the surface, to the use of said high-performance composite part that is electrically conductive at the surface in electric and electronic component casings, to the use of said process for improving the resistance of an electrically insulating part to rubbing, wear, and harsh atmospheric and/or chemical conditions, to the use of said process for ensuring the protection of an electrically insulating part against electromagnetic radiation (electromagnetic shielding) and/or against electrostatic discharges, and to the use of said process for improving the surface electrical conductivity of a material.


News Article | May 8, 2017
Site: phys.org

Their experiment was the first to use a newly installed x-ray detector, called Maia, mounted at NSLS-II's Submicron Resolution X-Ray Spectroscopy (SRX) beamline. Scientists from around the world come to SRX to create high-definition images of mineral deposits, aerosols, algae—just about anything they need to examine with millionth-of-a-meter resolution. Maia, developed by a collaboration between NSLS-II, Brookhaven's Instrumentation Division and Australia's Commonwealth Scientific and Industrial Research Organization (CSIRO), can scan centimeter-scale sample areas at micron scale resolution in just a few hours—a process that used to take weeks. "The Maia detector is a game-changer," said Juergen Thieme, lead scientist at the SRX beamline. "Milliseconds per image pixel instead of seconds is a huge difference." SRX beamline users now have time to gather detailed data about larger areas, rather than choosing a few zones to focus on. This greatly enhances the chance to capture rare "needle in a haystack" clues to ore forming processes, for example. "This is important when you are trying to publish a paper," said Thieme. "Editors want to make sure that your claim is based on many examples and not one random event." "We've already gathered enough data for one, if not two papers," said Margaux Le Vaillant, one of the visiting users from CSIRO and principal investigator for this experiment. Collaborator Giada Iacono Marziano of the French National Center for Scientific Research added, "Because we can now look at a larger image in detail, we might see things—like certain elemental associations—that we didn't predict." These kinds of surprises pose unexpected questions to scientists, pushing their research in new directions. Siddons and his collaborators at Brookhaven Lab and CSIRO have provided Maia detectors to synchrotron light sources around the world—CHESS at Cornell University in New York, PETRA-III at the DESY laboratory in Hamburg, Germany, and the Australian Synchrotron in Melbourne. The detector at SRX offers the advantage of using beams from NSLS-II, the brightest light source of its kind in the world. When scientists shine the x-ray beams at samples, they excite the material's atoms. As the atoms relax back to their original state they fluoresce, emitting x-ray light that the detector picks up. Different chemical elements will emit different characteristic wavelengths of light, so this x-ray fluorescence mapping is a kind of chemical fingerprinting, allowing the detector to create images of the sample's chemical makeup. The Maia detector has several features that help it map samples at high speeds and in fine detail. "Maia doesn't 'stop and measure' like other detectors," said physicist Pete Siddons, who led Brookhaven's half of the project. Most detectors work in steps, analyzing each spot on a sample one at a time, he explained, but the Maia detector scans continuously. Siddons' team has programmed Maia with a process called dynamic analysis to pick apart the x-ray spectral data collected and resolve where different elements are present. Maia's analysis systems also make it possible for scientists to watch images of their samples appear on the computer screen in real-time as Maia scans. If samples are very similar, Maia will recycle the dynamic analysis algorithms it used to create multi-element images from the first sample's fluorescence signals to build the subsequent sample's images in real-time, without computational lag. Part of Maia's speed is also attributable to the 384 tiny photon-sensing detector elements that make up the large detector. This large grid of sensors can pick up more re-emitted x-rays than standard detectors, which typically use less than 10 elements. Siddons' instrumentation team designed special readout chips to deal with the large number of sensors and allow for efficient detection. The 20-by-20 grid of detectors has a hole in the middle, but that's intentional, Siddons explained. "The hole lets us put the detector much closer to the sample," Siddons said. Rather than placing the sample in front of the x-ray beam and the detector off to the side, SRX beamline scientists have aligned the beam, sample, and detector so that the x-ray beam shines through the hole to reach the sample. With this arrangement, the detector covers a wide angle and captures a large fraction of fluoresced x-rays. That sensitivity allows researchers to scan faster, which can be used either to save time or to cut back on the intensity of x-rays striking the sample, reducing any damage the rays might cause. Siddons noted that the team is currently developing new readout chips for the detector, and incorporating a new type of sensor, called a silicon drift detector array. Together these will heighten the detector's ability to distinguish between photons of similar energy, unfolding detail in complex spectra and making for even more accurate chemical maps. Explore further: Multilaboratory collaboration brings new X-ray detector to light


News Article | May 8, 2017
Site: www.eurekalert.org

An international research team has revealed for the first time that testosterone protects males against developing asthma, helping to explain why females are two times more likely to develop asthma than males after puberty. The study showed that testosterone suppresses the production of a type of immune cell that triggers allergic asthma. The finding may lead to new, more targeted asthma treatments. One in nine Australians (2.5 million people) and around one in 12 Americans (25 million) have asthma, an inflammatory airway condition. During an asthma attack, the airways swell and narrow, making it difficult to breathe. In adults asthma is two times more prevalent and more severe in women than men, despite more being more common in boys than girls before puberty. In 2016, the city of Melbourne, Australia, experienced a 'thunderstorm asthma' event that was unprecedented internationally in its scale and severity of consequences, with almost 10,000 people visiting hospitals over a two-day period. Thunderstorm asthma refers to allergic asthma thought to be initiated by an allergy to grass pollen. Many people with no history of asthma experienced severe asthma attacks. Dr Cyril Seillet and Professor Gabrielle Belz from Melbourne's Walter and Eliza Hall Institute, with Dr Jean-Charles Guéry and his team at the Physiopathology Center of Toulouse-Purpan, France, led the study, published today in the Journal of Experimental Medicine. Dr Seillet said hormones were speculated to play a significant role in the incidence and severity of asthma in women. "There is a very interesting clinical observation that women are more affected and develop more severe asthma than men, and so we tried to understand why this was happening," Dr Seillet said. "Our research shows that high levels of testosterone in males protect them against the development of allergic asthma. We identified that testosterone is a potent inhibitor of innate lymphoid cells, a newly-described immune cell that has been associated with the initiation of asthma." The research team found that innate lymphoid cells - or ILC2s - 'sensed' testosterone and responded by halting production of the cells. "Testosterone directly acts on ILC2s by inhibiting their proliferation," Dr Seillet said. "So in males, you have less ILC2s in the lungs and this directly correlates with the reduced severity of asthma." ILC2s are found in the lungs, skin and other organs. These cells produce inflammatory proteins that can cause lung inflammation and damage in response to common triggers for allergic asthma, such as pollen, dust mites, cigarette smoke and pet hair. Professor Belz said understanding the mechanism that drives the sex differences in allergic asthma could lead to new treatments for the disease. "Current treatments for severe asthma, such as steroids, are very broad based and can have significant side effects," Professor Belz said. "This discovery provides us with a potential new way of treating asthma, by targeting the cells that are directly contributing to the development of allergic asthma. While more research needs to be done, it does open up the possibility of mimicking this hormonal regulation of ILC2 populations as a way of treating or preventing asthma. Similar tactics for targeting hormonal pathways have successfully been used for treating other diseases, such as breast cancer." A video related to this research can be found here. It is also under embargo for May 8th at 9 AM. This work was supported by the Australian National Health and Medical Research Council, the French National Center for Scientific Research, France, the French National Research Agency and the Victorian State Government Operational Infrastructure Support Program.


News Article | May 8, 2017
Site: www.businesswire.com

DEARBORN, Mich.--(BUSINESS WIRE)--EnvisionTEC, a leading global manufacturer of desktop and full-production 3D printers and materials, today unveils its first-ever line of research-grade materials for its 3D-Bioplotter Series printers as well as three new engineering-grade materials for industrial customers. With the broadest portfolio of additive manufacturing technologies in the world, EnvisionTEC is already recognized as having one of the most diverse portfolios of 3D printing materials on the market, including materials approved in the United States and Europe for medical use in the body. In all, EnvisionTEC now offers more than 170 materials, which come in a range of functionalities and colors. Parts printed in the new materials will be on display this week in Pittsburgh at RAPID + TCT, the premier event for 3D manufacturing in North America. EnvisionTEC also will be celebrating its 15th year anniversary and showcasing other machine and material innovations in booth 1813. “These new offerings showcase our commitment to material development as well as our close relationships with customers, who have asked us to develop specific materials for our highly accurate and reliable desktop and production machines,” said CEO Al Siblani. EnvisionTEC’s growing material R&D team is led by Dr. Vadim Nazarov, who studied photochemistry with renowned 3D printing expert Jean-Claude André of the French National Center for Scientific Research before joining EnvisionTEC in 2003. Three new industrial materials are now available for users of EnvisionTEC’s Desktop, Perfactory and 3SP printers. The company’s 3SP technology, first unveiled in 2013, offers a fast and unique vat photopolymerization method in large build envelopes up to 18 x 18 x 18 inches. The new materials include: What’s more, EnvisionTEC will also be launching its first-ever line of materials for the 3D-Bioplotter. That includes: More information about the company’s new materials can be found at EnvisionTEC.com/materials. EnvisionTEC is a leading global provider of professional-grade 3D printing solutions. Founded in 2002 with its pioneering commercial DLP printing technology, EnvisionTEC now sells more than 40 printers based on six distinct technologies that build objects from digital design files. The company’s premium 3D printers serve a variety of medical, professional and industrial markets, and are valued for precision, surface quality, functionality and speed. EnvisionTEC’s intellectual property includes more than 100 pending and granted patents and 70 proprietary materials. Learn more at EnvisionTEC.com.


Grant
Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 74.61M | Year: 2013

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.\nOur main scientific and technological objectives in the different tiers of the value chain are to develop material technologies for ICT and beyond, identify new device concepts enabled by graphene and other layered materials, and integrate them to systems that provide new functionalities and open new application areas.\nThese objectives are supported by operative targets to bring together a large core consortium of European academic and industrial partners and to create a highly effective technology transfer highway, allowing industry to rapidly absorb and exploit new discoveries.\nThe Flagship will be aligned with European and national priorities to guarantee its successful long term operation and maximal impact on the national industrial and research communities.\nTogether, the scientific and technological objectives and operative targets will allow us to reach our societal goals: the Flagship will contribute to sustainable development by introducing new energy efficient and environmentally friendly products based on carbon and other abundant, safe and recyclable natural resources, and boost economic growth in Europe by creating new jobs and investment opportunities.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: NMP-03-2015 | Award Amount: 7.96M | Year: 2015

The recent 20 years have seen the discovery of new classes of nanoporous materials (NPM). It includes amorphous micro-mesoporous aluminosilicate type materials and more recently Metal-Organic Frameworks (MOF). Despite the great potential of this new class of materials, we cannot recognize industrial success yet at the level of initial expectations and business opportunities. The main reasons which limit the penetration of these materials on the market are that there is a very limited choice of materials available on the market with prices and shapes (powder) which are not compatible for a first demonstration. In this respect, the objectives of ProDIA are: - To develop production technologies and methods including shaping, for MOF and aluminosilicates, which are price competitive or at least in the same range as other state of the art porous solids such as advanced zeolites or carbons 10-100 /kg - To set-up production facilities in Europe for the production of a variety of NPM with chemical and mechanical stabilities and with safety requirements which allow them to be sold, distributed and used in the industry. The project will thus develop three innovative processes (water-based synthesis, mechanosynthesis, spray-drying) for cost-effective production of NPMs meeting industrial expectations with improved reliability and repeatability at pilot-scale. The industrial relevance of these NPMs will be demonstrated in four applications: gas storage, air purification, heat pump and health care. The consortium is composed of 5 RTO, 1 university and 1 association together with 6 industrial partners, including 2 SMEs and a spin-off being created; linking technology providers and academic partners with industrial end-users. The consortium has well-balanced skill sets to achieve its objectives. The financial resources mobilized by the 13 partners represent a total grant of 7 604 940 with a global effort of 757 PM.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.90M | Year: 2015

Development of fuel injection equipment (FIE) able to reduce pollutant emissions from liquid-fueled transportation and power generation systems is a top industrial priority in order to meet the forthcoming EU 2020 emission legislations. However, design of new FIE is currently constrained by the incomplete physical understanding of complex micro-scale processes, such as in-nozzle cavitation, primary and secondary atomization. Unfortunately, todays computing power does not allow for an all-scale analysis of these processes. The proposed program aims to develop a large eddy simulation (LES) CFD model that will account for the influence of unresolved sub-grid-scale (SGS) processes to engineering scales at affordable computing time scales. The bridging parameter between SGS and macro-scales flow processes is the surface area generation/destruction occurring during fuel atomisation; relevant SGS closure models will be developed through tailored experiments and DNS and will be implemented into the LES model predicting the macroscopic spray development as function of the in-nozzle flow and surrounding air conditions. Validation of the new simulation tool, currently missing from todays state-of-the-art models, will be performed against new benchmark experimental data to be obtained as part of the programme, in addition to those provided by the industrial partners. This will demonstrate the applicability of the model as an engineering design tool suitable for IC engines, gas turbines, fuel burners and even rocket engine fuel injectors. The proposed research and training programme will be undertaken by 15ESRs funded by the EU and one ESR funded independently from an Australian partner; ESRs will be recruited/seconded by universities, research institutes and multinational fuel injection and combustion systems manufacturers that will represent in the best possible way the international, interdisciplinary and intersectoral requirements of the Marie Curie Action guidelines.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 2.31M | Year: 2015

European particle physics groups interested in searching signals of new physics both with neutrinos, at T2K experiment, and at the intensity frontier, with the Belle-II experiment at the SUPERKEKB machine, want to share between them and with KEK laboratory their knowledge in data analysis and detector technologies. Such knowledge sharing will enhance skills and competences of all participants, will allow Europe to play a primary role in the search for deviations from the actually known fundamental physics in the flavour sector and, last but not least, will produce an unprecedented collaboration with japanese scientists on the ground of dissemination and outreach.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-02-2014 | Award Amount: 6.71M | Year: 2015

GateOnes mission is to accelerate smart systems adoption by European SMEs in facilitating their access to advanced technologies for the development of innovative and smart solutions. GateOne offers Innovation as a Service to the benefit of SMEs in structuring a complete and adapted innovation chain to contribute to the Smartization of Europe. The concept is based on an innovative and pragmatic approach to cross the valley of death. Our Innovation Action is designed to enter efficiently into a new management paradigm in implementing critical size mechanisms. We will work on a unique Pan European portfolio of smart systems technologies to make them attractive and available for evaluation by a large panel of European SMEs. 20% of the portfolio will be related to bioelectronics technologies. In implementing the New Product Introduction process, our service will provide a collaboration framework between SMEs and RTOs, to progress from Lab to Market. From a complementary smart systems technologies portfolio we will work on 50 small scale projects to deliver innovation concept in the form of demonstrators. They will be produced at the only condition that an SME expresses interest and engages to enter into a testing phase. Our innovation service will allow low risk evaluation conditions. We will introduce product concept designed on a business case to meet SMEs expectations. We will structure, an adapted innovation chain, while validating the cost efficient manufacturability of the solution. A broad diffusion will make GateOne a European entry point of state-of-the-art technology for smart systems. Inherited from COWIN CSA success and commitment of RTOs to further apply and develop the COWIN approach, GateOne will lead to a major breakthrough for European competitiveness in engaging SMEs in the smartization wave. The support of the European Commission will validate the concept and prepare its sustainability with RTOs, industrials and private investors support.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-2-2015 | Award Amount: 1.50M | Year: 2016

Euro-BioImaging (EuBI) is the pan-European research infrastructure project for imaging technologies in biological and medical sciences and has been on the ESFRI Roadmap since 2008. In close match with the scope and objectives of the INFRADEV2 call, Preparatory Phase II (PPII) funding will enable EuBI: to finalize the submission and approval procedure of its ERIC statutes with the EC and bring them to signature by the EuBI Member States and EMBL to launch the EuBI-ERIC; obtain commitments for the sustainable funding for the EuBI-ERIC by its Member States; implement the operational EuBI Hub and recruit its staff to provide user access and services; define and sign the service level agreements between EuBI-ERIC and the 1st generation of EuBI Nodes; establish a procedure to increase EuBI-ERIC membership, so that new countries can continuously join the EuBI-ERIC with clear national benefits and contributions. From Dec 2010 until May 2014, EuBI successfully completed its EU FP7-funded Preparatory Phase I, which addressed key technical and strategic questions and provided a blueprint for infrastructure implementation. 14 European countries (BE, BG, CZ, FI, FR, IL, IT, NO, PL, PT, SK, ES, NL, UK), and the PPI coordinator EMBL have signed the EuBI Memorandum of Understanding to jointly undertake the remaining steps required to draft and submit the EuBI ERIC application to the EC. The MoU signatories constitute the EuBI Interim Board (IB), which now governs the Interim Phase. To maintain the successful momentum of Member State engagement, the EuBI PPII project consortium comprises and is fully supported by all IB Members. We have jointly defined clear and measurable objectives that will bring EuBI to full maturity in order to start operation and provide its services to European researchers immediately upon launch of the EuBI-ERIC. The award of PPII funding would leapfrog the start of EuBI-ERIC user access and service provision by at least 1,5 years time or more.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: INSO-1-2014 | Award Amount: 3.36M | Year: 2015

ROUTE-TO-PA is a multidisciplinary innovation project, that, by combining expertise and research in the fields of e-government, computer science, learning science and economy, is aiming at improving the impact, towards citizens and within society, of ICT-based technology platforms for transparency. ROUTE-TO-PA envisions that Information and Communication Technologies for Transparency must improve the engagement of citizens by making them able to socially interact over open data, by forming or joining existing online communities that share common interest and discuss common issues of relevance to local policy, service delivery, and regulation; moreover, ROUTE-TO-PA aims at engaging citizens to a higher degree by providing a robust and more holistic understanding of transparency, by underpinning the next generation open-data based transparency initiatives, ensuring that published data are those of value to citizens, with a personalized view in different forms to different segments of the citizens and public based on their profiles for facilitate better understanding. ROUTE-TO-PA will deliver the experimented innovative and engaging ICT platforms to ensure citizen-friendly, conscious, and effective access to open-data, by offering easy understanding of, and social collaboration on, open data offered by PAs. The objectives of Route-To-PA are: (1) develop a Social Platform for Open Data (SPOD) enabling social interactions among open data users and between open data users and government data ; (2) build Transparency-Enhancing Toolset (TET) as extensions for existing major Open Data Platforms; and (3) develop a set of recommendations (GUIDE) as good practice guide for open data publishers for achieving higher quality transparency through open data. The objectives are deployed, tested and experimented in a real setting, with at least 5 pilot studies in five different European countries.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.86M | Year: 2016

NEUTRINOS and DARK MATTER (DM) are the most abundant and also the most elusive building-blocks of nature because of their tenuous couplings to the ordinary matter we are made of. Each particle has a mirror image with identical mass and opposite charge: its antiparticle. What is the essential nature of particles and antiparticles? This is a most fundamental open question in science. The laws of physics are almost -but not quite- symmetric for particles and antiparticles, and this could explain why the universe is made of matter, i.e. why we are here. Tiny differences detected in visible matter are largely insufficient, while an asymmetric behaviour of neutrinos or of DM may be the seed. In turn, the unnaturally symmetric behaviour of strong interactions points to a new particle, the axion, also a superb DM candidate. For the first time, the connection between these asymmetries in the visible and invisible world will be addressed. Very timely, an ambitious experimental search of asymmetric behaviour has been launched on neutrinos, axions and other DM, and the Higgs, with imminent major breakthroughs. The path to understand the Universe and build the New Standard Model must confront this problem. The mission of Elusives ITN is to form the new generation of researchers to accomplish this task, focusing on phenomenology with the necessary link to experiment. This is the first transnational such program, exploiting the capital investment in new experiments and overcoming the fragmentation of the research effort. ELUSIVES ITN is uniquely placed for it: * World-leadership in all relevant areas; * Multidisciplinarity; * Key theorists and experimentalists; * Outstanding training record; * CERN, Fermilab, SuperKamiokande and ADMX partners; * World leading cutting-edge research-related industry; * Highest professional beneficiary dissemination; * Top-quality expertise from emerging countries; * Optimal gender balance with over 50% female international leaders as coordinators.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.72M | Year: 2015

Artificial lighting is a global and growing industry. New forms of efficient solid state lighting (SSL) in particular are rapidly gaining a market share. New OLED technologies (Organic Light Emitting Diode) can revolutionise this industry as they have done in displays because of their potential flexible structure, infinite tailoring of their properties, efficiency and high colour quality. Industrial forecasts predict that the OLED lighting market will grow from $200 million in 2015 to $1.7 billion by 2020. In order to fully benefit from this huge market potential, Europe`s academia and industry are eager to develop new technologies and recruit highly qualified staff. The high demand for OLED SSL lighting however will place drastic demands on the use of very expensive and rare iridium. EXCILIGHT aims to explore exciplex emitters and thermally activated delayed fluorescence (TADF) in OLEDs that will enable us to replace Ir complexes whilst retaining ultrahigh efficiency and giving many new possibilities to simplify OLED design, helping to reduce costs and increase yields of production. Our network will train 15 Early Stage Researchers (ESRs) in the development and application of exciplex and TADF emitters, who can apply their expertise directly in future positions. EXCILIGHT is characterised by an innovative multidisciplinary approach, based on i) a combination of synthesis, physical characterisation and development of devices with the lighting industry, ii) an appropriate balance between research and transferable skills training, and iii) a strong contribution from the private sector, including leading industry and SMEs, through mentoring, courses and secondments. EXCILIGHT will positively impact the employability of its ESRs in the OLED industry through scientific and industrial training at the local and network level. With this approach we aim to train a new generation of scientists at the same time as integrating this exciting new technology into industry.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.50M | Year: 2015

Biomedical imaging is a research field that is producing ground breaking scientific discoveries that enhance the health and life quality of European citizens and have a huge economic impact. In order to maintain Europes leading position in the field, it is crucial to invest in the people who will lead R&D, and to promote the academic-private sector partnerships that will transfer the novel technologies to the market. In order to meet these needs, BE-OPTICAL will provide a unique and structured training programme to 14 ESRs in a wide range of optical imaging technologies and signal processing tools, including fluorescence spectroscopy and microscopy, optical coherence tomography, optogenetics, engineered nanomaterials and signal processing tools. The research is structured in 4 WPs: super-resolution optical imaging for the analysis of cellular processes (WP1), high-resolution optical imaging of cardiac tissue (WP2), advanced instrumentation for ophthalmic imaging (WP3), and optical components, methods and software for image analysis (WP4). Comprising 7 leading academic groups and 2 non-academic partners in 5 European countries, BE-OPTICAL brings together an interdisciplinary team of physicists, engineers and medical doctors, with complementary expertise in optical imaging, nanotechnology, computer science, complex systems and data analysis. The non-academic partners are a leading company in fluorescence instrumentation and an internationally recognised ophthalmology clinic, with the most advanced technology and expertise in ocular diseases. The training programme will provide the ESRs with a broad understanding of how a wide range of optical imaging technologies and data processing tools work, and will open for them a wide range of job opportunities. The ESRs will apply this knowledge to advance the early diagnosis of highly significant diseases. The ESRs will also gain insight into clinical studies of novel imaging technologies and the commercialization process.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.89M | Year: 2016

Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism and grazing. Consequently, our understanding of community function is partial, limiting our ability to study environmental change. While, from an evolutionary perspective, we are missing major components of the Tree of Life giving rise to a fragmented understanding of how major cellular functions have evolved. Single cell genomics (SCG), including single cell transcriptomics, is an emerging technology that has the potential to retrieve genomic information from individual uncultured microbes recovered directly from natural environments and promises to provide new tools to investigate microeukaryotes in unparalleled detail. The aim of this ITN is therefore to train a new generation of scientists with the highest expertise, in SCG, from the initial stages of cell sorting to genome sequencing and gene annotation, to the full exploitation of the data obtained. Such progress will allow the European research community for the first time to address critical ecological and evolutionary questions. SINGEK will drive training through research by both local and network-wide activities, secondments, and workshops, and by establishing an environment that extends far beyond each partner team. This training environment will also provide the transferable skills essential for successful career development. This network of well connected and highly qualified scientists with expertise in eukaryotic SCG will be ready to implement this technology beyond ecology and evolution to other fields such as biomedicine or biotechnology driving innovation across the EU.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-9-2015 | Award Amount: 2.96M | Year: 2015

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part of the regulation of gene expression is implicitly coded in the way in which chromatin is folded. As technology has advanced and information of the folded state of chromatin has emerged, a new branch of genomics (3D/4D genomics) has emerged. Hundreds of laboratories are now defining a young and active community that, though in the end concerned with the same scientific problem, uses many different approaches to study it that individually target radically different length and timescales. The community faces severe practical problems related to: i) how huge, noisy, and diverse data related to widely different size and time scales can be integrated, ii) the lack of standardized analysis and simulation tools, iii) the complete disconnection of associated informatics databases, and iv) the lack of validated and flexible visualization engines. MuG is born at the critical point in the evolution of the field, in a bottom-up approach from the biologist who are suffering severe IT problemes. MuG, supported by European leaders in the field, join three different expertise: biologist with interest in chromatin structure, methods developers and HPC facilities with strong history of supporting Bio-computational problems. We believe that MuG will be a steep-forward in approaching the potential of High Performance Computing to the development of 3D/4D genomics, and will contribute to give a structure to this new and exciting field.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-26-2014 | Award Amount: 11.93M | Year: 2015

One of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. Not only does the complexity of the MNM present a problem for regulators, the validity of data decreases with time, so that the well-known principle of the half-life of facts (Samuel Arbesman, 2012) means that what is an accepted truth now is no longer valid in 20 or 30 years time. The challenge is to build a regulatory system which is flexible enough to be able to deal with new targets and requirements in the future, and this can be helped by the development and introduction of Safe by Design (SbD) principles. The credibility of such a regulatory system, underpinned by the implementation of SbD, is essential for industry, who while accepting the need for regulation demand it is done in a cost effective and rapid manner. The NANoREG II project, built around the challenge of coupling SbD to the regulatory process, will demonstrate and establish new principles and ideas based on data from value chain implementation studies to establish SbD as a fundamental pillar in the validation of a novel MNM. It is widely recognized by industries as well as by regulatory agencies that grouping strategies for NM are urgently needed. ECETOC has formed a task force on NM grouping and also within the OECD WPMN a group works on NM categorisation. However, so far no reliable and regulatory accepted grouping concepts could be established. Grouping concepts that will be developed by NanoREG II can be regarded as a major innovation therefore as guidance documents on NM grouping will not only support industries or regulatory agencies but would also strongly support commercial launch of new NM.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-17-2014 | Award Amount: 7.97M | Year: 2015

Lithium sulphur batteries (LSB) are viable candidate for commercialisation among all post Li-ion battery technologies due to their high theoretical energy density and cost effectiveness. Despites many efforts, there are remaining issues that need to be solved and this will provide final direction of LSB technological development. Some of technological aspects, like development of host matrices, interactions of host matrix with polysulphides and interactions between sulphur and electrolyte have been successfully developed within Eurolis project. Open porosity of the cathode, interactions between host matrices and polysulphides and proper solvatation of polysulphides turned to be important for complete utilisation of sulphur, however with this approach didnt result long term cycling. Additionally we showed that effective separation between electrodes enables stable cycling with excellent coulombic efficiency. The remaining issues are mainly connected with a stability of lithium anode during cycling, with engineering of complete cell and with questions about LSB cells implementation into commercial products (ageing, safety, recycling, battery packs). Instability of lithium metal in most of conventional electrolytes and formation of dendrites due to uneven distribution of lithium upon the deposition cause several difficulties. Safety problems connected with dendrites and low coulombic efficiency with a constant increase of inner resistance due to electrolyte degradation represent main technological challenges. From this point of view, stabilisation of lithium metal will have an impact on safety issues. Stabilised interface layer is important from view of engineering of cathode composite and separator porosity since this is important parameter for electrolyte accommodation and volume expansion adjustment. Finally the mechanism of LSB ageing can determine the practical applicability of LSB in different applications.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NFRP-01-2014 | Award Amount: 13.89M | Year: 2015

The overall aim of the SOTERIA project is to improve the understanding of the ageing phenomena occurring in reactor pressure vessel (RPV) steels and in the internal steels (internals) in order to provide crucial information to regulators and operators to ensure safe long-term operation (LTO) of existing European nuclear power plants (NPPs). SOTERIA has set up a collaborative research consortium which gathers the main European research centres and industrial partners who will combine advanced modelling tools with the exploitation of experimental data to focus on four technical objectives: i) to carry out experiments aiming to explore flux and fluence effects on RPV and internals in pressurised water reactors, ii) to assess the residual lifetime of RPV taking into account metallurgical heterogeneities, iii) to assess the effect of the chemical and radiation environment on cracking in internals and iv) to develop modelling tools and provide a single platform integrating developed modelling tools and experimental data for reassessment of structural components during NPPs lifetime. Building on industry-specific key questions and material, SOTERIA will fill current gaps in safety assessment related to ageing phenomena, by providing a set of modelling tools directly applicable in an industrial environment. Guidelines for better use of modelling, material testing reactors and surveillance data will also be an output of paramount importance. Another important parallel objective is the education of the nuclear engineering and research community of SOTERIA results to improve and harmonise knowledge about NPPs ageing and thereby ensure a high impact of project results. The knowledge and tools generated in SOTERIA will contribute to improving EU nuclear safety policy, to increasing the leadership of the EU in safety related equipment and information and to contribute to improved NPP safety world-wide. The SOTERIA proposal received the NUGENIA label on 10 August 2014.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 8.63M | Year: 2015

ExaNoDe will investigate, develop and pilot (technology readiness level 7) a highly efficient, highly integrated, multi-way, high-performance, heterogeneous compute element aimed towards exascale computing and demonstrated using hardware-emulated interconnect. It will build on multiple European initiatives for scalable computing, utilizing low-power processors and advanced nanotechnologies. ExaNoDe will draw heavily on the Unimem memory and system design paradigm defined within the EUROSERVER FP7 project, providing low-latency, high-bandwidth and resilient memory access, scalable to Exabyte levels. The ExaNoDe compute element aims towards exascale compute goals through: Integration of the most advanced low-power processors and accelerators across scalar, SIMD, GPGPU and FPGA processing elements supported by research and innovation in the deployment of associated nanotechnologies and in the mechanical requirements to enable the development of a high-density, high-performance integrated compute element with advanced thermal characteristics and connectivity to the next generation of system interconnect and storage; Undertaking essential research to ensure the ExaNoDe compute element provides necessary support of HPC applications including I/O and storage virtualization techniques, operating system and semantically aware runtime capabilities and PGAS, OpenMP and MPI paradigms; The development of an instantiation of a hardware emulation of interconnect to enable the evaluation of Unimem for the deployment of multiple compute elements and the evaluation, tuning and analysis of HPC mini-apps. Each aspect of ExaNoDE is aligned with the goals of the ETP4HPC. The work will be steered by first-hand experience and analysis of high-performance applications, their requirements and the tuning of their kernels.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 7.97M | Year: 2015

The main target of the Mont-Blanc 3 project European Scalable and power efficient HPC platform based on low-power embedded technology is the creation of a new high-end HPC platform (SoC and node) that is able to deliver a new level of performance / energy ratio whilst executing real applications. The technical objectives are: 1. To design a well-balanced architecture and to deliver the design for an ARM based SoC or SoP (System on Package) capable of providing pre-exascale performance when implemented in the time frame of 2019-2020. The predicted performance target must be measured using real HPC applications. 2. To maximise the benefit for HPC applications with new high-performance ARM processors and throughput-oriented compute accelerators designed to work together within the well-balanced architecture. 3. To develop the necessary software ecosystem for the future SoC. This additional objective is important to maximize the impact of the project and make sure that this ARM architecture path will be successful in the market. The project shall build upon the previous Mont-Blanc & Mont-Blanc 2 FP7 projects, with ARM, BSC & Bull being involved in Mont-Blanc 1, 2 and 3 projects. It will adopt a co-design approach to make sure that the hardware and system innovations are readily translated into benefits for HPC applications. This approach shall integrate architecture work (WP3 & 4 - on balanced architecture and computing efficiency) together with a simulation work (to feed and validate the architecture studies ) and work on the needed software ecosystem.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-16-2014 | Award Amount: 15.99M | Year: 2015

Terrestrial and marine ecosystems provide essential services to human societies. Anthropogenic pressures, however, cause serious threat to ecosystems, leading to habitat degradation, increased risk of collapse and loss of ecosystem services. Knowledge-based conservation, management and restoration policies are needed to improve ecosystem benefits in face of increasing pressures. ECOPOTENTIAL makes significant progress beyond the state-of-the-art and creates a unified framework for ecosystem studies and management of protected areas (PA). ECOPOTENTIAL focuses on internationally recognized PAs in Europe and beyond in a wide range of biogeographic regions, and it includes UNESCO, Natura2000 and LTER sites and Large Marine Ecosystems. Best use of Earth Observation (EO) and monitoring data is enabled by new EO open-access ecosystem data services (ECOPERNICUS). Modelling approaches including information from EO data are devised, ecosystem services in current and future conditions are assessed and the requirements of future protected areas are defined. Conceptual approaches based on Essential Variables, Macrosystem Ecology and cross-scale interactions allow for a deeper understanding of the Earths Critical Zone. Open and interoperable access to data and knowledge is assured by a GEO Ecosystem Virtual Laboratory Platform, fully integrated in GEOSS. Support to transparent and knowledge-based conservation and management policies, able to include information from EO data, is developed. Knowledge gained in the PAs is upscaled to pan-European conditions and used for planning and management of future PAs. A permanent stakeholder consultancy group (GEO Ecosystem Community of Practice) will be created. Capacity building is pursued at all levels. SMEs are involved to create expertise leading to new job opportunities, ensuring long-term continuation of services. In summary, ECOPOTENTIAL uses the most advanced technologies to improve future ecosystem benefits for humankind.


Grant
Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SC5-15-2015 | Award Amount: 52.36M | Year: 2016

In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments making difficult the sharing of data and knowledge to stakeholders and policy makers for supporting key economic and societal sectors. The overarching goal of ERA-PLANET is to strengthen the European Research Area in the domain of Earth Observation in coherence with the European participation to Group on Earth Observation (GEO) and the Copernicus. The expected impact is to strengthen the European leadership within the forthcoming GEO 2015-2025 Work Plan. ERA-PLANET will reinforce the interface with user communities, whose needs the Global Earth Observation System of Systems (GEOSS) intends to address. It will provide more accurate, comprehensive and authoritative information to policy and decision-makers in key societal benefit areas, such as Smart cities and Resilient societies; Resource efficiency and Environmental management; Global changes and Environmental treaties; Polar areas and Natural resources. ERA-PLANET will provide advanced decision support tools and technologies aimed to better monitor our global environment and share the information and knowledge in different domain of Earth Observation.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.17M | Year: 2014

ABYSS is a training and career development platform for young scientists in Geodynamics, Mineralogy, Hydrodynamics, Thermodynamics and (Bio-)Geochemistry focusing on mid-ocean ridge processes and their environmental and economic impacts. It brings together 10 European research groups internationally recognized for their excellence in complementary disciplines and 4 Associated Partners from the Private Sector. ABYSS will provide training for 12 Early Stage Researchers and 3 Experienced Researchers through a structured and extensive program of collaboration, training and student exchange. ABYSS aims at developing the scientific skills and multi-disciplinary approaches to make significant advances in the understanding of the coupled tectonic, magmatic, hydrothermal and (bio-)geochemical mechanisms that control the structure and composition of the oceanic lithosphere and the microbial habitats it provides. An improved understanding of these complex processes is critical to assess the resource potential of the deep-sea. ABYSS will specifically explore processes with implications for economy and policy-making such as carbonation (CO2 storage), hydrogen production (energy generation) and the formation of ore-deposits. ABYSS will also emphasize the importance of interfacial processes between the deep Earth and its outer envelopes, including microbial ecosystems with relevance to deep carbon cycling and life growth on the Primitive Earth. The ABYSS training and outreach programme is set up to promote synergies between research and industry, general public and policy makers. The main outcome of ABYSS will be twofold (i) develop a perennial network of young scientists, sharing a common technical and scientific culture for bridging the gaps in process understanding and make possible the exploitation of far off-shore mining of marine resources; (ii) to address the need to develop pertinent policies at the European and international level for preserving these unique environments.


Grant
Agency: European Commission | Branch: H2020 | Program: ERA-NET-Cofund | Phase: SC5-02-2015 | Award Amount: 78.28M | Year: 2016

Within the European Research Area (ERA), the ERA4CS Consortium is aiming to boost, research for Climate Services (CS), including climate adaptation, mitigation and disaster risk management, allowing regions, cities and key economic sectors to develop opportunities and strengthen Europes leadership. CS are seen by this consortium as driven by user demands to provide knowledge to face impacts of climate variability and change, as well as guidance both to researchers and decisionmakers in policy and business. ERA4CS will focus on the development of a climate information translation layer bridging user communities and climate system sciences. It implies the development of tools, methods, standards and quality control for reliable, qualified and tailored information required by the various field actors for smart decisions. ERA4CS will boost the JPI Climate initiative by mobilizing more countries, within EU Member States and Associated Countries, by involving both the research performing organizations (RPOs) and the research funding organizations (RFOs), the distinct national climate services and the various disciplines of academia, including Social Sciences and Humanities. ERA4CS will launch a joint transnational co-funded call, with over 16 countries and up to 75M, with two complementary topics: (i) a cash topic, supported by 12 RFOs, on co-development for user needs and action-oriented projects; (ii) an in-kind topic, supported by 28 RPOs, on institutional integration of the research components of national CS. Finally, ERA4CS additional activities will initiate a strong partnership between JPI Climate and others key European and international initiatives (as Copernicus, KIC-Climate, JPIs, WMO/GFCS, Future Earth, Belmont Forum) in order to work towards a common vision and a multiyear implementation strategy, including better co-alignment of national programs and activities up to 2020 and beyond.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: SST.2013.3-1. | Award Amount: 13.01M | Year: 2013

OPTICITIES vision is to help European cities tackle complex mobility challenges. OPTICITIES strategy focuses on the optimisation of transport networks through the development of public/private partnerships and the experimentation of innovative ITS services. OPTICITIES addresses both passenger and freight transport issues supporting a user-centred approach. OPTICITIES delivers significant innovation breakthroughs: - New governance scheme between public and private stakeholders through a contractual architecture fostering data quality and implementing data access policy; - European standard for urban multimodal data set including interfaces with information services; - Decision support tools based on predictive data for proactive transport management and Multimodal Traffic Control Systems connecting road traffic and public transport data in cities; - Multimodal real-time urban navigator interfaced with in-car navigation systems as a first world trial; - Urban freight navigator to support drivers and fleet operators in optimising their deliveries. The European dimension of the project is ensured by a consortium of 25 partners from 8 EU member states. The consortium includes 6 city authorities, major ITS actors (research institutes, information service providers, car industry) and the most important networks of European cities and international public transport operators. Led by public authorities the consortium supports 3 key approaches: effectiveness of solutions ensuring deployment perspectives of maximum 5 years; scalability of services tailored to diverse European urban typologies; transferability of results to foster further deployments in other European cities. OPTICITIES main expected impacts are: - 6% modal shift inducing a yearly gain of 1.5 MT of CO2 - Increase in market size (211 M per year) thanks to the new governance scheme and implementation of innovative services - 10% decrease in private car use generating a gain of 3.6 M m2 of public space


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.17. | Award Amount: 8.57M | Year: 2014

Solar Energy, as the primary source of renewable energy, will contribute a major part of this share, and its conversion by concentrating technologies for concentrating solar power (CSP) and heat generation has long been proven cost-effective for a wide range of applications. Several CSP projects have recently been put into operation. Some 2.400 MW are under construction and several GW are in advanced stages of planning, particularly in Spain, but also in other Southern European countries, like France, Greece and Portugal. In view of this challenge for research, development and application of concentrating solar systems involving a growing number of European industries and utilities in global business opportunities, the purpose of this project is to integrate, coordinate and further focus scientific collaboration among the leading European research institutions in solar concentrating systems that are the partners of this project and offer European research and industry access to the best-qualified research and test infrastructures. This proposal deals with the continuation of the successful SFERA, now looking for a closer approach to the European CSP industry.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-02-2014 | Award Amount: 5.23M | Year: 2015

The objective of this proposal is to develop and demonstrate a scalable, thermally-enabled 3D integrated optoelectronic platform that can meet the explosion in data traffic growth within ICT. The Thermally Integrated Smart Photonics Systems (TIPS) program will heterogeneously integrate micro-thermoelectric coolers (TEC) and micro-fluidics (Fluidics) with optoelectronic devices (lasers, modulators, etc.) in order to precisely control device temperature and thus device wavelength compared to commercially available discrete technology. Data traffic is projected to increase sharply (40-80 by 2020) and this is driving an increase in network complexity and the requirement for scalable optoelectronic integration. A major bottleneck to this large scale integration is thermal management. Active photonic devices generate extremely high heat flux levels (~1 kW/cm2) that must be efficiently removed to maintain performance and reliability; furthermore, active photonic devices must be controlled at temperature precision better than 0.1C. Todays thermal technology is at the limit and cannot scale with growth in the network. As a comparison, electronics produce lower heat flux levels (~100 W/cm2) and have a less restrictive temperature requirement of 852C. Integration of thermal management onto optoelectronic devices has not been addressed to date in academic or industrial investigations and therefore presents a significant knowledge gap that must be filled to enable impact and ensure the EU is at the forefront of optoelectronic technology. While the end goal is driven by telecom or datacom industrial requirements there are many scientific knowledge gaps that will be filled by the TIPS consortium. The application space for a thermally-integrated smart optoelectronic solution is large and spans multiple communication length scales from long reach to inter/ intrachip communications as well as other applications like sensors that seek to leverage silicon photonics platforms


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: NMP-03-2015 | Award Amount: 7.94M | Year: 2016

The main idea of POROUS4APP project is based on the fabrication of functional nanoporous carbonaceous materials at pilot plant scale from natural resources (polysaccharide). The process for nanoporous carbon fabrication is already well known as one of the POROUS4APP partner has developed the STARBON technology at TRL5 which consist of swelling, drying and pyrolysis of natural resources and in this case Starch. What POROUS4APP project will bring to the European community is the development of new metal/metal-oxide doped-nanoporous carbonaceous materials based on a known technology. This technology needs to be upscaled and modified to enable a full flexibility of the material characteristics to be applied to various industrial applications. The use of abundant renewable resources like starch has been proven to be a low cost and reliable raw material source for industrial production of carbonaceous materials having porosity in the nanometer range. In POROUS4APP it will be intended to produce not only carbonaceous nanoporous materials but carbonaceous material with enhanced functionality by using impregnation and sol/gel strategy. This will allow POROUS4APP materials to reach the challenging requirements of state of the art high added value materials at lower cost for applications in energy storage such as lithium-ion battery and also in chemical catalysis process. These applications need materials with well defined porosity to reach high efficiency level of their functional systems.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 9.98M | Year: 2015

HYDRALAB is an advanced network of environmental hydraulic institutes in Europe, which has been effective in providing access to a suite of major and unique environmental hydraulic facilities from across the whole European scientific community. A continuation project will prepare environmental hydraulic modelling for the upcoming urgent technical challenges associated with adaptations for climate change. A multi-disciplinary approach is essential to meet these challenges. We denote the project HYDRALAB\, in recognition of the added value that will follow from our network changing to enhance the collaboration between specialists and engaging with a new range of stakeholders. The issues associated with climate change impacts on rivers and coasts are significant enough to ask the scientific community to which we open up our facilities to focus their research efforts on adaptations for climate change. We plan to issue themed calls for proposals for access to the facilities, with scientific merit as the main selection criterion, but with preference to the proposals that also address issues of adaptation to climate change impact. In HYDRALAB\, with the prospect of climate change, we will build networking activities that will also involve the wider hydraulic community in the process of generating the deliverables of the project. The first Workshop in the project will be devoted to working together with the larger European hydraulics community not directly involved in HYDRALAB. Increased emphasis will be placed by HYDRALAB\ on engagement with industry a theme that will be delivered initially through the vehicle of a focussed Workshop between HYDRALAB researchers and industry. We will work together with industry to have HYDRALAB\ become part of the innovation cycle by bringing development to market this is particularly relevant for the instruments we develop - to involve industry in our range of project deliverables.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.3-1 | Award Amount: 13.58M | Year: 2013

SUN (Sustainable Nanotechnologies) is the first project addressing the entire lifecycle of nanotechnologies to ensure holistic nanosafety evaluation and incorporate the results into tools and guidelines for sustainable manufacturing, easily accessible by industries, regulators and other stakeholders. The project will incorporate scientific findings from over 30 European projects, national and international research programmes and transatlantic co-operations to develop (i) methods and tools to predict nanomaterials exposure and effects on humans and ecosystems, (ii) implementable processes to reduce hazard and exposure to nanomaterials in different lifecycle stages, (iii) innovative technological solutions for risk management in industrial settings, and (iv) guidance on best practices for securing both nano-manufacturing processes and nanomaterials ultimate fate, including development of approaches for safe disposal and recycling. In summary, SUN stands for an integrated approach for the long-term sustainability of nanotechnologies through the development of safe processes for production, use and end-of-life processing of nanomaterials and products, as well as methods reducing both adverse effects and exposure to acceptable levels.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.84M | Year: 2015

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and across the atomic, molecular and continuum scales. The ambitious goals of E-CAM will be achieved through three complementary instruments: 1. development, testing, maintenance, and dissemination of robust software modules targeted at end-user needs; 2. advanced training of current and future academic and industrial researchers able to exploit these capabilities; 3. multidisciplinary, coordinated, top-level applied consultancy to industrial end-users (both large multinationals and SMEs). The creation and development of this infrastructure will also impact academic research by creating a training opportunity for over 300 researchers in computational science as applied to their domain expertise. It will also provide a structure for the optimisation and long-term maintenance of important codes and provide a route for their exploitation. Based on the requests from its industrial end-users, E-CAM will deliver new software in a broad field by creating over 200 new, robust software modules. The modules will be written to run with maximum efficiency on hardware with different architectures, available at four PRACE centres and at the Hartree Centre for HPC in Industry. The modules will form the core of a software library (the E-CAM library) that will continue to grow and provide benefit well beyond the funding period of the project. E-CAM has a 60 month duration, involves 48 staff years of effort, has a total budget of 5,836,897 and is requesting funding from the EC of 4,836,897, commensurate with achieving its ambitious goals.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.23M | Year: 2015

Demand for highly trained scientists with a deep understanding of wave propagation in complex media, and capable of exploiting this knowledge to develop imaging tools for seismology and acoustics, is very high in the Earth and environmental sciences. Wave-based imaging serves to map spatial and temporal variations in the structure of the Earths interior, of the oceans and atmosphere; it is used to monitor faults and volcanoes and detect natural-resource reservoirs. It is relevant to other disciplines, medical imaging being one of its most widespread applications. Todays Earth scientists are faced with a set of questions that require the application of wave-based imaging at unprecedented resolution. WAVES aims at fostering scientific and technological advances in this context, stimulating knowledge exchange between seismologists and acousticians, and researchers in the public/private domains. A unique strength of our network resides in the participation of novel physical acoustics laboratories, managed by beneficiaries/partners of WAVES, with a strong record of experimental research on inter-disciplinary and seismology-related topics. WAVES will train young scientists working in academia or industry in how to use this resource effectively, re-introducing the laboratory into the ideas-to-applications pipeline. Experimental work will serve to develop new theory, addressing topics of current interest such as acoustic time-reversal, scattering-based imaging. A truly multidisciplinary network, WAVES will apply these new ideas in a number of contexts: medical elastography is used as a tool to implement novel analogue models of seismic faults; wave sources are localized by a bio-inspired system making use of very few receivers, etc. Through WAVES, a critical mass of expertise will consolidate, defining the study of acoustic/elastic wave propagation and wave-based imaging/monitoring as an independent discipline, rich in applications of intellectual and societal relevance.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-08-2014 | Award Amount: 25.06M | Year: 2015

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal. TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative bottom-up approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive top-down portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.30M | Year: 2015

Electroactive polymers (EAP) consist of materials capable of changing dimensions and/or shape in response to electrical stimuli. Most EAPs are also capable of generating electrical energy in response to applied mechanical forces. These polymeric materials exhibit properties well beyond what conventional metal or plastic-based actuators can offer, including very high mechanical flexibility (can be stretched to twice their initial size), low density, a high grade of processability, scalability, microfabrication readiness and, in most cases, low cost. Micro-EAPs enable a new broad range of applications for which large strains and forces are desirable, and for which built-in intelligence is necessary. The main objective of the project will be the improvement of the career perspectives (in academia and in industry) of young researchers by training them at the forefront of research in the field of smart soft systems made of EAP microactuators for advanced miniaturized devices. The overall objective for the scientific programme is research and development of EAP materials and their integration for industrial applications. Special attention will be devoted to the development of microactuators. The field of smart materials is growing extremely fast. Materials whose stiffness and shape can be controlled, and that are capable of sensing their shape allow new classes of compliant complex systems. Through the MICACT programme, we hope to ensure that European researchers keep their leading role in this blossoming field, and to help them transition to industrial positions.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: DRS-01-2015 | Award Amount: 14.54M | Year: 2016

The ultimate purpose of ANYWHERE is to empower exposed responder institutions and citizens to enhance their anticipation and pro-active capacity of response to face extreme and high-impact weather and climate events. This will be achieved through the operational implementation of cutting-edge innovative technology as the best way to enhance citizens protection and saving lives. ANYWHERE proposes to implement a Pan-European multi-hazard platform providing a better identification of the expected weather-induced impacts and their location in time and space before they occur. This platform will support a faster analysis and anticipation of risks prior the event occurrence, an improved coordination of emergency reactions in the field and help to raise the self-preparedness of the population at risk. This significant step-ahead in the improvement of the pro-active capacity to provide adequate emergency responses is achievable capitalizing on the advanced forecasting methodologies and impact models made available by previous RTD projects, maximizing the uptake of their innovative potential not fully exploited up to now. The consortium is build upon a strong group of Coordinators of previous key EC projects in the related fields, together with 12 operational authorities and first responders institutions and 6 leading enterprises of the sector. The platform will be adapted to provide early warning products and locally customizable decision support services proactively targeted to the needs and requirements of the regional and local authorities, as well as public and private operators of critical infrastructures and networks. It will be implemented and demonstrated in 4 selected pilot sites to validate the prototype that will be transferred to the real operation. The market uptake will be ensured by the cooperation with a SME and Industry Collaborative Network, covering a wide range of sectors and stakeholders in Europe, and ultimately worldwide.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 31.03M | Year: 2015

The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists the understanding of stratigraphy (the timing and distribution of layers of sediment on Earth) and the discovery of the concept of plate tectonics being among the most significant. Our ability to monitor the Earth is rapidly evolving through development of new sensor technology, both on- and below-ground and from outer space; we are able to deliver this information with increasing rapidity, integrate it, provide solutions to geological understanding and furnish essential information for decision makers. Earth science monitoring systems are distributed across Europe and the globe and measure the physico-chemical characteristics of the planet under different geological regimes. EPOS will bring together 24 European nations and combine national Earth science facilities, the associated data and models together with the scientific expertise into one integrated delivery system for the solid Earth. This infrastructure will allow the Earth sciences to achieve a step change in our understanding of the planet; it will enable us to prepare for geo-hazards and to responsibly manage the subsurface for infrastructure development, waste storage and the use of Earths resources. With a European Research Infrastructure Consortium (ERIC) to be located in Rome (Italy), EPOS will provide an opportunity for Europe to maintain world-leading European Earth sciences and will represent a model for pan-European federated infrastructure.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 616.50K | Year: 2015

Innovation technologies in ground vehicle engineering require strong interdisciplinary and intersectoral investigations with an international dimension. In this context the project EVE proposes sustainable approach based on intensive staff exchange that leads to collaborative research and training between universities and industrial organizations from Germany, Belgium, Spain, Sweden, The Netherlands, South Africa, and the USA. The project includes basic and applied research, development design, experimentations, networking, and dissemination and exploitation activities. The research objectives are focused on the development of (i) experimental tyre database that can be used in the design of new chassis control systems and subjected to inclusion into Horizon 2020 pilot on Open Research Data, (ii) advanced models of ground vehicles and automotive subsystems for real-time applications, and (iii) novel integrated chassis control methods. It will lead to development and improvement of innovative vehicle components such as (i) an integrated chassis controller targeting simultaneous improvements in safety, energy efficiency and driving comfort, (ii) new hardware subsystems for brakes, active suspension and tyre pressure control for on-road and off-road mobility, and (iii) remote network-distributed vehicle testing technology for integrated chassis systems. The project targets will be achieved with intensive networking measures covering (i) knowledge transfer and experience sharing between participants from academic and non-academic sectors and (ii) professional advancement of the consortium members through intersectoral and international collaboration and secondments. The project EVE is fully consistent with the targets of H2020-MSCA-RISE programme and will provide excellent opportunities for personal career development of staff and will lead to creation of a strong European and international research group to create new hi-tech ground vehicle systems.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 1.53M | Year: 2017

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on Microscopy and Image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.


Grant
Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: European Commission | Branch: H2020 | Program: FCH2-RIA | Phase: FCH-01.1-2015 | Award Amount: 6.88M | Year: 2016

The objective is to develop and integrate the most advanced critical PEMFC stack components, many from recent FCH JU programmes, into an automotive stack showing BOL performance of 1.5 W/cm2 at 0.6V, <10% power degradation after 6,000 hours, with a technical and economic assessment showing a cost of less than 50/kW at a 50,000 annual production scale. This will be achieved by leading industrial and academic partners with expertise in the design and manufacture of PEMFC stacks, their components and materials. They will select and build on components which can achieve key target metrics, e.g. catalyst materials showing mass activities of 0.44 A/mg Pt. There will be focus on integration of the key components and optimisation of the interfaces regarding the electrochemistry, mass and heat transport, and mechanical interactions. Several iterations of an advanced stack design will be evaluated. Work is organised to optimise the flow of development, which begins with catalysts being advanced and down-selected, scaled then fed into the design and development of catalyst layers, integration with membranes and the demonstration of CCM performance. The CCMs feed into stack component development where they will be integrated with GDLs to form MEAs; and where bipolar plates will be designed and developed and supplied with the MEAs for iterative stack design, assembly and testing. All mandatory and optional objectives of the FCH 2 JU Work Plan are addressed. Performance and durability are evaluated from small single cell to stack level using standardised test protocols. Degradation is addressed by stability testing, structural visualisation and modelling. Interfaces and specification alignment is an important focus, being integrated with the evaluation of new architectures and synthesis methods and informing balance of plant component specifications. Dismantling and recycling for the recovery and re-use of all critical MEA components is included in the costing evaluation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.8.2 | Award Amount: 7.05M | Year: 2013

Massive amounts of culturally rich, educating content has been made available through European efforts and private public partnerships. However, since content dissemination on the Web is driven by a small number of large central hubs like social networks or search engines, this cultural and scientific treasures has hardly been recognized by the general public or utilized in scientific and educational processes.\nHence EEXCESS vision is to unfold the treasure of cultural, scientific and educational long-tail content for the benefit of all users. Unfolding this treasure will improve interconnectedness between cultural, scientific and educational domains. For unfolding this treasure, we focus on the simple principle of bringing the content to the user, instead of brining the user to the content.\nThrough personalized and contextualized recommendation technologies we aim to augment existing content dissemination channels users habitually use, like for example social media and content creation techniques users regularly conduct, like writing blog entries. In order to ensure large-scale high quality recommendations we emphasizes the analysis user behaviour and content consumption patterns as well as the integration of knowledge from memory organisation on their user base. To ensure user acceptance, we will develop methods for retaining the uses privacy while offering the full range of personalisation. User privacy preservation has become a key issue demanded by users, but neglected by all major web players.\nSince all results will be made available as open source framework along with necessary training materials, EEXCESS will have substantial impact on the utilization of cultural and scientific resources within Europe and beyond.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 9.04M | Year: 2015

Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcome these barriers, EMBRIC (European Marine Biological Resource Infrastructure Cluster) will link biological and social science research infrastructures (EMBRC, MIRRI, EU-OPENSCREEN, ELIXIR, AQUAEXCEL, RISIS) and will build inter-connectivity along three dimensions: science, industry and regions. The objectives of EMBRIC are to: (1) develop integrated workflows of high quality services for access to biological, analytical and data resources, and deploy common underpinning technologies and practices; (2) strengthen the connection of science with industry by engaging companies and by federating technology transfer (TT) services; (3) defragment RDI policies and involve maritime regions with the construction of EMBRIC. Acceleration of the pace of scientific discovery and innovation from marine bioresources will be achieved through: (i) establishment of multidisciplinary service-oriented technological workflows; (ii) joint development activities focusing on bioprospection for novel marine natural products, and marker-assisted selection in aquaculture; (iii) training and knowledge transfer; (iv) pilot transnational access to cluster facilities and services. EMBRIC will also connect TT officers from contrasted maritime regions to promote greater cohesion in TT practices. It will engage with policy-makers with the aim of consolidating a perennial pan-European virtual infrastructure cluster rooted in the maritime regions of Europe and underpinning the blue bioeconomy.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2016

ENSAR2 is the integrating activity for European nuclear scientists who are performing research in three of the major subfields defined by NuPECC: Nuclear Structure and Dynamics, Nuclear Astrophysics and Nuclear Physics Tools and Applications. It proposes an optimised ensemble of Networking (NAs), Joint Research (JRAs) and Transnational Access Activities (TAs), which will ensure qualitative and quantitative improvement of the access provided by the current ten infrastructures, which are at the core of this proposal. The novel and innovative developments that will be achieved by the RTD activities will also assure state-of-the-art technology needed for the new large-scale projects. Our community of nuclear scientists profits from the diverse range of world-class research infrastructures all over Europe that can supply different ion beams and energies and, with ELI-NP, high-intensity gamma-ray beams up to 20 MeV. We have made great effort to make the most efficient use of these facilities by developing the most advanced and novel equipment needed to pursue their excellent scientific programmes and applying state-of-the-art developments to other fields and to benefit humanity (e.g. archaeology, medical imaging). Together with multidisciplinary and application-oriented research at the facilities, these activities ensure a high-level socio-economic impact. To enhance the access to these facilities, the community has defined a number of JRAs, using as main criterion scientific and technical promise. These activities deal with novel and innovative technologies to improve the operation of the facilities. The NAs of ENSAR2 have been set-up with specific actions to strengthen the communities coherence around certain resarch topics and to ensure a broad dissemination of results and stimulate multidisciplinary, application-oriented research and innovation at the Research Infrastructures.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-3 | Award Amount: 11.79M | Year: 2013

With the target of limiting global warming to 2C increasingly difficult to achieve, policymakers, businesses and other decision-makers need to plan to adapt to changes in climate under higher levels of global warming. This requires coherent information on the future climate conditions, and the consequences of different adaptation actions. International negotiations on limiting global warming also require clear information on the consequences of different levels of climate change. While a vast array of projections, scenarios and estimates of future climate change and its impacts already exists, much is conflicting, unclear, of unknown levels of certainty and difficult to use to inform decisions. HELIX addresses this by providing a clear, coherent, internally-consistent view of a manageable number of future worlds under higher levels of global warming reached under a range of circumstances, supported by advice on which aspects are more certain and which less certain. This will be delivered through groundbreaking scientific research across a range of physical, natural and social science disciplines, in close engagement with experienced users of climate change information in order to ensure appropriate focus, clarity and utility. Since international climate policy often frames climate change in terms of levels of global warming relative to pre-industrial state, our research will focus on addressing the questions What do 4C and 6C worlds look like compared to 2C? and What are the consequences of different adaptation choices? Our core product will a set of eight coherent global scenarios of the natural and human world at these levels of warming achieved at different rates and with different pathways of adaptation by society. A second product will provide more detailed information in three focus regions; Europe, Sub-Saharan Africa in the Northern Hemisphere and the South Asia. This will all be supported by a comprehensive analysis of confidence and uncertainty.


Patent
French National Center for Scientific Research and French National Institute for Agricultural Research | Date: 2016-07-06

The present invention relates to the cloning of the sodium channel Para and its regulatory subunits in pollinator insect such as Apis mellifera and its uses thereof.


Patent
French National Center for Scientific Research, French National Institute for Agricultural Research, Institute Pasteur Paris and University Paris - Sud | Date: 2016-05-11

The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus (RSV).


Patent
French National Center for Scientific Research, French National Institute for Agricultural Research and INSA Toulouse | Date: 2016-06-23

The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or their specificity in the synthesis of the -1,6 bonds. The present invention relates to nucleic acid sequences of truncated or mutated dextransucrases, vectors containing the nucleic acid sequences and host cells transformed by sequences encoding truncated or mutated dextransucrases. In another aspect, the invention concerns a method for producing, in a recombinant manner, truncated or mutated dextransucrases which conserve their enzymatic activity or which conserve their specificity in the synthesis of -1,6 bonds and can produce, from saccharose, dextrans with high molar mass and modified rheological properties compared with the properties of dextran obtained with the native enzyme and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and isomalto-oligosaccharides of the invention can be used namely as texturing agents or as prebiotics.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 2.54M | Year: 2016

Soft chemical-ionization mass-spectrometry (SCIMS) is an exquisitely sensitive analytical technique with applications to health, the environment and security that are vital to the EU. However, the recent, rapid and widespread adoption of this technique has caught Europe unprepared. The resultant shortage in analytical chemical expertise has created an urgent need for highly skilled young researchers to be trained in the wide variety of SCIMS methods. IMPACT addresses this skills shortage by establishing an intersectoral and multidisciplinary SCIMS training network. IMPACT also brings cohesion to the fragmented SCIMS research and development activities within the EU. To date, most SCIMS developments have been driven not by users but by manufacturers, whose main focus has been on increased sensitivity. However, just as crucial is improved selectivity. Indeed, many users consider improved selectivity to be the key to taking SCIMS technology to a whole new level. Instead of private and public sectors working independently, we need a fresh, intersectoral approach. IMPACT will achieve this through intersectoral work packages and multidisciplinary research projects. In place of major and costly changes in instrumental design, IMPACTs projects will focus on developing new methods for improved chemical specificity by manipulating ion chemistry. Hence, IMPACTs fresh approach will produce a step change in SCIMS instrumentation to deliver both economic and societal benefit to the EU. Specifically, IMPACT will train 10 ESRs within an integrated partnership of commercial, governmental and academic organisations, with planned secondments, 5 Advanced Training Courses, 7 interactive Complementary Skills Workshops, and 4 ESR Centred Research Meetings. IMPACT will therefore provide Europe with both a world-class capability in SCIMS technology and a cohort of highly trained researchers who will bring the benefits of that technology to citizens across the EU.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 9.29M | Year: 2016

Atmospheric simulation chambers are the most advanced tools for elucidating processes that occur in the atmosphere. They lay the foundations for air quality and climate models and also aid interpretation of field measurements. EUROCHAMP-2020 will further integrate the most advanced European atmospheric simulation chambers into a world-class infrastructure for research and innovation. A co-ordinated set of networking activities will deliver improved chamber operability across the infrastructure, as well as standard protocols for data generation and analysis. Outreach and training activities will foster a strong culture of cooperation with all stakeholders and users. Collaborative links will be established with other environmental research infrastructures to promote integration and sustainability within the European Research Area. Cooperation with private sector companies will be actively promoted to exploit the innovation potential of the infrastructure by supporting development of scientific instruments, sensor technologies and de-polluting materials. Trans-national access will be extended to sixteen different chambers and four calibration centres. A new, upgraded data centre will provide virtual access to a huge database of experimental chamber data and advanced analytical resources. Joint research activities will enhance the capability of the infrastructure to provide improved services for users. Measurement techniques and experimental protocols will be further developed to facilitate new investigations on climate change drivers, impacts of air quality on health and cultural heritage, while also stimulating trans-disciplinary research. Advanced process models will be developed for interpretation of chamber experiments and wider use in atmospheric modelling. Overall, EUROCHAMP-2020 will significantly enhance the capacity for exploring atmospheric processes and ensure that Europe retains its place as the world-leader in atmospheric simulation chamber research.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-5-2016 | Award Amount: 1.57M | Year: 2016

This proposal intends to make a ground-breaking advance in magnetometry with the development of a new portable and compact multi-sensor instrument for on ground exploration which measures the complex susceptibility with high resolution. The combination of complex susceptibility and vector measurements would provide for the first time a complete and non-invasive in situ magnetic characterization of rocks from planetary surface and subsurfaces. These topics represent a challenge since present magnetic prospectionsare principally based on measurements of magnetic field intensities and on ground surveys have never been complemented with in situ measurements of complex susceptibility. In the design of such an instrument the consortium will include two important innovative developments: on the one hand a challenging system of frequency generation and measurement (ultra precise and with accuracies better than 1:106), and on the other hand an original system for the power generation of multiple voltages based on magnetic amplifiers which apart from being intrinsically immune to radiation, are expected to improve the energy efficiency. NEWTON project will open a breach for magnetic instrumentation on board landers and rovers with the inclusion of novel instrument in short-term and mid-term future missions.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.39M | Year: 2016

In EU and Australia, every year thousands of square miles of forests and other lands burn due to wildfires. These fires cause important economic and ecological losses, and often, human casualties. Both EU and Australian governments are aware of how crucial it is to improve wildfires management and containment . Scientists from different specialties, both in EU and Australia, have already developed methods and models in order to improve the management and decision process pertaining to preparedness and response phases in case of bushfire. The present project, named Geospatial based Environment for Optimisation Systems Addressing Fire Emergencies (GEO SAFE), aims at creating a network enabling the two regions to exchange knowledge, ideas and experience , thus boosting the progress of wildfires knowledge and the related development of innovative methods for dealing efficiently with such fires. More precisely, the GEO SAFE project will focus on developing the tools enabling to set up an integrated decision support system optimizing the resources during the response phase, through: Developing a dynamic risk cartography of a region with regard to the possibility of a wildfire. The task will involve data collection (satellite and remote sensors), risk analysis and development of a tool enabling to forecast fire extension i, and in particular to predict fire and risk evolution during the response phase Designing and testing a resource allocation tool for the response phase using the dynamic risk cartography. One of the problems to consider will be the resource allocation for securing key places (schools, hospitals, .) given time dependent constraints. Problems will be identified through connections with final users, and the proposed solutions will be tested on simulated data. Developing analyses of relevant management processes as well as training tools in order to facilitate the implementation of such solutionto be completed


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-09-2016 | Award Amount: 15.49M | Year: 2016

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 3.31M | Year: 2016

Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scientists and operators of radio-astronomical facilities, by widely advocating its science capabilities and its role as research infrastructure provider within the international radio astronomy community. These activities will focus on outreach and on reinforcing science cases for the next decade. New partnerships will be pursued, and in addition JIVE will expand its potential user base by offering geodetic and enhanced astrometric processing. Finally, the possibility of the International LOFAR Telescope using the same ERIC governance structure in the future will be investigated. With respect to global VLBI, the aim is to place JIV-ERIC in a leading role in the definition of scientific and technical standards in the SKA era. JIVE will take charge of a number of operational interfaces that will be essential for truly global VLBI, and establish close connections with the African VLBI Network and the SKA as the main strategic partners for the next decade.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.00M | Year: 2017

Experimentation in mesocosms is arguably the single most powerful approach to obtain a mechanistic quantitative understanding of ecosystem-level impacts of stressors in complex systems, especially when embedded in long-term observations, theoretical models and experiments conducted at other scales. AQUACOSM builds on an established European network of mesocosm research infrastructures (RI), the FP7 Infra project MESOAQUA (2009-2012), where 167 users successfully conducted 74 projects. AQUACOSM greatly enhances that network on pelagic marine systems in at least 3 ways: first by expanding it to 10 freshwater (rivers and lakes), 2 brackish and 2 benthic marine facilities, and by involving 2 SMEs and reaching out to more, thereby granting effective transnational access to world-leading mesocosm facilities to >340 users on >11500 days; second, by integrating scattered know-how between freshwater and marine RI; and third, by uniting aquatic mesocosm science in an open network beyond the core consortium, with industry involved in an ambitious innovation process, to promote ground-breaking developments in mesocosm technology, instrumentation and data processing. A new dimension of experimental ecosystem science will be reached by coordinated mesocosm experiments along transects from the Mediterranean to the Arctic and beyond salinity boundaries. These efforts will culminate in a joint research activity (JRA) to assess aquatic ecosystem responses across multiple environmental gradients to a selected climate-related key stressor with repercussions for ecosystem services. Overall, AQUACOSM will fill a global void by forging an integrated freshwater and marine research infrastructure network. Long-term sustainability is sought through assessing governance models based on science priorities and economic innovation opportunities. Linkages to and synergies with ESFRI RI and other large initiatives are ensured by AQUACOSM partners and Advisory Board members in those programs.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-18-2016 | Award Amount: 5.00M | Year: 2016

PULSE (Participatory Urban Living for Sustainable Environments) will leverage diverse data sources and big data analytics to transform public health from a reactive to a predictive system, and from a system focused on surveillance to an inclusive and collaborative system supporting health equity. Working within five global cities, PULSE will harvest open city data, and data from health systems, urban and remote sensors, personal devices and social media to enable evidence-driven and timely management of public health events and processes. The clinical focus of the project will be respiratory diseases (asthma) and metabolic diseases (Type 2 Diabetes) in adult populations. The project will develop risk stratification models based on modifiable and non-modifiable risk factors in each urban location, taking account of biological, behavioural, social and environmental risk factors. Following the recommendations of WHO Europe (2015), the project will also focus on the development of metrics, and data-driven approaches, to community resilience and well-being in cities. Deploying a Health in All Policies (HiAP) perspective, and a whole-of-city model, the project will integrate and analyze data from the health, environment, planning and transport sectors in each city. PULSE will pioneer the development and testing of dynamic spatio-temporal health impact assessments using geolocated population-based data. PULSE will also develop simulation models of potential policy scenarios to allow decision-makers, citizens and businesses to ascertain the impact of proposed policies. The project will culminate in the establishment of Public Health Observatories in each urban location. These observatories will serve as linked hubs that utilize knowledge-driven processes and big data to shape intersectoral public policy and service provision, support citizen health, and encourage entrepreneurship in the fields of data science and mobile health.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.00M | Year: 2016

The SeaDataNet pan-European infrastructure has been developed by NODCs and major research institutes from 34 countries. Over 100 marine data centres are connected and provide discovery and access to data resources for all European researchers. Moreover, SeaDataNet is a key infrastructure driving several portals of the European Marine Observation and Data network (EMODnet), initiated by EU DG-MARE for Marine Knowledge, MSFD, and Blue Growth. SeaDataNet complements the Copernicus Marine Environmental Monitoring Service (CMEMS), coordinated by EU DG-GROW. However, more effective and convenient access is needed to better support European researchers. The standards, tools and services developed must be reviewed and upgraded to keep pace with demand, such as developments of new sensors, and international and IT standards. Also EMODnet and Copernicus pose extra challenges to boost performance and foster INSPIRE compliance. More data from more data providers must be made available, from European and international research projects and observing programmes. SeaDataCloud aims at considerably advancing SeaDataNet services and increasing their usage, adopting cloud and HPC technology for better performance. More users will be engaged and for longer sessions by including advanced services in a Virtual Research Environment. Researchers will be empowered with a collection of services and tools, tailored to their specific needs, supporting marine research and enabling generation of added-value products. Data concern the wide range of in situ observations and remote sensing data. To have access to the latest cloud technology and facilities, SeaDataNet will cooperate with EUDAT, a network of computing infrastructures that develop and operate a common framework for managing scientific data across Europe. SeaDataCloud will improve services to users and data providers, optimise connecting data centres and streams, and interoperate with other European and international networks.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 2.32M | Year: 2016

NEUTRINOS (Ns) and DARK MATTER (DM) are the most abundant particles in the universe. Their couplings to ordinary matter are so tenuous that they remained undiscovered -invisible- until very recently. N masses and DM constitute the first evidence ever of physics beyond the Standard Model of particle physics. The path to build the New Standard Model must confront the fundamental nature of the particles in the invisible sector at large. Furthermore, for each particle there is a mirror image with identical mass and opposite charge(s): its antiparticle. The laws of physics are almost particle-antiparticle symmetric: an asymmetry in Ns and/or DM properties may be the required seed that explains why the universe is made of matter and not antimatter, i.e. how come we are here, a fact unexplained by standard physics. In turn, the unnaturally symmetric behavior of strong interactions points to a new particle, the axion, a superb dark matter candidate. Very timely, an ambitious international experimental search has been launched on Ns, axions, other DM and Higgs physics with major breakthroughs expected soon. InvisiblesPlus will be the first transnational program addressing the N and DM properties at large, their interfaces, and in addition the connections of their particle/antiparticle asymmetries with those of the visible universe. It will also complement, continue and specially extend to a new qualitative realm the knowledge sharing and long-term collaboration of the well-established ITN Invisibles. InvisiblesPlus is ideally suited to the task: i) World leadership in all relevant areas; ii) Multidisciplinarity; iii) Key theorists and experimentalists; iv) XENON, Fermilab, CERN, SuperKamiokande and ADMX participate; iv) Innovative virtual institute; v) Top quality expertise from emerging countries; vi) Outstanding outreach, vii) Excellent junior/senior ratio in secondments; viii) Optimal in gender balance with over 50% female scientists in charge, plus the coordinator.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-11d-2015 | Award Amount: 9.78M | Year: 2016

SOLSA is the first automated expert system for on-site cores analysis. With access to data on-line, great savings are expected on the number of drill holes, the accuracy of geo-models and economic evaluation of ore reserves. SOLSA responds perfectly to the need for New sustainable exploration technologies and geo-models of SC5-11d-2015. The objective is to develop new or improved highly efficient and cost-effective, sustainable exploration technologies. It includes (1) integrated drilling optimized to operate in the difficult lateritic environment with the challenge of a mixture of hard and soft rocks, extensible also to other ore types, (2) fully automated scanner and phase identification software, usable as well in other sectors. SOLSA combines for the first time the non-destructive sensors X-ray fluorescence, X-ray diffraction, vibrational spectroscopies and 3D imaging along the drill core. For that purpose, SOLSA will develop innovative, user-friendly and intelligent software, at the TRL 4-6 levels. To minimize the risk and capitalize on the newest technologies, the subsystems for the hardware, will be selected on the market of miniaturized sensors. To align SOLSA to the industrial needs and to guarantee market uptake at the end of the project, the SOLSA multidisciplinary consortium includes an end-user (ERAMET) with mining and commercial activities in laterite ores, the case study selected for the project. Industrially driven, the consortium is composed of LE, SMEs and academic experts (ERAMET (PI), F; SSD, NL; BRGM, F; INEL, F; Univ. Vilnius, Lt; CNRS-CRISMAT, F; Univ. Trento, I; Univ. Verona, I; TU Delft, NL) covering exploration, database management, instrumentation and software development, drilling rigs, analytical prototypes and marketing strategies. SOLSA is expected to revolutionize exploration and push Europe in front, by reducing the exploration time at 50%, the analysis time from 3 - 6 months to real-time and thus the environmental footprint.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INT-05-2015 | Award Amount: 2.50M | Year: 2016

The EUNPACK project unpacks EU crisis response mechanisms, with the aim to increase their conflict sensitivity and efficiency. By combining bottomup perspectives with an institutional approach, EUNPACK will increase our understanding of how EU crisis responses function and are received on the ground in crisis areas. This entails exploring local agencies and perceptions in target countries without losing sight of the EUs institutions and their expectations and ambitions. It also entails examining the whole cycle of crisis, from pre-crisis, through crisis, and into post-crisis phase. EUNPACK analyses two gaps in EU crisis response. First, the intentionsimplementation gap, which relates to 1) the capacity to make decisions and respond with one voice and to deploy the necessary resources, 2) how these responses are implemented on the ground by various EU institutions and member states, and 3) how other actors local and international enhance or undermine the EUs activities. Second, the project addresses the gap between the implementation of EU policies and approaches, and how these policies and approaches are received and perceived in target countries, what we refer to as the implementationlocal reception/perceptions gap. Our main hypothesis is that the severity of the two gaps is a decisive factor for the EUs impacts on crisis management and thereby its ability to contribute more effectively to problem-solving on the ground. We analyse these gaps through cases that reflect the variation of EU crisis responses in three concentric areas surrounding the EU: the enlargement area (Kosovo, Serbia), the neighbourhood area (Ukraine, Libya), and the extended neighbourhood (Mali, Iraq, Afghanistan). The results of our research will enable us to present policy recommendations fine-tuned to making the EUs crisis response mechanisms more conflict and context sensitive, and thereby more efficient and sustainable.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.89M | Year: 2017

The network Collective effects and optomechanics in ultra-cold matter (ColOpt) will train early-stage researchers (ESR) in fundamental science and applications in the areas of cold atom and quantum physics, optical technologies and complexity science to promote European competiveness in emergent quantum technologies. It consists of nine academic nodes and three companies from six European countries, supported by two partners in Brazil and the USA, five further non-academic partners and one public-private partnership. Collective, nonlinear dynamics and spontaneous self-organization are abundant in nature, sciences and technology and of central importance. Building on this interdisciplinary relevance, a particular novelty of ColOpt is the integration of classical and quantum self-organization. The research program focuses on collective interactions of light with laser-cooled cold and quantum-degenerate matter. We will explore innovative control of matter through optomechanical effects, identify novel quantum phases, enhance knowledge of long-range coupled systems and advance the associated trapping, laser and optical technologies, establishing new concepts in quantum information and simulation. ColOpt combines cutting-edge science with training in complex instrumentation and methods to the highest level of technical expertise, both experimentally and theoretically, and fosters the development of transferable skills and critical judgement. Each ESR will be exposed to a broad spectrum of experimental, theoretical and industrial environments, to obtain core competence in one of them and the collaborative experience and skills to thrive in a truly international and intersectorial framework. ESRs will develop the capabilities to analyse and understand complex interactions, and will gain awareness of societal and entrepreneurial needs and opportunities. Taken together, this will enable them to excel in a variety of sectors of our diverse and rapidly changing society.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 2.34M | Year: 2016

Regulators and industries are challenged by the difficulty to analyse and predict the impact of nonlinear environmental processes on short-term and long-term responses of ecosystems to environmental change. Until very recently, the development of most conventional monitoring, forecasting and prediction tools has been based on the assumption of stationary environmental systems. In the context of global change these tools are increasingly pushed towards and even beyond their design limits (the latter resulting in the first line from the prevailing limitations in spatial and temporal resolution of environmental observations). For this project, we propose a rationale stating that only novel, high-frequency/high-resolution environmental monitoring and predictive modelling will yield new process understanding of ecosystem functioning. Technological progress offers as many opportunities as it triggers challenges: what is needed now are new strategies to generate, manage and analyse BIG DATA at unprecedented spatial and temporal resolution. Innovation can only stand as a synonym for significant positive changes if [a] we manage to clearly state the challenges (global change & non-stationarity) and problems (generating and managing high-frequency information) and [b] transform them into solutions, i.e. the quantification and prediction of environmental responses to global change as a prerequisite for designing and implementing adaptation and/or mitigation strategies wherever needed. The timely outcomes of this research project will hence be of great relevance for the scientific community, regulatory agencies, and the private sector.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: BG-01-2016 | Award Amount: 12.22M | Year: 2017

The GENIALG project aims to boost the Blue Biotechnology Economy (BBE) by increasing the production and sustainable exploitation of two high-yielding species of the EU seaweed biomass: the brown alga Saccharina latissima and the green algae Ulva spp. GENIALG will demonstrate the economic feasibility and environmental sustainability of cultivating and refining seaweed biomass in multiple use demanded products of marine renewable origin. The consortium integrates available knowledge in algal biotechnology and ready to use reliable eco-friendly tools and methods for selecting and producing high yielding strains in economically feasible quantities and qualities. By cracking the biomass and supplying a wide diversity of chemical compounds for existing as well as new applications and markets, GENIALG will anticipate the economic, social and environmental impacts of such developments in term of economic benefit and job opportunities liable to increase the socio-economic value of the blue biotechnology sector. In a larger frame, conservation and biosafety issues will be addressed as well as more social aspects such as acceptability and competition for space and water regarding other maritime activities. To achieve these objectives GENIALG will foster a trans-sectorial and complementary consortium of scientists and private companies. GENIALG will involve a diversity of private companies already positioned in the seaweed sector individually for different applications (texturants, feed, agriculture, bioplastics, pharmaceuticals, personal care products) in order to strengthen interactions for developing a bio-refinery concept and accelerate efficient and sustainable exploitation of seaweed biomass to bring new high-value products on the market.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-21-2015 | Award Amount: 4.47M | Year: 2015

The first and core objective of City4Age is to enable Ambient Assisted Cities or Age-friendly Cities, where the urban communities of elderly people living in Smart Cities are provided with a range of ICT tools and services that - in a completely unobtrusive manner - will improve the early detection of risks related to cognitive impairments and frailty while they are at home or in the move within the city. The second objective is to provide a range of associated tools and services which - with the appropriate interventions - will mitigate the detected risks. The final objective of C4A is to define a model which will provide sustainability and extensibility to the offered services and tools by addressing the unmet needs of the elderly population in terms of (i) detecting risks related to other health type problems, (ii) stimulating and providing incentives to remain active, involved and engaged, (iii) creating an ecosystem for multi-sided market by matching needs and their fulfillments, (iv) contributing to the design and operation of the ultimate Age-friendly City, where the city itself provides support for detecting risks and providing interventions to those affected by mild cognitive impairment (MCI) and frailty. To achieve these objectives City4Age builds on: - behavioural, sociological and clinical research on frailty and MCI in the elderly population; - state of art ICT technology (i) for sensing personal data and exposing them as linked open data, (ii) for designing the algorithms and the APIs to extract relevant behaviour changes and correlated risks, and (iii) for designing interventions to counter the risks, - stakeholder engagement in order to be driven by relevant user needs to ensure end-user acceptance.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-10-2016 | Award Amount: 8.10M | Year: 2016

Blue-Action will provide fundamental and empirically-grounded, executable science that quantifies and explains the role of a changing Arctic in increasing predictive capability of weather and climate of the Northern Hemisphere.To achieve this Blue-Action will take a transdisciplinary approach, bridging scientific understanding within Arctic climate, weather and risk management research, with key stakeholder knowledge of the impacts of climatic weather extremes and hazardous events; leading to the co-design of better services.This bridge will build on innovative statistical and dynamical approaches to predict weather and climate extremes. In dialogue with users, Blue-Arctic will take stock in existing knowledge about cross-sectoral impacts and vulnerabilities with respect to the occurrence of these events when associated to weather and climate predictions. Modeling and prediction capabilities will be enhanced by targeting firstly, lower latitude oceanic and atmospheric drivers of regional Arctic changes and secondly, Arctic impacts on Northern Hemisphere climate and weather extremes. Coordinated multi-model experiments will be key to test new higher resolution model configurations, innovative methods to reduce forecast error, and advanced methods to improve uptake of new Earth observations assets are planned. Blue-Action thereby demonstrates how such an uptake may assist in creating better optimized observation system for various modelling applications. The improved robust and reliable forecasting can help meteorological and climate services to better deliver tailored predictions and advice, including sub-seasonal to seasonal time scales, will take Arctic climate prediction beyond seasons and to teleconnections over the Northern Hemisphere. Blue-Action will through its concerted efforts therefore contribute to the improvement of climate models to represent Arctic warming realistically and address its impact on regional and global atmospheric and oceanic circulation.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: REFLECTIVE-2-2015 | Award Amount: 2.52M | Year: 2016

SIGN-HUB aims to provide the first comprehensive response to the societal and scientific challenge resulting from generalized neglect of the cultural and linguistic identity of signing Deaf communities in Europe. It will provide an innovative and inclusive resource hub for the linguistic, historical and cultural documentation of the Deaf communities heritage and for sign language assessment in clinical intervention and school settings. To this end, it will create an open state-of-the-art digital platform with customized accessible interfaces. The project will initially feed that platform with core content in the following domains, expandable in the future to other sign languages: (i) digital grammars of 6 sign languages, produced with a new online grammar writing tool; (ii) an interactive digital atlas of linguistic structures of the worlds sign languages; (iii) online sign language assessment instruments for education and clinical intervention, and (iv) the first digital archive of life narratives by elderly signers, subtitled and partially annotated for linguistic properties. These components, made available for the first time through a centralized platform to specialists and to the general public, will (a) help explore and value the identity and the cultural, historical and linguistic assets of Deaf signing communities, (b) advance linguistic knowledge on the natural languages of the Deaf and (c) impact on the diagnosis of language deficits within these minorities. SIGN-HUB will thus contribute to the dissemination and reuse of those assets in broader contexts, as part of European identity. The project is a critical attempt to rescue, showcase and boost that largely unknown part of our common heritage, as well as to ultimately enhance the full participation of Deaf citizens in all spheres of public life on an equal footing with hearing citizens.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.73M | Year: 2017

The goal of Olive-Net project is to introduce a novel approach for the exploration, valorization and marketing of new products based on bioactive compounds from Olea europaea. This will be achieved through an extended and well-balanced scheme of researchers secondments between universities and enterprises from EU & Associated countries as well as universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing expertise will be the base of this proposal. Products and side-products of the olive tree such as olive oil, edible olive fruits, olive mill waste and olive tree leaves, will be subjected to a series of state-of-the-art extraction and isolation cascades in order to provide extracts, enriched fractions and isolated compounds of high purity. Target chemical categories will involve the well known olive oil polyphenols and secoiridoids, that will be assessed for their safety and pharmacological effects against inflammation, osteoarthritis, cardiovascular disease, etc. in cell-based and in vivo assays. All active ingredients will be identified and characterized with advanced analytical techniques, in order to be integrated in formulations and products in the area of nutraceuticals/dietary supplements. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). Olive-Net aspires to create a successful model promoting considerably researchers competences and long-lasting collaboration between Industry and Academia.


Patent
French National Institute for Agricultural Research, INSA Toulouse and French National Center for Scientific Research | Date: 2015-01-16

The invention relates to yeast cells modified to express a functional type I RuBisCO enzyme, and a class II phosphoribulokinase. The expression of these enzymes recreates a Calvin cycle in said yeasts in order to enable the yeasts to use carbon dioxide.


Patent
French National Center for Scientific Research and French National Institute for Agricultural Research | Date: 2016-12-14

The present invention relates to a recombinant process for the production of truncated and/or mutated dextransucrases while conserving their enzymatic activity and/or their specificity in the synthesis of the alpha-1,6 bonds. More precisely, the present invention relates to nucleic acid sequences of truncated and/or mutated dextransucrases, vectors containing said nucleic acid sequences and host cells transformed by sequences encoding truncated and/or mutated dextransucrases. In a further aspect, the invention concerns a method for producing, in a recombinant manner, truncated and/or mutated dextransucrases which conserve their enzymatic activity and/or which conserve their specificity in the synthesis of alpha-1,6 bonds and however can produce, from saccharose, dextrans with high molar mass and with modified rheological properties, compared with the properties of dextran obtained with the native enzyme in the same conditions and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and IMO of the invention can be used namely as texturing agents or as prebiotics.


Patent
French National Center for Scientific Research and Nice University Hospital Center | Date: 2016-01-27

The present invention relates to the protein THSD7A (Thrombospondin, Type I, Domain Containing 7A) as a biomarker autoantigen in membranous nephropathy, particularly idiopathic membranous nephropathy. The invention provides diagnostic, prognostic and monitoring methods for membranous nephropathy in a patient based on the detection of autoantibodies recognizing the THSD7A protein (anti-THSD7A autoantibodies) and associated kits. The invention also provides diagnostic methods and kits based on the detection of the THSD7A level. The invention further provides therapeutic methods for membranous nephropathy.


Patent
French National Institute for Agricultural Research, French National Center for Scientific Research, Vrije Universiteit Brussel and Vlaams Instituut Voor Biotechnologie Vzw | Date: 2015-07-29

The invention relates to plant resistant to GFLV. More specifically, the invention relates to plants exhibiting VHH-mediated resistance to GFLV. The invention also relates to methods for conferring resistance to GFLV on plants or methods for producing plants resistant to GFLV. Furthermore, the invention relates to anti-GFLV VHHs molecules, nucleic acid sequences, expression cassettes, and recombinant vectors thereof.


Patent
French National Institute for Agricultural Research, French National Center for Scientific Research and University Paul Sabatier | Date: 2016-01-25

The invention relates to lipochitooligosaccharides obtainable from arbuscular mycorrhizal fungi, and which are useful for stimulating arbuscular mycorrhizal symbiosis, and lateral root formation.


Patent
French National Center for Scientific Research and French National Institute for Agricultural Research | Date: 2016-06-08

The present invention relates to a method of treating in a reactor an effluent comprising ammonium ions, said method comprising:- at least one cycle comprising the following steps:-a step of supplying said reactor with effluent,-an aeration step to cause aerobic nitrification of ammonium ions and-a non-aeration step to cause anoxic denitrificationanda withdrawal step, of recovering of the treated effluent,wherein:-the aeration step comprises steps of:-measuring, in said reactor, the concentration of dissolved oxygen (DO) in said effluent,- continuously calculating the value of dDO/dt-noting dDO/dt and-when dDO/dt reaches a first threshold value:-waiting for a predetermined time and-stopping the aeration,and-the non-aeration step comprises steps of:-measuring, in said reactor, the redox potential (ORP) of said effluent,- continuously calculating the value of d^(2)ORP/dt^(2)-noting d^(2)ORP/dt^(2) and-when d^(2)ORP/dt^(2) reaches a second threshold value, terminating the non-aeration step.


Patent
French National Institute for Agricultural Research, INSA Toulouse and French National Center for Scientific Research | Date: 2016-10-26

The invention relates to a method for obtaining a mutant oleaginous yeast strain capable of growing on cellobiose as carbon source, comprising overexpressing in said strain two -glucosidase enzymes further comprising a N-terminal signal peptide. The invention also relates to a mutant yeast strain obtained by said method.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.12.1 | Award Amount: 11.49M | Year: 2013

The Mont-Blanc project aims to develop a European Exascale approach leveraging on commodity power-efficient embedded technologies. The project has developed a HPC system software stack on ARM, and will deploy the first integrated ARM-based HPC prototype by 2014, and is also working on a set of 11 scientific applications to be ported and tuned to the prototype system.\n\nThe rapid progress of Mont-Blanc towards defining a scalable power efficient Exascale platform has revealed a number of challenges and opportunities to broaden the scope of investigations and developments. Particularly, the growing interest of the HPC community in accessing the Mont-Blanc platform calls for increased efforts to setup a production-ready environment.\n\nThe Mont-Blanc 2 proposal has 4 objectives:\n1. To complement the effort on the Mont-Blanc system software stack, with emphasis on programmer tools (debugger, performance analysis), system resiliency (from applications to architecture support), and ARM 64-bit support\n2. To produce a first definition of the Mont-Blanc Exascale architecture, exploring different alternatives for the compute node (from low-power mobile sockets to special-purpose high-end ARM chips), and its implications on the rest of the system\n3. To track the evolution of ARM-based systems, deploying small cluster systems to test new processors that were not available for the original Mont-Blanc prototype (both mobile processors and ARM server chips)\n4. To provide continued support for the Mont-Blanc consortium, namely operations of the Mont-Blanc prototype, and hands-on support for our application developers\n\nMont-Blanc 2 contributes to the development of extreme scale energy-efficient platforms, with potential for Exascale computing, addressing the challenges of massive parallelism, heterogeneous computing, and resiliency. Mont-Blanc 2 has great potential to create new market opportunities for successful EU technology, by placing embedded architectures in servers and HPC.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.66M | Year: 2014

Cancer, the second most common form of death after cardiovascular disease, is a major European health concern. In 2006, 3.1 million new cases were diagnosed and 1.7 million deaths were attributed to cancer within Europe. The European Commission has a European Partnership for Action against Cancer (IP/09/1380) with the aim of reducing the number of cancer cases by 15% by 2020. A key challenge is to Develop a more coordinated approach to cancer-related research across Europe. Around 50% of patients receive radiotherapy as part of their cancer treatment and it is second only to surgery in its ability to cure cancer. However, radiotherapy is limited by the effects induced in the surrounding healthy tissues strongly, which very harmful for the patients. New approaches that enhance radiosensitivity within tumours have the potential to provide a major impact on the delivery of radiotherapy to patients. Two of the most promising approaches (hadron and nanoparticles-enhanced therapies) are driven by nanoscale phenomena. This proposal brings together world-leading researchers from the academic and private sectors aim at developing hadron and NP-enhanced therapies, united by the common purpose of optimising radiotherapy by understanding and exploiting nanoscale processes induced by radiation. Such an understanding will open a new era in which radiotherapy is revolutionised to provide more successful cancer treatment with subsequent economic and quality of life benefits for the EU population as a whole. The main objective of this intersectoral and multidisciplinary ITN is to create a new generation of researchers and experts able to create the platform on which next-generation cancer therapy will be built. The consortium aims to train a cohort of 13 ESRs to subsequently act as leaders and ambassadors in the field.


Grant
Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.2.1-4 | Award Amount: 16.45M | Year: 2013

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cognitive and behavioral impairments. EDD are the most frequent drug-resistant pediatric epilepsies carrying a lifelong perspective of disability and reduced quality of life. Although EDD collectively represent a major medical and socio-economic burden, their molecular diagnosis, pathogenic mechanisms (PM) and rationale treatment are poorly understood. Specific objectives of DESIRE are to advance the state of the art with respect to: (1) the genetic and epigenetic causes and PM of EDD, particularly epileptogenic MCD, to elucidate molecular networks and disrupted protein complexes and search for common bases for these apparently heterogeneous disorders. (2) the diagnostic tools (biomarkers) and protocols through the study of a unique and well-characterized cohort of children to provide standardized diagnosis for patient stratification and research across Europe. (3) treatment of EDD using randomized, multidisciplinary clinical protocols and testing preclinical strategies in experimental models to also address novel preventative strategies. The workplan spans from clinical observation, to whole exome studies, cellular and animal models and basic research, identification of biomarkers and improvement of diagnostic methods, and back to the clinical trials and assessment of innovative, targeted treatment strategies. The consortium partners have an outstanding track record in genetics, basic neurophysiology, neuropathology and clinical research. Specialized expertise will be made available by the SMEs involved to develop novel diagnostic tools for tailored treatment approaches.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2012.6.4-2 | Award Amount: 7.73M | Year: 2013

This project will improve the consortium capacity of assessment of volcanic hazards in Supersites of Southern Italy by optimising and integrating existing and new observation/monitoring systems, by a breakthrough in understanding of volcanic processes and by increasing the effectiveness of the coordination between the scientific and end-user communities. More than 3 million of people are exposed to potential volcanic hazards in a large region in the Mediterranean Sea, where two among the largest European volcanic areas are located: Mt. Etna and Campi Flegrei/Vesuvius. This project will fully exploit the unique detailed long-term in-situ monitoring data sets available for these volcanoes and integrate with Earth Observation (EO) data, setting the basic tools for a significant step ahead in the discrimination of pre-, syn- and post-eruptive phases. The wide range of styles and intensities of volcanic phenomena observed on these volcanoes, which can be assumed as archetypes of closed conduit and open conduit volcano, together with the long-term multidisciplinary data sets give an exceptional opportunity to improve the understanding of a very wide spectrum of geo-hazards, as well as implementing and testing a large variety of innovative models of ground deformation and motion. Important impacts on the European industrial sector are expected, arising from a partnership integrating the scientific community and SMEs to implement together new observation/monitoring sensors/systems. Specific experiments and studies will be carried out to improve our understanding of the volcanic internal structure and dynamics, as well as to recognise signals related to impending unrest or eruption. Hazard quantitative assessment will benefit by the outcomes of these studies and by their integration into the cutting edge monitoring approaches thus leading to a step-change in hazard awareness and preparedness and leveraging the close relationship between scientists, SMEs, and end-users.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.3.2 | Award Amount: 10.08M | Year: 2013

ACTPHAST is a unique one-stop-shop European access centre for photonics innovation solutions and technology support (Access CenTre for PHotonics innovAtion Solutions and Technology support). ACTPHAST will support and accelerate the innovation capacity of European SMEs by providing them with direct access to the expertise and state-of-the-art facilities of Europes leading photonics research centres, enabling companies to exploit the tremendous commercial potential of applied photonics. Technologies available within the consortium range from fibre optics and micro optics, to highly integrated photonic platforms, with capabilities extending from design through to full system prototyping. ACTPHAST has been geographically configured to ensure all of Europes SMEs can avail of timely, cost-effective, and investment-free photonics innovation support, and that the extensive range of capabilities within the consortium will impact across a wide range of industrial sectors, from communications to consumer-related products, biotechnology to medical devices. The access of predominantly SMEs to top-level experts and leading photonics technology platforms provided by the ACTPHAST consortium will be realised through focused innovation projects executed in relatively short timeframes with a critical mass of suitably qualified companies with high potential product concepts. As a result of these projects, the programme is expected to deliver a substantial increase in the revenues and employment numbers of the supported companies by supporting the development of new product opportunities and addressing emerging markets. Furthermore, through its extensive outreach activities, the programme will ensure there is an increased level of awareness and understanding across European industries of the technological and commercial potential of photonics.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.15. | Award Amount: 11.18M | Year: 2013

IS-ENES2 is the second phase project of the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). This network gathers together the European modelling community working on understanding and predicting climate variability and change. ENES organizes and supports European contributions to international experiments used in assessments of the Intergovernmental Panel on Climate Change. This activity provides the predictions on which EU mitigation and adaptation policies are built. IS-ENES2 further integrates the European climate modelling community, stimulates common developments of software for models and their environments, fosters the execution and exploitation of high-end simulations and supports the dissemination of model results to the climate research and impact communities. IS-ENES2 implements the ENES strategy published in 2012 by: extending its services on data from global to regional climate models, supporting metadata developments based on the FP7 METAFOR project, easing access to climate projections for studies on climate impact and preparing common high-resolution modeling experiments for the large European computing facilities. IS-ENES2 also underpins the communitys efforts to prepare for the challenge of future exascale architectures. IS-ENES2 combines expertise in climate modelling, computational science, data management and climate impacts. The central point of entry to IS-ENES2 services, the ENES Portal, integrates information on the European climate models and provides access to models and software environments needed to run and exploit model simulations, as well as to simulation data, metadata and processing utilities. Joint research activities improve the efficient use of high-performance computers and enhance services on models and data. Networking activities increase the cohesion of the European ESM community and advance a coordinated European Network for Earth System modelling.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.1.1-04 | Award Amount: 7.84M | Year: 2013

CLIPC will provide access to climate information of direct relevance to a wide variety of users, from scientists to policy makers and private sector decision makers. Information will include data from satellite and in-situ observations, climate models and re-analyses, transformed data products to enable impacts assessments and climate change impact indicators. The platform will complement existing Copernicus pre-operational components, but will focus on datasets which provide information on climate variability on decadal to centennial time scales from observed and projected climate change impacts in Europe, and will provide a toolbox to generate, compare and rank key indicators. Expanding climate data volumes will be supported with a distributed, scalable system, based on international standards. Guidance information on the quality and limitations of all data products will be provided. An on-going user consultation process will feed back into all the products developed within the project. The one-stop-shop platform will allow users to find answers to their questions related to climate and climate impacts data, and to ensure that the providence of science and policy relevant data products is thoroughly documented. Clarity of provenance will be supported by providing access to intermediate data products. Documentation will include information on the technical quality of data, on metrics related to scientific quality, and on uncertainties in and limitations of the data. A climate impacts toolkit will provide documentation on methods and data sources used to generate climate impact indicators. The toolkit will be made available for integration with Climate-ADAPT. The CLIPC consortium brings together the key institutions in Europe working on developing and making available datasets on climate observations and modelling, and on impact analysis.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2015

LASERLAB-EUROPE is the European consortium of major national laser research infrastructures, covering advanced laser science and applications in most domains of research and technology, with particular emphasis on areas with high industrial and social impact, such as bio- and nanophotonics, material analyses, biology and medicine. Recently the field of advanced lasers has experienced remarkable advances and breakthroughs in laser technologies and novel applications. Laser technology is a key innovation driver for highly varied applications and products in many areas of modern society, thereby substantially contributing to economic growth. Through its strategic approach, LASERLAB-EUROPE aims to strengthen Europes leading position and competitiveness in this key area. It facilitates the coordination of laser research activities within the European Research Area by integrating major facilities in most European member states with a long-term perspective and providing concerted and efficient services to researchers in science and industry. The main objectives of LASERLAB-EUROPE are to: promote, in a coordinated way and on a European scale, the use of advanced lasers and laser-based technologies for research and innovation, serve a cross-disciplinary user community, from academia as well as from industry, by providing access to a comprehensive set of advanced laser research installations, including two free-electron laser facilities, increase the European basis of human resources in the field of lasers by training new users, including users in new domains of science and technology and from geographical regions of Europe where laser user communities are still less developed, improve human and technical resources through technology exchange and sharing of expertise among laser experts and operators across Europe, and through coordinated Joint Research Activities enabling world-class research, innovations and applications beyond the present state-of-the-art.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.23M | Year: 2015

The Europlanet 2020 Research Infrastructure (EPN2020-RI) will address key scientific and technological challenges facing modern planetary science by providing open access to state-of-the-art research data, models and facilities across the European Research Area. Its Transnational Access activities will provide access to world-leading laboratory facilities that simulate conditions found on planetary bodies as well as specific analogue field sites for Mars, Europa and Titan. Its Virtual Access activities will make available the diverse datasets and visualisation tools needed for comparing and understanding planetary environments in the Solar System and beyond. By providing the underpinning facilities that European planetary scientists need to conduct their research, EPN2020-RI will create cooperation and effective synergies between its different components: space exploration, ground-based observations, laboratory and field experiments, numerical modelling, and technology. EPN2020-RI builds on the foundations of successful FP6 and FP7 Europlanet programmes that established the Europlanet brand and built structures that will be used in the Networking Activities of EPN2020-RI to coordinate the European planetary science communitys research. It will disseminate its results to a wide range of stakeholders including industry, policy makers and, crucially, both the wider public and the next generation of researchers and opinion formers, now in education. As an Advanced Infrastructure we place particular emphasis on widening the participation of previously under-represented research communities and stakeholders. We will include new countries and Inclusiveness Member States, via workshops, team meetings, and personnel exchanges, to broaden/widen/expand and improve the scientific and innovation impact of the infrastructure. EPN2020-RI will therefore build a truly pan-European community that shares common goals, facilities, personnel, data and IP across national boundaries


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 11.76M | Year: 2015

NFFA-EUROPE will implement the first open-access research infrastructure as a platform supporting comprehensive projects for multidisciplinary research at the nanoscale extending form synthesis to nanocharacterization to theory and numerical simulation. The integration and the extension of scope of existing specialized infrastructures within an excellence network of knowledge and know-how will enable a large number of researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. The full suite of key infrastructures for nanoscience will become, through the NFFA-EUROPE project, accessible to a broader community extended to research actors operating at different levels of the value chain, including SMEs and applied research, that are currently missing the benefits of these enabling technologies. NFFA-EUROPE sets out to offer an integrated, distributed infrastructure to perform comprehensive nanoscience and nanotechnology projects from synthesis and nanolithography (with nanofoundry installations) to advanced characterization and theoretical modellization/numerical simulation (with experimental installations including analytical large scale facilities and a distributed theoretical installation including high-performance computing). Coordinated access will be given to complementary facilities co-located in nine well distributed main sites in Europe, ensuring the optimal match between user proposal and technical offer. The research activity of the Consortium will realize innovative solutions on key bottlenecks of nanoscience research, therefore upgrading the facility quality and uniqueness.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 1.94M | Year: 2015

The Humanities at Scale project will further the DARIAH ERICs aim to integrate digitally enabled research in the arts and humanities in Europe and beyond and to operate a platform to enable trans-national arts and humanities research. The project will help DARIAH sustain existing knowledge in digital arts and humanities in Europe and enable new one. DARIAH connects various hubs of excellence in the domain and helps them share their results and innovations. By sharing knowledge, DARIAH works proactively to enhance the reach of digital arts and humanities within the European Research Area (ERA). This proposals aims to address some critical limitations of the current model of sharing knowledge in DARIAH and of connecting the national services in digital arts and humanities initiatives in Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-02-2014 | Award Amount: 139.30M | Year: 2015

The proposed pilot line project WAYTOGO FAST objective is to leverage Europe leadership in Fully Depleted Silicon on Insulator technology (FDSOI) so as to compete in leading edge technology at node 14nm and beyond preparing as well the following node transistor architecture. Europe is at the root of this breakthrough technology in More Moore law. The project aims at establishing a distributed pilot line between 2 companies: - Soitec for the fabrication of advanced engineered substrates (UTBB: Ultra Thin Body and BOx (buried oxide)) without and with strained silicon top film. - STMicroelectronics for the development and industrialization of state of the art FDSOI technology platform at 14nm and beyond with an industry competitive Power-Performance-Area-Cost (PPAC) trade-off. The project represents the first phase of a 2 phase program aiming at establishing a 10nm FDSOI technology for 2018-19. A strong added value network is created across this project to enhance a competitive European value chain on a European breakthrough and prepare next big wave of electronic devices. The consortium gathers a large group of partners: academics/institutes, equipment and substrate providers, semiconductor companies, a foundry, EDA providers, IP providers, fabless design houses, and a system manufacturer. E&M will contribute to the objective of installing a pilot line capable of manufacturing both advanced SOI substrates and FDSOI CMOS integrated circuits at 14nm and beyond. Design houses and electronics system manufacturer will provide demonstrator and enabling IP, to spread the FDSOI technology and establish it as a standard in term of leading edge energy efficient CMOS technology for a wide range of applications battery operated (consumer , healthcare, Internet of things) or not. Close collaboration between the design activities and the technology definition will tailor the PPAC trade-off of the next generation of technology to the applications needs.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.25. | Award Amount: 10.98M | Year: 2013

Optical-infrared astronomy in Europe is in a state of transition and opportunity, with the goal of a viable structured European scale community in sight. A strong astronomical community requires access to state of the art infrastructures (telescopes), equipped with the best possible instrumentation, and with that access being open to all on a basis of competitive excellence. Further, the community needs training in optimal use of those facilities to be available to all, Critically, it needs a viable operational model, with long-term support from the national agencies, to operate those infrastructures. The most important need for most astronomers is to have open access to a viable set of medium aperture telescopes, with excellent facilities, complemented by superb instrumentation on the extant large telescopes, while working towards next generation instrumentation on the future flagship, the European Extremely Large Telescope. OPTICON has made a substantial contribution to preparing the realisation of that ambition. OPTICON supported R&D has, and is developing critical next-generation technology, to enhance future instrumentation on all telescopes. The big immediate challenge is to retain a viable set of well-equipped medium aperture telescopes. The present project is to make the proof of principle that such a situation is possible - a situation developed by OPTICON under its previous contracts, in collaboration with the EC supported strategy network ASTRONET - and set the stage for the step to full implementation.


Grant
Agency: European Commission | Branch: FP7 | Program: CSA-ERA-Plus | Phase: INCO.2013-3.1 | Award Amount: 31.15M | Year: 2013

The Partnership for Modernisation between the European Union and Russia states as one of the priority areas to enhance cooperation in innovation, research and development. In this context the 24 consortium members of ERA.Net RUS Plus propose to implement a Single Joint Call for transnational and scientifically excellent research projects in the fields of Nanotechnologies/Materials/Production Technologies, Health, Environment/ Climate Change, Social Sciences/Humanities and Innovation. The national financial contributions of the partners to the Single Joint Call will sum up to approximately EUR 22.2 millions. The action will engage programme owners from various EU-Member States (MS), countries associated (AC) to the EU RTD Framework Programme and Russia. ERA.Net RUS Plus is a follow-up to the current ERA.Net RUS action that was set-up from 2009 to 2013 to link Russia to the European Research Area by a coordination of S&T programmes in EU MS/AC and Russia. ERA.Net RUS was the first joint call activity in which prominent Russian Funding Parties (RAS, RFBR, RFH and FASIE) were jointly participating in a multilateral funding scheme. The major objective of ERA.Net RUS Plus is to deepen the transnational collaboration between EU MS/AC and Russia and to reduce the fragmentation of research programmes along national funding lines. This joint undertaking will create synergies and strengthen the cooperation among the consortium members. Other principal goals of ERA.Net RUS Plus are to further develop the instrumental setting for joint funding activities and thus to provide a solid basis for a joint programmatic approach to be pursued in the near future. This programmatic approach will assure the desired and necessary sustainability of the cooperation between EU MS/AC and Russia and a lasting impact. ERA.Net RUS Plus will therefore be the next important step in further linking Russia and its key research communities to the European Research Area.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2015

The coastal area is the most productive and dynamic environment of the world ocean with significant resources and services for mankind. JERICO-NEXT (33 organizations from 15 countries) emphasizes that the complexity of the coastal ocean cannot be well understood if interconnection between physics, biogeochemistry and biology is not guaranteed. Such an integration requires new technological developments allowing continuous monitoring of a larger set of parameters. In the continuity of JERICO(FP7), the objective of JERICO-NEXT consists in strengthening and enlarging a solid and transparent European network in providing operational services for the timely, continuous and sustainable delivery of high quality environmental data and information products related to marine environment in European coastal seas Other objectives are: Support European coastal research communities, enable free and open access to data, enhance the readiness of new observing platform networks by increasing the performance of sensors, showcase of the adequacy of the so-developed observing technologies and strategies, propose a medium-term roadmap for coastal observatories through a permanent dialogue with stakeholders. Innovation JERICO-NEXT is based of a set of technological and methodological innovations. One main innovation potential is to provide a simple access to a large set of validated crucial information to understand the global change in coastal areas. Although JERICO-NEXT already includes industrial partners, it will be open to other research institutes, laboratories and private companies which could become associated partners to the project. Added values of JERICO NEXT JERICO-RI shall send data and information in an operational mode to European data systems, with dedicated service access. One of the strengths of JERICO-NEXT lies in the fact that technological and methodological developments shall be deployed in natural environment.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 13.00M | Year: 2015

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours. The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics. AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging. AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europes leadership of the field.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.86M | Year: 2015

The dynamic modulation of semiconductor structures using vibrations provides a powerful tool for the control of the materials properties required for novel functionalities. Surface acoustic waves (SAWs) with GHz-frequencies and micrometre-size wavelength can be generated using piezoelectric transducers fabricated with standard integrated circuit technology. Their small propagation velocity and high sensitivity to disturbances confined to a superficial region have long been exploited in electronic signal processing and sensor applications. The SAW-induced modulation of the electro-optical properties of semiconductor structures is now been used for a wide range of applications including advanced sensors, the control of chemical processes, as well as the coherent control of carriers, spins, photons, and phonons down to the single-particle level. The latter are presently been exploited for different functionalities including advanced waveguide modulators, tuneable optical resonators, and single-electron pumps and single-photon sources. SAWTrain puts together leading groups from Europe, Asia and North America working on SAWs on semiconductor and related nanostructures to create a PhD training network. The synergy resulting from the expertise of these groups will provide PhD students with training opportunities far superior to those offered in existing PhD programmes. Training in research skills with secondments at different hosts will cover state-of-the-art research in the interdisciplinary areas of basic physics, materials, technology, and device concepts related to SAWs. This will be achieved by exposing the trainees to multiple secondments, mandatory co-supervision from different institutions, including a non-academic mentorship. The coordinated training will further contain topical courses, schools, conferences, and workshops and be complemented by measures to develop key competences and transferable skills, fostering the future career plan of the young researchers.


Grant
Agency: European Commission | Branch: H2020 | Program: FCH2-RIA | Phase: FCH-01.2-2014 | Award Amount: 4.99M | Year: 2015

The principal aim of the project is to develop an EU-centric supply base for key automotive PEM fuel cell components that achieve high power density and with volume production capability along with embedded quality control as a key focus - to enable the establishment of a mature Automotive PEM fuel cell manufacturing capability in Europe. It will exploit existing EU value adding competencies and skill sets to enhance EU employment opportunities and competitiveness while supporting CO2 reduction and emissions reduction targets across the Transport sector with increased security of fuel supply (by utilising locally produced Hydrogen).


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 5.00M | Year: 2015

A collective effort is needed to create the environmental research infrastructure for answering pressing questions in a world of rapid social, economic and environmental change. The overall aim of the eLTER project is to advance the European network of Long-Term Ecosystem Research sites and socio-ecological research platforms to provide highest quality services for multiple use of a distributed research infrastructure. eLTERs major objectives and methods are to: (1) identify user needs for the research infrastructure in relation to major societal challenges through consultations with scientific, policy and business stakeholders and horizon scanning; (2) streamline the design of a cost-efficient pan-European network, able to address multiple ecosystem research issues, in collaboration with related global and European research infrastructures, e.g. LifeWatch; (3) develop the organisational framework for data integration and enable virtual access to the LTER data by enabling data publishing through distributed Data Nodes and by providing access to data on key research challenges through a Data Integration Platform; (4) foster the societal relevance, usability and multiple use of information, data and services through new partnerships with the providers of remotely sensed data, analytical services and scenario testing models, and via the adoption of new measurement technologies. The LTER-Europe network and the European Critical Zone community will collaborate to achieve these goals. 162 sites in 22 countries will provide data on long-term trends in environmental change, some reaching back 100 years. Test cases using these data will address a range of environmental and social issues to push innovation in network level services and steer conceptual developments. The envisaged LTER Infrastructure will enable European-scale investigation of major ecosystems and socio-ecological systems, and support knowledge-based decision making at multiple levels.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: BG-15-2014 | Award Amount: 2.17M | Year: 2015

The rapid changes occurring in the Polar Regions are significantly influencing global climate with consequences for global society. European polar research has contributed critical knowledge to identifying the processes behind these rapid changes but, in contrast to lower latitudes, datasets from the Polar Regions are still insufficient to fully understand and more effectively predict the effects of change on our climate and society. This situation can only be improved by a more holistic integrated scientific approach, a higher degree of coordination of polar research and closer cooperation with all relevant actors on an international level as requested in the Horizon 2020 work programme. The objectives of EU-PolarNet are to establish an ongoing dialogue between policymakers, business and industry leaders, local communities and scientists to increase mutual understanding and identify new ways of working that will deliver economic and societal benefits. The results of this dialogue will be brought together in a plan for an Integrated European Research Programme that will be co-designed with all relevant stakeholders and coordinated with the activities of many other polar research nations beyond Europe, including Canada and the United States, with which consortium partners already have productive links. This consortium brings together well-established, world-class, multi-disciplinary research institutions whose science programmes are internationally recognised for excellence. Alongside these scientific capabilities, the national programmes represented in this proposal possess a unique array of infrastructure and operational expertise to support science in both Polar Regions. The consortium is uniquely well positioned to significantly enhance Europes capabilities to undertake state of the art science and cost-efficiently operate infrastructure in the hostile polar environments.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-1-2014 | Award Amount: 8.65M | Year: 2015

Over the last decade, the European Grid Infrastructure (EGI) has built a distributed computing and data infrastructure to support over 21,000 researchers from many disciplines with unprecedented data analysis capabilities. EGI builds on the European and national investments and relies on the expertise of EGI.eu - a not-for-profit foundation that provides coordination to the EGI Community, including user groups, EGI.eu participants in the EGI Council, and the other collaborating partners. The mission of EGI-Engage is to accelerate the implementation of the Open Science Commons vision, where researchers from all disciplines have easy and open access to the innovative digital services, data, knowledge and expertise they need for their work. The Open Science Commons is grounded on three pillars: the e-Infrastructure Commons, an ecosystem of key services; the Open Data Commons, where any researcher can access, use and reuse data; and the Knowledge Commons, in which communities have shared ownership of knowledge and participate in the co-development of software and are technically supported to exploit state-of-the-art digital services. EGI-Engage will expand the capabilities offered to scientists (e.g. improved cloud or data services) and the spectrum of its user base by engaging with large Research Infrastructures (RIs), the long-tail of science and industry/SMEs. The main engagement instrument will be a network of eight Competence Centres, where National Grid Initiatives (NGIs), user communities, technology and service providers will join forces to collect requirements, integrate community-specific applications into state-of-the-art services, foster interoperability across e-Infrastructures, and evolve services through a user-centric development model. The project will also coordinate the NGI efforts to support the long-tail of science by developing ad hoc access policies and by providing services and resources that will lower barriers and learning curves.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 15.00M | Year: 2015

ENVRIPLUS is a cluster of research infrastructures (RIs) for Environmental and Earth System sciences, built around ESFRI roadmap and associating leading e-infrastructures and Integrating Activities together with technical specialist partners. ENVRIPLUS is driven by 3 overarching goals: 1) favoring cross-fertilization between infrastructures, 2) implementing innovative concepts and devices across RIs, and 3) facilitating research and innovation in the field of environment to an increasing number of users outside the RIs. ENVRIPLUS organizes its activities along a main strategic plan where sharing multi-disciplinary expertise will be most effective. It aims to improve Earth observation monitoring systems and strategies, including actions towards harmonization and innovation, to generate common solutions to many shared information technology and data related challenges, to harmonize policies for access and provide strategies for knowledge transfer amongst RIs. ENVRIPLUS develops guidelines to enhance trans-disciplinary use of data and data-products supported by applied use-cases involving RIs from different domains. ENVRIPLUS coordinates actions to improve communication and cooperation, addressing Environmental RIs at all levels, from management to end-users, implementing RI-staff exchange programs, generating material for RI personnel, and proposing common strategic developments and actions for enhancing services to users and evaluating the socio-economic impacts. ENVRIPLUS is expected to facilitate structuration and improve quality of services offered both within single RIs and at pan-RI level. It promotes efficient and multi-disciplinary research offering new opportunities to users, new tools to RI managers and new communication strategies for environmental RI communities. The produced solutions, services and other project results are made available to all environmental RI initiatives, thus contributing to the development of a consistent European RI ecosystem.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2015

Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials. iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications. iNEXT brings together leading European structural biology facilities under one interdisciplinary organizational umbrella and includes synchrotron sites for X-rays, NMR centers with ultra-high field instruments, and, for the first time, advanced electron microscopy and light imaging facilities. Together with key partners in biological and biomedical institutions, partners focusing on training and dissemination activities, and ESFRI projects (Instruct, Euro-BioImaging, EU-OPENSCREEN and future neutron-provider ESS), iNEXT forms an inclusive European network of world class. iNEXT joint research projects (fragment screening for drug development, membrane protein structure, and multimodal cellular imaging) and networking, training and transnational access activities will be important for SMEs, established industries and academics alike. In particular, iNEXT will provide novel access modes to attract new and non-expert users, which are often hindered from engaging in structural biology projects through lack of instrumentation and expertise: a Structural Audit procedure, whereby a sample is assessed for its suitability for structural studies; Enhanced Project Support, allowing users to get expert help in an iNEXT facility; and High-End Data Collection, enabling experienced users to take full benefit of the iNEXT state-of-the-art equipment.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 12.00M | Year: 2015

PARTHENOS aims at strengthening the cohesion of research in the broad sector of Linguistic Studies, Humanities, Cultural Heritage, History, Archaeology and related fields through a thematic cluster of European Research Infrastructures, integrating initiatives, e-infrastructures and other world-class infrastructures, and building bridges between different, although tightly, interrelated fields. PARTHENOS will achieve this objective through the definition and support of common standards, the coordination of joint activities, the harmonization of policy definition and implementation, and the development of pooled services and of shared solutions to the same problems. PARTHENOS will address and provide common solutions to the definition and implementation of joint policies and solutions for the humanities and linguistic data lifecycle, taking into account the specific needs of the sector that require dedicated design, including provisions for cross-discipline data use and re-use, the implementation of common AAA (authentication, authorization, access) and data curation policies, including long-term preservation; quality criteria and data approval/certification; IPR management, also addressing sensitive data and privacy issues; foresight studies about innovative methods for the humanities; standardization and interoperability; common tools for data-oriented services such as resource discovery, search services, quality assessment of metadata, annotation of sources; communication activities; and joint training activities. Built around the two ERICs of the sector, DARIAH and CLARIN, and involving all the relevant Integrating Activities projects, PARTHENOS will deliver guidelines, standards, methods, services and tools to be used by its partners and by all the research community. It will exploit commonalities and synergies to optimize the use of resources in related domains.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.36M | Year: 2015

Enabling Excellence offers integral R&D training at PhD level around one of the most active and exciting topics at the forefront of nanoscience and nanotechnology, graphene-based nanostructures and materials. We propose a training experience built on three interrelated pillars, namely COMPREHENSION AND CONTROL, COMMERCE, and COMMUNICATION. *Comprehension & Control* covers fundamental knowledge of the nano-objects, the development of functionalities and processing into macroscopic advanced materials and devices, accompanied by a broad set of characterization techniques, to understand the interrelation between local and global properties and the requirements for functional end products. *Commerce* aims at market-ready graphene-based materials and commercial local probe Raman/AFM systems for routine quality control of graphene products. This is accompanied by innovative measures for start-up development and pitching to venture capitalists. *Communication* is the unique keystone in Enabling Excellence. The project is a novel experiment to find how best to develop the communication skills in our ESRs, creating optimum conditions under which they are best able to flourish. The results will serve as a model adaptable to European training and research at all levels. Enabling Excellence is formed by five partners from academic institutions and four private companies specialized in the above mentioned fields spanning TRL1-9. They offer a common and highly complementary modular structured training programme. During 468 ESR months we will address the need in Europe for nanocarbon specialists, training a new generation of highly skilled interdisciplinary clear thinking researchers. We will develop in these young people creativity, confidence and the ability to communicate with the most eminent scientists, technologists and business people. Enabling Excellence will equip them with the tools and self-belief necessary to maximize their potential in their future careers.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.18M | Year: 2016

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the molecular frame (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by illuminating the molecule from within, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the development of novel instrumentation in the future.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-01-2014 | Award Amount: 3.25M | Year: 2015

The aim of this proposal is to develop wide band gap thin film solar cells based on kesterite absorbers for future application in high efficiency and low cost tandem PV devices. The SWInG working group will focus both on the development of the processes for the synthesis of such solar cells based on the Cu2ZnXY4 (with X=Sn, Si and Y= S, Se) compounds and on the understanding of the physical and electrical properties of the high band gap absorber in order to reach high conversion efficiency. The key research challenges will be: developing up-scalable processes for the synthesis of the absorbers; defining the specifications for high quality wide band gap absorbers as well as suitable back contact and buffer/window layers; assessing the potential of this technology for PV applications. The wide band gap thin films solar cells developed in this project are expected to reach a stable efficiency of 15 % on a laboratory scale and 12 % for a mini-module prototype. The publications of specifications for the synthesis of high quality Cu2ZnXY4 absorber as well as suitable back/front contact are expected. The lead users will be PV modules manufacturers that work so far with thin films technologies, as well as the companies that design and produce the machines for the synthesis of such devices. The results will be disseminated and communicated to the European PV industries and the scientific community. The intensive exchange of researchers between the partners during the project will also lead to an enhanced European collaboration in the research field of thin film solar cells.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 14.99M | Year: 2015

ASTERICS (Astronomy ESFRI & Research Infrastructure Cluster) aims to address the cross-cutting synergies and common challenges shared by the various Astronomy ESFRI facilities (SKA, CTA, KM3Net & E-ELT). It brings together for the first time, the astronomy, astrophysics and particle astrophysics communities, in addition to other related research infrastructures. The major objectives of ASTERICS are to support and accelerate the implementation of the ESFRI telescopes, to enhance their performance beyond the current state-of-the-art, and to see them interoperate as an integrated, multi-wavelength and multi-messenger facility. An important focal point is the management, processing and scientific exploitation of the huge datasets the ESFRI facilities will generate. ASTERICS will seek solutions to these problems outside of the traditional channels by directly engaging and collaborating with industry and specialised SMEs. The various ESFRI pathfinders and precursors will present the perfect proving ground for new methodologies and prototype systems. In addition, ASTERICS will enable astronomers from across the member states to have broad access to the reduced data products of the ESFRI telescopes via a seamless interface to the Virtual Observatory framework. This will massively increase the scientific impact of the telescopes, and greatly encourage use (and re-use) of the data in new and novel ways, typically not foreseen in the original proposals. By demonstrating cross-facility synchronicity, and by harmonising various policy aspects, ASTERICS will realise a distributed and interoperable approach that ushers in a new multi-messenger era for astronomy. Through an active dissemination programme, including direct engagement with all relevant stakeholders, and via the development of citizen scientist mass participation experiments, ASTERICS has the ambition to be a flagship for the scientific, industrial and societal impact ESFRI projects can deliver.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-23-2014 | Award Amount: 5.72M | Year: 2015

AEROARMS proposes the development of the first aerial robotic system with multiple arms and advanced manipulation capabilities to be applied in industrial inspection and maintenance (I&M). The objectives are: 1. R&D on aerial manipulation to perform I&M. This includes: 1.1 Based on previous partner results, developing systems which are able to grab and dock with one or more arms and perform dexterous accurate manipulation with another arm. Also develop helicopter-based aerial manipulators, with greater payload and flight endurance, and with a dexterous arm to provide advanced manipulation capabilities by means of force interactions and hand-eye coordination using a movable camera with another light arm; 1.2 New methods and technologies for platforms which can fly and manipulate with the coordinated motion of the arms addressing constrained scenarios in which it is dangerous to use the helicopter and where it is not possible to grab to perform I&M operation. 2. Validation of 1.1 in two applications: 1) Installation and maintenance of permanent NDT sensors on remote components; 2) Deploy and maintain a mobile robotic system permanently installed on a remote structure. To achieve the above objectives AEROARMS will develop the first aerial telemanipulation system with advanced haptic capabilities able to exert significant forces with an industrial robotic arm, as well as autonomous control, perception and planning capabilities. Special attention will be paid to the design and system development in order to receive future certification taking into account ATEX and RPAS regulations. AEROARMS is strongly related to ICT 232014: Robotics enabling the emergence of aerial robots, with manipulation capabilities to operate in industrial I&M, which will be validated in in oil and gas plants to reach TRL5. The consortium combines excellent capabilities in aerial robotics with leadership in aerial manipulation and key partners for the successful application of I&M.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 3.96M | Year: 2017

Controlling lightning is a long time dream of mankind. The goal of the present project is to investigate and develop a new type of lightning protection based on the use of upward lightning discharges initiated through a high repetition rate multi terawatt laser. The feasibility of the novel technique and the projects prospect of success are based on recent research providing new insights into the mechanism responsible for the guiding of electrical discharges by laser filaments, on cutting-edge high power laser technology and on the availability of the uniquely suitable Sntis lightning measurement station in Northeastern Switzerland. The LLR consortium is ideally positioned to succeed and to raise the competitiveness of Europe in lightning control as it relies on the integration of trans-disciplinary fields in laser development, nonlinear optics, plasma physics, remote sensing, and lightning: The project team is made up of leaders in the domains of high power nonlinear propagation of laser pulses in the atmosphere, laser control of electric discharges, lightning physics, high power laser development, and high-repetition-rate lasers. In addition, the largest European company in aeronautics brings its expertise in lightning direct effects and protection means on aircraft and infrastructures.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 3.88M | Year: 2017

The objectives of the IDEAAL Project are to explore all possibilities to develop GANIL infrastructure, with its new ESFRI SPIRAL2 facility, in order to ensure its long-term sustainability as one of the premiere European research institutes for nuclear physics, interdisciplinary sciences and related applications. The first objective of the IDEAAL Project is to enlarge the present GANIL membership to include academic institutions and private funding partners. This enlargement goes hand-in-hand with a reinforcement of the involvement of the current institutional funders and academic users of GANIL-SPIRAL2 in the decision-making process and management of the facility. The second objective of IDEAAL is to enhance the excellence of access to the infrastructure by optimizing support to the users, access policy, assessment on the cost of access to the facilities and to data, improvement of the performance capabilities as well as exchange and training of personnel with associated partners. Innovation is the third objective of IDEAAL. With the new facility SPIRAL2, it is essential to encourage industrial users of the uniqueness of this new machine for their research and applications and to allow them to develop new experimental tools at the existing GANIL facilities. Access provision dedicated to industrial users will greatly enhance their experience and increase their interest and trust in GANIL-SPIRAL2. In parallel, new ideas and topics for technology transfer will be clearly identified. The increase of innovation potential of GANIL will also be evaluated. These three objectives must be supported by a strong communication and outreach policy towards members and funding partners, users and the layman. This is the fourth objective of the project. Fulfilling all of these four objectives will allow a well-organized, highly efficient and sustainable development of the current GANIL structure.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.3-3 | Award Amount: 49.52M | Year: 2013

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answers needed by regulators and legislators on EHS by linking them to a scientific evaluation of data and test methods. Based on questions and requirements supplied by regulators and legislators, NANoREG will: (i) provide answers and solutions from existing data, complemented with new knowledge, (ii) Provide a tool box of relevant instruments for risk assessment, characterisation, toxicity testing and exposure measurements of MNMs, (iii) develop, for the long term, new testing strategies adapted to innovation requirements, (iv) Establish a close collaboration among authorities, industry and science leading to efficient and practically applicable risk management approaches for MNMs and products containing MNMs. The interdisciplinary approach involving the three main stakeholders (Regulation, Industry and Science) will significantly contribute to reducing the risks from MNMs in industrial and consumer products. NANoREG starts by analysing existing knowledge (from WPMN-, FP- and other projects). This is combined with a synthesis of the needs of the authorities and new knowledge covering the identified gaps, used to fill the validated NANoREG tool box and data base, conform with ECHAs IUCLID DB structure. To answer regulatory questions and needs NANoREG will set up the liaisons with the regulation and legislation authorities in the NANoREG partner countries, establish and intensify the liaisons with selected industries and new enterprises, and develop liaisons to global standardisation and regulation institutions in countries like USA, Canada, Australia, Japan, and Russia.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-22-2016 | Award Amount: 2.00M | Year: 2017

HIRMEOS will improve five important publishing platforms for the open access monographs in the SSH and enhance their technical capacities and services, rendering technologies and content interoperable and embedding them fully into the European Open Science Cloud. The project focuses on the monograph as a significant mode of scholarly communication in the SSH and tackles the main obstacles of the full integration of important platforms supporting open access monographs and their contents. HIRMEOS will prototype innovative services for monographs in view of full integration in the European Open Science Cloud by providing additional data, links and interactions to the documents, paving the way to new potential tools for research assessment, which is still a major challenge in the SSH. The platforms participating (OpenEdition Books, OAPEN Library, EKT Open Book Press, Ubiquity Press and Gttingen University Press ) will be enriched with tools that enable identification, authentication and interoperability (DOI, ORCID, Fundref), and tools that enrich information and entity extraction (INRIA (N)ERD), the ability to annotate monographs (Hypothes.is), and gather usage and alternative metric data. HIRMEOS will also enrich the technical capacities of the Directory of Open Access Books (DOAB), a most significant indexing service for open access monographs globally, to receive automated information for ingestion, while it will also develop a structured certification system to document monograph peer-review. Partners will develop shared minimum standards for their monograph publications, such that allow the full embedding of technologies and content in the European Science Cloud. Finally, the project will have a catalyst effect in including more disciplines into the Open Science paradigm, widening its boundaries towards the SSH.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-06-2016 | Award Amount: 4.26M | Year: 2017

PrEstoCloud project will make substantial research contributions in the cloud computing and real-time data intensive applications domains, in order to provide a dynamic, distributed, self-adaptive and proactively configurable architecture for processing Big Data streams. In particular, PrEstoCloud aims to combine real-time Big Data, mobile processing and cloud computing research in a unique way that entails proactiveness of cloud resources use and extension of the fog computing paradigm to the extreme edge of the network. The envisioned PrEstoCloud solution is driven by the microservices paradigm and has been structured across five different conceptual layers: i) Meta-management; ii) Control; iii) Cloud infrastructure; iv) Cloud/Edge communication and v) Devices, layers. This innovative solution will address the challenge of cloud-based self-adaptive real-time Big Data processing, including mobile stream processing and will be demonstrated and assessed in several challenging, complementary and commercially-promising pilots. There will be three PrEstoCloud pilots from the logistics, mobile journalism and security surveillance, application domains. The objective is to validate the PrEstoCloud solution, prove that it is domain agnostic and demonstrate its added-value for attracting early adopters, thus initialising the exploitation process early on.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-12-2016 | Award Amount: 4.99M | Year: 2016

Todays Internet is becoming increasingly centralised, slowing innovation and challenging its potential to revolutionise society and the economy in a pluralistic manner. DECODE will develop practical alternatives through the creation, evaluation and demonstration of a distributed and open architecture for managing online identity, personal and other data, and collective governance in a citizen-friendly and privacy-aware fashion. Strong digital rights that makes it possible for data subjects to determine access rights to their information through flexible entitlements and open standard-based agreements regarding data governance (on the model of Creative Commons licenses) will be woven into the technological architecture. DECODE will increase digital sovereignty of European citizens by enabling them to produce, access and control their data and exchange contextualised information in real-time, and in a confidential, and scalable manner. DECODE will develop a modular privacy-aware IoT hub with a free and open source operating system backed by a state of the art blockchain infrastructure supporting smart-contracts and privacy protections. The architecture will be demonstrated through four pilots in Barcelona and Amsterdam, in the field of digital democracy, citizen sensing, and collaborative economy. The pilots will be run with the active involvement of social entrepreneurs, hackers, and makers. Innovators will be able to build solutions on top of the platform through hackathons and open challenges, while ensuring their security, resilience and privacy preserving qualities. This aims to create a decentralised innovation ecosystem that will attract a critical mass able to shift the current centralised data-driven economy towards a decentralised, sustainable and commons-based economy. DECODE puts agency and data control in the hands of citizens, to improve citizens well-being and society for the collective benefit of all.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 972.00K | Year: 2016

Microalgae were always an exciting target for Aquaculture and Biotechnology, as they represent a largely untapped reservoir of novel and valuable bioactive compounds. ALGAE4A-B (ALGAE For Aquaculture and Beauty) project seeks to exploit the microalgae diversity, as a source for state-of-the art high-added-value biomolecules in aquaculture and cosmetics. The diversification of microalgae biomass production towards two independent applications will allow the microalgae industry to gain access to alternative markets in an uncertain, highly competitive and fast changing commercial environment. The project will combine both basic and applied multidisciplinary research in the fields of omics technologies, biochemistry and applied biotechnology in order to: a) Develop and optimize of low input and application-based microalgae culture systems, b) Develop of -omic resources for both microalgae and fishes, c) Develop of downstream processing of high value added products from microalgae, with an emphasis in polysaccharides, proteins, enzymes, antioxidants, d) Develop, formulate and in vitro evaluate a new range of cosmetic and nutraceutical products for aquaculture. The implementation of the project will offer the industrial partners the opportunity to translate scientific research into well defined knowledge-based end products and analytical tools. Apart from scientific objectives the ALGAE4A-B will provide a platform for an efficient dissemination, transfer of knowledge and training between academic, commercial partners and society. Overall, ALGAE4A-B aspires to foster both the European capacity building and the strategic objectives of EU Blue Growth and Marine Biotechnology to harness the untapped potential of Europes seas and coasts for training and sustainable growth.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 5.00M | Year: 2017

MAGENTA proposes a brand new technological path in thermoelectric materials research for waste-heat recovery applications. The originality of the project is based on the newly discovered thermal-to-electric energy conversion capacity of ionic-liquids and ferrofluids; i.e., colloidal dispersions of magnetic nanoparticles in ionic liquids (IL-FFs). It is an inter-disciplinary and cross-sector R&D project combining concepts and techniques from physics, chemistry and electrochemistry with an active participation from 3 SME and 1 industrial partners implicated in the materials supply-chain, the device design/performance and the market-uptake assessment. Both experimental and theoretical approaches will be employed to build foundational knowledge on novel magneto-thermoelectric phenomena in ferrofluids. Computational simulations will allow bottom-up construction of IL-FFs with optimal conditions for harvesting energy. The end-products of MAGENTA, application specific magneto-thermoelectric materials and devices, will provide innovation leadership to European companies in waste-heat recovery industries. The lead-user industries targeted by MAGENTA are automobile and microelectronic sectors, but demonstration-type thermoelectric generators will also be produced for public outreach actions on waste-heat recovery technologies. Through its foundational, interdisciplinary and cross-sector research & innovation actions, the consortium will become a seed community for building an innovation ecosystem around the novel magneto-thermoelectric technology, presenting long-term impacts on future renewal energy science and technology from which the society as a whole can benefit. Withal, MAGENTA offers breakthrough thermoelectric materials that are versatile, cost-effective and non-toxic to assist the economically and environmentally sustainable energy transition in Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 15.59M | Year: 2016

ZIKAlliance is a multidisciplinary project with a global One Health approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-05-2015 | Award Amount: 1.69M | Year: 2016

The MiARD project will use a wide range of data sets from the Rosetta mission (including the Philae lander) to refine the 3D topography of specific areas of comet 67P/Churyumov-Gerasimenko, to study the activity and changes caused by subliming volatiles as the comet nears the Sun, to make inferences about the nature of the top 10 cm of the surface of the comet, to assess whether the landing site on the comet is representative of the entire comet, and to create an improved outgassing model. The new knowledge will be used to improve models of cometary orbits and dust generation in order to allow better hazard assessment. A strong emphasis will be placed upon public communication activities, making full use of the visual nature of the data products to be produced by the project.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.01M | Year: 2017

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europes nations. OPTICON has a proven record supporting European astrophysical excellence through development of new technologies, through training of new people, through delivering open access to the best infrastructures, and through strategic planning for future requirements in technology, innovative research methodologies, and trans-national coordination. Europes scientific excellence depends on continuing effort developing and supporting the distributed expertise across Europe - this is essential to develop and implement new technologies and ensure instrumentation and infrastructures remain cutting edge. Excellence depends on continuing effort to strengthen and broaden the community, through networking initiatives to include and then consolidate European communities with more limited science expertise. Excellence builds on training actions to qualify scientists from European communities which lack national access to state of the art research infrastructures to compete successfully for use of the best available facilities. Excellence depends on access programmes which enable all European scientists to access the best infrastructures needs-blind, purely on competitive merit. Global competitiveness and the future of the community require early planning of long-term sustainability, awareness of potentially disruptive technologies, and new approaches to the use of national-scale infrastructures under remote or robotic control. OPTICON will continue to promote this excellence, global competitiveness and long-term strategic planning.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRASUPP-01-2016 | Award Amount: 2.10M | Year: 2017

The OPEN SESAME project will ensure optimal exploitation of the Synchrotron light for Experimental Science and Applications in the Middle East (SESAME) light source. With this aim, OPEN SESAME has three key objectives: 1. To train SESAME staff in the storage ring and beamline instrumentation technology, research techniques and administration for optimal use of a modern light source facility. 2. To build-up human capacity in Middle East researchers to optimally exploit SESAMEs infrastructure. 3. To train SESAME staff and its user community in public outreach and corporate communications, and to support SESAME and its stakeholders in building awareness and demonstrating its socio-economic impact to assure longer term exploitation. Each objective is tackled by a work package. Firstly, SESAME staff training is addressed by 65 staff exchanges planned between SESAME and the European partners. Secondly, capacity-building is targeted by five training schools, a short-term fellowship programme and an industrial workshop. Finally, a proactive communications strategy will be created, including an educational roadshow to all of the SESAME Members, and a training programme in research infrastructure administration and their economic role and impact for young science managers of SESAME Member stakeholders. The project directly addresses the INFRASUPP-2016-2017 call to support SESAME. OPEN SESAME is well aligned to the broader scope of the work programme with activities that will have a lasting impact on a reinforced European Research Area, and particularly in strengthening international cooperation for research infrastructures with a key Region located close to Europe. The project has been developed closely with SESAME, its Directors and international Training Advisory Committee. The OPEN SESAME consortium is composed of ten European institutes (six light sources, The Cyprus Institute, CERN, CNRS and Instruct) along with SESAME itself.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: NMBP-17-2016 | Award Amount: 5.10M | Year: 2016

Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells with high Manufacturability (ARCIGS-M) This projects goal is advanced materials and nanotechnologies for novel CIGS PV device architectures with efficiencies 23.0 %, thus beyond that of the current state-of-the-art technologies. The technology targets the BIPV sector and enables several innovative solutions for BIPV. The novel functional materials and material combinations are (1) surface functionalized steel substrates, (2) nano-structuring strategies for optical management of rear contact layers, (3) passivation layers with nano-sized point openings, and (4) ultra-thin CIGS thin film absorber layers. The concepts will be developed and established in production viable equipment. Additionally, this new design will also increase the systems lifetime and materials resource efficiency, mainly due to the use of ultra-thin CIGS layers (less In and Ga), and barrier and passivation layers that hinder alkali metal movement. Hence, this project will lead to enhanced performance, but also yield and stability, while maintaining manufacturability. The consortium includes SMEs and industrial partners positioned throughout the complete solar module manufacturing value chain. Their roles will be to develop and commercialize new equipment, products and/or services. The consortium already pioneered the proposed advanced material solutions up to technology readiness level (TRL) 4, and this project targets to bring these innovative concepts to TRL 6 in a low-cost demonstrator. The aim is to develop and validate innovative, economic and sustainable BIPV applications, as a near future high value market for the European PV industries. An exploitation strategy, developed with the support of TTO (www.tto.dk), identifying BIPV as the most promising market has been used to validate the choice of technologies and will be further developed during the course of the project.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.1.1 | Award Amount: 10.28M | Year: 2013

Preparing NUGENIA for HORIZON 2020 The objective of the NUGENIA\ project is to support the NUGENIA Association in its role to coordinate and integrate European research on safety of the Gen II and III nuclear installations in order to better ensure their safe long term operation, integrating private and public efforts, and initiating international collaboration that will create added value in its activity fields. The project consists of two parts, the first part being a Coordination and Support Action and the second part a Collaborative Project. The aim of the first part, the Coordination and Support Action, is to establish an efficient, transparent and high quality management structure to carry out the planning and management of R&D including project calls, proposal evaluation, project follow-up dissemination and valorisation of R&D results in the area of safety of existing Gen II and future Gen III nuclear installations. The preparatory work will encompass governance, organizational, legal and financial work, as well as the establishment of annual work plans, with the aim to structure public-public and/or private-public joint programming enabling NUGENIA to develop into the integrator of the research in the respective field in Europe. The management structure will build on the existing organisation of the NUGENIA Association, currently grouping over 70 nuclear organisations from research and industry (utilities, vendors and small and medium enterprises) active in R&D. In the second part, the Collaborative project, one thematic call for research proposals will be organized among the technical areas of plant safety and risk assessment, severe accident prevention and management, core and reactor performance, integrity assessment of systems, structures and components, innovative Generation III design and harmonisation of procedures and methods. The call will take place one year after the start of the project. The call will implement the priorities recognised in the NUGENIA Roadmap, in line with the Sustainable Nuclear Energy Technology Platform (SNETP) and International Atomic Energy Agency (IAEA) strategies. The research call which is going to be organised within the project is open to all eligible organisations. The NUGENIA\ project will benefit from the experience of the NUGENIA Association member organisations on managing national research programmes and from the track record of the NUGENIA project portfolio.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: SPIRE-03-2016 | Award Amount: 6.68M | Year: 2017

According to European Commission, 13.1 million tons of poultry meat was produced only in the European Union (EU-28) in 2014 with an estimated generation of 3.1 million tons feather waste. At present the majority of poultry feathers are converted into low nutritional value animal food or disposed in landfills, causing environmental and health hazards. In this context, the overall objective of KaRMA2020 is the industrial exploitation of such underutilized waste to obtain added value raw materials for the chemical sector: keratin, bioplastics, flame retardant coatings, non-woven and thermoset biobased resins. This will be accomplished through either: i) innovative and sustainable approaches (already patented by some of KaRMA2020 partners), or ii) conventional and economic techniques. The obtained raw materials will be manufactured at industrial scale and further used for the production of novel bio-based products such as: slow release fertilizers, biodegradable food packaging plastics, flame retardant coated textiles and flame retardant thermoset biobased composites. The sustainability of the new raw materials and end-products will be evaluated through LCA assessment. Additionally, an integrated waste management plan will be elaborated to minimize environmental impacts generated by wastes. Communication and knowledge transfer as well as a detailed business plan will allow maximizing overall profitability of KaRMA2020 results. The well balanced composition of the consortium including industry, RTD performers and academia give KaRMA2020 the maximum chance of success.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-07-2016-2017 | Award Amount: 7.17M | Year: 2016

FIThydro addresses the decision support in commissioning and operating hydropower plants (HPP) by use of existing and innovative technologies. It concentrates on mitigation measures and strategies to develop cost-efficient environmental solutions and on strategies to avoid individual fish damage and enhancing population developments. Therefore HPPS all over Europe are involved as test sites. The facilities for upstream and downstream migration are evaluated, different bypass systems including their use as habitats and the influence of sediment on habitat. In addition existing tools and devices will be enhanced during the project and will be used in the experimental set-ups in the laboratories and at the test sites for e.g. detection of fish or prediction of behavior. This includes sensor fish, different solutions for migration as e.g. trash rack variations, different fish tracking systems, but also numerical models as habitat and population model or virtual fish swimming path model. Therefore a three-level-based workplan was created with preparatory desk work at the beginning to analyze shortcomings and potential in environment-friendly hydropower. Following the experimental tests will be conducted at the different test sites to demonstrate and evaluate the effects of the different options not covered by the desk-work. Thirdly, these results are fed into a risk based Decision Support System (DSS) which is developed for planning, commissioning and operating of HPPs. It is meant to enable operators to fulfill the requirements of cost-effective production and at the same time meet the environmental obligations and targets under European legislation and achieve a self-sustained fish population.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: BG-13-2016 | Award Amount: 3.00M | Year: 2016

The BLUEMED Project is a Coordination and Support Action for the exploitation of the BLUEMED Research and Innovation Initiative for blue jobs and growth in the Mediterranean area, with particular reference to the implementation of the BLUEMED Strategic Research and Innovation Agenda (SRIA). The ultimate objective is to support the activation of sustainable blue innovation and growth, by fostering integration of knowledge and efforts of relevant stakeholders from EU Member States of the Mediterranean Basin, and then among these, other EU and non-EU Countries. To this end, the project will set the scene for the effective coordination of marine and maritime research and innovation activities in the long term. In particular, the Work Package 2 will consolidate the BLUEMED SRIA, develop the BLUEMED Implementation Plan, and promote joint implementation. Four dedicated working Platforms on knowledge, economy, technology, and policy will be set up to allow representatives from research, private sector, public administration, and civil society to work together, pivoting on identified key players of these sectors at national level. The Work Package 3 will address relevant framework conditions for efficiently implementing actions, including indicators and assessment methodologies, and key enabling factors such as research infrastructures, data policies, and human resources. Feasibility studies on specific priorities will be developed by the Start-up Actions under Work Package 4. The Work Package 5 will be finally devoted to enlarge the participation to non-EU countries, through connection with project and other suitable activities for promoting the BLUEMED concept and involve all countries in the perspective of a global Mediterranean. The coordination and management of the project, the functioning of the governance as well as communication and dissemination activities will be carried out within Work Package 1.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-01-2016 | Award Amount: 7.59M | Year: 2017

Objectives The H-CCAT project designs, upscales and shapes hybrid catalysts for the C-H functionalization of aromatic compounds. These solid catalysts will possess better recoverability, higher turnover numbers and better selectivity than current homogeneous catalysts for these reactions. The solid catalysts are applied at demonstration scale in the step-economical production of arylated or alkenylated aromatics, yielding motifs of active pharmaceutical ingredients. Methodology We will design heterogeneous hybrid catalysts featuring deactivation-resistant active sites, based on N-heterocyclic carbenes (NHCs) or diimine ligands and active metal ions. Via efficient, one-step protocols based on self-assembly, these sites will be embedded in robust porous hybrid materials like hybrid silica or metal-organic frameworks. Deactivation or metal aggregation will be prevented by site isolation or by efficient metal reoxidation (for the oxidative alkenylations). Metal leaching is precluded by using strong bonds between metals and embedded ligands like NHCs. Flow protocols will be designed to maximize the turnover numbers. Catalyst synthesis will be scaled up to kg scale, using efficient one-step protocols, minimizing use of solvents or waste formation. Soft shaping methods, e.g. spray drying, will preserve porosity and activity of the hybrid solids. A demonstration is conducted at minipilot scale at the J&J site (Belgium), allowing LCA analysis, techno-economic assessment and elaboration of the business plan. Relevance to work program The catalysts feature new, deactivation resistant active sites; their TOF/TON is maximized by an appropriate porous structure which even can be swelling. Catalysts are produced using innovative one-step protocols to form porous hybrid catalysts as powders or even immediately as shaped objects. The molecules targeted have strong biological and pharmaceutical relevance; they target diseases like influenza, cancer or HIV (case study: Rilpivirine).


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.3.4-2 | Award Amount: 7.92M | Year: 2013

The trypanosomatid diseases, leishmaniasis, Human African trypanosomiasis (HAT) and Chagas disease (CD), continue to impart a heavy toll on human health. The treatments available are limited and threatened by drug resistance with few newdrugs in the pipeline. The KINDReD consortium integrates five leading academic laboratories in Europe (Portugal, United Kingdom, and Switzerland), the USA (California) and South America (Brazil) with high throughput screening (HTS) facilities equally distributed between all three major kinetoplastid parasites. Intracellular amastigote screening will be employed as the most relevant for Leishmania spp and T cruzi. Compound libraries (focused, diversity oriented or natural) will be screened in these systems, as well as compound series devised through target screening and in silico approaches. For carefully chosen protein targets, all three kinetoplastid parasite homologs will be screened against the closest human homolog to establish selectivity. Promising lead compounds will be optimised for efficacy and tolerability in cell-based and animal disease models. Toxicological markers will be evaluated in human cell lines prior to toxicity (acute,subacute,chronic) testing in lower then higher mammals. In parallel, and in line with the FDAs Critical Path Initiative, several check point controls will be built into the pipeline to flag, identify and allow early correction of potential toxicity/efficacy issues. These will include (i) a systems biology approach to identify drug target and off-target interactions via activity-based chemoproteomics (ii) uptake and metabolismas potential modulators of drug efficacy and/or resistance and (iii) the establishment of a firm set of rules for drug efficacy and safety in kinetoplastid chemotherapy. Our goal is to strengthen the drug development pipeline in order to achieve at least one new Phase I clinical candidate for each trypanosomatid disease at or shortly after the project completion date.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SPACE | Award Amount: 6.00M | Year: 2014

The main objective of the MyOcean Follow On project will be to operate a rigorous, robust and sustainable Ocean Monitoring and Forecasting component of the pre-operational Copernicus Marine Service delivering ocean physical state and ecosystem information to intermediate and downstream users in the areas of marine safety, marine resources, marine and coastal environment and weather, climate and seasonal forecasting. This is highly consistent with the objective of the HORIZON 2020 Work Programme 2014-2015 establishing the need for interim continuity of the pre-operational services developed by MyOcean 2 before the fully operational services of Copernicus. The project proposes to sustain the current pre-operational marine activities until March 2015 in order to avoid any interruption in the critical handover phase between pre-operational and fully operational services. In effect, any significant interruption in these services could potentially jeopardize several important high-level policy objectives and undermine other related scientific activities. In the period from October 2014 to March 2015, MyOcean-FO will ensure a controlled continuation and extension of the services already implemented in MyOcean and MyOcean2 FP7 projects that have advanced the pre-operational marine service capabilities. To enable the move to full operations, MyOcean-FO is targeting the prototype operations, and developing the management and coordination to continue the provision of Copernicus Marine service products and the link with independent R&D activities. MyOcean-FO will produce and deliver services based upon the common-denominator ocean state variables that are required to help meet the needs for information for environmental and civil security policy making, assessment and implementation. MyOcean-FO is also expected to have a significant impact on the emergence of a technically robust and sustainable Copernicus Service infrastructure in Europe.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BIOTEC-1-2014 | Award Amount: 7.06M | Year: 2015

P4SB is about the utilization of the conceptual and material tools of contemporary Synthetic Biology to bring about the sustainable and environmentally friendly bioconversion of oil-based plastic waste into fully biodegradable counterparts by means of deeply engineered, whole-cell bacterial catalysts. These tools will be used to design tailor-made enzymes for the bio-depolymerization of PET (polyethylene terephthalate) and PU (polyurethane), but also for the custom design of a Pseudomonas putida Cell Factory capable of metabolizing the resulting monomers. Pseudomonas putida will undergo deep metabolic surgery to channel these diverse substrates efficiently into the production of polyhydroxyalkanoates (PHA) and derivatives. In addition, synthetic downstream processing modules based on the programmed non-lytic secretion of PHA will facilitate the release and recovery of the bioplastic from the bacterial biomass. These industry driven objectives will help to address the market need for novel routes to valorise the gigantic plastic waste streams in the European Union and beyond, with direct opportunities for SME partners of P4SB spanning the entire value chain from plastic waste via Synthetic Biology to biodegradable plastic. As a result we anticipate a completely biobased process reducing the environmental impact of plastic waste by establishing it as a novel bulk second generation carbon source for industrial biotechnology, while at the same time opening new opportunities for the European plastic recycling industry and helping to achieve the ambitious recycling targets set by the European Union for 2020.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.46M | Year: 2013

Clouds are a very important, yet not well understood feedback factor in climate change and they contribute to the effective radiative forcing (ERF) from aerosol-cloud interactions (ACI). The uncertainty in ERFaci is larger than for any other forcing agent. Also, feedbacks between the terrestrial and marine biosphere and the atmosphere involving ACI are thought to play an important role in regulating climate change but their relevance remains poorly quantified. BACCHUS proposes to quantify key processes and feedbacks controlling ACI, by combining advanced measurements of cloud and aerosol properties with state-of-the-art numerical modelling. The analysis of contrasting environments will be the guiding strategy for BACCHUS. We will investigate the importance of biogenic versus anthropogenic emissions for ACI in regions that are key regulators of Earths climate (Amazonian rain forest) or are regarded as tipping elements in the climate system (Arctic). BACCHUS will generate a unique database linking long-term observations and field campaign data of aerosol, cloud condensation and ice nuclei and cloud microphysical properties; this will enable a better quantification of the natural aerosol concentrations and the anthropogenic aerosol effect. BACCHUS will advance the understanding of biosphere aerosol-cloud-climate feedbacks that occur via emission and transformation of biogenic volatile organic compounds, primary biological aerosols, secondary organic aerosols and dust. Integration of new fundamental understanding gained in BACCHUS in Earth Systems Models allows to reduce the uncertainty in future climate projections. This will have a direct impact on decision-making addressing climate change adaptation and mitigation. BACCHUS brings together a critical mass of experimentalists and modellers with the required scientific expertise to address these complex topics and a high commitment to communicate their findings in many ways in order to ensure a high-impact project.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.11. | Award Amount: 8.61M | Year: 2013

The Fixed point Open Ocean Observatory network (FixO3) seeks to integrate European open ocean fixed point observatories and to improve access to these key installations for the broader community. These will provide multidisciplinary observations in all parts of the oceans from the air-sea interface to the deep seafloor. Coordinated by the National Oceanography Centre, UK, FixO3 will build on the significant advances achieved through the FP7 programmes EuroSITES, ESONET and CARBOOCEAN. With a budget of 7.00 Million Euros over 4 years (starting September 2013) the proposal has 29 partners drawn from academia, research institutions and SMEs. In addition 14 international experts from a wide range of disciplines comprise an Advisory Board. The programme will be achieved through: 1. Coordination activities to integrate and harmonise the current procedures and processes. Strong links will be fostered with the wider community across academia, industry, policy and the general public through outreach, knowledge exchange and training. 2. Support actions to offer a) access to observatory infrastructures to those who do not have such access, and b) free and open data services and products. 3. Joint research activities to innovate and enhance the current capability for multidisciplinary in situ ocean observation. Open ocean observation is currently a high priority for European marine and maritime activities. FixO3 will provide important data on environmental products and services to address the Marine Strategy Framework Directive and in support of the EU Integrated Maritime Policy. The FixO3 network will provide free and open access to in situ fixed point data of the highest quality. It will provide a strong integrated framework of open ocean facilities in the Atlantic from the Arctic to the Antarctic and throughout the Mediterranean, enabling an integrated, regional and multidisciplinary approach to understand natural and anthropogenic change in the ocean.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SPACE | Award Amount: 5.00M | Year: 2014

MACC-III is the last of the pre-operational stages in the development of the Copernicus Atmosphere Service. Its overall institutional objective is to function as the bridge between the developmental precursor projects - GEMS, PROMOTE, MACC and MACC-II- and the Atmosphere Service envisaged to form part of Copernicus Operations. MACC-III will provide continuity of the atmospheric services provided by MACC-II. Its continued provision of coherent atmospheric data and information, either directly or via value-adding downstream services, is for the benefit of European citizens and helps meet global needs as a key European contribution to the Global Climate Observing System (GCOS) and the encompassing Global Earth Observation System of Systems (GEOSS). Its services cover in particular: air quality, climate forcing, stratospheric ozone, UV radiation and solar-energy resources. MACC-IIIs services are freely and openly available to users throughout Europe and in the world. MACC-III and its downstream service sector will enable European citizens at home and abroad to benefit from improved warning, advisory and general information services and from improved formulation and implementation of regulatory policy. MACC-III, together with its scientific-user sector, also helps to improve the provision of science-based information for policy-makers and for decision-making at all levels. The most significant economic benefit by far identified in the ESA-sponsored Socio-Economic Benefits Analysis of Copernicus report published in July 2006 was the long-term benefit from international policy on climate change. Long-term benefit from air quality information ranked second among all Copernicus benefits in terms of present value. Immediate benefits can be achieved through efficiency gains in relation to current policies. The estimated benefits substantially outweigh the costs of developing and operating the proposed services.


Grant
Agency: European Commission | Branch: FP7 | Program: ERC-SyG | Phase: ERC-2013-SyG | Award Amount: 14.98M | Year: 2014

Evolved stars are the factories of interstellar dust. This dust is injected into the interstellar medium and plays a key role in the evolution of astronomical objects from galaxies to the embryos of planets. However, the processes involved in dust formation and evolution are still a mystery. The increased angular resolution of new generation telescopes, will provide for the first time a detailed view of the conditions in the dust formation zone of evolved stars, as shown by our first observations with ALMA. We propose to combine astronomical observations, modelling, and top-level experiments to produce star dust analogues in the laboratory and identify the key species and steps that govern their formation. We will build two innovative setups: the Stardust chamber to simulate the atmosphere of evolved stars, and the gas evolution chamber to identify novel molecules in the dust formation zone. We will also improve existing laboratory setups and combine different techniques to achieve original studies on individual dust grains, their processing to produce complex polycyclic aromatic hydrocarbons, the chemical evolution of grain precursors and how dust grains interact with abundant astronomical molecules. Our simulation chambers will be equipped with state-of-the-art in situ and ex situ diagnostics. Our astrophysical models, improved by the interplay between observations and laboratory studies, will provide powerful tools for the analysis of the wealth of data provided by the new generation of telescopes. In addition, new broad-band state-of-the-art High Electron Mobility Transistor receivers will be built, allowing us to perform an unprecedented astronomical survey of evolved stars and providing an invaluable legacy for any scientist in the field. The synergy between astronomers, vacuum and microwave engineers, molecular and plasma physicists, surface scientists, and theoreticians in NANOCOSMOS is the key to provide a cutting-edge view of cosmic dust.


Grant
Agency: European Commission | Branch: FP7 | Program: ERC-SyG | Phase: ERC-2012-SyG | Award Amount: 9.83M | Year: 2013

Quantum mechanics is the basis of our understanding of the microscopic world. It is also central to the collective behaviour of matter at low temperatures, leading to unique properties that defy our classical intuition. The comprehension of such quantum matter and the ability to master it using a newly developing set of quantum technologies is not only of fundamental interest but holds the promise of revolutionizing material and information science as well as metrology. Our aim is to take this interdisciplinary research field to a qualitatively new level, by taking advantage of the most recent spectacular advances in the control of ultracold atomic and molecular systems. To this end, we have gathered a team of PIs with well-recognized and complementary expertise in the domains of quantum optics, atomic and condensed matter physics, and information science. Our project is structured around three grand challenges: (i) Produce, understand and classify novel states of matter, including strongly correlated and topological quantum phases, and establish connections with simulation of field theories; (ii) Explore novel aspects of many-body dynamics, identify its universal regimes, and implement new classes of dissipative evolution; (iii) Engineer quantum matter to propose and implement new paradigms for information processing. We believe that only a joint effort, combining experimental tools beyond the state-of-the-art and novel theoretical approaches, will allow us to reach these outstanding goals. An essential element of the project, which will embody the synergy between the different perspectives brought by the PIs, will be the joint construction of an experiment employing transformative technologies. Our overall research program will allow us to address key questions on the nature of quantum matter and its potential high impact applications.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-08-2014 | Award Amount: 20.65M | Year: 2015

The overarching objective of AtlantOS is to achieve a transition from a loosely-coordinated set of existing ocean observing activities to a sustainable, efficient, and fit-for-purpose Integrated Atlantic Ocean Observing System (IAOOS), by defining requirements and systems design, improving the readiness of observing networks and data systems, and engaging stakeholders around the Atlantic; and leaving a legacy and strengthened contribution to the Global Ocean Observing System (GOOS) and the Global Earth Observation System of Systems (GEOSS). AtlantOS will fill existing in-situ observing system gaps and will ensure that data are readily accessible and useable. AtlantOS will demonstrate the utility of integrating in-situ and Earth observing satellite based observations towards informing a wide range of sectors using the Copernicus Marine Monitoring Services and the European Marine Observation and Data Network and connect them with similar activities around the Atlantic. AtlantOS will support activities to share, integrate and standardize in-situ observations, reduce the cost by network optimization and deployment of new technologies, and increase the competitiveness of European industries, and particularly of the small and medium enterprises of the marine sector. AtlantOS will promote innovation, documentation and exploitation of innovative observing systems. All AtlantOS work packages will strengthen the trans-Atlantic collaboration, through close interaction with partner institutions from Canada, United States, and the South Atlantic region. AtlantOS will develop a results-oriented dialogue with key stakeholders communities to enable a meaningful exchange between the products and services that IAOOS can deliver and the demands and needs of the stakeholder communities. Finally, AtlantOS will establish a structured dialogue with funding bodies, including the European Commission, USA, Canada and other countries to ensure sustainability and adequate growth of IAOOS.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-08-2014 | Award Amount: 2.10M | Year: 2015

The goals of the UPWARDS project match the topics, challenges and scope of the Compet-8-2014 call. UPWARDS has as its overarching objective the revision and exploitation of data from the European Mars Express (MEx) mission as well as other Martian missions using a synergistic combination of state-of-the-art atmospheric/subsurface models and novel retrieval tools. UPWARDS will 1) address major open science questions which require an integrated understanding of the Mars coupled system from the subsurface to the upper atmosphere; 2) prepare for ExoMars 2016 Trace Gas Orbiter data analysis and exploitation; and 3) deliver enhanced scientific context and datasets for ExoMars 2018 Rover operations and future missions. The UPWARDS Consortium undertake five grand science themes which challenge our current understanding of the complex couplings of the Mars climate: 1) exchange of trace species between subsurface & atmosphere; 2) global cycle of Martian water; 3) surface properties and behaviour of suspended aerosols and dust storms; 4) drastic changes at the day/night terminator; 5) coupling of the lower and upper atmosphere and escape to space. All topics are addressed by experts in the field, exchanging results and knowledge in a truly synergistic and interdisciplinary collaboration. All topics share a common methodology and work flow: 1) compilation of new or unexploited data from MEx; 2) generation of added-value products with new/validated tools developed in the Consortium; 3) analysis and combination of the results with state-of-the-art models. Included is a novel data-assimilation devoted to supply as an end-product, the first of its-kind 4-D (x,y,z,t) database for ExoMars and beyond. The dissemination of UPWARDS high-level data products and the outreach activities by the scientists who produce them, will pave the way for establishing a long-term competency in Martian research at a global recognized level, and breed a new generation of European scientists.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.79M | Year: 2015

Algal aquaculture is developing exponentially worldwide, with multiple applications in the food, chemical and pharmaceutical industries. Current research in algal biotechnology mostly focuses on metabolite discovery, aquaculture yield improvement and engineering bottlenecks. However, agronomical experience shows that controlling the interaction of land crops with mutualistic or pathogenic microbes is most critical to successful production. Likewise, controlling the microbial flora associated with algae (the algal microbiome) is emerging as the biggest biological challenge for their increased usage. Bacteria can control the morphogenesis of algae, while others are indispensable to algal survival. Pathogens are causing devastating diseases, the impact of which worsens with the intensification of aquaculture practices. Thus, the overarching aim of ALFF is to train 15 ESRs (researchers and technologists) within a multinational consortium, whilst bringing a scientific step-change in our understanding of these interactions, leading to the development of superior mass algal cultivation and biocontrol strategies. ALFF tackles: 1) the identification, taxonomy and utilisation of naturally-occurring algal symbionts and pathogens; 2) inter- and intra-species signalling and chemical ecology in aquaculture, natural environment and simplified systems (i.e. axenic cultures \/- symbionts); 3) and harnesses state of the art genomics, molecular, and biochemical techniques to characterise these interactions. A highly interdisciplinary team underpins an ambitious theoretical, field, hands-on training and research program. With the support of high profile institutions, ALFF foresees an exceptionally broad range of dissemination and outreach initiatives to help policy makers and the general public better understand the opportunities and issues relating to the sustainable use of our aquatic freshwater and marine resources, within and beyond the EU.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.3.1 | Award Amount: 8.65M | Year: 2013

The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarities and synergies with the major actors of the field. The JPNM partners propose, through MatISSE, a combination of Collaborative Projects and Coordination and Support Actions to face the challenge of implementing a pan-European integrated research programme with common research activities establishing, at the same time, appropriate strategy and governance structure. Focusing on cross-cutting activities related to materials used in fuel and structural elements of safe and sustainable advanced nuclear systems, the project aims at covering the key priorities identified in the JPNM: pre-normative research in support of ESNII systems, Oxide Dispersed Strengthened steels, refractory composites for the high temperature applications, development of predictive capacities. MatISSE will foster the link between the respective national research programmes through networking and integrating activities on material innovations for advanced nuclear systems, sharing partners best practices and setting-up efficient communication tools. It is expected that, through MatISSE, a real boost toward Joint Programming among the Member States, the European Commission and the main European research actors, will be achieved.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: Fission-2013-1.1.2 | Award Amount: 14.73M | Year: 2013

The CAST project (CArbon-14 Source Term) aims to develop understanding of the generation and release of 14C from radioactive waste materials under conditions relevant to waste packaging and disposal to underground geological disposal facilities. The project will focus on releases from irradiated metals (steels, Zircaloys) and from ion-exchange materials as dissolved and gaseous species. A study to consider the current state of the art knowledge with regards to 14C release from irradiated graphite will also be undertaken, to further our knowledge from existing projects in this area i.e. CARBOWASTE. The scientific understanding obtained from these studies will then be considered in terms of national disposal programmes and impact on safety assessments. The knowledge gained from the whole of CAST will be disseminated within the project partners and to wider stakeholders and organisation, with a specific objective on education and training.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.32M | Year: 2013

StratoClim will produce more reliable projections of climate change and stratospheric ozone by a better understanding and improved representation of key processes in the Upper Troposphere and Stratosphere (UTS). This will be achieved by an integrated approach bridging observations from dedicated field activities, process modelling on all scales, and global modelling with a suite of chemistry climate models (CCMs) and Earth system models (ESMs). At present, complex interactions and feedbacks are inadequately represented in global models with respect to natural and anthropogenic emissions of greenhouse gases, aerosol precursors and other important trace gases, the atmospheric dynamics affecting transport into and through the UTS, and chemical and microphysical processes governing the chemistry and the radiative properties of the UTS. StratoClim will (a) improve the understanding of the microphysical, chemical and dynamical processes that determine the composition of the UTS, such as the formation, loss and redistribution of aerosol, ozone and water vapour, and how these processes will be affected by climate change; (b) implement these processes and fully include the interactive feedback from UTS ozone and aerosol on surface climate in CCMs and ESMs. Through StratoClim new measurements will be obtained in key regions: (1) in a tropical campaign with a high altitude research aircraft carrying an innovative and comprehensive payload, (2) by a new tropical station for unprecedented ground and sonde measurements, and (3) through newly developed satellite data products. The improved climate models will be used to make more robust and accurate predictions of surface climate and stratospheric ozone, both with a view to the protection of life on Earth. Socioeconomic implications will be assessed and policy relevant information will be communicated to policy makers and the public through a dedicated office for communication, stakeholder contact and international co-operation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.4-1 | Award Amount: 11.55M | Year: 2013

The target of the Smartonics project is the development of Pilot lines that will combine smart technologies with smart nanomaterials for the precision synthesis of Organic Electronic (OE) devices. The Smartonics objectives are: 1.Development of smart Nanomaterials for OEs (polymer & small molecule films, plasmonic NPs and super-barriers) by process and computational modeling optimization. 2.Development of smart Technologies (r2r printing and OVPD machines combined with precision sensing & laser tools and processes). 3.Integration of Nanomaterials & Technologies in Pilot lines for precision synthesis of Nanomaterials & OE devices, optimization, demonstration and evaluation for Industrial applications. Smartonics will develop three Pilot lines: a) OVPD Pilot line equipped with in-line optical sensing tools, b) r2r printing Pilot line, which will combine optical sensing and laser processing tools, and c) s2s Pilot line for the precision fabrication of OE devices (e.g. OLEDs, sensors from state-of-the-art Nanomaterials) and for the evaluation of encapsulation of these devices. The above will be up-scaled in Industrial processes. More specifically: - The parameters for small molecule OPVs will be up-scaled to Industrial scale OVPD machine. - The process parameters for r2r OPVs will be up-scaled and demonstrated in r2r printing machines. - The advances and precision in the synthesis of nanomaterials by the optical sensing tool will be evaluated for flexible displays. - The advances for the r2r printing process will be evaluated for large-scale production of OPVs. - The flexible OPVs will be validated and implemented in automotives applications. All the above are consistent with the topic NMP.2012.1.4-1 since the the targets of project are including the development of Pilot lines that will be combined with production machines (gas (transport and printing), precision and fabrication tools and processes for the precision synthesis of Nanomaterials and OEs.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.1-1 | Award Amount: 11.92M | Year: 2014

To meet short term European 20-20-20 objectives and long term targets of European Energy Roadmap 2050, an energy paradigm shift is needed for which biomass conversion into advanced biofuels is essential. This new deal has challenges in catalyst development which so far hinders implementation at industrial level: Firstly, biomass is much more complex and reactive than conventional feedstock; secondly development of such catalysts is traditionally done by lengthy empirical approaches. FASTCARD aims at: -Developing a novel rational design of nano-catalysts for better control; optimised based on advanced characterisation methods and systematic capture of knowledge by scalable mathematical and physical models, allowing prediction of performance in the context of bio-feedstocks; -Developing industrially relevant, insightful Downscaling methodologies to allow evaluation of the impact of diverse and variable bio-feedstocks on catalyst performance; -Addressing major challenges impacting on the efficiency and implementation of 4 key catalytic steps in biobased processes: Hydrotreating (HT) and co-Fluid Catalytic Cracking forming the pyrolysis liquid value chain for near term implementation in existing refining units as a timely achievement of the 20-20-20 objectives: addressing challenges of selectivity and stability in HT; increased bio-oil content in co-FCC. Hydrocarbon (HC) reforming and CO2 tolerant Fischer Tropsch (FT) forming the gasification value chain for longer term implementation in new European relevant infrastructure, representing 100% green sustainable route for Energy Roadmap 2050: addressing challenges of stability and resistance in HC reforming; stability and selectivity for FT. Advances in rational design of nano-catalysts will establish a fundamental platform that can be applied to other energy applications. The project will thus speed-up industrialisation of safer, greener, atom efficient, and stable catalysts, while improving the process efficiency.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-4 | Award Amount: 8.01M | Year: 2013

LUC4C will advance our fundamental knowledge of the climate change - land use change interactions, and develop a framework for the synthesis of complex earth system science into guidelines that are of practical use for policy and societal stakeholders. Policies in support of climate change mitigation through land management, and the societal demand for other services from terrestrial ecosystems are currently rather disconnected, in spite of the large potential for co-benefits, but also the need for trade-offs. To identify the beneficial and detrimental aspects of alternative land use options, we will improve and evaluate a suite of modelling approaches at different levels of integration and complexity in order to (i) discern key elements of land-use that have the largest effect on climate, including dependencies across time and space, (ii) develop innovative methods to better quantify the dynamic interactions between land use and the climate system at different time and space scales, and (iii) deliver a portfolio of best practice guidelines for the identification of trade-offs, benefits or adverse effects of land-based mitigation policy options across different scenarios. In particular, LUC4C aims to: 1. enhance our ability to understand the societal and environmental drivers of land use and land cover change (LULCC) relevant to climate change; 2. assess regional and global effects of different mitigation policies and adaptation measures within alternative socio-economic contexts; 3. quantify how the LULCC-climate change interplay affects regional vs. global, and biophysical vs. biogeochemical ecosystem-atmosphere exchange, and how the relative magnitude of these interactions varies through time; 4. advance our ability to represent LULCC in climate models; 5. assess LULCC-climate effects on multiple land ecosystem services and analyse these in relation to other societal needs that provide either a synergy or trade-off to climate mitigation and adaptation.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.2.2 | Award Amount: 3.27M | Year: 2014

Through the DRONIC project, the consortium will showcase a new, innovative blue-green algae (cyanobacteria) monitoring and treatment robotic system, that can localize hotpots of blue-green algae blooms and only treats the part of the lake which is experiencing blue-green algae bloom. Because of the direct and localized treatment, the system is environmentally friendly, with a minimal impact on the ecology of the lake.The new water robot concerns the retrieval, prevention and abatement of harmful algae blooms in lakes and in inland water reservoirs used for drinking water production.\n\nIn lakes and reservoirs, species of blue-green algae and their concentrations can vary locally due to wind or water flow direction and local variations in temperature, nutrients and depths. In lakes and reservoirs, hotspots of blue-green algal blooms can be often detected only in one area of the water body whereas other areas experience no problems due to blue-green algae. Therefore, it is important to map the algal concentration over extended at flexible, different areas in order to localize algal hotspots. The mobility of the robot will allow targeted intensive algae reduction at hotspot locations, thereby increasing the efficiency of the abatement measure.\n\nMeasurements directly related to algae concentration will be combined with measures of water quality and dimension related parameters to locate the algae, make an estimation of the local water quality and hydrographic parameters.\n\nThis new robotic approach offers the first cost-effective method to control algal blooms in larger lakes, reservoirs, canals and rivers with low water velocity (< 1 m/s). With DRONIC technology blooms of blue-green algae will be treated locally at the place where the blooms are present and there is no need to treat the complete surface of the lake or reservoir anymore. Besides that, with the local use of higher power ultrasound, also the cyanobacterial by-products like toxins can be neutralized.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.24. | Award Amount: 23.40M | Year: 2013

Research accelerators are facing important challenges that must be addressed in the years to come: existing infrastructures are stretched to all performance frontiers, new world-class facilities on the ESFRI roadmap are starting or nearing completion, and strategic decisions are needed for future accelerators and major upgrades in Europe. While current projects concentrate on their specific objectives, EuCARD-2 brings a global view to accelerator research, coordinating a consortium of 40 accelerator laboratories, technology institutes, universities and industry to jointly address common challenges. By promoting complementary expertise, cross-disciplinary fertilisation and a wider sharing of knowledge and technologies throughout academia and with industry, EuCARD-2 significantly enhances multidisciplinary R&D for European accelerators. This new project will actively contribute to the development of a European Research Area in accelerator science by effectively implementing a distributed accelerator laboratory in Europe. Transnational access will be granted to state-of-the-art test facilities, and joint R&D effort will build upon and exceed that of the ongoing EuCARD project. Researchers will concentrate on a few well-focused themes with very ambitious deliverables: 20 T accelerator magnets, innovative materials for collimation of extreme beams, new high-gradient high-efficiency accelerating systems, and emerging acceleration technologies based on lasers and plasmas. EuCARD-2 will include six networks on strategic topics to reinforce synergies between communities active at all frontiers, extending the scope towards innovation and societal applications. The networks concentrate on extreme beam performance, novel accelerator concepts with outstanding potential, energy efficiency and accelerator applications in the fields of medicine, industry, environment and energy. One network will oversee the whole project to proactively catalyze links to industry and the innovation potential.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.6-01 | Award Amount: 11.70M | Year: 2013

The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising biopolymers, with excellent physico-chemical and material properties, and a wide range of biological functionalities, but their economic potential is far from being exploited due to i) problems with reproducibility of biological activities as todays chitosans are rather poorly defined mixtures, and ii) the threat of allergen contamination from their typical animal origin. The Nano3Bio project will overcome these hurdles to market entry and penetration by producing in vitro and in vivo defined oligo- and polymers with controlled, tailor-made DP, DA, and PA. Genes for chitin synthases, chitin deacetylases, and transglycosylating chitinases/chitosanases will be mined from different (meta)genomic sources and heterologously expressed, the recombinant enzymes characterized and optimized by protein engineering through rational design and molecular evolution, e.g. targeting engineered glycosynthases. These enzymes and genes will be used for in vitro and in vivo biosynthesis in microbial and microalgal systems, focusing on bacteria and diatoms. The bioinspired chitosans will be formulated into biomineralised hydrogels, nanoparticles, nanoscaffolds, etc., to impart novel properties, including by surface nano-imprinting, and will be bench-marked against their conventional counterparts in a variety of cell based assays and routine industrial tests for e.g. cosmetics and pharma markets. The process will be accompanied by comprehensive life cycle assessments including thorough legal landscaping, and by dissemination activities targeted to the scientific community and the general public.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 11.78M | Year: 2013

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.\nWe plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.\nWe will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-3-2014 | Award Amount: 4.70M | Year: 2015

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting different aspects of the same experimental and theoretical tools. By implementing not only one but a whole family of Rydberg Quantum Simulators, the project will address both the coherent and incoherent dissipative dynamics of many-body quantum systems, with potential applications in the understanding and design of artificial light harvesting systems, large quantum systems with controlled decoherence, and novel materials. This will be achieved by building upon a novel generic approach to quantum simulation, where Rydberg atoms allow both digital (gate) and analog (interaction) simulations. In addition to solving problems in fundamental and applied science, the project will build up core competences for quantum science and technologies in mainstream engineering, by using innovative methods for communication, dissemination and exploitation of results. In summary, RYSQ plans (A) to develop a collection of novel experimental and theoretical tools for Rydberg quantum simulators, and (B) to use them as a basis for implementing many important applications of quantum simulations. The project is structured in such a way to allow for efficient exchanges within the consortium, and to maximize the overall outcome of the work.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-08-2014 | Award Amount: 2.00M | Year: 2015

Sample return missions (SRMs) are a critical next step in our exploration of the Solar System and are identified as strategic missions by international space agencies. Europe has a very strong legacy in the curation and research of precious extraterrestrial materials. To maintain European leadership and ensure high-level involvement in future SRMs, a dedicated European Sample Curation Facility (ESCF) to receive and curate returned samples from the Moon, asteroids and Mars, is of critical importance. Euro-CARES will focus on 5 key themes for developing a ESCF: o Planetary Protection- protocols and methods for future SRMs o Instrumentation and Analytical Methods- in the fields of cosmo/geochemistry and biosciences o Facilities and Infrastructures- to curate sensitive extraterrestrial or biological materials o Analogue Materials- that are most appropriate and can be used in end to end SRM planning o Portable Receiving Technologies- used to move samples whilst retaining scientific integrity and bio-containment (for Mars samples) Using the 5 key themes Euro-CARES will: 1) Evaluate and critically assess the state of the art within Europe and internationally to identify critical requirements for the ESCF 2) Determine and verify European readiness levels to identify where investment is required and opportunities for European leadership in scientific and engineering fields related to curating extraterrestrial samples 3) Engage with scientific, industrial, governmental and public stakeholders through community workshops, conferences, publications and educational opportunities 4) Deliver recommendations and roadmaps defining the steps necessary to deliver a ESCF to ensure high-level involvement in future ESA and international SRMs Euro-CARES comprises a team of scientists and engineers from across Europe with internationally recognised expertise in astrobiology, biosciences, cosmo/geochemistry, extraterrestrial sample curation, planetary protection and space exploration.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-4.1.2 | Award Amount: 9.33M | Year: 2013

The CHANDA project main objective is to address the challenges in the field of nuclear data for nuclear applications and its acronym stands for solving CHAllenges in Nuclear DAta The project will prepare a proposal for an organization that will coordinate the nuclear data research program, and the infrastructures and capabilities of the EU Member States in a stable structure, well integrated with R&D coordination tools (EERA, HORIZON 2020) , and with priorities aligned with the SET Plan and the SRAs of the EURATOM Technological Platforms, including the following general objectives: - to provide the nuclear data required for the safe and sustainable operation, and development, of existing and new reactors and nuclear fuel cycle facilities, - to prepare solutions for the challenges risen by the nuclear data measurements needed by nuclear systems, like the data for highly radioactive, short lived or rare materials, - to prepare tools that solve the challenges of quantifying and certifying the accuracy of the results of simulations based on available nuclear data and models (uncertainties), - to identify and promote synergies with other nuclear data applications. Using these tools will allow EU to upgrade the nuclear data up to the level needed by simulation codes to fulfill present requirements. In particular, the simulations should be able to: reduce the number of expensive experimental validations, to support the new tendencies in safety assessments to use best estimate codes to understand the limits of the plat safety towards extreme operational conditions, to optimize safety and performance of present and future reactors and other radioactive facilities. Other applications will benefit from this accuracy in nuclear data, notably in medical applications to optimize performance and minimize dose of radiation for diagnose and treatment.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-16-2014 | Award Amount: 2.94M | Year: 2015

FrakRisk further develops the knowledge base for understanding, preventing and mitigating the potential impact of the exploration and exploitation of shale gas reserves found throughout Europe. This will include international experience, state of the art process understanding, state of the art modelling techniques and the further development of fully accepted risk assessment tools for site screening, selection and management specifically for shale gas exploitation. FracRisk focuses on key knowledge gaps identified from the literature, research and industrial experience. Central to the project is the modelling of six exemplary scenarios selected to represent the highest risk environmental impact scenarios identified as generally of most concern. The modelling of the scenarios is directed by the aim to reduce the uncertainty and assess the risk of different events during shale gas exploration and exploitation. Using an iterative modelling and risk reduction approach, cost effective data density requirements to limit uncertainty will be evaluated. The modelled scenarios will be validated against existing data from several sites within the EU and in the USA. Effective monitoring procedures and applicable mitigation techniques will be determined and evaluated. Scientific recommendations will be formulated and legislative refinement suggested. Public concerns about the management of risk related to fracking operations will be addressed. A firm scientific basis and demonstrable data to validate recommendations will be provided. The technological readiness level from a number of multidisciplinary approaches and applications will be noticeably improved. FrakRisk will lead to a more focused, coherent and scientifically founded approach that can be useful to member states willing to enable and regulate the shale gas industry.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-1-2014 | Award Amount: 4.25M | Year: 2015

The DOLFINS project addresses the global challenge of making the financial system better serve society by placing scientific evidence and citizens participation at the centre of the policy process in finance. The project strives to give scientific evidence and citizens participation central roles in the policy process concerning finance. DOLFINS will focus on two crucial and interconnected policy areas that will shape the public debate in the coming 5 years: How to achieve financial stability and how to facilitate the long-term investments required by the transition to a more sustainable, more innovative, less unequal and greener EU economy. The expected impact is to achieve crucial advances in reshaping the policy process to overcome the financial and political crisis faced by the EU. We will deliver quantitative tools to evaluate policies aiming to tame systemic risk and to foster sustainable investing. The tools will be based on fundamental research combining network models and algorithmic game theory with broader economic insights. This approach can provide a more satisfactory understanding of credit, risk and sustainable investments in an interconnected world. We will investigate how to engage citizens in the early stage of the policy making process and will develop evidence-based narratives in order to better shape policies in the public interest. To this end, our project will take advantage of semantic web technologies, big data and ICT in general. Given the highly technical nature of key issues in finance, we will explore how ICT and art can facilitate citizens engagement through innovative narratives, leading to better coordinated actions of stakeholders.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.1.4-1 | Award Amount: 8.01M | Year: 2013

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient treatment, quality of life and long-term graft survival. Also, there is an unmet need for better understanding of the immune and non-immune mechanisms of interstitial fibrosis /tubular atrophy and graft loss. Combining all the skills required to build upon previous findings, BIOMARGIN will offer such opportunities in renal transplantation by integrating several omics approaches (mRNA, miRNA, peptides, proteins, lipids and metabolites) in blood, graft tissue and urine, in a well thought out, multistage discovery-to-validation translational programme, following the highest European ethics and regulatory requirements, as well as quality controls and quality assessments at all clinical and analytical steps. It is probably one of the first programmes to pursue such an integrated and systematic research approach. BIOMARGIN aims to: (i) discover, select and validate blood and/or urine biomarkers of renal allograft lesions in adult and pediatric kidney transplant recipients; (ii) provide renal transplant physicians with non-invasive, robust diagnostic tests and interpretation algorithms enabling closer, more accurate, more predictive and/or less invasive monitoring of transplanted patients; (iii) help to avoid or diminish the use of biopsies and improve patient treatment, quality of life and long-term graft survival; (iv) help understand the mechanisms involved in the allograft injury processes which, combined with mass spectrometry imaging should offer pathologists new molecular targets and tools for renal graft biopsy analysis.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 14.84M | Year: 2015

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological mechanisms and accelerate its translation into medical care. Biological and medical research that addresses the grand challenges of health and ageing span a broad range of scientific disciplines and user communities. The BMS RIs play a central, facilitating role in this groundbreaking research: inter-disciplinary biomedical and translational research requires resources from multiple research infrastructures such as biobank samples, and resources from multiple research infrastructures such as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure capabilities into the scientific workflow of advanced users. Furthermore CORBEL will enable the BMS RIs to support users throughout the execution of a scientific project: from planning and grant applications through to the long-term sustainable management and exploitation of research data. By harmonising user access, unifying data management, creating common ethical and legal services, and offering joint innovation support CORBEL will establish and support a new model for biological and medical research in Europe. The BMS RI joint platform will visibly reduce redundancy and simplify project management and transform the ability of users to deliver advanced, cross-disciplinary research.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: SSH.2013.3.2-3 | Award Amount: 3.31M | Year: 2014

The main objective of the proposed research project is to create knowledge that will further advance the contributions that the third sector and volunteering can make to the socio-economic development of Europe. These unique renewable resources for social and economic problem-solving and civic engagement in Europe are needed more than ever at this time of social and economic distress and enormous pressures on governmental budgetsnot as an alternative to government but as a full-fledged partner in the effort to promote European progress. To take full advantage of this resource we need a clearer understanding of the third sectors scope and scale, its existing and potential impacts, and the barriers to its full contributions to the continents common welfare. Building on our previous work, this project seeks to: 1) Clarify the concept of the third sector in its European manifestations; 2) Identify the major contours of the sector so definedits size, structure, composition, sources of support, and recent trends; 3) Identify the impacts of this sector, its contributions to European economic development, innovation, citizen well-being, civic engagement, and human development, and to create capabilities to measure these contributions into the future; 4) Identify barriers both internal to organizations and external to them and suggest ways these barriers might be overcome; and 5) Forge a partnership between the research community and European Third Sector practitioners so that the understanding of the Third Sector generated by this work remains grounded in reality and enjoy sufficient support among key stakeholders to ensure respectful attention from policy makers and sector leaders long after the project is completed. By drawing on the combined strengths of the academic community, government, and the third sector itself. As such, the proposal provides a solid embodiment of the FP7 theme of science in society, of generating knowledge to advance the quality of life.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-15-2014 | Award Amount: 6.00M | Year: 2015

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential candidates to overcome this clinical short-coming. Autologous adipose-derived mesenchymal stromal cells (ASCs) are attractive for cellular therapy given the abundance of tissue, high frequency of MSCs and minimally invasive harvest procedure. The EU consortium ADIPOA has shown in a first in man 2-centre Phase I safety study that intraarticular injection of a single dose of autologous ASCs to the knee (18 patients, 12 month follow-up) was well-tolerated, had no adverse effects, and resulted in an improvement in pain score and functional outcome. ADIPOA2 will deliver a large-scale clinical trial in regenerative medicine for OA. The purpose of the project is to design and implement a phase IIb study to assess the safety and efficacy of autologous (patient-derived) ACSs in the treatment of advanced OA of the knee. The cells will be prepared from samples of adipose tissue harvested from patients by lipoaspiration. ADIPOA2 will comprise a multi-centre, randomized clinical trial comparing culture-expanded, autologous adult ASCs in subjects with knee OA with another widely used therapeutic approach for knee degeneration (injection of Hyaluronan). There are two large elements of the study: (1) the production of consistent batches of high-quality autologous ASCs under GMP-compliant conditions and (2) delivery of these cell doses to patients in a trial which will meet all national and European regulatory and ethical standards and which will have sufficient statistical power to provide an unambiguous and definitive assessment of safety and efficacy.


Grant
Agency: European Commission | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-1 | Award Amount: 9.99M | Year: 2014

Water and water-related services are major components of the human wellbeing, and as such are major factors of socio-economic development in Europe; yet freshwater systems are under threat by a variety of stressors (organic and inorganic pollution, geomorphological alterations, land cover change, water abstraction, invasive species and pathogens. Some stressors, such as water scarcity, can be a stressor on its own because of its structural character, and drive the effects of other stressors. The relevance of water scarcity as a stressor is more important in semi-arid regions, such as the Mediterranean basin, which are characterized by highly variable river flows and the occurrence of low flows. This has resulted in increases in frequency and magnitude of extreme flow events. Furthermore, in other European regions such as eastern Germany, western Poland and England, water demand exceeds water availability and water scarcity has become an important management issue. Water scarcity is most commonly associated with inappropriate water management, with resulting river flow reductions. It has become one of the most important drivers of change in freshwater ecosystems. Conjoint occurrence of a myriad of stressors (chemical, geomorphological, biological) under water scarcity will produce novel and unfamiliar synergies and most likely very pronounced effects. Within this context, GLOBAQUA has assembled a multidisciplinary team of leading scientists in the fields of hydrology, chemistry, ecology, ecotoxicology, economy, sociology, engineering and modeling in order to study the interaction of multiple stressors within the frame of strong pressure on water resources. The aim is to achieve a better understanding how current management practices and policies could be improved by identifying the main drawbacks and alternatives.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 19.05M | Year: 2015

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that science can currently imagine, with unprecedented volumes of biological data to manage. Data will only generate long-term value if it is Findable, Accessible, Interoperable and Re-usable (FAIR). This requires a scalable infrastructure that connects local, national and European efforts and provides standards, tools and training for data stewardship. Formally established as a legal entity in January 2014, ELIXIR - the European life science Infrastructure for Biological Information - is a distributed organisation comprising national bioinformatics research infrastructures and the European Bioinformatics Institute (EMBL-EBI). This coordinated infrastructure includes data standards, exchange, interoperability, storage, security and training. Recognising the importance of a data foundation for European life sciences, the ESFRI and European Council named ELIXIR as one of Europes priority Research Infrastructures. In response ELIXIR have developed ELIXIR-EXCELERATE. The project will fast-track ELIXIRs early implementation phase by i) coordinate and enhance existing resources into a world-leading data service for academia and industry, ii) grow bioinformatics capacity and competence across Europe, and iii) complete the management processes needed for a large distributed infrastructure. ELIXIR-EXCELERATE will deliver a step-change in the life sciences. It will enable cost-effective and sustainable management and re-use of data for millions of users across the globe and improve the competitiveness of European life science industries through accessible data and robust standards and tools.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA | Phase: ENERGY.2013.10.1.10 | Award Amount: 21.20M | Year: 2014

Concentrating Solar Thermal Energy encompasses Solar Thermal Electricity (STE), Solar Fuels, Solar Process Heat and Solar Desalination that are called to play a major role in attaining energy sustainability in our modern societies due to their unique features: 1) Solar energy offers the highest renewable energy potential to our planet; 2) STE can provide dispatchable power in a technically and economically viable way, by means of thermal energy storage and/or hybridization, e.g. with biomass. However, significant research efforts are needed to achieve this goal. This Integrated Research Programme (IRP) engages all major European research institutes, with relevant and recognized activities on STE and related technologies, in an integrated research structure to successfully accomplish the following general objectives: a) Convert the consortium into a reference institution for concentrating solar energy research in Europe, creating a new entity with effective governance structure; b) Enhance the cooperation between EU research institutions participating in the IRP to create EU added value; c) Synchronize the different national research programs to avoid duplication and to achieve better and faster results; d) Accelerate the transfer of knowledge to industry in order to maintain and strengthen the existing European industrial leadership in STE; e) Expand joint activities among research centres by offering researchers and industry a comprehensive portfolio of research capabilities, bringing added value to innovation and industry-driven technology; f) Establish the European reference association for promoting and coordinating international cooperation in concentrating solar energy research. To that end, this IRP promotes Coordination and Support Actions (CSA) and, in parallel, performs Coordinated Projects (CP) covering the full spectrum of current concentrating solar energy research topics, selected to provide the highest EU added value and filling the gaps among national programs.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: EINFRA-3-2014 | Award Amount: 4.00M | Year: 2015

The Research Data Alliance (RDA) is rapidly building the social and technical bridges that enable open sharing and re-use of data on a global level. RDA/Europe - the European plug-in to the global Research Data Alliance activities will ensure that European research, industrial, e-infrastructure and policy stakeholders are all aware of its achievements, engaged with and actively involved in the global RDA activities and will advance the use of its results. European domain scientists and data scientists are involved in and driving a series of working and interest groups, generating first results of RDA and this momentum should be maintained and even increased. A collaborative web platform, currently under strong development, is widely used by the RDA members and coordinating administration. RDA Europe will look for innovative ways of facilitating the take-up and implementation of RDA outputs in Europe, both in academia and industry, and will continue to develop and maintain the RDA web-based collaboration framework. Further steps will be taken in steering, planning and implementing the sustainability of RDA through a legal entity, established in Europe, and investigating the most appropriate business models for long term sustainability. This RDA/Europe proposal will mainly build on the successful consortium of the previous years but strengthen its anchoring at policy, scientific and industrial uptake to drive forward RDA Europe objectives that are all grounded in technological excellence and innovation and have clear international ties. RDA Europe partners are very actively involved in the strategic planning, implementation, marketing & communication of RDA through the governance bodies of RDA.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-33-2016 | Award Amount: 2.86M | Year: 2017

Despite process heat is recognized as the application with highest potential among solar heating and cooling applications, Solar Heat for Industrial Processes (SHIP) still presents a modest share of about 0.3% of total installed solar thermal capacity. As of todays technology development stage economic competitiveness restricted to low temperature applications; technology implementation requiring interference with existing heat production systems, heat distribution networks or even heat consuming processes - Solar thermal potential is mainly identified for new industrial capacity in outside Americas and Europe. In this context, INSHIP aims at the definition of a ECRIA engaging major European research institutes with recognized activities on SHIP, into an integrated structure that could successfully achieve the coordination objectives of: more effective and intense cooperation between EU research institutions; alignment of different SHIP related national research and funding programs, avoiding overlaps and duplications and identifying gaps; acceleration of knowledge transfer to the European industry, to be the reference organization to promote and coordinate the international cooperation in SHIP research from and to Europe, while developing coordinated R&D TRLs 2-5 activities with the ambition of progressing SHIP beyond the state-of-the-art through: an easier integration of low and medium temperature technologies suiting the operation, durability and reliability requirements of industrial end users; expanding the range of SHIP applications to the EI sector through the development of suitable process embedded solar concentrating technologies, overcoming the present barrier of applications only in the low and medium temperature ranges; increasing the synergies within industrial parks, through centralized heat distribution networks and exploiting the potential synergies of these networks with district heating and with the electricity grid.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.26. | Award Amount: 8.20M | Year: 2013

This project aims at integrating the major European infrastructures in the field of high-resolution solar physics. The following actions will be taken: (i) realise Trans-national Access to external European users; (ii) enhance and spread data acquisition and processing expertise to the Europe-wide community; (iii) increase the impact of high-resolution data by offering science-ready data and facilitating their retrieval and usage; (iv) encourage combination of space and ground-based data by providing unified access to pertinent data repositories; (v) foster synergies between different research communities by organising meetings where each presents state-of-the-art methodologies; (vi) train a new generation of solar researchers through setting up schools and an ambitious mobility programme; (vii) develop prototypes for new-generation post-focus instruments; (vii) study local and non-local atmospheric turbulence, their impact on image quality, and ways to negate their effects; (viii) improve the performance of existing telescopes; (ix) improve designs of future large European ground-and space-based solar telescopes; (x) lay foundations for combined use of facilities around the world and in space; (xi) reinforce partnership with industry to promote technology transfer through existing networks; and (xii) dissemination activities towards society. The project involves all pertinent European research institutions, infrastructures, and data repositories. Together, these represent first-class facilities. The additional participation by private companies and non-European research institutions maximizes the impact on the world-wide scale. In particular, the project achievements will be of principal importance in defining the exploitation of the future 4-meter European Solar Telescope.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2013.5.1.2 | Award Amount: 10.50M | Year: 2014

The key objective of the M4CO2 project is to develop and prototype Mixed Matrix Membranes based on highly engineered Metal organic frameworks and polymers (M4) that outperform current technology for CO2 Capture (CO2) in pre- and post-combustion, meeting the energy and cost reduction targets of the European SET plan. By applying the innovative concept of M4 by a consortium of world key players, continuous separation processes of unsurpassed energy efficiency will be realized as a gas-liquid phase change is absent, reducing the energy penalty and resulting in smaller CO2 footprints. Further, gas separation membrane units are safer, environmentally friendly and, in general, have smaller physical footprints than other types of plants like amine stripping. In this way this project aims at a quantum leap in energy reduction for CO2 separation with associated cost efficiency and environmental impact reduction. The developed membranes will allow CO2 capture at prices below 15 /ton CO2 ( 10-15 /MWh), amply meeting the targets of the European SET plan (90% of CO2 recovery at a cost lower than 25/MWh). This will be underpinned experimentally as well as through conceptual process designs and economic projections by the industrial partners. By developing optimized M4s, we will combine: i) easy manufacturing, ii) high fluxes per unit volume and iii) high selectivity through advanced material tailoring. The main barriers that we will take away are the optimization of the MOF-polymer interaction and selective transport through the composite, where chemical compatibility, filler morphology and dispersion, and polymer rigidity all play a key role. Innovatively the project will be the first systematic, integral study into this type of membranes with investigations at all relevant length scales; including the careful design of the polymer(s) and the tuning of MOF crystals targeting the application in M4s and the design of the separation process.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRADEV-04-2016 | Award Amount: 9.95M | Year: 2017

The EOSCpilot project will support the first phase in the development of the European Open Science Cloud (EOSC) as described in the EC Communication on European Cloud Initiatives [2016]. It will establish the governance framework for the EOSC and contribute to the development of European open science policy and best practice; It will develop a number of pilots that integrate services and infrastructures to demonstrate interoperability in a number of scientific domains; and It will engage with a broad range of stakeholders, crossing borders and communities, to build the trust and skills required for adoption of an open approach to scientific research . These actions will build on and leverage already available resources and capabilities from research infrastructure and e-infrastructure organisations to maximise their use across the research community. The EOSCpilot project will address some of the key reasons why European research is not yet fully tapping into the potential of data. In particular, it will: reduce fragmentation between data infrastructures by working across scientific and economic domains, countries and governance models, and improve interoperability between data infrastructures by demonstrating how data and resources can be shared even when they are large and complex and in varied formats, In this way, the EOSC pilot project will improve the ability to reuse data resources and provide an important step towards building a dependable open-data research environment where data from publicly funded research is always open and there are clear incentives and rewards for the sharing of data and resources.


Berthier L.,CNRS Charles Coulomb Laboratory | Biroli G.,CEA Saclay Nuclear Research Center | Biroli G.,French National Center for Scientific Research
Reviews of Modern Physics | Year: 2011

A theoretical perspective is provided on the glass transition in molecular liquids at thermal equilibrium, on the spatially heterogeneous and aging dynamics of disordered materials, and on the rheology of soft glassy materials. We start with a broad introduction to the field and emphasize its connections with other subjects and its relevance. The important role played by computer simulations in studying and understanding the dynamics of systems close to the glass transition at the molecular level is given. The recent progress on the subject of the spatially heterogeneous dynamics that characterizes structural relaxation in materials with slow dynamics is reviewed. The main theoretical approaches are presented describing the glass transition in supercooled liquids, focusing on theories that have a microscopic, statistical mechanics basis. We describe both successes and failures and critically assess the current status of each of these approaches. The physics of aging dynamics in disordered materials and the rheology of soft glassy materials are then discussed, and recent theoretical progress is described. For each section, an extensive overview is given of the most recent advances, but we also describe in some detail the important open problems that will occupy a central place in this field in the coming years. © 2011 American Physical Society.


Krause M.,King's College London | Gautreau A.,French National Center for Scientific Research
Nature Reviews Molecular Cell Biology | Year: 2014

Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell migration in many normal and pathological situations. Lamellipodial protrusion is powered by actin polymerization, which is mediated by the actin-related protein 2/3 (ARP2/3)-induced nucleation of branched actin networks and the elongation of actin filaments. Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration. This Review highlights how the balance between actin filament branching and elongation, and between the positive and negative feedback loops that regulate these activities, determines lamellipodial persistence. Importantly, directional persistence, which results from lamellipodial persistence, emerges as a critical factor in steering cell migration. © 2014 Macmillan Publishers Limited.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-10-2014 | Award Amount: 6.49M | Year: 2015

Wide scale implementation of renewable energy will require growth in production of inexpensive, efficient energy storage systems. The extension of battery technology to large-scale storage will become necessary as intermittent renewable energy sources such as wind, solar and wave become more prevalent and integrated into electrical grid. Lithium-ion battery appears as quite mature for this application but its cost per mWh remains high in comparison to high temperature technology such as Zebra, which integrate low cost sodium base materials. Furthermore, as the use of large format lithium battery becomes widespread; increase demand for lithium commodity chemicals combined with geographically constrained Li mineral reserves will drive up prices. Based on the wide availability and low cost of sodium, ambient temperature sodium-based batteries have the potential for meeting large scale grid energy storage needs. In NAIADES we will demonstrate the feasibility of ambient temperature Na-ion battery from the knowledge and achievement that has been done at the laboratory scale, up to a module demonstration in a realistic application environment. Several European industrials, institutes and universities belonging to ALISTORE-ERI have decided to join their efforts to assess the Na-ion technology for stationary storage application through building a 1 kW modules system Na-ion cell which will serve as data base to demonstrate economical and public acceptance. These module prototypes will be developed to meet performances in a 1kW system in a cost-effective, sustainable and environmental-friendly manner. New energy policy will be developed to integer the Na-ion battery in the Smart Grid initiative and promote the penetration of renewable energy in the electric network.


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.9.7 | Award Amount: 8.27M | Year: 2013

The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible.\nThe objectives of DIADEMS are to develop\n- Wide field magnetic imagers with 1 nT sensivities,\n- Scanning probe magnetometer with sensitivity 10 nT and spatial resolution 10 nm,\n- Sensor heads with resolution 1 pT.\n\nTo reach such performances, DIADEMS will:\n- Use new theoretical protocols for sensing,\n- Develop ultrahigh purity diamond material with controlled single nitrogen implantation with a precision better than 5 nm,\n- Process scanning probe tips with diametre in the 20 nm range,\n- Transfer them to AFM cantilever, improve the emission properties of NV by coupling them with photonic cavities and photonic waveguides.\n\nDIADEMS outputs will demonstrate new ICT functionalities that will boost applications with high impact on society:\n- Calibration and optimization of write/read magnetic heads for future high capacity (3 Tbit per square inch) storage disk required for intense computing,\n- Imaging of electron-spin in graphene and carbon nanotubes for next generation of electronic components based on spintronics,\n- Non-invasive investigation of living neuronal networks to understand brain function,\n- Demonstration of magnetic resonance imaging of single spins allowing single protein imaging for medical research.\n\nDIADEMS aims at integrating the efforts of the European Community on NV centres to push further the limits of this promising technology and to keep Europes prominent position.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FoF-01-2014 | Award Amount: 3.67M | Year: 2014

MAShES proposes a breakthrough approach to image-based laser processing closed-loop control. Firstly, a compact, snapshot, and multispectral imaging system in the VIS/MWIR spectral range will be developed. This approach will enable a multimodal process observation that combines different imaging modalities. Moreover, it will enable an accurate estimation of temperature spatially resolved and independent on emissivity values, even for non-grey bodies and dissimilar materials. Secondly, a fully embedded approach to real time (RT) control will be adopted for efficient processing of acquired data and high speed -multiple inputs/ multiple outputs- closed-loop control. Thirdly, a cognitive control system based on the use of machine learning techniques applied to process quality diagnosis and self-adjustment of the RT control will be developed. As a result, a unified and compact embedded solution for RT-control and high speed monitoring will be developed that brings into play: - The accurate measurement of temperature distribution, - The 3D seam profile and 2D melt pool geometry, - The surface texture dynamics, and process speed. MAShES control will act simultaneously on multiple process variables, including laser power and modulation, process speed, powder and gas flow, and spot size. MAShES will deal with usability and interoperability issues for compliance with cyber-physical operation of the system in a networked and cognitive factory. Moreover, standardisation issues will be addressed regarding the processes and the control system and contributions in this regard are envisaged. MAShES will be designed under a modular approach, easily customizable for different laser processing applications in highly dynamic manufacturing scenarios. Validation and demonstration of prototypes of MAShES system will be done for laser welding and laser metal deposition (LMD) in operational scenarios at representative end-user facilities.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETOPEN-1-2014 | Award Amount: 2.80M | Year: 2015

The generation of ultrafast and intense light pulses is an underpinning technology across the electromagnetic spectrum enabling the study of fundamental light-matter interactions, as well as industrial exploitation in a plethora of applications across the physical, chemical and biological sciences. A benchmark system for such studies is the modelocked Ti:Sapphire laser, which has grown from being a laboratory curiosity to an essential tool in a broad range of application sectors. Beyond Ti:Sapphire systems, there have been impressive developments in semiconductor based devices for pulse generation in the optical range. These benefit from low system costs and are an enabling technology in new application domains including high speed communications. However, in the terahertz (THz) frequency range, with its proven applications in imaging, metrology and non-destructive testing, a semiconductor based technology platform for intense and short pulse generation has yet to be realised. Ultrafast excitation of photoconductive switches or nonlinear crystals offer only low powers, low frequency modulation or broadband emission with little control of the spectral bandwidth. In the ULTRAQCL project we will breakthrough this technological gap, using THz quantum cascade lasers (QCLs) as a foundational semiconductor device for generating intense and short THz pulses. QCLs are the only practical semiconductor system that offer gain at THz frequencies, hence making them suitable for pulse generation, with the bandstructure-by-design nature of QCLs allowing the frequency, bandwidth and pulse width to be entirely engineered. We will demonstrate: the first self-starting (passive) mode-locked THz QCL; the first hybrid modelocked THz QCL; the first gain-switched modelocked QCL; and, the first QCL-based THz ultrafast pulse amplifier. The ULTRAQCL project will implement these radical schemes for pulse generation enabling ultrafast QCLs to become a ubiquitous technology for the THz range.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.74M | Year: 2014

The main goal of the project is to provide excellent initial training to young researchers in the field of high energy particle physics, paving the road for new discoveries about the fundamental nature of the Universe at a time when new discoveries are expected, and when the new Standard Model of Particle Physics is going to be forged. The research goal of HiggsTools is the investigation of electroweak symmetry breaking. This question lies at the very frontier of knowledge of theoretical particle physics and phenomenology and, in fact, the primary goal of the Large Hadron Collider (LHC) at CERN is to unveil the mechanism of electroweak symmetry breaking. During the period of the network it is certain that the mechanism of electroweak symmetry breaking will be further decoded and that the theoretical ideas that date back to 1964 will either be confirmed or supplemented through the discovery of new additional particles that contribute to it. The experiments at the LHC have already made an impressive step forward in answering this question, by discovering a particle that is looking more and more like a Higgs boson. It remains an open question, however, whether this is the Higgs boson of the Standard Model of particle physics, or possibly the lightest of several bosons predicted in some theories that go beyond the Standard Model. Finding the answer to this question will take time. The outcome of the Higgs studies at the LHC will either carve our present understanding of electroweak interactions in stone or will be the beginning of a theoretical revolution. We will therefore create a cohort of 21 early-stage researchers (ESR) who will all be in the network for the same 36 month period and therefore be able to obtain the full benefit from the training provided by the network. We request 500 person-months for early-stage researchers (ESR) in accordance with the rules of the People FP7 Programme. The remaining 256 person-months will be funded from local sources.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.89M | Year: 2014

The worldwide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive. Novel therapeutic approaches are urgently required to deliver the well-documented existing drugs in an optimized fashion to: i) protect them toward degradation; ii) increase their bioavailability; iii) reduce toxic side effects; iv) increase patient compliance and iv) reduce treatment duration and related costs. In this sense, nanocarriers based on cyclodextrins (CDs) are particularly appealing for the delivery of antibiotics. This approach is of main interest for tuberculosis (TB), infections related to Salmonella Typhimurium, Staphyloccocus aureus and for species most frequently implicated in hospital infections such as enteric gram-negative rods. We will design and characterize CD-based nanocarriers, test their ability to encapsulate drugs, study their efficacy in vitro on bacteria and infected cells. The best formulation will be tested in vivo and scaled up. The objectives of the CycloN Hit project are to take full advantage of nanotechnology and of the high level interdisciplinary expertise of the partners to efficiently encapsulate and protect antibiotics in nanocarriers to combat resistant bacteria, and study the mechanisms in biological systems using state-of-the art techniques. This will be accomplished through a strong and demanding training program for 11 Early Stage and 5 young Experienced Researchers which will gather interdisciplinary expertise of 11 Full partners and 6 Associated partners, of which 7 are SMEs. Using the most recent advances in the nanomedicine field, the final goal of the CycloN Hit project is to bring to the preclinical studies an antibiotic formulation for the treatment of TB and more tailored alternative therapeutic approaches for other resistant microorganisms.

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