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Robinson R.,Freelance Science Writer
PLoS Biology | Year: 2015

The protein P0 has long been known to play a crucial role in holding together the myelin sheath that insulates peripheral nerves. A new study reveals that P0 is also important for organizing the nodes of Ranvier that occupy the gaps in the insulation. Read the Research Article. © 2015 Richard Robinson.


Sedwick C.,Freelance Science Writer
PLoS Biology | Year: 2015

A study of Anopheles gambiae mosquitoes shows that a molecule involved in defense against the malaria parasite also plays a role in male fertility, identifying a potential evolutionary trade-off between immunity and reproductive fitness. Read the Research Article. © 2015 Caitlin Sedwick.


Robinson R.,Freelance Science Writer
PLoS Biology | Year: 2015

HIV-1 is already known to have an extremely fast mutation rate, but a new study shows it to be more than two orders of magnitude higher than previously believed, and that this is largely due to host cytidine deaminases. Read the Research Article. © 2015 Richard Robinson.


Weaver J.,Freelance Science Writer
PLoS Biology | Year: 2015

A new study reveals that despite their limited visual acuity, 7-week-old babies have a surprisingly advanced visual cortex, including the ability to integrate visual and vestibular motion information. Read the accompanying Research Article. © 2015 Janelle Weaver.


Fanourgiakis J.,Freelance Science Writer | Kanoupakis E.,University of Crete
Expert Review of Pharmacoeconomics and Outcomes Research | Year: 2014

Greece from May 2010 has been following Troika's (European Commission, European Central Bank and International Monetary Fund) austere policies in all over the public finance sector. Troika's instructions which are adopted by the politicians resulted to depressed and weak citizens. The consequences in health care sector are becoming visible across the society. A big part of Greek's society is uninsured without any access to public health care system. The vulnerable social groups confront catastrophic health care expenditures and impoverishment with no social net protection. Greeks are paying the price of their irrational way of living. The current paper has gathered from the literature the early effects of the implementation of these policies on public health and healthcare. © Informa UK, Ltd.


Tzfira T.,Ben - Gurion University of the Negev | Weinthal D.,Ben - Gurion University of the Negev | Marton I.,Danziger Innovations Ltd. | Marton I.,Hebrew University of Jerusalem | And 3 more authors.
Plant Biotechnology Journal | Year: 2012

Genome editing, i.e. the ability to mutagenize, insert, delete and replace sequences, in living cells is a powerful and highly desirable method that could potentially revolutionize plant basic research and applied biotechnology. Indeed, various research groups from academia and industry are in a race to devise methods and develop tools that will enable not only site-specific mutagenesis but also controlled foreign DNA integration and replacement of native and transgene sequences by foreign DNA, in living plant cells. In recent years, much of the progress seen in gene targeting in plant cells has been attributed to the development of zinc finger nucleases and other novel restriction enzymes for use as molecular DNA scissors. The induction of double-strand breaks at specific genomic locations by zinc finger nucleases and other novel restriction enzymes results in a wide variety of genetic changes, which range from gene addition to the replacement, deletion and site-specific mutagenesis of endogenous and heterologous genes in living plant cells. In this review, we discuss the principles and tools for restriction enzyme-mediated gene targeting in plant cells, as well as their current and prospective use for gene targeting in model and crop plants. © 2012 The Authors. Plant Biotechnology Journal © 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd.


Fogg C.N.,Freelance Science Writer | Kovats D.E.,Freelance Science Writer
Bioinformatics (Oxford, England) | Year: 2015

UNLABELLED: The International Society for Computational Biology (ISCB; http://www.iscb.org) honors a senior scientist annually for his or her outstanding achievements with the ISCB Accomplishment by a Senior Scientist Award. This award recognizes a leader in the field of computational biology for his or her significant contributions to the community through research, service and education. Cyrus Chothia, an emeritus scientist at the Medical Research Council Laboratory of Molecular Biology and emeritus fellow of Wolfson College at Cambridge University, England, is the 2015 ISCB Accomplishment by a Senior Scientist Award winner.Chothia was selected by the Awards Committee, which is chaired by Dr Bonnie Berger of the Massachusetts Institute of Technology. He will receive his award and deliver a keynote presentation at 2015 Intelligent Systems for Molecular Biology/European Conference on Computational Biology in Dublin, Ireland, in July 2015.CONTACT: dkovats@iscb.org. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.


PubMed | Freelance Science Writer
Type: Comment | Journal: PLoS biology | Year: 2015

How does the bodys immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. Read the Research Article.


PubMed | Freelance science writer
Type: Review | Journal: Future science OA | Year: 2016

Metabolic profiling provides a powerful diagnostic tool complementary to genomics and proteomics. The pain, discomfort and probable iatrogenic injury associated with invasive or minimally invasive diagnostic methods, render them unsuitable in terms of patient compliance and participation. Metabolic profiling of biomatrices like urine, breath, saliva, sweat and feces, which can be collected in a painless manner, could be used for noninvasive diagnosis. This review article covers the noninvasive metabolic profiling studies that have exhibited diagnostic potential for diseases and disorders. Their potential applications are evident in different forms of cancer, metabolic disorders, infectious diseases, neurodegenerative disorders, rheumatic diseases and pulmonary diseases. Large scale clinical validation of such diagnostic methods is necessary in future.


PubMed | Freelance Science Writer
Type: Comment | Journal: PLoS biology | Year: 2015

A new study shows that synaptotagmins, known to regulate the fusion of neurotransmitter vesicles with synaptic membranes, are also needed for the prior tethering and priming of vesicles. Read the Research Article.

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