Frantsevych Institute for Problems of Material Science of NAS of Ukraine

Kiev, Ukraine

Frantsevych Institute for Problems of Material Science of NAS of Ukraine

Kiev, Ukraine
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Ivashchenko O.A.,Frantsevych Institute for Problems of Material Science of NAS of Ukraine | Uvarova I.V.,Frantsevych Institute for Problems of Material Science of NAS of Ukraine | Bahley N.M.,Frantsevych Institute for Problems of Material Science of NAS of Ukraine | Protsenko L.S.,Frantsevych Institute for Problems of Material Science of NAS of Ukraine | And 5 more authors.
Advanced Science Letters | Year: 2010

The kinetics of rifampicin release from nanopowders of hydroxyapitate and magnet-sensitive iron(III) oxide has been investigated in vitro. The contents of rifampicin and calcium (for hydroxyapitate) released from the nanopowders into a 0.9% NaCl solution within 10 days have been calculated. For both powders, a low level of rifampicin desorption from their surfaces was observed despite their high adsorption activity towards this preparation. Swelling of the rifampicin shell on particles/aggregates of the nanopowders after interaction with the 0.9% NaCl solution was revealed using the SEM analysis, and a scheme of this process is proposed. A marked shell swelling induces a conclusion that it can be dissolved under other conditions. Since desorption processes in the living organism may be supposed to be significantly (by tens of times) more intense compared to those in the physiological solution, the studied rifampicin-loaded nanopowders are promising as a depot of rifampicin in the organism, which can provide prolongation of the therapeutic action of this medical preparation. © 2010 American Scientific Publishers.

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